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Steering group for the LipoQuality program project

Administrative Group

Project AreaQuality of lipids in biological systems
Project/Area Number 15H05897
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

ARITA Makoto  国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー (80292952)

Co-Investigator(Kenkyū-buntansha) 有田 正規  国立遺伝学研究所, 情報研究系, 教授 (10356389)
瀬藤 光利  浜松医科大学, 国際マスイメージングセンター, センター長 (20302664)
反町 典子  国立研究開発法人国立国際医療研究センター, その他部局等, 分子炎症制御プロジェクト長 (30217468)
藤本 豊士  順天堂大学, 医学(系)研究科(研究院), 特任教授 (50115929)
佐々木 雄彦  東京医科歯科大学, 難治疾患研究所, 教授 (50333365)
矢冨 裕  東京大学, 医学部附属病院, 教授 (60200523)
横溝 岳彦  順天堂大学, 医学(系)研究科(研究院), 教授 (60302840)
岡村 康司  大阪大学, 医学系研究科, 教授 (80201987)
杉本 幸彦  熊本大学, 大学院生命科学研究部(薬), 教授 (80243038)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥260,650,000 (Direct Cost: ¥200,500,000、Indirect Cost: ¥60,150,000)
Fiscal Year 2019: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2018: ¥36,530,000 (Direct Cost: ¥28,100,000、Indirect Cost: ¥8,430,000)
Fiscal Year 2017: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2016: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Fiscal Year 2015: ¥111,020,000 (Direct Cost: ¥85,400,000、Indirect Cost: ¥25,620,000)
Keywords研究支援センター / 領域事務局 / 脂質データベース / 広報活動 / 脂質 / 領域マネジメント / 領域会議の開催
Outline of Final Research Achievements

To understand the importance of Lipid Quality (LipoQuality) in biological systems, we developed a steering group including 5 research support centers that help to promote the LipoQuality program project efficiently by sharing methods, technologies and resources for all members including those who had little experience in lipid biology research. Especially the advanced lipidomics platform played important roles by developing the cutting-edge analytical technologies and bioinformatics to accelerate the whole program. Moreover, we organized annual project meetings, homepage, lipid database, newsletters, international symposia, workshop for young scientists, to prevail our research concept and achievements of this program project.

Academic Significance and Societal Importance of the Research Achievements

脂質分子の質的違い(リポクオリティの違い)に注目する研究は黎明期にあり、世界的に見ても個々の研究者が個別の研究を進めている状況であった。本総括班の形成によりもたらされた成果は、脂質の構造多様性を読み解くための革新的な分析・可視化技術を軸に、脂質分子種の多様性の生物学的意義についての学術的理解を与え、次世代のライフイノベーション研究に独創的な波及効果をもたらすことが期待される。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(1122 results)

All 2021 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (29 results) Journal Article (454 results) (of which Int'l Joint Research: 109 results,  Peer Reviewed: 334 results,  Open Access: 254 results,  Acknowledgement Compliant: 85 results) Presentation (598 results) (of which Int'l Joint Research: 207 results,  Invited: 280 results) Book (21 results) Remarks (10 results) Patent(Industrial Property Rights) (8 results) (of which Overseas: 1 results) Funded Workshop (2 results)

  • [Int'l Joint Research] Rockfeller University/Columbia University/Icahn School of Medicine at Mount Sinai(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Cambridge/University of Edinburgh/Babraham Institute(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Toronto(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] National University of Singapore(シンガポール)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Friedrich-Schiller-University Jena(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] National University of Singapore(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School/Univ. of California Davis/Johns Hopkins University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Laval University(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Imperial College London/Babraham Institute(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Mahidol University(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School/Univ. of California Davis/Johns Hopkins Univ. School of Med.(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Shanghai Jiao Tong University(中国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Babraham Institute/Imperial College London(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] チェコ科学アカデミー(チェコ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Univ. Groningen(Netherlands)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School/Univ. of California Davis/UC Irvine(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University College London/Babraham Institute/Imperial College London(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] IMBA(Austria)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Institute of Molecular Genetics, ASCR(チェコ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Lyon/Claude Bernard Lyon 1 University(France)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Univ. of Colorado/Mayo Clinic Alizona,/Harvard Medical School(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University College London/Cambridge/Babraham Inst(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Univ. of Monash/Women's & Children's Hospital(Australia)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] I2MC, I.G.B.M.C./Institut Pasteur de Lille(France)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Università degli Studi di Torino/University of Milan/Università degli Studi di Milano(Italy)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease2021

    • Author(s)
      Nakashima Y, Sakai Y, Mizuno Y, Furuno K, Hirono K, Takatsuki S, Suzuki H, Onouchi Y, Kobayashi T, Tanabe K, Hamase K, Miyamoto T, Aoyagi R, Arita M, Yamamura K, Tanaka T, Nishio H, Takada H, Ohga S, Hara T.
    • Journal Title

      Cardiovasc Res

      Volume: - Pages: 0-0

    • DOI

      10.1093/cvr/cvz305

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cysteinyl leukotriene metabolism of human eosinophils in allergic disease2020

    • Author(s)
      Miyata Jun、Fukunaga Koichi、Kawashima Yusuke、Ohara Osamu、Arita Makoto
    • Journal Title

      Allergol. Int.

      Volume: 69 Issue: 1 Pages: 28-34

    • DOI

      10.1016/j.alit.2019.06.002

    • NAID

      130007788667

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Homeostatic Function of Dermokine in the Skin Barrier and Inflammation.2020

    • Author(s)
      Akira Utsunomiya, Takenao Chino, Natsuko Utsunomiya, Vu Huy Luong, Atsushi Tokuriki, Tatsuro Naganuma, Makoto Arita, Kiyoshi Higashi, Koichi Saito, Noriyuki Suzuki, Ayako Ohara, Manabu Sugai, Koji Sugawara, Daisuke Tsuruta, Noritaka Oyama, Minoru Hasegawa
    • Journal Title

      J Invest Dermatol

      Volume: 140 Pages: 838-849

    • DOI

      10.1016/j.jid.2019.09.011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A lipidome atlas in MS-DIAL 4.2020

    • Author(s)
      Tsugawa H, Ikeda K, Takahashi M, Satoh A, Mori Y, Uchino H, Okahashi N, Yamada Y, Tada I, Bonini P, Higashi Y, Okazaki Y, Zhou Z, Zhu Z, Koelmel J, Cajka T, Fiehn O, Saito K, Arita M, Arita M.
    • Journal Title

      Nature Biotechnology

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice2020

    • Author(s)
      Kimura I, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K.
    • Journal Title

      Science

      Volume: 367 Pages: 6481-6481

    • DOI

      10.1126/science.aaw8429

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of Phosphatidylcholines Possessing Functionalized Acids at sn-2, and 13C-14N and 13C-31P Couplings in Their 13C NMR Spectra2020

    • Author(s)
      Morita Masao、Saito Shun、Shinohara Riku、Aoyagi Ryohei、Arita Makoto、Kobayashi Yuichi
    • Journal Title

      Synlett

      Volume: 31 Pages: 718-722

    • DOI

      10.1055/s-0039-1691584

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal omega-3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice2020

    • Author(s)
      Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, Ono S, Shibuya N, Saito E, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Tomonaga T, Kiyono H, Kabashima K, Arita M, and Kunisawa J
    • Journal Title

      Allergy

      Volume: - Pages: 0-0

    • DOI

      10.1111/all.14217

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition.2020

    • Author(s)
      Ishihara E, Nagaoka Y, Okuno T, Kofuji S, Ishigami-Yuasa M, Kagechika H, Kamimura K, Terai S, Yokomizo T, Sugimoto Y, Fujita Y, Suzuki A, Nishina H.
    • Journal Title

      FASEB J

      Volume: 25(3) Pages: 14528-14541

    • DOI

      10.1111/gtc.12750

    • NAID

      120006873037

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Induced Prostanoid Synthesis Regulates the Balance between Th1- and Th2-Producing Inflammatory Cytokines in the Thymus of Diet-Restricted Mice2020

    • Author(s)
      Razali N, Hohjoh H, Inazumi T, Maharjan BD, Nakagawa K, Konishi M, Sugimoto Y, Hasegawa H.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 43 Issue: 4 Pages: 649-662

    • DOI

      10.1248/bpb.b19-00838

    • NAID

      130007825267

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the selective EP2 receptor agonist omidenepag on adipocyte differentiation in 3T3-L1 cells2020

    • Author(s)
      Yamamoto Y, Taniguchi T, Inazumi T, Iwamura R, Yoneda K, Odani-Kawabata N, Matsugi T, Sugimoto Y, Shams NK.
    • Journal Title

      J. Ocul. Pharmacol. Ther.

      Volume: 36 Pages: 162-169

    • DOI

      10.1089/jop.2019.0079

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] プロスタグランジンD2レセプターのシグナル伝達2020

    • Author(s)
      稲住知明, 杉本幸彦
    • Journal Title

      臨床免疫・アレルギー科(科学評論社)

      Volume: 73 (13) Pages: 58-63

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Secreted phospholipase PLA2G2D contributes to metabolic health by mobilizing omega3 polyunsaturated fatty acids in WAT2020

    • Author(s)
      Sato H, Taketomi Y, Miki Y, Murase R, Yamamoto K, Murakami M.
    • Journal Title

      Cell Reports

      Volume: in press Pages: 0-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress2020

    • Author(s)
      Fujihira Haruhiko、Masahara-Negishi Yuki、Akimoto Yoshihiro、Hirayama Hiroto、Lee Hyeon-Cheol、Story Benjamin A.、Mueller William F.、Jakob Petra、Clauder-M?nster Sandra、Steinmetz Lars M.、Radhakrishnan Senthil K.、Kawakami Hayato、Kamada Yoshihiro、Miyoshi Eiji、Yokomizo Takehiko、Suzuki Tadashi
    • Journal Title

      Biochim. Biophys. Acta Mol. Basis Dis.

      Volume: 1866 Pages: 165588-165588

    • DOI

      10.1016/j.bbadis.2019.165588

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Loss of autophagy impairs physiological steatosis by accumulation of NCoR1.2020

    • Author(s)
      Takahashi SS, Sou YS, Saito T, Kuma A, Yabe T, Sugiura Y, Lee HC, Suematsu M, Yokomizo T, Koike M, Terai S, Mizushima N, Waguri S, Komatsu M.
    • Journal Title

      Life Sci Alliance.

      Volume: 3 Pages: 201900513-201900513

    • DOI

      10.26508/lsa.201900513

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing M?ller BDNF in Diabetic Retinopathy2020

    • Author(s)
      Suzumura Ayana、Kaneko Hiroki、Funahashi Yasuhito、Takayama Kei、Nagaya Masatoshi、Ito Seina、Okuno Toshiaki、Hirakata Toshiaki、Nonobe Norie、Kataoka Keiko、Shimizu Hideyuki、Namba Rina、Yamada Kazuhisa、Ye Fuxiang、Ozawa Yoko、Yokomizo Takehiko、Terasaki Hiroko
    • Journal Title

      Diabetes

      Volume: 69 Pages: 724-735

    • DOI

      10.2337/db19-0550

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of propofol hydroxyl group in 5-lipoxygenase recognition2020

    • Author(s)
      Yuki Koichi、Bu Weiming、Eckenhoff Roderic G.、Yokomizo Takehiko、Okuno Toshiaki
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: In press Pages: 909-914

    • DOI

      10.1016/j.bbrc.2020.03.037

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Leukotriene B4 receptor type 2 (BLT2) accelerates the healing of intestinal lesions by promoting epithelial cell proliferation2020

    • Author(s)
      Matsumoto Y, Matsuya Y, Kano N, Amagase K, Saeki K, Matsumoto K, Yokomizo T, Kato S
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 373 Pages: 1-9

    • DOI

      10.1124/jpet.119.263145

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aging exacerbates high‐fat diet‐induced steatohepatitis through alteration in hepatic lipid metabolism in mice2020

    • Author(s)
      Ishizuka Kei、Kon Kazuyoshi、Lee‐Okada Hyeon‐Cheol、Arai Kumiko、Uchiyama Akira、Yamashina Shunhei、Yokomizo Takehiko、Ikejima Kenichi
    • Journal Title

      journal of gastroenterology and hepatology

      Volume: In press Pages: 1437-1448

    • DOI

      10.1111/jgh.15006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ESCRT machinery mediates selective microautophagy of endoplasmic reticulum.2020

    • Author(s)
      Schafer J, Schessner JP, Tsuju T, Funaya C, Bircham PW, Schaeff K, Ruffini G, Fujimoto T, Schuck S.
    • Journal Title

      EMBO J

      Volume: 39

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Possible involvement of PS-PLA1 and lysophosphatidylserine receptor (LPS1) in hepatocellular carcinoma.2020

    • Author(s)
      Uranbileg B, Kurano M, Sato M, Ikeda H, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 2659-2659

    • DOI

      10.1038/s41598-020-59590-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism.2020

    • Author(s)
      Nakawatari K, Kurano M, Araki O, Nishikawa M, Shimamoto S, Igarashi K, Aoki J, Murakami M, Yatomi Y.
    • Journal Title

      Clinica Chimica Acta

      Volume: 503 Pages: 99-106

    • DOI

      10.1016/j.cca.2020.01.011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine-1-Phosphate.2020

    • Author(s)
      Kurano M, Tsukamoto K, Shimizu T, Kassai H, Nakao K, Aiba A, Hara M, Yatomi Y.
    • Journal Title

      Diabetes

      Volume: 69 Pages: 867-881

    • DOI

      10.2337/db19-0811

    • NAID

      40022523253

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of the lysophosphatidic acid and its precursor lysophosphatidylcholine levels in spinal cord stenosis: A study using a rat cauda equina compression model.2020

    • Author(s)
      Uranbileg B, Ito N, Kurano M, Saigusa D, Saito R, Uruno A, Kano K, Ikeda H, Yamada Y, Sumitani M, Sekiguchi M, Aoki J, Yatomi Y.
    • Journal Title

      Sci Rep

      Volume: 9 Pages: 16578-16578

    • DOI

      10.1038/s41598-019-52999-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of urinary sphingolipids using liquid chromatography-tandem mass spectrometry in diabetic nephropathy.2020

    • Author(s)
      Morita Y, Kurano M, Sakai E, Nishikawa T, Nishikawa M, Sawabe M, Aoki J, Yatomi Y.
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 11 Pages: 441-449

    • DOI

      10.1111/jdi.13154

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tenascin C in the Tumor-Nerve Microenvironment Enhances Perineural Invasion and Correlates With Locoregional Recurrence in Pancreatic Ductal Adenocarcinoma.2020

    • Author(s)
      Furuhashi S, Sakaguchi T, Murakami T, Fukushima M, Morita Y, Ikegami K, Kikuchi H, Setou M, Takeuchi H.
    • Journal Title

      Pancreas

      Volume: 49 Pages: 442-454

    • DOI

      10.1097/mpa.0000000000001506

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engineering an enhanced voltage-sensing phosphatase2020

    • Author(s)
      Kawanabe Akira、Mizutani Natsuki、Polat Onur K.、Yonezawa Tomoko、Kawai Takafumi、Mori Masayuki X.、Okamura Yasushi
    • Journal Title

      J Gen Physiol.

