1990 Fiscal Year Final Research Report Summary
Development of Novel Sensors Using Macrocyclic Polyamines as Sensory Elements
| Project/Area Number |
63840019
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Research Field |
分析・地球化学
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| Research Institution | Hokkaido University |
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Principal Investigator |
UMEZAWA Yoshio Hokkaido University, Faculty of Science, Professor, 理学部, 教授 (80011724)
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| Co-Investigator(Kenkyū-buntansha) |
KOIKE Tohru Hiroshima University School of Medicine, Lecturer, 医学部, 講師 (90186586)
KIMURA Eiichi Hiroshima University School of Medicine, Professor, 医学部, 教授 (30034010)
KATAOKA Masamitsu Hokkaido University, Faculty of Science, Instructor, 理学部, 助手 (40091425)
SUGAWARA Masao Hokkaido University, Faculty of Science, Instructor, 理学部, 助手 (50002176)
ODASHIMA Kazunori Hokkaido University, Faculty of Science, Lecturer, 理学部, 講師 (30152507)
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| Project Period (FY) |
1988 – 1989
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| Keywords | Macrocyclic Polyamine / Anion-selective Electrode / Adenosine Nucleotide / Dicarboxylic Acid / Potentiometry / Langmuir-Blodgett (LB) Membrane Sensor / Permeability Change / Cyclic Voltammetry |
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| Research Abstract |
A novel type of chemical sensors were constructed by using macrocyclic polyamines and related compounds as sensory elements. Potentiometric responses and selectivities were investigated and the following results were obtained, demonstrating a remarkable potentiality of this class of hosts as novel sensory elements.
(1) The macrocyclic polyamine liquid membrane electrodes showed strong potentiometric responses and marked selectivities for organic anions such as adenosine nucleotides and dicarboxylates. Potentiometric selectivities based on the magnitude of charge or the distance between charges within the guest molecule were observed.
(2) These electrodes also showed potentiometric responses to catechol and related compounds that are in the nonionic forms at the experimental pH. A systematic investigation demonstrated proton ejection as a possible mechanism for potentiometric responses to the uncharged molecules.
(3) Sapphyrin (expanded porphyrin) and cytosine-pendant triamine were examined as novel sensory elements for anion-selective liquid membrane electrodes.
(4) Anion responsive Langmuir-Blodgett (LB) membrane sensors were fabricated with polyamine hosts. Selectivities for organic anions were evaluated on the basis of analyte-induced permeability changes detected by cyclic voltammetry.
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