1990 Fiscal Year Final Research Report Summary
Clinical Features and Thyroid Histology of T3-Predominant Graves' Disease.
| Project/Area Number |
63570553
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内分泌・代謝学
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| Research Institution | Osaka Medical College |
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Principal Investigator |
TAKAMATSU Junta Osaka Medical College Assistant Professor., 医学部, 講師 (00140137)
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| Co-Investigator(Kenkyū-buntansha) |
OHSAWA Nakaaki Osaka Medical College, Professor., 医学部, 教授 (90010090)
NAKAI Masayo Osaka Medical College, Professor., 医学部, 教授 (42084832)
KITAOKA Haruko Osaka Medical College, Assistant, 医学部, 助手 (00214784)
HOSOYA Toichiro Chiba Univ. Pharmaceutical Sci., Professor., 薬学部, 教授 (10019648)
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| Project Period (FY) |
1988 – 1990
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| Keywords | Graves' disease / Triiodothyronine / Thyroid peroxidase / Thyroglobulin / Antithyroid drug / Radioiodine therapy / Thyroid epithelial cell / 5'-deiodinase |
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| Research Abstract |
When patients with T_3 -predominant Graves' disease were compared with usual Graves' disease patients,
1. Serum autoantibodies to thyroid peroxidase and TSH receptor were higher, while autoantibodies to thyroglobulin were not different. Thyroid-stimulating antibodies determined by cultured porcine thyroid cells were greater.
2. The goiter size was greater with more hyperplastic epithelium and more intracolloidal vacuoles.
3. Thyroid ^<123>I uptake was higher at 3h than 24h, suggesting enhanced thyroidal iodine turnover.
4. The degree of exophthalmos of Graves' disease was not different.
5. The activity of thyroid peroxidase was greater, while thyroglobulin content in the thyroid was smaller. Iodine content in thyroglobulin was also smaller. Thyroid 5' -deiodinase was greater, which may be one of the causes of increased serum T_3 relative to T_4.
6. An experiment of coupling reaction using individual microsomal fractions and pooled thyroglobulin showed relatively increased T_3 production than T_4, suggesting a unique characteristic of thyroid peroxidase in this disorder.
7. Clinical follow-up study showed that remission of hyperthyroidism was hardly obtained by antithyroid drug therapy. After subtotal thyroidectomy, the frequency of relapse was greater. While, after radioiodine therapy, the frequency of late-onset hypothyroidism was lower, indicating that radioiodine therapy is beneficial in this type of Graves' disease.
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[Publications] Takeda K, Takamatsu J, Sakane S, Ikegami Y, Majima M, Kitaoka H, Akagi H, Kobayashi A, Matsuzuka F, Kuma K.: "Determination of thyroid gland volume by a newly developed ultrasound technique." Bulletin of the Osaka Medical College. 34(1, 2). 61-67 (1988)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Sakane S, Takamatsu, J, Yoshida S, Takeda K, Ohsawa N, Katayama S, Kuma K, Kohno Y and Hosoya T.: "Clinical features and characteristics of thyroid function in Graves' disease patients with multiple edeomatous hyperplasia" Progress in Thyroidology 1989 (Proceedings of the 4th. Asia and Oceania Thyroid Association, eds : Lee M, Koh CS, Eastman CJ. Nagataki S). Korea Medical Publishing Co, Seoul, Korea. 403-406 (1990)
Description
「研究成果報告書概要(欧文)」より