      Volume: 152

    • DOI

      10.1085/jgp.201912491

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A common signaling pathway leading to degranulation in mast cells and its regulation by CCR1 ligand.2020

    • Author(s)
      Chang HW, Kanegasaki S, Jin F, Deng Y, You Z, Chang JH, Kim DY, Timilshina M, Kim JR, Lee YJ, Toyama-Sorimachi N, Tsuchiya T.
    • Journal Title

      Allergy

      Volume: in press Pages: 0-0

    • DOI

      10.1111/all.14186

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Soluble SLAMF7 Promotes the Growth of Myeloma Cells via Homophilic Interaction with Surface SLAMF7.2020

    • Author(s)
      Kikuchi J, Hori M, Iha H, Toyama-Sorimachi N, Hagiwara S, Kuroda Y, Koyama D, Izumi T, Yasui H, Suzuki A, Furukawa Y.
    • Journal Title

      Leukemia

      Volume: 34 Pages: 180-195

    • DOI

      10.1038/s41375-019-0525-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] リポクオリティの違いを捉えるノンターゲット脂質解析2019

    • Author(s)
      内野春希、津川裕司、有田誠
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 269 Pages: 1238-1244

    • Related Report
      2019 Annual Research Report
  • [Journal Article] アレルギー疾患における好酸球の脂肪酸代謝異常2019

    • Author(s)
      宮田純、福永興壱、有田誠
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 269 Pages: 1008-1014

    • Related Report
      2019 Annual Research Report
  • [Journal Article] ω3脂肪酸クオリティによる疾患制御2019

    • Author(s)
      有田誠
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 269 Pages: 967-970

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 脂質クオリティ研究の基礎と臨床(企画・編集)2019

    • Author(s)
      有田誠
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 269

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 腸内細菌のリポクオリティと生体制御2019

    • Author(s)
      安田柊、岡橋伸幸、上田政宏、有田誠
    • Journal Title

      The Lipid(メディカルレビュー社)

      Volume: 30 Pages: 393-399

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 脂肪酸クオリティによる炎症の制御2019

    • Author(s)
      有田誠
    • Journal Title

      The Lipid(メディカルレビュー社)

      Volume: 30 Pages: 355-361

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 生体制御にかかわる多彩なリポクオリティ 基礎から病態まで(企画・編集)2019

    • Author(s)
      有田誠
    • Journal Title

      The Lipid(メディカルレビュー社)

      Volume: 30

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis2019

    • Author(s)
      Ishihara Tomoaki、Yoshida Mio、Arita Makoto
    • Journal Title

      Int Immunol

      Volume: - Pages: 559-567

    • DOI

      10.1093/intimm/dxz001

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipidomics needs more standardization2019

    • Author(s)
      Lipidomics Standards Initiative Consortium
    • Journal Title

      Nature Metabolism

      Volume: 1 Pages: 745-747

    • DOI

      10.1038/s42255-019-0094-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mass Spectrometry Data Repository Enhances Novel Metabolite Discoveries with Advances in Computational Metabolomics2019

    • Author(s)
      Tsugawa Hiroshi、Satoh Aya、Uchino Haruki、Cajka Tomas、Arita Makoto、Arita Masanori
    • Journal Title

      Metabolites

      Volume: 9 Pages: 119-119

    • DOI

      10.3390/metabo9060119

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis2019

    • Author(s)
      Miyata Jun、Fukunaga Koichi、Kawashima Yusuke、Watanabe Takashi、Saitoh Akina、Hirosaki Tomomi、Araki Yasutomo、Kikawada Toru、Betsuyaku Tomoko、Ohara Osamu、Arita Makoto
    • Journal Title

      Allergy

      Volume: 74 Pages: 1113-1124

    • DOI

      10.1111/all.13726

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preferential Incorporation of Administered Eicosapentaenoic Acid Into Thin-Cap Atherosclerotic Plaques2019

    • Author(s)
      Sato Tomohito、Horikawa Makoto、Takei Shiro、Yamazaki Fumiyoshi、Ito Takashi K.、Kondo Takeshi、Sakurai Takanobu、Kahyo Tomoaki、Ikegami Koji、Sato Shumpei、Sato Ryota、Jinno Yasutaka、Kawano Hiroyuki、Naoe Satoko、Arita Makoto、Kashiwagi Yukiyasu、Setou Mitsutoshi
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 39 Pages: 1802-1816

    • DOI

      10.1161/atvbaha.119.313093

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids2019

    • Author(s)
      Miyamoto J, Igarashi M, Watanabe K, Karaki SI, Mukouyama H, Kishino S, Li X, Ichimura A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Miki T, Ogawa J, Drucker DJ, Arita M, Itoh H, Kimura I
    • Journal Title

      Nat Commun.

      Volume: 10 Pages: 1-15

    • DOI

      10.1038/s41467-019-11978-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of Lipid Profiles after Dietary Intake of Polyunsaturated Fatty Acids Using Integrated Untargeted and Targeted Lipidomics2019

    • Author(s)
      Naoe Satoko、Tsugawa Hiroshi、Takahashi Mikiko、Ikeda Kazutaka、Arita Makoto
    • Journal Title

      Metabolites

      Volume: 9 Pages: 241-241

    • DOI

      10.3390/metabo9100241

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary omega-3 fatty acid dampens allergic rhinitis via eosinophilic production of the anti-allergic lipid mediator 15-hydroxyeicosapentaenoic acid in mice2019

    • Author(s)
      Sawane K, Nagatake T, Hosomi K, Hirata SI, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Fukumitsu S, Aida K, Tomonaga T, Arita M, and Kunisawa J
    • Journal Title

      Nutrients

      Volume: 11 Pages: 2868-2868

    • DOI

      10.3390/nu11122868

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice2019

    • Author(s)
      Shishikura Kyosuke、Kuroha Sayoko、Matsueda Shinnosuke、Iseki Hachiro、Matsui Takeshi、Inoue Azusa、Arita Makoto
    • Journal Title

      FASEB J

      Volume: 33 Pages: 14194-14203

    • DOI

      10.1096/fj.201901074r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface2019

    • Author(s)
      Toyoda Y, Morimoto K, Suno R, et al.
    • Journal Title

      Nature chemical biology

      Volume: 15 Pages: 18-26

    • DOI

      10.1038/s41589-018-0131-3

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche2019

    • Author(s)
      Kitadate Y., Jorg DJ., Tokue M,. Maruyama A., Ishikawa R., Tsuchiya S., Segi-Nishida E., Nakagawa T., Uchida A., Kimura-Yoshida C., Mizuno S., Sugiyama F., Azami T., Ema M., Noda C., Kobayashi S., Matsuo I., Kanai Y., Nagasawa T., Sugimoto Y., Takahashi S., Simons BD., Yoshida S.
    • Journal Title

      Cell Stem Cell.

      Volume: 24 Pages: 1-2

    • DOI

      10.1016/j.stem.2018.11.013

    • NAID

      120007128265

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming2019

    • Author(s)
      Muraoka Naoto、Nara Kaori、Tamura Fumiya、Kojima Hidenori、Yamakawa Hiroyuki、Sadahiro Taketaro、Miyamoto Kazutaka、Isomi Mari、Haginiwa Sho、Tani Hidenori、Kurotsu Shota、Osakabe Rina、Torii Satoru、Shimizu Shigeomi、Okano Hideyuki、Sugimoto Yukihiko、Fukuda Keiichi、Ieda Masaki
    • Journal Title

      Nat Commun

      Volume: 10 Pages: 1-15

    • DOI

      10.1038/s41467-019-08626-y

    • NAID

      120007128245

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Essential role of prostaglandin E2 and the EP3 receptor in lymphatic vessel development during zebrafish embryogenesis2019

    • Author(s)
      Iwasaki R, Tsuge K, Kishimoto K, Hayashi Y, Iwaana T, Hohjoh H, Inazumi T, Kawahara A, Tsuchiya S, Sugimoto Y.
    • Journal Title

      Sci. Rep.

      Volume: 9 Pages: 7650-7650

    • DOI

      10.1038/s41598-019-44095-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases.2019

    • Author(s)
      Tsuge K, Inazumi T, Shimamoto A, Sugimoto Y.
    • Journal Title

      International immunology

      Volume: 印刷中 Pages: 1-10

    • DOI

      10.1093/intimm/dxz021

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis.2019

    • Author(s)
      Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, Nakajima S, Matsumoto R, Nakano Y, Otsuka M, Iwakura Y, Grinberg-Bleyer Y, Ghosh S, Sugimoto Y, Guttman-Yassky E, Krueger JG, Kabashima K.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 144(4) Pages: 1036-1049

    • DOI

      10.1016/j.jaci.2019.06.019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional Hierarchy of Uterotonics Required for Successful Parturition in Mice2019

    • Author(s)
      Yoshida M, Takayanagi Y, Ichino-Yamashita A, Sato K, Sugimoto Y, Kimura T, Nishimori K.
    • Journal Title

      Endocrinology

      Volume: 160 Pages: 2800-2810

    • DOI

      10.1210/en.2019-00499

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] シクロオキシゲナーゼ経路によるリポクオリティ認識2019

    • Author(s)
      稲住知明, 杉本幸彦
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 269 (1) Pages: 1002-1007

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Novel functions of Phospholipase A2s: Overview.2019

    • Author(s)
      Murakami M.
    • Journal Title

      Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

      Volume: 1864 Pages: 763-765

    • DOI

      10.1016/j.bbalip.2019.02.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Group IID, IIE, IIF and III secreted phospholipase A2s.2019

    • Author(s)
      Murakami M, Miki Y, Sato H, Murase R, Taketomi Y, Yamamoto K.
    • Journal Title

      Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

      Volume: 1864 Pages: 803-818

    • DOI

      10.1016/j.bbalip.2018.08.014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function2019

    • Author(s)
      Hirabayashi Tetsuya、Murakami Makoto、Kihara Akio
    • Journal Title

      Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

      Volume: 1864 Pages: 803-818

    • DOI

      10.1016/j.bbalip.2018.09.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling.2019

    • Author(s)
      Mori A, Hatano T, Inoshita T, Shiba-Fukushima K, Koinuma T, Meng H, Kubo SI, Spratt S, Cui C, Yamashita C, Miki Y, Yamamoto K, Hirabayashi T, Murakami M, Takahashi Y, Shindou H, Nonaka T, Hasegawa M, Okuzumi A, Imai Y, Hattori N.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 116(41) Pages: 20689-20699

    • DOI

      10.1073/pnas.1902958116

    • NAID

      120007132272

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The orphan nuclear receptor NR4A1 promotes FcepsilonRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.2019

    • Author(s)
      Jin F, Li X. Deng Y, Timilshina M. Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW
    • Journal Title

      Allergy

      Volume: 74 Pages: 1145-1156

    • DOI

      10.1111/all.13702

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 脂質メディエーターとイムノメタボリズム2019

    • Author(s)
      佐藤弘泰、村上誠
    • Journal Title

      The Lipid(メディカルレビュー社)

      Volume: 30 (2) Pages: 61-71

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 脂質メディエーターが繋ぐ臓器連関と動的恒常性2019

    • Author(s)
      村上誠
    • Journal Title

      実験医学(羊土社)

      Volume: 37 (7) Pages: 149-155

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 脂質メディエーターとアレルギー2019

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      実験医学(羊土社)

      Volume: 37 (10) Pages: 88-95

    • Related Report
      2019 Annual Research Report
  • [Journal Article] ホスホリパーゼA2 による代謝と疾患の制御2019

    • Author(s)
      村上誠
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 269 (13) Pages: 1024-1028

    • Related Report
      2019 Annual Research Report
  • [Journal Article] リピドミクスから見えてきた酸化脂肪酸によるマスト細胞の制御機構2019

    • Author(s)
      嶋中雄太、村上誠
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 270 (5) Pages: 401-407

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice2019

    • Author(s)
      Kamata Mariko、Amano Hideki、Ito Yoshiya、Fujita Tomoe、Otaka Fumisato、Hosono Kanako、Kamata Kouju、Takeuchi Yasuo、Yokomizo Takehiko、Shimizu Takao、Majima Masataka
    • Journal Title

      PLoS One

      Volume: 14 Pages: 202842-202842

    • DOI

      10.1371/journal.pone.0202842

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses.2019

    • Author(s)
      Tamada K, Nakajima S, Ogawa N, Inada M, Shibasaki H, Sato A, Takasawa R, Yoshimori A, Suzuki Y, Watanabe N, Oyama T, Abe H, Inoue S, Abe T, Yokomizo T, Tanuma S.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 511 Pages: 665-670

    • DOI

      10.1016/j.bbrc.2019.01.136

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyclooxygenase inhibition in mice heightens adaptive‐ and innate‐type responses against inhaled protease allergen and IL ‐332019

    • Author(s)
      Maruyama Natsuko、Takai Toshiro、Kamijo Seiji、Suchiva Punyada、Ohba Mai、Takeshige Tomohito、Suzuki Mayu、Hara Mutsuko、Matsuno Kei、Harada Sonoko、Harada Norihiro、Nakae Susumu、Sudo Katsuko、Okuno Toshiaki、Yokomizo Takehiko、Ogawa Hideoki、Okumura Ko、Ikeda Shigaku
    • Journal Title

      Allergy.

      Volume: 印刷中 Pages: 2237-2240

    • DOI

      10.1111/all.13831

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] BLT1 Mediates Commensal Bacteria-Dependent Innate Immune Signals to Enhance Antigen-Specific Intestinal IgA Responses2019

    • Author(s)
      Nagatake T, Hirata SI, Koga T, Kuroda E, Kobari S, Suzuki H, Hosomi K, Matsumoto N, Yanrismet Y, Shimojou M, Morimoto S, Sasaki F, Ishii KJ, Yokomizo T, Kunisawa J.
    • Journal Title

      Mucosal Immunol

      Volume: 12 Pages: 1082-1082

    • DOI

      10.1038/s41385-019-0175-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Alternative Pathway to Leukotriene B4 Enantiomers Involving a 1,8-Diol-Forming Reaction of an Algal Oxylipin.2019

    • Author(s)
      Jagusch H., Werner M., Okuno T., Yokomizo T., Werz O., Pohnert G.
    • Journal Title

      Organic Letters

      Volume: 21 Pages: 4667-4670

    • DOI

      10.1021/acs.orglett.9b01554

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis.2019

    • Author(s)
      Lee H. C., Tominaga M., Yasukawa K., Ohba M., Takahashi N., Honda K., Okuno T., Takamori K., Yokomizo T.
    • Journal Title

      Journal of Dermatological Science

      Volume: 95 Pages: 130-133

    • DOI

      10.1016/j.jdermsci.2019.07.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction.2019

    • Author(s)
      Koutsogiannaki S., Hou L., Babazada H., Okuno T., Blazon-Brown N., Soriano S. G., Yokomizo T., Yuki K.
    • Journal Title

      The FASEB Journal

      Volume: 33 Pages: 12668-12679

    • DOI

      10.1096/fj.201901360r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system.2019

    • Author(s)
      Okuno T., Koutsogiannaki S., Hou L., Bu W., Ohto U., Eckenhoff R. G., Yokomizo T., Yuki K.
    • Journal Title

      The FASEB Journal

      Volume: 33 Pages: 14528-14541

    • DOI

      10.1096/fj.201901570r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation.2019

    • Author(s)
      Zhang, S Kohira, Y Oerita, S Ishimine, M Kobayashi, T Chua, S M B Nakaoka, H Inoue, I Hino, O Yokomizo, T Fukunaga, T H.C., L-O
    • Journal Title

      BPB Rep

      Volume: 2 Pages: 130-133

    • NAID

      130007940492

    • Related Report
      2019 Annual Research Report
  • [Journal Article] ロイコトリエンB4第1受容体は滲出型加齢黄斑変性症の新規治療標的となる2019

    • Author(s)
      佐々木文之 横溝岳彦
    • Journal Title

      実験医学

      Volume: 37 Pages: 411-414

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Lysophosphatidylinositol‐acyltransferase‐1 is involved in cytosolic Ca2+ oscillations in macrophages2019

    • Author(s)
      Takemasu Shinya、Ito Masaki、Morioka Shin、Nigorikawa Kiyomi、Kofuji Satoshi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Matsuoka Isao、Sasaki Junko、Sasaki Takehiko、Hazeki Kaoru
    • Journal Title

      Genes to cells

      Volume: - Pages: 1-11

    • DOI

      10.1111/gtc.12681

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites2019

    • Author(s)
      McCormick Barry, Craig Helen E., Chu Julia Y., Carlin Leo M., Canel Marta, Wollweber Florian, Toivakka Matilda, Michael Melina, Astier Anne L., Norton Laura, Lilja Johanna, Felton Jennifer M., Sasaki Takehiko, Ivaska Johanna, Hers Ingeborg, Dransfield Ian, Rossi Adriano G., Vermeren Sonja
    • Journal Title

      The Journal of Immunology

      Volume: 203 Pages: 1579-1588

    • DOI

      10.4049/jimmunol.1900443

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency2019

    • Author(s)
      Nishio Miki、Miyachi Yousuke、Otani Junji、Tane Shoji、Omori Hirofumi、Ueda Fumihito、Togashi Hideru、Sasaki Takehiko、Mak Tak Wah、Nakao Kazuwa、Fujita Yasuyuki、Nishina Hiroshi、Maehama Tomohiko、Suzuki Akira
    • Journal Title

      FASEB JOURNAL

      Volume: 33 Pages: 5548-5560

    • DOI

      10.1096/fj.201802005r

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection2019

    • Author(s)
      Fujioka Y, Satoh AO, Horiuchi K, Fujioka M, Tsutsumi K, Sasaki J, Nepal P, Kashiwagi S, Paudel S, Nishide S, Nanbo A, Sasaki T, Ohba Y
    • Journal Title

      Cell Struct. Funct.

