1991 Fiscal Year Final Research Report Summary
Effect of H2-blockers on hepatic regeneration
| Project/Area Number |
63570644
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Medical College of Oita |
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Principal Investigator |
金 良一 大分医科大学, 医学部, 講師 (40185905)
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| Co-Investigator(Kenkyū-buntansha) |
御手洗 義信 大分医科大学, 医学部, 助手 (70166049)
小林 迪夫 大分医科大学, 医学部, 教授 (20038657)
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| Project Period (FY) |
1988 – 1990
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| Keywords | H2-blocker / cimetidine / ranitidine / famotidine / liver regeneration / liver resection |
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| Research Abstract |
The effect of H2-blockers(cimetidine, ranitidine and famotidine)on liver regeneration was studied in rats. Cimetidine and ranitidine significantly inhibited hepatocyte proliferation after both types(70% and 90%)of hepatectomy. Although famotidine did not suppress liver regeneration in case of 70% hepatectomy, this agent also suppress the hepatocyte division after 90% ablation of the whole liver.
These data suggest that the inhibition of rat liver regeneration by these agents can be connected to the common properties of H2-receptor antagonist. On the other hand, we did no find hepatotoxic effects of H2-blockers, in terms of serum biochemistry, in the patients undergoing liver resection.
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