1990 Fiscal Year Final Research Report Summary
Modification Properties of Heparinized Apatite-Collagen Composites
| Project/Area Number |
63570915
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
補綴理工系歯学
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| Research Institution | Osaka University |
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Principal Investigator |
OKAZAKI Masayuki Osaka University Faculty of Dentistry, Dept. of Dent. Tech., Asst. Professor, 歯学部, 講師 (30107073)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGA Tamotsu Osaka University Faculty of Dentistry, Dept. of Dent. Tech., Asst. Professor, 歯学部, 講師 (30127310)
SOHMURA Taiji Osaka University Faculty of Dentistry, Dept. of Dent. Tech., Assistant, 歯学部, 助手 (10154692)
TERAOKA Fumio Osaka University Faculty of Dentistry, Dept. of Dent. Tech., Assistant, 歯学部, 助手 (00099805)
TAKAHASHI Junzo Osaka University Faculty of Dentistry, Dept. of Dent. Tech., Assoc. Professor, 歯学部, 助教授 (80029149)
KIMURA Hiroshi Osaka University Faculty of Dentistry, Dept. of Dent. Tech., Professor, 歯学部, 教授 (70036218)
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| Project Period (FY) |
1988 – 1990
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| Keywords | Apatite / Collagen / UV-irradiation / Composites / Heparin / BMP |
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| Research Abstract |
Hydroxyapatite is useful as an implantable material because of its good biocompatibility with surrounding tissues. Apatites have been applied in dentistry to fill up resorbed bone after tooth extraction and in defective areas of mandibular bone. However, most commercial hydroxyapatites are Sintered. Furthermore, conventional block-type hydroxyapatite is difficult to process into complex form and granular-type hydroxyapatite does not readily retain the required form. In this study to obtain better handling properties, carbonate-apatite with chemical composition and crystallinity similar to those of human bone, was synthesized and mixed with collagen solution. As a pellet, the composite was well biocompatible with soft and hard tissues. UV-irradiated samples kept their shape for longer periods. Furthermore, heparin was bound onto the composites to attach the bone morphological protein (BMP), which has an ability to induce bone formation. Analysis of heparin was carried out successfully. However, since the affinity of heparin for BMP was not enough to apply, further investigations are in progress.
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