      Volume: 印刷中 Issue: 1 Pages: 61-74

    • DOI

      10.1247/csf.19001

    • NAID

      130007636814

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.2019

    • Author(s)
      Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T, Sasaki T.
    • Journal Title

      Sci Rep.

      Volume: 9 Pages: 13257-13257

    • DOI

      10.1038/s41598-019-49744-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polarized PtdIns(4,5)P2distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility2019

    • Author(s)
      Kawai Takafumi、Miyata Haruhiko、Nakanishi Hiroki、Sakata Souhei、Morioka Shin、Sasaki Junko、Watanabe Masahiko、Sakimura Kenji、Fujimoto Toyoshi、Sasaki Takehiko、Ikawa Masahito、Okamura Yasushi
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 116 Pages: 26020-26026

    • DOI

      10.1073/pnas.1916867116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細胞膜での蛋白質-イノシトールリン脂質相互作用へのアシル基の関与2019

    • Author(s)
      佐々木雄彦, 山本詠士, 佐々木純子
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 269 Pages: 1068-1072

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution2019

    • Author(s)
      Tsuji Takuma、Cheng Jinglei、Tatematsu Tsuyako、Ebata Aoi、Kamikawa Hiroki、Fujita Akikazu、Gyobu Sayuri、Segawa Katsumori、Arai Hiroyuki、Taguchi Tomohiko、Nagata Shigekazu、Fujimoto Toyoshi
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 116 Pages: 13368-13373

    • DOI

      10.1073/pnas.1822025116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma2019

    • Author(s)
      Yamaguchi T, Hayashi M, Ida L, Yamamoto M, Lu C, Kajino T, Cheng J, Nakatochi M, Isomura H, Yamazaki M, Suzuki M, Fujimoto T, Takahashi T.
    • Journal Title

      Oncogene

      Volume: - Pages: 5142-5157

    • DOI

      10.1038/s41388-019-0785-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Definition of phosphoinositide distribution in the nanoscale2019

    • Author(s)
      Tsuji Takuma、Takatori Sho、Fujimoto Toyoshi
    • Journal Title

      Curr Op Cell Biol

      Volume: 57 Pages: 33-39

    • DOI

      10.1016/j.ceb.2018.10.008

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Duo in a mystical realm - nuclear lipid droplets and the inner nuclear membrane.2019

    • Author(s)
      Soltysik K, Ohsaki Y, Fujimoto T.
    • Journal Title

      Contact

      Volume: 2 Pages: 1-11

    • DOI

      10.1177/2515256419896965

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 電子顕微鏡を用いた観察2019

    • Author(s)
      辻琢磨、藤本豊士
    • Journal Title

      実験医学(別冊)「脂質解析ハンドブック」

      Volume: - Pages: 260-267

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 核内脂肪滴の形成機序と機能の解明2019

    • Author(s)
      大崎雄樹、藤本豊士
    • Journal Title

      The Lipid

      Volume: 30 Pages: 346-351

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Regulation of plasma glycero-lysophospholipid levels by lipoprotein metabolism.2019

    • Author(s)
      Kurano M, Kano K, Hara M, Tsukamoto K, Aoki J, Yatomi Y.
    • Journal Title

      Biochemical Journal

      Volume: 476 Pages: 3565-3581

    • DOI

      10.1042/bcj20190498

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum phosphatidylserine-specific phospholipase A1 as a novel biomarker for monitoring systemic lupus erythematosus disease activity.2019

    • Author(s)
      Sawada T, Kurano M, Shirai H, Iwasaki Y, Tahara K, Hayashi H, Igarashi K, Fujio K, Aoki J, Yatomi Y.
    • Journal Title

      International Journal of Rheumatic Diseases

      Volume: 22 Pages: 2059-2066

    • DOI

      10.1111/1756-185x.13689

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox state of albumin affects its lipid mediator binding characteristics.2019

    • Author(s)
      Kurano M, Yasukawa K, Ikeda H, Aoki J, Yatomi Y.
    • Journal Title

      Free Radical Research

      Volume: 53 Pages: 892-900

    • DOI

      10.1080/10715762.2019.1641603

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Lysophospholipid Measurement in Cerebrospinal Fluid Samples using Liquid Chromatography-Tandem Mass Spectrometry.2019

    • Author(s)
      Morita Y, Kurano M, Sakai E, Nishikawa M, Sawabe M, Aoki J, Yatomi Y.
    • Journal Title

      Lipids

      Volume: 54 Pages: 487-500

    • DOI

      10.1002/lipd.12175

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum GM3(d18:1-16:0) and GM3(d18:1-24:1) levels may be associated with lymphoma: An exploratory study with haematological diseases.2019

    • Author(s)
      Nishikawa M, Kurano M, Nitta T, Kanoh H, Inokuchi JI, Yatomi Y.
    • Journal Title

      Scientific Reports

      Volume: 19 Pages: 6308-6308

    • DOI

      10.1038/s41598-019-42817-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] リポクオリティと臨床検査2019

    • Author(s)
      蔵野 信,矢冨 裕
    • Journal Title

      The Lipid(メディカルレビュー社)

      Volume: 30 Pages: 417-423

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 臨床検査におけるリポクオリティ2019

    • Author(s)
      蔵野 信,矢冨 裕
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 269 Pages: 1251-1256

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Creating a Reliable Mass Spectral-Retention Time Library for All Ion Fragmentation-Based Metabolomics2019

    • Author(s)
      Tada Ipputa、Tsugawa Hiroshi、Meister Isabel、Zhang Pei、Shu Rie、Katsumi Riho、Wheelock Craig E.、Arita Masanori、Chaleckis Romanas
    • Journal Title

      Metabolites

      Volume: 9 Pages: 251-251

    • DOI

      10.3390/metabo9110251

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A cheminformatics approach to characterize metabolomes in stable-isotope-labeled organisms2019

    • Author(s)
      Tsugawa Hiroshi、Nakabayashi Ryo、Mori Tetsuya、Yamada Yutaka、Takahashi Mikiko、Rai Amit、Sugiyama Ryosuke、Yamamoto Hiroyuki、Nakaya Taiki、Yamazaki Mami、Kooke Rik、Bac-Molenaar Johanna A.、Oztolan-Erol Nihal、Keurentjes Joost J. B.、Arita Masanori、Saito Kazuki
    • Journal Title

      Nat Methods

      Volume: 16 Pages: 295-298

    • DOI

      10.1038/s41592-019-0358-2

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dietary Intake of Green Nut Oil or DHA Ameliorates DHA Distribution in the Brain of a Mouse Model of Dementia Accompanied by Memory Recovery.2019

    • Author(s)
      Takeyama E, Islam A, Watanabe N, Tsubaki H, Fukushima M, Mamun MA, Sato S, Sato T, Eto F, Yao I, Ito TK, Horikawa M, Setou M.
    • Journal Title

      Nutrients

      Volume: 11

    • DOI

      10.3390/nu11102371

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unsupervised machine learning using an imaging mass spectrometry dataset automatically reassembles grey and white matter.2019

    • Author(s)
      Nampei M, Horikawa M, Ishizu K, Yamazaki F, Yamada H, Kahyo T, Setou M.
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 13213-13213

    • DOI

      10.1038/s41598-019-49819-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Change in Brain Plasmalogen Composition by Exposure to Prenatal Undernutrition Leads to Behavioral Impairment of Rats2019

    • Author(s)
      Hino K, Udagawa J, et al.
    • Journal Title

      J Neurosci

      Volume: 39 Pages: 7689-7702

    • DOI

      10.1523/jneurosci.2721-18.2019

    • NAID

      120006712956

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of potential anti-aging beverage Pru, a traditional Cuban refreshment, by desorption electrospray innization-mass spectrometry and FTICR tandem mass spectrometry.2019

    • Author(s)
      Mamun MA, Valdes Gonzalez-T, Islam A, Sato T,Sato S, Ito KT, Horikawa M, Yamazaki Fm Alarcon RC, Ido T, Setou M.
    • Journal Title

      Journal of Food and Drug Analysis

      Volume: 27 Pages: 833-840

    • DOI

      10.1016/j.jfda.2019.05.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] リポクオリティの可視化2019

    • Author(s)
      菊島健児、瀬藤光利
    • Journal Title

      The Lipid

      Volume: 30 Pages: 67-74

    • Related Report
      2019 Annual Research Report
  • [Journal Article] イメージングMS2019

    • Author(s)
      佐藤智仁、佐藤駿平、堀川誠、瀬藤光利
    • Journal Title

      実験医学別冊

      Volume: - Pages: 268-276

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 質量顕微鏡法2019

    • Author(s)
      荒牧修平、佐藤智仁、堀川誠、華表友暁、瀬藤光利
    • Journal Title

      炎症と免疫

      Volume: 27 Pages: 79-82

    • NAID

      130001888663

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 量子科学技術の生体応用2019

    • Author(s)
      荒牧修平、瀬藤光利
    • Journal Title

      脳神経外科

      Volume: 17 Pages: 719-731

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 組織リポクオリティのマスイメージング2019

    • Author(s)
      櫻井孝信、瀬藤光利
    • Journal Title

      週刊 医学のあゆみ

      Volume: 269 Pages: 1245-1249

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 細胞と組織の質量分析イメージング2019

    • Author(s)
      大山壮歩、堀川誠、櫻井孝信、瀬藤光利
    • Journal Title

      化学工業

      Volume: 70

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Functional analysis of a double-point mutation in the KCNJ2 gene identified in a family with Andersen-Tawil syndrome.2019

    • Author(s)
      Fukumura S, Yamauchi K, Kawanabe A, Yamamoto A, Nakaza M, Kubota T, Kato S, Sasaki R, Okamura Y, Takahashi M.
    • Journal Title

      Journal of the Neurological Sciences.

      Volume: 407 Pages: 0-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct functional properties of two electrogenic isoforms of the SLC 34 Na‐Pi cotransporter2019

    • Author(s)
      Mizutani Natsuki、Okochi Yoshifumi、Okamura Yasushi
    • Journal Title

      Physiol. Reports

      Volume: 7

    • DOI

      10.14814/phy2.14156

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Real-time functional analysis of Hv1 channel in neutrophils: a new approach from zebrafish model2019

    • Author(s)
      Ratanayotha Adisorn、Kawai Takafumi、Okamura Yasushi
    • Journal Title

      American Journal of Physiology

      Volume: 316 Pages: 819-831

    • DOI

      10.1152/ajpregu.00326.2018

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of coupling to voltage sensors in voltage-evoked cellular signals2019

    • Author(s)
      Okamura Y, Okochi Y.
    • Journal Title

      Proc Jpn Acad Ser B Phys Biol Sci.

      Volume: 95 Pages: 111-135

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic structural rearrangements and functional regulation of voltage-sensing phosphatase2019

    • Author(s)
      Sakata S .Okamura Y.
    • Journal Title

      J. Physiol.

      Volume: 597 Pages: 29-40

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ホスフォイノシチドによるチャネル・トランスポーターの制御2019

    • Author(s)
      岡村康司、水谷夏希、大河内善史
    • Journal Title

      医学のあゆみ

      Volume: 269 Pages: 1108-1113

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Cullin‐3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2‐positive breast cancer cells2019

    • Author(s)
      Murakami Akari、Maekawa Masashi、Kawai Katsuhisa、Nakayama Jun、Araki Nobukazu、Semba Kentaro、Taguchi Tomohiko、Kamei Yoshiaki、Takada Yasutsugu、Higashiyama Shigeki
    • Journal Title

      Cancer Sci.

      Volume: 110 Pages: 650-661

    • DOI

      10.1111/cas.13899

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FAM48A mediates compensatory autophagy induced by proteasome impairment.2019

    • Author(s)
      Arata Y, Watanabe A, Motosugi R, Iemura SI, Natsume T, Mukai K, Taguchi T, Hirayama S, Hamazaki J, Murata S.
    • Journal Title

      Genes to Cells

      Volume: 24 Pages: 559-568

    • DOI

      10.1111/gtc.12708

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Innate immunity signalling and membrane trafficking2019

    • Author(s)
      Taguchi Tomohiko、Mukai Kojiro
    • Journal Title

      Curr. Opin. Cell Biol.

      Volume: 59 Pages: 1-7

    • DOI

      10.1016/j.ceb.2019.02.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9.2019

    • Author(s)
      Tanigawa K, Maekawa M, Kiyoi T, Nakayama J, Kitazawa R, Kitazawa S, Semba K, Taguchi T, Akita S, Yoshida M, Ishimaru K, Watanabe Y, Higashiyama S.
    • Journal Title

      Journal of Cellular Physiology

      Volume: in press Pages: 17280-17294

    • DOI

      10.1002/jcp.28346

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] STING palmitoylation as a therapeutic target2019

    • Author(s)
      Hansen Anne Louise、Mukai Kojiro、Schopfer Francisco J.、Taguchi Tomohiko、Holm Christian K.
    • Journal Title

      Cell Mol Immunol

      Volume: 16 Pages: 236-241

    • DOI

      10.1038/s41423-019-0205-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Type I interferon limits mast-cell-mediated anaphylaxis by controlling secretory-granule homeostasis.2019

    • Author(s)
      Kobayashi T, Shimabukuro-Demoto S, Tsutsui H, Toyama-Sorimachi N
    • Journal Title

      PLoS Biol.

