1990 Fiscal Year Final Research Report Summary
Research for Clarifying Aetiologic Factors of Periodontal Disease -the Role of Neutrophil-
| Project/Area Number |
63870115
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Aichigakuin University |
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Principal Investigator |
NOGUCHI Toshihide School of Dentistry, Aichigakuin University Professor, 歯学部, 教授 (50014262)
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| Co-Investigator(Kenkyū-buntansha) |
AOYAMA Yukihiko School of Dentistry, Aichigakuin University assistant, 歯学部, 助手 (80221034)
UMEMURA Masataka School of Dentistry, Aichigakuin University assistant, 歯学部, 助手 (70191921)
FUKUDA Mitsuo School of Dentistry, Aichigakuin University Lecturer, 歯学部, 講師 (40156790)
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| Project Period (FY) |
1988 – 1990
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| Keywords | Periodontal disease / Systemic factor / Neutrophil / G-CSF / Methotrexate / 好中球減少症 / GーCSF |
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| Research Abstract |
The purpose of the present study was to investigate the role of neutrophil on the development of periodontal disease. In animal study, the effect of a long-term methotrexate-induced neutropenia on the periodontal resion was histrogically and histometrically investigated.
In the experimental side of the animals, a suturing nylon thread was inserted into the interdental space between the left maxillary 1 st and 2 nd molars.
The right side of the animals of the same area was used as control side without doing any treatments. Then, the animals were divided equally into two groups.
The animals in one group were injected with 1.0mg/kg of methotrexate (MTX), whereas in the another group with no injection of M T X. Results obtained were as follows.
The numbers of white blood cell and neutrophil in the M T X injected group decreased remarkably from 3 to 9 weeks. The experimental side of non M T X injected group showed a slight gingival inflammation and moderate alveolar bone resorption at 7 and 9 weeks. In the experimental side of M T X- injected group, severe alveolar bone resorptions were found at 7 and 9 weeks.
The difference of bone resorption between these two groups was statistically significant. The results of the present study indicated that long-term M T X induced neutropenia changed the moderate periodontitis into the severe one. From the study of congenital neutropenia in human beings, it was also suggested that neutrophil play a important role for developing of periodontal disease.
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Research Products
(8 results)
