1990 Fiscal Year Final Research Report Summary
Treatment of SSPE by Liposome Fusion
| Project/Area Number |
63870104
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Research Field |
医学一般
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| Research Institution | Osaka University |
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Principal Investigator |
OKADA Y Inst. Mol. & Cellular Biol. Osaka Univ. Prof., 細胞工学センター, 教授 (30029756)
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| Co-Investigator(Kenkyū-buntansha) |
IKUTA F Inst. Brain Research, Niigata Univ. Prof., 脳研究所, 教授 (20018592)
ITOIGAWA M Faculty of Human Sciences, Osaka Univ. Prof., 人間科学部, 教授 (90027962)
UEDA S Res. Inst. Microbial Diseases, Osaka Univ. Prof., 微生物病研究所, 教授 (90068453)
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| Project Period (FY) |
1988 – 1990
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| Keywords | SSPE Virus / Liposome / Diphthebia Toxin Fragment A / Hamster / ハムスタ- / 日本猿 |
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| Research Abstract |
1) It has become possible to induce SSPE in hamsters by the introduction of SSPE virus infected hel cells intracerebrally. This try to treat SSPE has been done using this SSPE hamsters.
2) We have reported that siple liposomes containing diphtheria toxin fragment a can kill SSPE virus infected cells selectively. The liposomes was used for the treatment of SSPE hamsters.
3) It was successful to treat SSPE hamsters by the introduction of large volumes of the liposome suspension intracerebrally.
4) Observation about side effests induced by this treatment procedure is now going on using Japanese monkey.
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[Publications] Okuno, Y. Nakao, T. Ishida, N. Konno, T. Mizutani, H. Fukuyama, Y. Sato, T. Isomura, S. Ueda, S. Kitamura, I. and kaji, M.: "Incidence of Subacute Screlosing Panencepharitis following measles and measles vaccination in Japan." International J. Epidemiol.18. 684-689 (1989)
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