      Volume: 17

    • DOI

      10.1371/journal.pbio.3000530

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] オルガネラを基軸とした炎症制御機構の理解と疾患治療戦略2019

    • Author(s)
      反町典子、Nguyen Tien Dat、小林俊彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 72 Pages: 313-321

    • Related Report
      2019 Annual Research Report
  • [Journal Article] リソソーム局在型アミノ酸トランスポーターを標的とした免疫難病治療への挑戦2019

    • Author(s)
      反町典子、小林俊彦
    • Journal Title

      医学のあゆみ

      Volume: 271 Pages: 17-25

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis2019

    • Author(s)
      Soltysik K., Ohsaki Y., Tatematsu T., Cheng J., Fujimoto T.
    • Journal Title

      Nature Communications

      Volume: 10 Pages: 473-473

    • DOI

      10.1038/s41467-019-08411-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autotaxin and soluble IL-2 receptor concentrations in cerebrospinal fluids are useful for the diagnosis of central nervous system invasion caused by haematological malignancies2019

    • Author(s)
      Shimura Takuya、Kurano Makoto、Morita Yoshifumi、Yoshikawa Naoyuki、Nishikawa Masako、Igarashi Koji、Shimamoto Satoshi、Aoki Junken、Yatomi Yutaka
    • Journal Title

      Annals of Clinical Biochemistry: International Journal of Laboratory Medicine

      Volume: 56 Pages: 240-246

    • DOI

      10.1177/0004563218818197

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein M suppresses the phenotypes of IgA nephropathy in hyper-IgA mice2019

    • Author(s)
      Kurano Makoto、Tsuneyama Koichi、Morimoto Yuki、Nishikawa Masako、Yatomi Yutaka
    • Journal Title

      The FASEB Journal

      Volume: 33 Pages: 5181-5195

    • DOI

      10.1096/fj.201801748r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum autotaxin levels are associated with Graves’ disease2019

    • Author(s)
      Nojiri Takahiro、Kurano Makoto、Araki Osamu、Nakawatari Kazuki、Nishikawa Masako、Shimamoto Satoshi、Igarashi Koji、Kano Kuniyuki、Aoki Junken、Kihara Shinji、Murakami Masami、Yatomi Yutaka
    • Journal Title

      Endocr J

      Volume: - Issue: 5 Pages: 409-422

    • DOI

      10.1507/endocrj.ej18-0451

      10.1507/endocrj.EJ18-0451

    • NAID

      130007655267

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular mechanisms of coupling to voltage sensors in voltage-evoked cellular signals2019

    • Author(s)
      OKAMURA Yasushi、OKOCHI Yoshifumi
    • Journal Title

      Proc. Jpn. Acad., Ser. B

      Volume: 95 Issue: 3 Pages: 111-135

    • DOI

      10.2183/pjab.95.010

    • NAID

      130007610041

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dynamic structural rearrangements and functional regulation of voltage‐sensing phosphatase2019

    • Author(s)
      Sakata S and Okamura Y
    • Journal Title

      The Journal of Physiology

      Volume: 597 Pages: 29-40

    • DOI

      10.1113/jp274113

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NaV チャネル全史-細菌からヒトまで-2019

    • Author(s)
      西野 敦雄,岡村 康司
    • Journal Title

      生化学

      Volume: 91 Pages: 1-14

    • Related Report
      2018 Annual Research Report
  • [Journal Article] アレルギー性好酸球における脂質代謝異常のメタボローム解析2019

    • Author(s)
      宮田純、有田誠
    • Journal Title

      臨床免疫・アレルギー科(科学評論社)

      Volume: 71 Pages: 34-40

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Discovery of lipid biomarkers correlated with disease progression in clear cell renal cell carcinoma using desorption electrospray ionization imaging mass spectrometry2019

    • Author(s)
      Tamura Keita、Horikawa Makoto、Sato Shumpei、Miyake Hideaki、Setou Mitsutoshi
    • Journal Title

      Oncotarget

      Volume: 10 Pages: 1688-1703

    • DOI

      10.18632/oncotarget.26706

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MALDI imaging mass spectrometry revealed atropine distribution in the ocular tissues and its transit from anterior to posterior regions in the whole-eye of rabbit after topical administration2019

    • Author(s)
      Mori Naoto、Mochizuki Takaharu、Yamazaki Fumiyoshi、Takei Shiro、Mano Hidetoshi、Matsugi Takeshi、Setou Mitsutoshi
    • Journal Title

      PLOS ONE

      Volume: 14 Pages: 0211376-0211376

    • DOI

      10.1371/journal.pone.0211376

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysophosphatidic acid precursor levels decrease and an arachidonic acid-containing phosphatidylcholine level increases in the dorsal root ganglion of mice after peripheral nerve injury2019

    • Author(s)
      Mihara Yuki、Horikawa Makoto、Sato Shumpei、Eto Fumihiro、Hanada Mitsuru、Banno Tomohiro、Arima Hideyuki、Ushirozako Hiroki、Yamada Tomohiro、Xu Dongmin、Okamoto Ayako、Yamazaki Fumiyoshi、Takei Shiro、Omura Takao、Yao Ikuko、Matsuyama Yukihiro、Setou Mitsutoshi
    • Journal Title

      Neuroscience letters

      Volume: 698 Pages: 69-75

    • DOI

      10.1016/j.neulet.2018.12.035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary omega-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses.2019

    • Author(s)
      Hirakata T., Lee H. C., Ohba M., Saeki K., Okuno T., Murakami A., Matsuda A., Yokomizo T.
    • Journal Title

      The FASEB Journal

      Volume: 33 Pages: 3392-3403

    • DOI

      10.1096/fj.201801805r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing2019

    • Author(s)
      Matsuda Akira、Asada Yosuke、Suita Naomasa、Iwamoto Satoshi、Hirakata Toshiaki、Yokoi Norihiko、Ohkawa Yasuyuki、Okada Yukinori、Yokomizo Takehiko、Ebihara Nobuyuki
    • Journal Title

      J Allergy Clin Immunol

      Volume: 143 Pages: 1610-1614

    • DOI

      10.1016/j.jaci.2018.11.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autophagy regulates lipid metabolism through selective turnover of NCoRl2019

    • Author(s)
      Saito Tetsuya、Kuma Akiko、Sugiura Yuki、Ichimura Yoshinobu、Obata Miki、Kitamura Hiroshi、Okuda Shujiro、Lee Hyeon-Cheol、Ikeda Kazutaka、Kanegae Yumi、Saito Izumu、Auwerx Johan、Motohashi Hozumi、Suematsu Makoto、Soga Tomoyoshi、Yokomizo Takehiko、Waguri Satoshi、Mizushima Noboru、Komatsu Masaaki
    • Journal Title

      Nature Communication

      Volume: 10 Issue: 1 Pages: 1567-1567

    • DOI

      10.1038/s41467-019-08829-3

    • NAID

      120006884308

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lipids and lipid domains of the yeast vacuole2018

    • Author(s)
      Tsuji Takuma、Fujimoto Toyoshi
    • Journal Title

      Biochemical Society transactions

      Volume: 46 Pages: 1047-1054

    • DOI

      10.1042/bst20180120

    • NAID

      120006554476

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient RNA polymerase II-dependent transcription2018

    • Author(s)
      Sobol Margarita、Krausova Alzbeta、Yildirim Sukriye、Kalasova Ilona、Faberova Veronika、Vrkoslav Vladimir、Philimonenko Vlada、Marasek Pavel、Pastorek Lukas、Capek Martin、Lubovska Zuzana、Ulicna Livia、Tsuji Takuma、Lisa Miroslav、Cvacka Josef、Fujimoto Toyoshi、Hozak Pavel
    • Journal Title

      Journal of cell science

      Volume: 131

    • DOI

      10.1242/jcs.211094

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3.2018

    • Author(s)
      Kimura H, Arasaki K, Ohsaki Y, Fujimoto T, Ohtomo T, Yamada J, Tagaya M.
    • Journal Title

      J. Lipid Res.

      Volume: in press Pages: 805-819

    • DOI

      10.1194/jlr.m081679

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UBXN3B positively regulates STING-mediated antiviral immune responses2018

    • Author(s)
      Yang Long、Wang Leilei、Ketkar Harshada、Ma Jinzhu、Yang Guang、Cui Shuang、Geng Tingting、Mordue Dana G.、Fujimoto Toyoshi、Cheng Gong、You Fuping、Lin Rongtuan、Fikrig Erol、Wang Penghua
    • Journal Title

      Nature Communications

      Volume: 9 Pages: 2329-2329

    • DOI

      10.1038/s41467-018-04759-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy2018

    • Author(s)
      Sugo Masashi、Kimura Hana、Arasaki Kohei、Amemiya Toshiki、Hirota Naohiko、Dohmae Naoshi、Imai Yuzuru、Inoshita Tsuyoshi、Shiba‐Fukushima Kahori、Hattori Nobutaka、Cheng Jinglei、Fujimoto Toyoshi、Wakana Yuichi、Inoue Hiroki、Tagaya Mitsuo
    • Journal Title

      EMBO J.

      Volume: 37

    • DOI

      10.15252/embj.201798899

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunoelectron Microscopy of Gangliosides2018

    • Author(s)
      Tsuji Takuma、Fujita Akikazu、Fujimoto Toyoshi
    • Journal Title

      Immunoelectron Microscopy of Gangliosides

      Volume: 1804 Pages: 231-239

    • DOI

      10.1007/978-1-4939-8552-4_11

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膜リン脂質クオリティの可視化2018

    • Author(s)
      辻琢磨、藤本豊士
    • Journal Title

      実験医学

      Volume: 36 Pages: 89-96

    • Related Report
      2018 Annual Research Report
  • [Journal Article] プロスタグランジンE2による炎症病態制御機構2018

    • Author(s)
      稲住知明, 杉本幸彦.
    • Journal Title

      細胞.

      Volume: 50 Pages: 118-121

    • Related Report
      2018 Annual Research Report
  • [Journal Article] リポクオリティの違いに基づくプロスタノイドのがん疾患制御2018

    • Author(s)
      土屋創健, 杉本幸彦.
    • Journal Title

      実験医学

      Volume: 36 Pages: 1675-1680

    • Related Report
      2018 Annual Research Report
  • [Journal Article] プロスタグランジンE2による炎症,免疫調節機構.2018

    • Author(s)
      稲住知明, 杉本幸彦.
    • Journal Title

      臨床免疫・アレルギー科. 炎症と免疫.

      Volume: 70 Pages: 216-220

    • Related Report
      2018 Annual Research Report
  • [Journal Article] プロスタノイド受容体を介した免疫・炎症応答亢進機構.2018

    • Author(s)
      土屋創健, 杉本幸彦
    • Journal Title

      炎症と免疫.

      Volume: 26 Pages: 375-379

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Epithelial TRAF6 drives IL-17?mediated psoriatic inflammation2018

    • Author(s)
      Matsumoto Reiko、Dainichi Teruki、Tsuchiya Soken、Nomura Takashi、Kitoh Akihiko、Hayden Matthew S.、Ishii Ken J.、Tanaka Mayuri、Honda Tetsuya、Egawa Gyohei、Otsuka Atsushi、Nakajima Saeko、Sakurai Kenji、Nakano Yuri、Kobayashi Takashi、Sugimoto Yukihiko、Kabashima Kenji
    • Journal Title

      JCI Insight.

      Volume: 3 Pages: 1-14

    • DOI

      10.1172/jci.insight.121175

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preventive effect of <i>Dioscorea japonica</i> on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E<sub>2</sub> synthetic pathway2018

    • Author(s)
      Tsukayama I, Toda K, Takeda Y, Mega T, Tanaka M, Kawakami Y, Takahashi Y, Kimoto M, Yamamoto K, Miki Y, Murakami M, Suzuki-Yamamoto T.
    • Journal Title

      J. Clin. Biochem. Nutr.

      Volume: 62 Issue: 2 Pages: 139-147

    • DOI

      10.3164/jcbn.17-54

    • NAID

      130006407477

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] イノシトールリン脂質におけるリン酸化クオリティ制御の病態生理学的意義2018

    • Author(s)
      高須賀俊輔、佐々木雄彦
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36 Pages: 1591-1607

    • Related Report
      2018 Annual Research Report
  • [Journal Article] TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis2018

    • Author(s)
      Morioka Shin、Nigorikawa Kiyomi、Okada Eri、Tanaka Yoshimasa、Kasuu Yoshihiro、Yamada Miho、Kofuji Satoshi、Takasuga Shunsuke、Nakanishi Hiroki、Sasaki Takehiko、Hazeki Kaoru
    • Journal Title

      Journal of Cell Science

      Volume: 131 Pages: 213272-213272

    • DOI

      10.1242/jcs.213272

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metabolic determinants of sensitivity to phosphatidylinositol 3-kinase pathway inhibitor in small-cell lung carcinoma2018

    • Author(s)
      Makinoshima H et al.
    • Journal Title

      Cancer Res

      Volume: - Pages: 2179-2190

    • DOI

      10.1158/0008-5472.can-17-2109

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PIKfyve regulates melanosome biogenesis2018

    • Author(s)
      Liggins Marc C.、Flesher Jessica L.、Jahid Sohail、Vasudeva Priya、Eby Victoria、Takasuga Shunsuke、Sasaki Junko、Sasaki Takehiko、Boissy Raymond E.、Ganesan Anand K.
    • Journal Title

      PLOS Genetics

      Volume: 14

    • DOI

      10.1371/journal.pgen.1007290

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 脂肪酸クオリティに着目した新しい臨床検査への可能性.2018

    • Author(s)
      蔵野 信,矢冨 裕.
    • Journal Title

      医学のあゆみ

      Volume: 264 Pages: 979-983

    • Related Report
      2018 Annual Research Report
  • [Journal Article] リゾリン脂質と病態2018

    • Author(s)
      蔵野 信,矢冨 裕.
    • Journal Title

      細胞

      Volume: 50 Pages: 132-135

    • Related Report
      2018 Annual Research Report
  • [Journal Article] リポクオリティに注目した臨床検査の可能性2018

    • Author(s)
      蔵野 信,矢冨 裕.
    • Journal Title

      実験医学

      Volume: 36 Pages: 1767-1772

    • Related Report
      2018 Annual Research Report
  • [Journal Article] ヒト疾患におけるリゾリン脂質メディエーター.2018

    • Author(s)
      蔵野 信,矢冨 裕.
    • Journal Title

      生化学

      Volume: 90 Pages: 643-650

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P2 and S1P3 Expression in Colon Cancer.2018

    • Author(s)
      Uranbileg B, Nishikawa T, Ikeda H, Kurano M, Sato M, Saigusa D, Aoki J, Watanabe T, Yatomi Y.
    • Journal Title

      Clinical Colorectal Cancer

      Volume: Nov 21. pii: Pages: 30369-9

    • DOI

      10.1016/j.clcc.2017.11.004

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma2018

    • Author(s)
      Kurano Makoto、Miyagaki Tomomitsu、Miyagawa Takuya、Igarashi Koji、Shimamoto Satoshi、Ikeda Hitoshi、Aoki Junken、Sato Shinichi、Yatomi Yutaka
    • Journal Title

      The Journal of Dermatology

      Volume: - Pages: 571-579

    • DOI

      10.1111/1346-8138.14278

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay2018

    • Author(s)
      Ohkawa Ryunosuke、Kurano Makoto、Sakai Noboru、Kishimoto Tatsuya、Nojiri Takahiro、Igarashi Koji、Hosogaya Shigemi、Ozaki Yukio、Dohi Tomotaka、Miyauchi Katsumi、Daida Hiroyuki、Aoki Junken、Okubo Shigeo、Ikeda Hitoshi、Tozuka Minoru、Yatomi Yutaka
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 1-12

    • DOI

      10.1038/s41598-018-23009-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.2018

    • Author(s)
      Kurano M, Tsuneyama K, Morimoto Y, Shimizu T, Jona M, Kassai H, Nakao K, Aiba A, Yatomi Y
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 印刷中 Pages: 1021-1035

    • DOI

      10.1055/s-0038-1641750

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the metabolism of apolipoprotein M and sphingosine 1-phosphate by hepatic PPARγ activity2018

