2017 Fiscal Year Annual Research Report
ヒトにおける頭蓋顔面形態形成および外鼻形態進化の解析
Publicly Offered Research
| Project Area | Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy |
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| Project/Area Number |
17H05296
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| Research Institution | Kyoto University |
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Principal Investigator |
山田 重人 京都大学, 医学研究科, 教授 (80432384)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Keywords | Craniofacial development / Human Embryology |
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| Outline of Annual Research Achievements |
Based on observations of human development, the shape of craniofacial structures drastically changes between the embryonic and the early fetal periods; therefore, this is considered as the most important period to elucidate the pathogenesis of congenital craniofacial anomalies. Recent developments in medical imaging modalities, e.g., magnetic resonance imaging (MRI) and/or computed tomography (CT), allowed us to study these small specimens in detail. In this study, we aimed to elucidate the morphogenesis of craniofacial structures in humans using imaging data. We applied landmark-based geometric morphometrics (GM) to analyze the shape change along with growth. In GM, the landmark coordinates of the shape are used as the variables without dividing the shape. Hence, the landmark configurations are preserved through this analysis, and the outcomes are represented as a shift of landmark coordinates. Visualization of shape change is the major advantage of geometric morphometrics.
In 2017, we applied linear approximation for the growth of the facial skeleton during late embryonic and early fetal periods and constructed a spatio-temporal statistical model correspondingly. Evaluating the tendency of growth patterns and showing the difference of the growth speed were effective. However, our results showed a non-linear trajectory of the development of the facial skeleton. In future, we would like to apply non-linear regression for the development of the facial skeleton and make a more precise spatio-temporal statistical model of the facial skeleton of the human fetus.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
平成29年度に予定していた 1.胚子、胎児の画像データ取得、2．頭蓋底、鼻中隔および顔面の形態形成の解析 について順調に解析が進んだだけでなく、海外（ブリティッシュ・コロンビア大学）との共同研究が始まるなど、予想以上に研究が進行しているため。
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| Strategy for Future Research Activity |
当初計画に含まれている「胚子、胎児の画像データ取得」「脳の発達過程と顔面の形態形成の関係性の解明」「三次元モデルの作成」に取り組みつつ、昨年度より始まった国際共同研究を推進し、人種間での比較にも取り組んでいく予定である。
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[Presentation] Relationship between self-perception and social factors in people with Down syndrome(Poster)2017
Author(s)
Miyake H, Yamada S, Fujii Y, Taniguchi-Ikeda M, Urano M, Ozasa Y, Kanai M, Fukushima A, Matsubara Y, Saito K, Konishi I.
Organizer
The 21h International Conference on Prenatal Diagnosis and Therapy
Int'l Joint Research
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[Presentation] Trends of genetic prenatal testing in Japan; 1998-2016(Poster)2017
Author(s)
Sasaki A, Sago H, Yoshihash H, Yamada S, Miyake H, Suzumori N, Takada F, Masuzaki H, Hirahara F, Kugu K, Konishi I.
Organizer
The 21h International Conference on Prenatal Diagnosis and Therapy
Int'l Joint Research
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[Presentation] Three dimensional utilization of human embryo specimens of the “Kyoto Collection” (Poster)2017
Author(s)
Makishima H, Katsube M, Miyazaki R, Yamaguchi Y, Kobayashi S, Uwabe C, Yamamoto A, Imai H, Yoneyama A, Funatomi T, Morimoto N, Takeda T, Nakatsukasa M, Kose K, Takakuwa T, Yamada S.
Organizer
第50回日本発生生物学会大会
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