    • Author(s)
      Kurano Makoto、Ikeda Hitoshi、Iso-O Naoyuki、Hara Masumi、Tsukamoto Kazuhisa、Yatomi Yutaka
    • Journal Title

      Biochemical Journal

      Volume: 475 Pages: 2009-2024

    • DOI

      10.1042/bcj20180052

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased aqueous autotaxin and lysophosphatidic acid levels are potential prognostic factors after trabeculectomy in different types of glaucoma2018

    • Author(s)
      Igarashi Nozomi、Honjo Megumi、Kurano Makoto、Yatomi Yutaka、Igarashi Koji、Kano Kuniyuki、Aoki Junken、Aihara Makoto
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 11304-11304

    • DOI

      10.1038/s41598-018-29649-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dihydro-sphingosine 1-phosphate interacts with carrier proteins in a manner distinct from that of sphingosine 1-phosphate2018

    • Author(s)
      Mishima Yuko、Kurano Makoto、Kobayashi Tamaki、Nishikawa Masako、Ohkawa Ryunosuke、Tozuka Minoru、Yatomi Yutaka
    • Journal Title

      Bioscience Reports

      Volume: 38

    • DOI

      10.1042/bsr20181288

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study2018

    • Author(s)
      Kuwajima Ken、Sumitani Masahiko、Kurano Makoto、Kano Kuniyuki、Nishikawa Masako、Uranbileg Baasanjav、Tsuchida Rikuhei、Ogata Toru、Aoki Junken、Yatomi Yutaka、Yamada Yoshitsugu
    • Journal Title

      PLOS ONE

      Volume: 13 Pages: 0207310-0207310

    • DOI

      10.1371/journal.pone.0207310

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysophospholipids in laboratory medicine2018

    • Author(s)
      YATOMI Yutaka、KURANO Makoto、IKEDA Hitoshi、IGARASHI Koji、KANO Kuniyuki、AOKI Junken
    • Journal Title

      Proc. Jpn. Acad., Ser. B

      Volume: 94 Issue: 10 Pages: 373-389

    • DOI

      10.2183/pjab.94.025

    • NAID

      130007529097

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リポクオリティ認識プローブの開発と応用2018

    • Author(s)
      田口友彦,小林俊彦,反町典子,仁木隆裕
    • Journal Title

      実験医学

      Volume: 36 Pages: 217-221

    • Related Report
      2018 Annual Research Report
  • [Journal Article] エンドリソソーム環境に依存した自然免疫応答偏向2018

    • Author(s)
      反町典子、小林俊彦
    • Journal Title

      医学のあゆみ

      Volume: 265 Pages: 1094-1100

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 炎症・感染応答を担うオルガネラ2018

    • Author(s)
      小林俊彦、向井康治朗、田口友彦、反町典子
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 69 Pages: 99-106

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice2018

    • Author(s)
      Watanabe-Takahashi, M., Yamasaki, S., Murata, M., Kano, F., Motoyama, J., Yamate, J., Omi, J., Sato, W., Ukai, H., Shimasaki, K., Ikegawa, M., Tamura-Nakano, M., Yanoshita, R., Nishino, Y., Miyazawa, A., Natori, Y., Toyama-Sorimachi, N., Nishikawa, N.
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 10776-10776

    • DOI

      10.1038/s41598-018-29128-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolutionary History of Voltage-Gated Sodium Channels.2018

    • Author(s)
      Nishino Atsuo, Okamura Yasushi
    • Journal Title

      Handbook of Experimental Pharmacology, Springer

      Volume: Epub ahead of print Pages: 1-30

    • DOI

      10.1007/164_2017_70

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of divalent cation permeability by heterologous expression of a voltage sensor domain2018

    • Author(s)
      Arima Hiroki、Tsutsui Hidekazu、Sakamoto Ayako、Yoshida Manabu、Okamura Yasushi
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Biomembranes

      Volume: 1860 Pages: 981-990

    • DOI

      10.1016/j.bbamem.2018.01.004

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Conservation of the Ca2+-permeability through the voltage sensor domain of mammalian CatSper subunit2018

    • Author(s)
      Arima Hiroki、Tsutsui Hidekazu、Okamura Yasushi
    • Journal Title

      Channels

      Volume: 12 Pages: 240-248

    • DOI

      10.1080/19336950.2018.1476791

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tracking the sarcoplasmic reticulum membrane voltage in muscle with a FRET biosensor2018

    • Author(s)
      Sanchez Colline、Berthier Christine、Allard Bruno、Perrot Jimmy、Bouvard Cl?ment、Tsutsui Hidekazu、Okamura Yasushi、Jacquemond Vincent
    • Journal Title

      The Journal of General Physiology

      Volume: 150 Pages: 1163-1177

    • DOI

      10.1085/jgp.201812035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Zn2+-Binding to the Voltage-Gated Proton Channel Hv1/VSOP2018

    • Author(s)
      Iwaki Masayo、Takeshita Kohei、Kondo Hiroko X.、Kinoshita Kengo、Okamura Yasushi、Takano Yu、Nakagawa Atsushi、Kandori Hideki
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 122 Pages: 9076-9080

    • DOI

      10.1021/acs.jpcb.8b04890

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase2018

    • Author(s)
      Kawanabe A, Hashimoto M, Mishizawa M, Nishizawa N, Narita H, Yonezawa T, Jinno Y, Sakata S, Nakawaga A and Okamura Y
    • Journal Title

      eLife

      Volume: 7 Pages: 2097-2131

    • DOI

      10.7554/elife.41653

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Voltage-Sensing Phosphatases: Biophysics, Physiology, and Molecular Engineering2018

    • Author(s)
      Okamura Yasushi、Kawanabe Akira、Kawai Takafumi
    • Journal Title

      Physiological Reviews

      Volume: 98 Pages: 2097-2131

    • DOI

      10.1152/physrev.00056.2017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 脂質-イオンチャネル相互連関2018

    • Author(s)
      岡村康司、大澤匡範
    • Journal Title

      「脂質クオリティ」実験医学増刊

      Volume: 36 Pages: 97-104

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent2018

    • Author(s)
      Kawashima Yusuke、Miyata Jun、Watanabe Takashi、Shioya Juri、Arita Makoto、Ohara Osamu
    • Journal Title

      Journal of Proteome Research

      Volume: 18 Pages: 301-308

    • DOI

      10.1021/acs.jproteome.8b00609

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reelin deficiency leads to aberrant lipid composition in mouse brain.2018

    • Author(s)
      Mizukami T, Ikeda K, Shimanaka Y, Korogi K, Zhou C, Takase H, Tsuiji H, Kono N, Kohno T, Arai H, Arita M, Hattori M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 505 Pages: 81-86

    • DOI

      10.1016/j.bbrc.2018.09.089

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An omega-3 polyunsaturated fatty acid derivative, 18-HEPE, protects against CXCR4-associated melanoma metastasis2018

    • Author(s)
      Li Jieping、Chen Chih-Yu、Arita Makoto、Kim Kuijin、Li Xiangyong、Zhang Hongman、Kang Jing X
    • Journal Title

      Carcinogenesis

      Volume: 39 Pages: 1380-1388

    • DOI

      10.1093/carcin/bgy117

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines2018

    • Author(s)
      Burla Bo、Arita Makoto、Arita Masanori et al.
    • Journal Title

      Journal of Lipid Research

      Volume: 59 Pages: 2001-2017

    • DOI

      10.1194/jlr.s087163

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thromboxane A2 facilitates IL-17A production from Vγ4+ γδ T cells and promotes psoriatic dermatitis in mice.2018

    • Author(s)
      Ueharaguchi Y, Honda T, Kusuba N, Hanakawa S, Adachi A, Sawada Y, Otsuka A, Kitoh A, Dainich T, Egawa G, Nakachima C, Nakajima S, Murata T, Ono S, Arita M, Narumiya S, Miyachi Y, Kabashima K
    • Journal Title

      J Allergy Clin Immunol.

      Volume: in press

    • DOI

      10.1016/j.jaci.2018.01.054

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques2018

    • Author(s)
      Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J
    • Journal Title

      J Allergy Clin Immunol.

      Volume: S0091-6749 Pages: 32949-32944

    • DOI

      10.1016/j.jaci.2017.09.053

    • NAID

      40021650879

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling2018

    • Author(s)
      Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, Yamazaki K
    • Journal Title

      Sci Rep

      Volume: 8 Pages: 1-12

    • DOI

      10.1038/s41598-018-27408-y

    • NAID

      120006546008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid2018

    • Author(s)
      Isobe Yosuke、Itagaki Mai、Ito Yuko、Naoe Satoko、Kojima Kotoe、Ikeguchi Mitsunori、Arita Makoto
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 7954-7954

    • DOI

      10.1038/s41598-018-26325-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Facile determination of sphingolipids under alkali condition using metal-free column by LC-MS/MS2018

    • Author(s)
      B. Gowda Siddabasave Gowda、Ikeda Kazutaka、Arita Makoto
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 410 Pages: 4793-4803

    • DOI

      10.1007/s00216-018-1116-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of lipid accumulation rescues Bietti’s crystalline dystrophy phenotypes2018

    • Author(s)
      Hata Masayuki、Ikeda Hanako O.、Iwai Sachiko、Iida Yuto、Gotoh Norimoto、Asaka Isao、Ikeda Kazutaka、Isobe Yosuke、Hori Aya、Nakagawa Saori、Yamato Susumu、Arita Makoto、Yoshimura Nagahisa、Tsujikawa Akitaka
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 115 Pages: 3936-3941

    • DOI

      10.1073/pnas.1717338115

    • NAID

      120006416205

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid2018

    • Author(s)
      Isobe Yosuke、Kawashima Yusuke、Ishihara Tomoaki、Watanabe Kenji、Ohara Osamu、Arita Makoto
    • Journal Title

      ACS Chem Biol.

      Volume: 13 Pages: 887-893

    • DOI

      10.1021/acschembio.7b01092

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脂肪酸代謝バランスによるマクロファージの機能制御2018

    • Author(s)
      青木秀憲、有田誠
    • Journal Title

      実験医学(羊土社)

      Volume: 36 Pages: 2353-2357

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 「脂質クオリティ」生命機能と健康を支える脂質の多様性(企画・編集)2018

    • Author(s)
      有田誠
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 概論/リポクオリティから解き明かす生命現象2018

    • Author(s)
      有田誠
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36 Pages: 1580-1584

    • Related Report
      2018 Annual Research Report
  • [Journal Article] リポクオリティを識別するリピドミクス解析技術2018

    • Author(s)
      池田和貴、青柳良平、有田誠
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36 Pages: 1797-1803

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 脂質クオリティを捉える解析手法とデータベース2018

    • Author(s)
      津川裕司、池田和貴、有田誠、有田正規
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36 Pages: 1804-1811

    • Related Report
      2018 Annual Research Report
  • [Journal Article] UBL3 modification influences protein sorting to small extracellular vesicles.2018

    • Author(s)
      Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
    • Journal Title

      Nature Communications

      Volume: 9 Pages: 1-14

    • DOI

      10.1038/s41467-018-06197-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of caveolin-1 in hepatocellular carcinoma arising from non-alcoholic fatty liver disease2018

    • Author(s)
      Takeda Makoto、Sakaguchi Takanori、Hiraide Takanori、Shibasaki Yasushi、Morita Yoshifumi、Kikuchi Hirotoshi、Ikegami Koji、Setou Mitsutoshi、Konno Hiroyuki、Takeuchi Hiroya
    • Journal Title

      Cancer Science

      Volume: 109 Pages: 2401-2411

    • DOI

      10.1111/cas.13659

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis2018

    • Author(s)
      Sato Shumpei、Horikawa Makoto、Kondo Takeshi、Sato Tomohito、Setou Mitsutoshi
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 10315-10315

    • DOI

      10.1038/s41598-018-28667-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] リポクオリティの可視化と操作2018

    • Author(s)
      堀川誠、武井史郎、瀬藤光利
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36 Pages: 103-210

    • Related Report
      2018 Annual Research Report
  • [Journal Article] The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer2018

    • Author(s)
      Ishimine M, Lee HC, Nakaoka H, Orita H, Kobayashi T, Mizuguchi K, Endo M, Inoue I, Sato K, Yokomizo T
    • Journal Title

      Dis Markers

      Volume: - Pages: 1-7

    • DOI

      10.1155/2018/5280736

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Urinary prostaglandin D2 metabolite excretion during the first six months of life was significantly lower in breast-fed than formula-fed infants2018

    • Author(s)
      Shoji Hiromichi、Ikeda Naho、Kitamura Tomohiro、Suganuma Hiroki、Ohba Mai、Okuno Toshiaki、Yokomizo Takehiko、Shimizu Toshiaki
    • Journal Title

      Acta Paediatr

      Volume: 107 Pages: 95-100

    • DOI

      10.1111/apa.14068

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle2018

    • Author(s)
      Kawanishi Noriaki、Takagi Kana、Lee Hyeon-Cheol、Nakano Daiki、Okuno Toshiaki、Yokomizo Takehiko、Machida Shuichi
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 印刷中

    • DOI

      10.1152/ajpregu.00371.2017

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT12018

    • Author(s)
      Hori Tetsuya、Okuno Toshiaki、Hirata Kunio、Yamashita Keitaro、Kawano Yoshiaki、Yamamoto Masaki、Hato Masakatsu、Nakamura Motonao、Shimizu Takao、Yokomizo Takehiko、Miyano Masashi、Yokoyama Shigeyuki
    • Journal Title

      Nat Chem Biol

      Volume: 14 Pages: 262-269

    • DOI

      10.1038/nchembio.2547

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered eicosanoid production and phospholipid remodeling during cell culture2018

    • Author(s)
      Okuno Toshiaki、Gij?n Miguel A.、Zarini Simona、Martin Sarah A.、Barkley Robert M.、Johnson Christopher A.、Ohba Mai、Yokomizo Takehiko、Murphy Robert C.
    • Journal Title

      J Lipid Res

      Volume: 59 Pages: 542-549

    • DOI

      10.1194/jlr.m083030

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Leukotriene B4 receptor 2 regulates the proliferation migration and barrier integrity of bronchial epithelial cells2018

    • Author(s)
      M Liu J Shen H Yuan F Chen H Song H Qin Y Li J Xu Q Ye S Li K Saeki T Yokomizo
    • Journal Title

      Journal of Cellular Physiology

      Volume: 印刷中 Pages: 6117-6124

    • DOI

      10.1002/jcp.26455

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4.2018

    • Author(s)
      Nakanishi,Y., Tan,M., Ichiki,T., Inoue,A. Yoshihara,J., Maekawa,N., Takenoshita.I., Yanagida,K., Yamahira,S., Yamaguchi,S., Aoki,J. Nagamune,T., Yokomizo,T., Shimizu,T., and Nakamura,M
    • Journal Title

      Science Signaling

      Volume: 11 (544) Pages: 5390-5390

    • DOI

      10.1126/scisignal.aao5390

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method.2018

    • Author(s)
      Ohba M., Saeki K., Koga T., Okuno T., Kobayashi Y., Yokomizo T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 504 Pages: 562-568

    • DOI

      10.1016/j.bbrc.2018.06.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models.2018

    • Author(s)
      Sasaki F., Koga T., Ohba M., Saeki K., Okuno T., Ishikawa K., Nakama T., Nakao S., Yoshida S., Ishibashi T., Ahmadieh H., Kanavi M. R., Hafezi-Moghadam A., Penninger J. M., Sonoda K. H., Yokomizo T.
    • Journal Title

      JCI Insight

      Volume: 3 Pages: 96902-96902

    • DOI

      10.1172/jci.insight.96902

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Applications of mass spectrometry-based targeted and non-targeted lipidomics2018

    • Author(s)
      Lee Hyeon-Cheol、Yokomizo Takehiko
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 504 Pages: 576-581

    • DOI

      10.1016/j.bbrc.2018.03.081

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2.2018

    • Author(s)
      Okuno T., Yokomizo T.
    • Journal Title

      Inflammation and Regeneration

      Volume: 38 Pages: 29-29

    • DOI

      10.1186/s41232-018-0087-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Leukotriene receptors and experience as potential therapeutic targets.2018

    • Author(s)
      Yokomizo,T., Nakamura,M., and Shimizu,T
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128 Pages: 2691-2701

    • DOI

      10.1172/jci97946

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生理活性脂質ロイコトリエンB4とその受容体による免疫調節機構2018

    • Author(s)
      古賀友紹, 佐伯和子, 横溝岳彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 70 Pages: 209-215

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 【生理活性脂質研究の最前線】 BLT2受容体の上皮保護作用2018

    • Author(s)
      岩本 怜., 横溝 岳彦
    • Journal Title

      炎症と免疫

      Volume: 26 Pages: 380-383

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 脂肪酸由来の脂質メディエーターによるアレルギー炎症の制御2018

    • Author(s)
      平形寿彬, 李賢喆, 横溝岳彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 69 Pages: 569-575

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 【脂質クオリティ 生命機能と健康を支える脂質の多様性】 (第3章)リポクオリティによる疾患制御 ロイコトリエン受容体の生理・病態における役割2018

    • Author(s)
      横溝 岳彦
    • Journal Title

      実験医学

      Volume: 36

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Alveolar macrophages drive hepatocellular carcinoma lung metastasis by generating leukotriene B4.2018

    • Author(s)
      Nosaka T, Baba T, Tanabe Y, Sasaki S, Nishimura T, Imamura Y, Yurino H, Hashimoto S, Arita M, Nakamoto Y, Mukaida N.
    • Journal Title

      J Immunol.

      Volume: 200 Pages: 1839-1852

    • DOI

      10.4049/jimmunol.1700544

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 12-OH-17,18-Epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs2018

    • Author(s)
      Mochimaru T.、Fukunaga K.、Miyata J.、Matsusaka M.、Masaki K.、Kabata H.、Ueda S.、Suzuki Y.、Goto T.、Urabe D.、Inoue M.、Isobe Y.、Arita M.、Betsuyaku T.
    • Journal Title

      Allergy

      Volume: 73 Pages: 369-378

    • DOI

      10.1111/all.13297

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stereoselective Total Synthesis of Macrophage-Produced Prohealing 14,21-Dihydroxy Docosahexaenoic Acids2018

    • Author(s)
      Nishimura Keita、Sakaguchi Tsuyoshi、Nanba Yutaro、Suganuma Yuta、Morita Masao、Hong Song、Lu Yan、Jun Bokkyoo、Bazan Nicolas G.、Arita Makoto、Kobayashi Yuichi
    • Journal Title

      J Org Chem

      Volume: 83 Pages: 154-166

    • DOI

      10.1021/acs.joc.7b02510

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resolvin D1 is immunoresolvent of lung inflammation caused by pseudominas aeruginosa acute and chronic infections.2018

    • Author(s)
      Codagnone M, Cianci E, Lamolinara A, Mari VC, Nespoli A, Isopi E, Mattoscio D, Arita M, Bragonzi A, Iezzi M, Romano M, Recchiuti A.
    • Journal Title

      Mucosal Immunology

      Volume: in press Pages: 35-49

    • DOI

      10.1038/mi.2017.36

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 脂肪酸クオリティの多様性と病態(企画・編集)2018

    • Author(s)
      有田誠
    • Journal Title

      医学のあゆみ (医歯薬出版)

      Volume: 264

    • Related Report
      2017 Annual Research Report
  • [Journal Article] ω3脂肪酸由来脂質メディエーターと炎症制御2018

    • Author(s)
      吉田美桜、礒部洋輔、石原知明、有田誠
    • Journal Title

      細胞(ニューサイエンス社)

      Volume: 50 Pages: 8-12

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics2018

    • Author(s)
      Lai Z, Tsugawa H, Wohlgemuth G, Mehta S, Mueller M, Zheng Y, Ogiwara A, Meissen J, Showalter M, Takeuchi K, Kind T, Beal P, Arita M, Fiehn O
    • Journal Title

      Nat Methods

      Volume: 15 Pages: 53-56

    • DOI

      10.1038/nmeth.4512

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Leukotriene receptors as potential therapeutic target.2018

    • Author(s)
      Yokomizo, T Nakamura, M Shimizu, T
    • Journal Title

      J Clin Invest

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method.2018

    • Author(s)
      Ohba, M Saeki, K Koga, T Okuno, T Konbayashi, Y Yokomizo, T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚保護作用を有する脂質メディエーター12-HHT2018

    • Author(s)
      石井由美子 劉珉 佐伯和子 横溝岳彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 67 Pages: 106-114

    • NAID

      40021064298

    • Related Report
      2017 Annual Research Report
  • [Journal Article] The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis2018

    • Author(s)
      Kimura Hirotaka、Matsuyama Yasushi、Araki Sachiko、Koizumi Atsushi、Kariya Yumi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Sasaki Junko、Sasaki Takehiko
    • Journal Title

      Modern Rheumatology

      Volume: 28 Pages: 1-12

    • DOI

      10.1080/14397595.2017.1367116

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice2018

    • Author(s)
      Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 2094-2094

    • DOI

      10.1038/s41598-018-21120-7

    • NAID

      120006551757

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Profiling and Imaging of Phospholipids in Brains of Abcd1-Deficient Mice.2018

    • Author(s)
      Hama K, Fujiwara Y, Morita M, Yamazaki F, Nakashima Y, Takei S, Takashima S, Setou M, Shimozawa N, Imanaka T, Yokoyama K.
    • Journal Title

      Lipids

      Volume: 53 Pages: 85-102

    • DOI

      10.1002/lipd.12022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of local phosphatidylcholine synthesis within hippocampal neurons using a compartmentalized culture system and imaging mass spectrometry2018

    • Author(s)
      Sugiyama Eiji、Yao Ikuko、Setou Mitsutoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Pages: 1048-1054

    • DOI

      10.1016/j.bbrc.2017.11.108

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms2018

    • Author(s)
      Ikedo Taichi、Minami Manabu、Kataoka Hiroharu、Hayashi Kosuke、Nagata Manabu、Fujikawa Risako、Yamazaki Fumiyoshi、Setou Mitsutoshi、Yokode Masayuki、Miyamoto Susumu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Pages: 332-338

    • DOI

      10.1016/j.bbrc.2017.10.133

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cross-talk between prostaglandin and retinoic acid signaling.2018

    • Author(s)
      Inazumi, T., and Sugimoto, Y.
    • Journal Title

      Carotenoid Sci

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ゼブラフィッシュにおけるプロスタグランジンシステム2018

    • Author(s)
      土屋創健、杉本幸彦
    • Journal Title

      生化学

      Volume: 89 Pages: 445-445

    • NAID

      40021265217

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プロスタグランジンE2による炎症病態制御機構2018

    • Author(s)
      稲住知明、杉本幸彦
    • Journal Title

      細胞

      Volume: 50 Pages: 118-121

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Sitosterol prevents obesity-related chronic inflammation2018

    • Author(s)
      Kurano Makoto、Hasegawa Koji、Kunimi Motoei、Hara Masumi、Yatomi Yutaka、Teramoto Tamio、Tsukamoto Kazuhisa
    • Journal Title

      Biochim Biophys Acta

      Volume: 1863 Pages: 191-198

    • DOI

      10.1016/j.bbalip.2017.12.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphingosine 1-Phosphate and Atherosclerosis2018

    • Author(s)
      Kurano Makoto、Yatomi Yutaka
    • Journal Title

      J Atheroscler Thromb

      Volume: 25 Issue: 1 Pages: 16-26

    • DOI

      10.5551/jat.rv17010

      10.5551/jat.RV17010

    • NAID

      130006301107

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚疾患と脂質メディエーター2018

    • Author(s)
      本田哲也, 椛島健治
    • Journal Title

      アレルギー・免疫 医薬ジャーナル社

      Volume: 25 Pages: 30-37

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 炎症・感染応答を担うオルガネラ2018

    • Author(s)
      小林俊彦、向井康治朗、田口友彦、反町典子
    • Journal Title

      臨床免疫アレルギー科

      Volume: 63 Pages: 99-106

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Voltage-Sensing Phosphatases: Biophysics, Physiology and Engineering2018

    • Author(s)
      Okamura Y, Kawanabe A, Kawai T.
    • Journal Title

      Physiological reviews

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels(VSOP/Hv1)2018

    • Author(s)
      Kawai T, Tatsumi S, Kihara S, Sakimura K, Okamura Y.
    • Journal Title

      Channels

      Volume: 12 Issue: 1 Pages: 43108-43108

    • DOI

      10.1080/19336950.2017.1385684

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The importance of bioinformatics for connecting data-driven lipidomics and biological insights.2017

    • Author(s)
      Tsugawa H, Ikeda K, Arita M.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

      Volume: 1862 Pages: 762-765

    • DOI

      10.1016/j.bbalip.2017.05.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library2017

    • Author(s)
      Aoyagi Ryohei、Ikeda Kazutaka、Isobe Yosuke、Arita Makoto
    • Journal Title

      J Lipid Res

      Volume: 58 Pages: 2229-2237

    • DOI

      10.1194/jlr.d077123

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut microbiota promotes obesity-associated liver cancer throug PGE2-mediated suppression of antitumor immunity2017

    • Author(s)
      Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N
    • Journal Title

      Cancer Discovery

      Volume: in press Pages: 522-538

    • DOI

      10.1158/2159-8290.cd-16-0932

    • Description
      Epub ahead of print
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation2017

    • Author(s)
      Shimanaka Yuta、Kono Nozomu、Taketomi Yoshitaka、Arita Makoto、Okayama Yoshimichi、Tanaka Yuki、Nishito Yasumasa、Mochizuki Tatsuki、Kusuhara Hiroyuki、Adibekian Alexander、Cravatt Benjamin F、Murakami Makoto、Arai Hiroyuki
    • Journal Title

      Nat Med

      Volume: 23 Pages: 1287-1297

    • DOI

      10.1038/nm.4417

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation2017

    • Author(s)
      Yotsumoto Satoshi、Muroi Yuito、Chiba Tatsuya、Ohmura Rio、Yoneyama Maki、Magarisawa Megumi、Dodo Kosuke、Terayama Naoki、Sodeoka Mikiko、Aoyagi Ryohei、Arita Makoto、Arakawa Satoko、Shimizu Shigeomi、Tanaka Masato
    • Journal Title

      Journal, Scientific Reports

      Volume: 7 Pages: 16026-16026

    • DOI

      10.1038/s41598-017-15668-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways2017

    • Author(s)
      Aikawa Shizu、Kano Kuniyuki、Inoue Asuka、Wang Jiao、Saigusa Daisuke、Nagamatsu Takeshi、Hirota Yasushi、Fujii Tomoyuki、Tsuchiya Soken、Taketomi Yoshitaka、Sugimoto Yukihiko、Murakami Makoto、Arita Makoto、Kurano Makoto、Ikeda Hitoshi、Yatomi Yutaka、Chun Jerold、Aoki Junken
    • Journal Title

      EMBO Journal

      Volume: 36 Pages: 2146-2160

    • DOI

      10.15252/embj.201696290

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] リポクオリティと炎症・免疫の制御(企画・編集)2017

    • Author(s)
      有田誠
    • Journal Title

      炎症と免疫(先端医学社)

      Volume: 25

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 脂肪酸クオリティと炎症・アレルギーの制御2017

    • Author(s)
      永沼達郎、有田誠
    • Journal Title

      炎症と免疫(先端医学社)

      Volume: 25 Pages: 265-270

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Identification of small molecules using accurate mass MS/MS search2017

    • Author(s)
      Kind T, Tsugawa H, Cajka T, Ma Y, Lai Z, Mehta SS, Wohlgemuth G, Barupal DK, Showalter MR, Arita M, Fiehn O
    • Journal Title

      Mass Spectrom Rev

      Volume: -

    • DOI

      10.1002/mas.21535

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 化学とメタボロミクス2017

    • Author(s)
      有田正規、津川裕司
    • Journal Title

      化学

      Volume: 72 Pages: 26-30

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 22017

    • Author(s)
      Iwamoto Satoshi、Koga Tomoaki、Ohba Mai、Okuno Toshiaki、Koike Masato、Murakami Akira、Matsuda Akira、Yokomizo Takehiko
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 1-10

    • DOI

      10.1038/s41598-017-13122-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification, signaling, and functions of LTB4 receptors.2017

    • Author(s)
      Saeki K, Yokomizo T
    • Journal Title

      Seminars in Immunology

      Volume: 33 Pages: 30-36

    • DOI

      10.1016/j.smim.2017.07.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1.2017

    • Author(s)
      Sasaki F, Koga T, Saeki K, Okuno T, Kazuno S, Fujimura T, Ohkawa Y, Yokomizo T
    • Journal Title

      PLoS One.

      Volume: 12 Pages: 0185133-0185133

    • DOI

      10.1371/journal.pone.0185133

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration2017

    • Author(s)
      Takeda Tomoki、Komiya Yukiko、Koga Takayuki、Ishida Takumi、Ishii Yuji、Kikuta Yasushi、Nakaya Michio、Kurose Hitoshi、Yokomizo Takehiko、Shimizu Takao、Uchi Hiroshi、Furue Masutaka、Yamada Hideyuki
    • Journal Title

      J Biol Chem

      Volume: 292 Pages: 10586-10599

    • DOI

      10.1074/jbc.m116.764332

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.2017

    • Author(s)
      Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T
    • Journal Title

      JCI insight

      Volume: 2 Pages: 89462-89478

    • DOI

      10.1172/jci.insight.89462

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia2017

    • Author(s)
      Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 7 Pages: 1-11

    • DOI

      10.1038/srep45050

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis2017

    • Author(s)
      Iizuka-Hishikawa Yoshiko、Hishikawa Daisuke、Sasaki Junko、Takubo Keiyo、Goto Motohito、Nagata Katsuyuki、Nakanishi Hiroki、Shindou Hideo、Okamura Tadashi、Ito Chizuru、Toshimori Kiyotaka、Sasaki Takehiko、Shimizu Takao
    • Journal Title

      J Biol Chem

      Volume: 292 Pages: 12065-12076

    • DOI

      10.1074/jbc.m117.791277

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells2017

    • Author(s)
      Shindou Hideo、Koso Hideto、Sasaki Junko、Nakanishi Hiroki、Sagara Hiroshi、Nakagawa Koh M.、Takahashi Yoshikazu、Hishikawa Daisuke、Iizuka-Hishikawa Yoshiko、Tokumasu Fuyuki、Noguchi Hiroshi、Watanabe Sumiko、Sasaki Takehiko、Shimizu Takao
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 292 Pages: 1205412064-1205412064

    • DOI

      10.1074/jbc.m117.790568

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K2017

    • Author(s)
      Malek M、Kielkowska A、Chessa T、Anderson K E.、Barneda D、Pir P、Nakanishi H、Eguchi S、Koizumi A、Sasaki J、Juvin V、Kiselev VY.、Niewczas I、Gray A、Valayer A、Spensberger D、Imbert M、Felisbino S、Habuchi T、Beinke S、Cosulich S、Le Novere N、Sasaki T、Clark J、Hawkins PT.、Stephens LR.
    • Journal Title

      Mol Cell

      Volume: 68 Pages: 566-580

    • DOI

      10.1016/j.molcel.2017.09.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production2017

    • Author(s)
      Huang Mingguo、Narita Shintaro、Inoue Takamitsu、Koizumi Atsushi、Saito Mitsuru、Tsuruta Hiroshi、Numakura Kazuyuki、Satoh Shigeru、Nanjo Hiroshi、Sasaki Takehiko、Habuchi Tomonori
    • Journal Title

      Oncotarget

      Volume: 8 Pages: 111780-111794

    • DOI

      10.18632/oncotarget.22908

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A New Electron Microscopic Method to Observe the Distribution of Phosphatidylinositol 3,4-bisphosphate2017

    • Author(s)
      Aktar S, Takatori S, Tsuji T, Orii M, Ohsaki Y, Cheng J, Fujimoto T
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 50(5) Issue: 5 Pages: 141-147

    • DOI

      10.1267/ahc.17025

    • NAID

      130006179489

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatocyte-specific depletion of ubiquitin regulatory X domain containing protein 8 accelerates fibrosis in a mouse non-alcoholic steatohepatitis model2017

    • Author(s)
      Imai Norihiro、Suzuki Michitaka、Ishizu Yoji、Kuzuya Teiji、Honda Takashi、Hayashi Kazuhiko、Ishigami Masatoshi、Hirooka Yoshiki、Ishikawa Tetsuya、Goto Hidemi、Fujimoto Toyoshi
    • Journal Title

      Histochem Cell Biol

      Volume: 148 Pages: 219-227

    • DOI

      10.1007/s00418-017-1572-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for ESCRT- and clathrin-dependent microautophagy.2017

    • Author(s)
      Masahide Oku, Yuichiro Maeda, Yoko Kagohashi, Takeshi Kondo, Mai Yamada, Toyoshi Fujimoto, Yasuyoshi Sakai
    • Journal Title

      The Journal of Cell Biology

      Volume: 216 Pages: 3263-3274

    • DOI

      10.1083/jcb.201611029

    • NAID

      120006454716

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole2017

    • Author(s)
      Tsuji T, Fujimoto M, Tatematsu T, Cheng J, Orii M, Takatori S, Fujimoto T
    • Journal Title

      eLife

      Volume: 6

    • DOI

      10.7554/elife.25960

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Freeze-fracture-etching Electron Microscopy for Facile Analysis of Yeast Ultrastructure2017

    • Author(s)
      Tsuji Takuma、Fujimoto Toyoshi
    • Journal Title

      BIO-PROTOCOL

      Volume: 7

    • DOI

      10.21769/bioprotoc.2556

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The lipid droplet and the endoplasmic reticulum2017

    • Author(s)
      Ohsaki, Y., Soltysik, K., and Fujimoto, T
    • Journal Title

      Adv Exp Med Biol

      Volume: 997 Pages: 111-120

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency2017

    • Author(s)
      Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.
    • Journal Title

      Frontiers in Genetics

      Volume: 8 Pages: 113-113

    • DOI

      10.3389/fgene.2017.00113

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues2017

    • Author(s)
      Hosokawa Yuko、Masaki Noritaka、Takei Shiro、Horikawa Makoto、Matsushita Shoko、Sugiyama Eiji、Ogura Hiroyuki、Shiiya Norihiko、Setou Mitsutoshi
    • Journal Title

      PLOS ONE

      Volume: 12

    • DOI

      10.1371/journal.pone.0183724

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical expression analysis of leucine-rich PPR-motif-containing protein (LRPPRC), a candidate colorectal cancer biomarker identified by shotgun proteomics using iTRAQ2017

    • Author(s)
      Nishio Tomohisa、Kurabe Nobuya、Goto-Inoue Naoko、Nakamura Toshio、Sugimura Haruhiko、Setou Mitsutoshi、Maekawa Masato
    • Journal Title

      Clinica Chimica Acta

      Volume: 471 Pages: 276-282

    • DOI

      10.1016/j.cca.2017.06.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts2017

    • Author(s)
      Kato Hikaru、Kai Aika、Kawabata Tetsuro、Sunderhaus James D.、McAfoos Timothy J.、Finefield Jennifer M.、Sugimoto Yukihiko、Williams Robert M.、Tsukamoto Sachiko
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Pages: 4975-4978

    • DOI

      10.1016/j.bmcl.2017.10.017

    • NAID

      120006897984

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gαs.2017

    • Author(s)
      Yano A, Takahashi Y, Moriguchi H, Inazumi T, Koga T, Otaka A, Sugimoto Y.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

      Volume: 1862 Pages: 615-622

    • DOI

      10.1016/j.bbalip.2017.03.006

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 雌性生殖生理におけるプロスタグランジン受容体の役割2017

    • Author(s)
      杉本幸彦
    • Journal Title

      別冊BIO Clinica 慢性炎症と疾患

      Volume: 6 Pages: 16-21

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes2017

    • Author(s)
      Kurano M, Nishikawa M, Kuma H, Jona M, Yatomi Y.
    • Journal Title

      PLos One

      Volume: 12

    • DOI

      10.1371/journal.pone.0177543

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells2017

    • Author(s)
      Nakamizo Satoshi、Honda Tetsuya、Adachi Akimasa、Nagatake Takahiro、Kunisawa Jun、Kitoh Akihiko、Otsuka Atsushi、Dainichi Teruki、Nomura Takashi、Ginhoux Florent、Ikuta Koichi、Egawa Gyohei、Kabashima Kenji
    • Journal Title

      Sci. Rep.

      Volume: 7 Pages: 14076-14076

    • DOI

      10.1038/s41598-017-14292-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Advances in atopic dermatitis and urticarial in 20162017

    • Author(s)
      Honda Tetsuya、Nomura Takashi、Kabashima Kenji
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 140 Pages: 369-376

    • DOI

      10.1016/j.jaci.2017.06.005

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells2017

    • Author(s)
      Kobayashi Toshihiko、Tsutsui Hidemitsu、Shimabukuro-Demoto Shiho、Yoshida-Sugitani Reiko、Karyu Hitomi、Furuyama-Tanaka Kaori、Ohshima Daisuke、Kato Norihiro、Okamura Tadashi、Toyama-Sorimachi Noriko
    • Journal Title

      Int Immunol.

      Volume: 29 Pages: 551-566

    • DOI

      10.1093/intimm/dxx063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice.2017

    • Author(s)
      Wang XX, Hu Y, Keep RF, Toyama-Sorimachi N, Smith DE.
    • Journal Title

      Biochemical Pharmacology

      Volume: 15 Pages: 94-102

    • DOI

      10.1016/j.bcp.2016.11.012

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 炎症抑制に関わる電位依存性プロトンチャネルHv1/VSOPの機能(リポクオリティによる膜タンパク質の機能制御と炎症・免疫)2017

    • Author(s)
      大河内善史、川鍋陽、岡村康司
    • Journal Title

      炎症と免疫 2017年7月号

      Volume: 25 Pages: 17-22

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Domain-to-domain coupling in voltage-sensing phosphatase2017

    • Author(s)
      Sakata S, Matsuda M, Kawanabe A, Okamura Y.
    • Journal Title

      BIOPHYSICS

      Volume: 1 Issue: 0 Pages: 85-97

    • DOI

      10.2142/biophysico.14.0_85

    • NAID

      130007041363

    • ISSN
      2189-4779
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production.2017

    • Author(s)
      Kawai T, Okochi Y, Ozaki T, Imura Y, Koizumi S, Yamazaki M, Abe M, Sakimura K, Yamashita T, Okamura Y.
    • Journal Title

      J Neurochem.

      Volume: 142 Issue: 5 Pages: 686-699

    • DOI

      10.1111/jnc.14106

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular and functional characterization of the voltage-gated proton channel in zebrafish neutrophils2017

    • Author(s)
      Ratanayotha Adisorn、Kawai Takafumi、Higashijima Shin-ichi、Okamura Yasushi
    • Journal Title

      Physiol Rep

      Volume: 5

    • DOI

      10.14814/phy2.13345

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 電位センサードメインを用いた膜電位プローブの進歩2017

    • Author(s)
      河合 喬文、筒井 秀和、岡村 康司
    • Journal Title

      生体の科学

      Volume: 68 Issue: 5 Pages: 444-445

    • DOI

      10.11477/mf.2425200686

    • ISSN
      0370-9531, 1883-5503
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library.2017

    • Author(s)
      Tsugawa H, Ikeda K, Tanaka W, Senoo Y, Arita M, Arita M.
    • Journal Title

      Journal of cheminformatics

      Volume: 9 Pages: 19-19

    • DOI

      10.1186/s13321-017-0205-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.2017

    • Author(s)
      Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Mu&ntilde;oz-Garcia A, Brash A, Ikeda K, Arita M, Akiyama M, Murakami M.
    • Journal Title

      Nat. Commun.

      Volume: 8 Pages: 14609-14609

    • DOI

      10.1038/ncomms14609

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ω3脂肪酸の代謝と抗炎症作用に関する研究2017

    • Author(s)
      有田誠
    • Journal Title

      脂質栄養学(日本脂質栄養学会)

      Volume: 26 Pages: 27-34

    • NAID

      130006894081

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different desmin peptides are distinctly deposited in cytoplasmic aggregations and cytoplasm of desmin-related cardiomyopathy patients.2017

    • Author(s)
      Shintani-Domoto Y, Hayasaka T, Maeda D, Masaki N, Ito TK, Sakuma K, Tanaka M, Kabashima K, Takei S, Setou M, Fukayama M.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

      Volume: S1570-9639 Pages: 30048-1

    • DOI

      10.1016/j.bbapap.2017.03.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside.2017

    • Author(s)
      Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N.
    • Journal Title

      Gene.

      Volume: S0378-1119 Pages: 30139-7

    • DOI

      10.1016/j.gene.2017.03.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proper cytoskeletal architecture beneath the plasma membrane of red blood cells requires Ttll4.2017

    • Author(s)
      Ijaz F, Hatanaka Y, Hatanaka T, Tsutsumi K, Iwaki T, Umemura K, Ikegami K, Setou M.
    • Journal Title

      Mol Biol Cell.

      Volume: 28 Pages: 535-544

    • DOI

      10.1091/mbc.e16-02-0089

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Selective improvement of peptides imaging on tissue by supercritical fluid wash of lipids for matrix-assisted laser desorption/ionization mass spectrometry.2017

    • Author(s)
      Matsushita S, Masaki N, Sato K, Hayasaka T, Sugiyama E, Hui SP, Chiba H, Mase N, Setou M.
    • Journal Title

      Anal. Bioanal. Chem.

      Volume: 409 Pages: 1475-1475

    • DOI

      10.1007/s00216-016-0119-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision2017

    • Author(s)
      Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T
    • Journal Title

      Cell

      Volume: 168 Pages: 264-279

    • DOI

      10.1016/j.cell.2016.12.032

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The lipid droplet and the endoplasmic reticulum2017

    • Author(s)
      Ohsaki Y, Soltysik K, Fujimoto T
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 997

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 電子顕微鏡による脂肪滴と膜脂質の探索2017

    • Author(s)
      藤本豊士、大﨑雄樹、辻琢磨
    • Journal Title

      Proc. Clin. Electron Microsc

      Volume: 35 Pages: 1-3

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Interleaflet coupling, pinning and leaflet asymmetry- major players in plasma membrane nanodomain formation2017

    • Author(s)
      Fujimoto T, Parmryd I
    • Journal Title

      Frontier Cell Dev Biol

      Volume: 4 Pages: 155-155

    • DOI

      10.3389/fcell.2016.00155

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genetically encoded bioluminescent voltage indicator for multi-purpose use in wide range of bioimaging.2017

    • Author(s)
      Inagaki S, Tsutsui H, Suzuki K, Agetsuma M, Arai Y, Jinno Y, Bai G, Daniels M, Okamura Y, Matsuda M, and Nagai T
    • Journal Title

      Scientific Report

      Volume: 7 Pages: 42398-42398

    • DOI

      10.1038/srep42398

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate2017

    • Author(s)
      Shinobu Hirai, Kohji Hotta, Yoshihiro Kubo, Atsuo Nishino, Shigeo Okabe, Yasushi Okamura, Haruo Okado
    • Journal Title

      PNAS

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Domain-to-domain coupling in voltage-sensing phosphatase2017

    • Author(s)
      Souhei Sakata, Makoto Matsuda, Akira Kawanabe, Yasushi Okamura
    • Journal Title

      Biophysics and Physiobiology

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 炎症抑制に関わる電位依存性プロトンチャネルHv1/VSOPの機能(リポクオリティによる膜タンパク質の機能制御と炎症・免疫2017

    • Author(s)
      大河内善史、川鍋陽、岡村康司
    • Journal Title

      炎症と免疫

      Volume: in press

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Analysis of glycero-lysophospholipids in gastric cancerous ascites.2017

    • Author(s)
      Emoto, S., Kurano, M., Kano, K., Matsusaki, K., Yamashita, H., Nishikawa, M., Igarashi, K., Ikeda, H., Aoki, J., Kitayama, J., and Yatomi, Y.
    • Journal Title

      Journal of Lipid Research

      Volume: 58 Pages: 763-771

    • DOI

      10.1194/jlr.p072090

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of Cholesteryl Ester Transfer Protein in the Shift of Sphingosine 1-Phosphate Among Lipoproteins and in the Modulation of its Functions.2017

    • Author(s)
      Kurano, M., Hara, M., Ikeda, H., Tsukamoto, K., and Yatomi, Y
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 37 Pages: 506-514

    • DOI

      10.1161/atvbaha.116.308692

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Different Origins of Lysophospholipid Mediators between Coronary and Peripheral Arteries in Acute Coronary Syndrome.2017

    • Author(s)
      Kurano, M., Kano, K., Dohi, T., Matsumoto, H., Igarashi, K., Nishikawa, M., Ohkawa, R., Ikeda, H., Miyauchi, K., Daida, H., Aoki, J., and Yatomi, Y.
    • Journal Title

      J Lipid Res.

      Volume: 58 Pages: 433-442

    • DOI

      10.1194/jlr.p071803

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression2017

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
    • Journal Title

      J Atheroscler Thromb

      Volume: in press Issue: 9 Pages: 954-969

    • DOI

      10.5551/jat.37663

    • NAID

      130006038432

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury2017

    • Author(s)
      Shigematsu, M., Koga, T., Ishimori, A., Saeki, K., Ishii, Y., Taketomi, Y., Ohba, M., Jo-Watanabe, A., Okuno, T., Harada, N., Harayama, T., Shindou, H., Li, J. D., Murakami, M., Hoka, S.,Yokomizo, T.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 34560-34560

    • DOI

      10.1038/srep34560

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inhibition of Leukotriene B4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice2017

    • Author(s)
      Hijioka, M., Anan, J., Ishibashi, H., Kurauchi, Y., Hisatsune, A., Seki, T., Koga, T., Yokomizo, T., Shimizu, T.,Katsuki, H.
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 360 Pages: 399-406

    • DOI

      10.1124/jpet.116.238824

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prolonged exposure to volatile anesthetic isoflurane worsens the outcome of polymicrobial abdominal sepsis2017

    • Author(s)
      Koutsogiannaki, S., Schaefers, M. M., Okuno, T., Ohba, M., Yokomizo, T., Priebe, G. P., DiNardo, J. A., Sulpicio, S. G.,Yuki, K.
    • Journal Title

      Toxicol Sci

      Volume: in press Pages: 402-411

    • DOI

      10.1093/toxsci/kfw261

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes2017

    • Author(s)
      Luo, L., Tanaka, R., Kanazawa, S., Lu, F., Hayashi, A., Yokomizo, T.,Mizuno, H.
    • Journal Title

      Journal of Diabetes and its Complications

      Volume: 31 Pages: 13-20

    • DOI

      10.1016/j.jdiacomp.2016.09.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production2017

    • Author(s)
      Okuno, T., Koutsogiannaki, S., Ohba, M., Chamberlain, M., Bu, W., Lin, F. Y., Eckenhoff, R. G., Yokomizo, T.,Yuki, K.
    • Journal Title

      The FASEB Journal

      Volume: 31 Pages: 1584-1594

    • DOI

      10.1096/fj.201601095r

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 皮膚保護作用を有する脂質メディエーター12-HHT2017

    • Author(s)
      石井由美子, 劉珉, 佐伯和子,横溝岳彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 67 Pages: 106-114

    • NAID

      40021064298

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy.2016

    • Author(s)
      Arita M
    • Journal Title

      Allergol Int

      Volume: 65

    • DOI

      10.1016/j.alit.2016.05.010

    • NAID

      130005418951

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hydrogen Rearrangement Rules: Computational MS/MS Fragmentation and Structure Elucidation Using MS-FINDER Software2016

    • Author(s)
      Tsugawa H, Kind T, Nakabayashi R, Yukihira D, Tanaka W, Cajka T, Saito K, Fiehn O, Arita M
    • Journal Title

      Analytical Chemistry

      Volume: 88 Pages: 7946-7958

    • DOI

      10.1021/acs.analchem.6b00770

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Editorial: Metabolome Informatics and Statistics: Current State and Emerging Trends2016

    • Author(s)
      Carroll AJ, Salek RM, Arita M, Kopka J, Walther D
    • Journal Title

      Front Bioeng Biotechnol

      Volume: 4 Pages: 63-63

    • DOI

      10.3389/fbioe.2016.00063

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SPLASH, a hashed identifier for mass spectra2016

    • Author(s)
      Wohlgemuth G, Mehta SS, Mejia RF, Neumann S, Pedrosa D, Pluskal T, Schymanski EL, Willighagen EL, Wilson M, Wishart DS, Arita M, Dorrestein PC, Bandeira N, Wang M, Schulze T, Salek RM, Steinbeck C, Nainala VC, Mistrik R, Nishioka T, Fiehn O
    • Journal Title

      Nature Biotechnol

      Volume: 34 Pages: 1099-1101

    • DOI

      10.1038/nbt.3689

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 生体内の低分子代謝産物を網羅的に捉えるための新技術2016

    • Author(s)
      津川裕司、有田正規
    • Journal Title

      化学と生物

      Volume: 54 Pages: 151-153

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Overview/リポクオリティが制御する血管医学2016

    • Author(s)
      有田誠
    • Journal Title

      血管医学(メディカルレビュー社)

      Volume: 17 Pages: 115-117

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 脂肪酸クオリティ制御と血管医学2016

    • Author(s)
      遠藤仁、有田誠
    • Journal Title

      血管医学(メディカルレビュー社)

      Volume: 17 Pages: 137-143

    • Related Report
      2016 Annual Research Report
  • [Journal Article] リピドミクスによる脂肪酸代謝と疾患制御の解析2016

    • Author(s)
      有田誠
    • Journal Title

      生体の科学(医学書院)

      Volume: 67 Pages: 189-192

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model.2016

    • Author(s)
      Morioka S, Nigorikawa K, Sasaki J, Hazeki K, Kasuu Y, Sasaki T, Hazeki O
    • Journal Title

      Innate Immun

      Volume: 6 Pages: 444-444

    • DOI

      10.1177/1753425916652714

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] イノシトールリン脂質のがん転移への関与 : "invadopodia"の形成機構2016

    • Author(s)
      坂東 倫行、佐々木 雄彦
    • Journal Title

      医学のあゆみ

      Volume: 257 Pages: 1211-1215

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Insufficient Lymph Drainage Causes Abnormal Lipid Accumulation and Vein Wall Degeneration2016

    • Author(s)
      Tanaka H, Yamamoto N, Suzuki M, Mano Y, Sano M, Zaima N, Sasaki T, Setou M, Unno N.
    • Journal Title

      AVD

      Volume: 9 Issue: 4 Pages: 277-284

    • DOI

      10.3400/avd.oa.16-00122

    • NAID

      130005252750

    • ISSN
      1881-641X, 1881-6428
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm.2016

    • Author(s)
      Kugo H, Zaima N, Tanaka H, Mouri Y, Yanagimoto K, Hayamizu K, Hashimoto K, Sasaki T, Sano M, Yata T, Urano T, Setou M, Unno N, Moriyama T.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 31268-31268

    • DOI

      10.1038/srep31268

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Accumulation of arachidonic acid-containing phosphatidylinositol at the outer edge of colorectal cancer.2016

    • Author(s)
      Hiraide T, Ikegami K, Sakaguchi T, Morita Y, Hayasaka T, Masaki N, Waki M, Sugiyama E, Shinriki S, Takeda M, Shibasaki Y, Miyazaki S, Kikuchi H, Okuyama H, Inoue M, Setou M, Konno H.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 29935-29935

    • DOI

      10.1038/srep29935

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Increased arachidonic acid-containing phosphatidylcholine is associated with reactive microglia and astrocytes in the spinal cord after peripheral nerve injury.2016

    • Author(s)
      Xu D, Omura T, Masaki N, Arima H, Banno T, Okamoto A, Hanada M, Takei S, Matsushita S, Sugiyama E, Setou M, Matsuyama Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Pages: 26427-26427

    • DOI

      10.1038/srep26427

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of sphingolipids and phospholipids in the fundic gland mucosa of human stomach using imaging mass spectrometry.2016

    • Author(s)
      Kurabe N, Igarashi H, Ohnishi I, Tajima S, Inoue Y, Takahashi Y, Setou M, Sugimura H.
    • Journal Title

      World J Gastrointest Pathophysiol.

      Volume: 7 Pages: 235-41

    • DOI

      10.4291/wjgp.v7.i2.235

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.2016

    • Author(s)
      Kitakaze K, Mizutani Y, Sugiyama E, Tasaki C, Tsuji D, Maita N, Hirokawa T, Asanuma D, Kamiya M, Sato K, Setou M, Urano Y, Togawa T, Otaka A, Sakuraba H, Itoh K
    • Journal Title

      J. Clin. Invest.

      Volume: in press Pages: 16911703-16911703

    • DOI

      10.1172/jci85300

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia.2016

    • Author(s)
      Miyawaki S, Imai H, Hayasaka T, Masaki N, Ono H, Ochi T, Ito A, Nakatomi H, Setou M, Saito N.
    • Journal Title

      Neuroscience

      Volume: 322 Pages: 66-77

    • DOI

      10.1016/j.neuroscience.2016.02.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 質量顕微鏡法の開発とその応用2016

    • Author(s)
      瀬藤光利
    • Journal Title

      J Mass Spectrom. Soc. Jpn

      Volume: 64 Pages: 201-218

    • NAID

      130005421348

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 脂質分解イメージングで脂質を"見る"2016

    • Author(s)
      堀川誠、武井史郎、瀬藤光利
    • Journal Title

      生体の科学

      Volume: 67 Pages: 198-202

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes.2016

    • Author(s)
      Makino A, Hullin-Matsuda F, Murate M, Abe M, Tomishige N, Fukuda M, Yamashita S, Fujimoto T, Vidal H, Lagarde M, Delton I, Kobayashi T.
    • Journal Title

      Mol. Biol. Cell

      Volume: 27 Pages: 3293-3304

    • DOI

      10.1091/mbc.e15-10-0730

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Esterification of 24(S)-hydroxycholesterol induces formation of atypical lipid droplet-like structures, leading to neuronal cell death2016

    • Author(s)
      Takabe W, Urano Y, Vo D-K H, Shibuya K, Tanno M, Kitagishi H, Fujimoto T, Noguchi N
    • Journal Title

      J Lipid Res.

      Volume: 57 Pages: 2005-2014

    • DOI

      10.1194/jlr.m068775

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison between mouse and sea urchin orthologs of voltage-gated proton channel suggests role of S3 segment in activation gating2016

    • Author(s)
      Sakata S, Miyawaki N, McCormack TJ, Arima H, Kawanabe A, Ozkucur N, Kurokawa T, Jinno Y, Fujiwara Y, Okamura Y
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1858 Pages: 2972-2983

    • DOI

      10.1016/j.bbamem.2016.09.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Voltage-dependent motion of the catalytic region of voltage-sensing phosphatase monitored by a fluorescent amino acid2016

    • Author(s)
      Sakata S, Jinno Y, Kawanabe A, Okamura Y
    • Journal Title

      Proc Natil Acad Sci USA

      Volume: 113 Pages: 7521-7526

    • DOI

      10.1073/pnas.1604218113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Simple scheme of lipid enzyme can explain complex lives of phosphoinositides.2016

    • Author(s)
      Okamura Y.
    • Journal Title

      PNAS

      Volume: 113 Pages: 7012-7014

    • DOI

      10.1073/pnas.1607427113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 細胞膜の機能的区画化におけるクラスターとドメインの概念とその制御2016

    • Author(s)
      反町典子
    • Journal Title

      生体の科学 特集号「脂質ワールド」

      Volume: 67 Pages: 220-226

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Resveratrol exerts a biphasic effect on apolipoprotein M.2016

    • Author(s)
      Kurano M, Hara M, Nojiri T, Ikeda H, Tsukamoto K, Yatomi Y.
    • Journal Title

      Br. J. Pharmacol.

      Volume: 173 Pages: 222-233

    • DOI

      10.1111/bph.13360

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence.2016

    • Author(s)
      Uranbileg B, Ikeda H, Kurano M, Enooku K, Sato M, Saigusa D, Aoki J, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      PLOS ONE

      Volume: 11

    • DOI

      10.1371/journal.pone.0149462

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.2016

    • Author(s)
      Enooku K, Uranbileg B, Ikeda H, Kurano M, Sato M, Kudo H, Maki H, Koike K, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI

      10.1371/journal.pone.0161825

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction2016

    • Author(s)
      Nagura, Y., Tsuno, NH., Kano, K., Inoue, A., Aoki, J., Hirowatari, Y., Kaneko, M., Kurano, M., Matsuhashi, M., Ohkawa, R., Tozuka, M., Yatomi, Y., and Okazaki, H.
    • Journal Title

      Transfus Med

      Volume: 26 Pages: 365-372

    • DOI

      10.1111/tme.12326

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human.2016

    • Author(s)
      Sato M, Ikeda H, Uranbileg B, Kurano M, Saigusa D, Aoki J, Maki H, Kudo H, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 32119-32119

    • DOI

      10.1038/srep32119

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 肝疾患による二次性脂質異常症.2016

    • Author(s)
      蔵野 信.
    • Journal Title

      臨床病理

      Volume: 64 Pages: 518-526

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 急性冠症候群の病態生理におけるマイナーリゾリン脂質の関与の可能性.2016

    • Author(s)
      蔵野 信.
    • Journal Title

      日本血栓止血学会誌

      Volume: 27 Pages: 460-465

    • Related Report
      2016 Annual Research Report
  • [Journal Article] HDLの抗血栓作用.2016

    • Author(s)
      蔵野 信.
    • Journal Title

      臨床病理

      Volume: 64 Pages: 66-71

    • Related Report
      2016 Annual Research Report
  • [Journal Article] スフィンゴシン1-リン酸とHDL.2016

    • Author(s)
      蔵野 信,矢冨 裕.
    • Journal Title

      医学のあゆみ

      Volume: 259 Pages: 878-879

    • Related Report
      2016 Annual Research Report
  • [Journal Article] The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes2016

    • Author(s)
      Chiba, T., Nakahara, T., Hashimoto-Hachiya, A., Yokomizo, T., Uchi, H.,Furue, M.
    • Journal Title

      Exp Dermatol

      Volume: 25 Pages: 532-536

    • DOI

      10.1111/exd.12976

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products, RAGE.2016

    • Author(s)
      Ichiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Yamamoto H, Sakaguchi M, Yokomizo T
    • Journal Title

      FASEB Journal

      Volume: 30 Pages: 000-000

    • DOI

      10.1096/fj.201500117

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Receptor for Advanced Glycation End Products Regulates Leukotriene B4 Receptor 1 Signaling2016

    • Author(s)
      Ichiki, T., Koga, T.,Yokomizo, T.
    • Journal Title

      DNA and Cell Biology

      Volume: 35 Pages: 747-750

    • DOI

      10.1089/dna.2016.3552

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins.2016

    • Author(s)
      Ishii Y, Saeki K, Liu M, Sasaki F, Koga T, Kitajima K, Meno C, Okuno T, Yokomizo T
    • Journal Title

      Faseb J

      Volume: 30 Pages: 933-47

    • DOI

      10.1096/fj.15-279653

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils2016

    • Author(s)
      Kojo, K., Ito, Y., Eshima, K., Nishizawa, N., Ohkubo, H., Yokomizo, T., Shimizu, T., Watanabe, M.,Majima, M.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 29650-29650

    • DOI

      10.1038/srep29650

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis2016

    • Author(s)
      Oba, J., Nakahara, T., Hashimoto-Hachiya, A., Liu, M., Abe, T., Hagihara, A., Yokomizo, T.,Furue, M.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI

      10.1371/journal.pone.0149285

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells2016

    • Author(s)
      Tabe, Y., Hatanaka, Y., Nakashiro, M., Sekihara, K., Yamamoto, S., Matsushita, H., Kazuno, S., Fujimura, T., Ikegami, T., Nakanaga, K., Matsumoto, H., Ueno, T., Aoki, J., Yokomizo, T., Konopleva, M., Andreeff, M., Miida, T., Iwabuchi, K.,Sasai, K.
    • Journal Title

      Int J Radiat Biol.

      Volume: 92 Pages: 24-34

    • DOI

      10.3109/09553002.2015.1106021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 【脂質ワールド】 新規脂質メディエーターと受容体 古くて新しい脂質メディエーター・12-ヒドロキシヘプタデカトリエン酸の生理作用2016

    • Author(s)
      横溝岳彦
    • Journal Title

      生体の科学

      Volume: 67 Pages: 232-236

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 快人快説 最先端の研究テクノロジー紹介 微量サンプル中の微量脂質を定量化する驚異の質量分析技術2016

    • Author(s)
      横溝岳彦
    • Journal Title

      LiSA

      Volume: 23 Pages: 1179-1188

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 「脂質マシナリー」研究 脂質メディエーターの最新の研究成果2016

    • Author(s)
      横溝岳彦
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 4 Pages: 610-617

    • NAID

      40021041094

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior.2016

    • Author(s)
      Yabuki Y, Koide T, Miyasaka N, Wakisaka N, Masuda M, Ohkura M, Nakai J, Tsuge K, Tsuchiya S, Sugimoto Y, Yoshihara Y
    • Journal Title

      Nature Neurosci

      Volume: 19 Pages: 897-904

    • DOI

      10.1038/nn.4314

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostaglandin D2 elicits the reversible neurite retraction in hypothalamic cell line.2016

    • Author(s)
      Tsuchiya H, Hohjoh H, Fujiwara Y, Sugimoto Y, Koshimizu TA.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 470 Pages: 804-810

    • DOI

      10.1016/j.bbrc.2016.01.091

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] プロスタノイド受容体を介した免疫・炎症応答亢進の分子機構2016

    • Author(s)
      告恭史郎、杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 256 Pages: 561-566

    • Related Report
      2016 Annual Research Report
  • [Journal Article] プロスタノイドクオリティと心血管系制御」血管医学2016

    • Author(s)
      告恭史郎、稲住知明、杉本幸彦
    • Journal Title

      血管医学

      Volume: 17 Pages: 37-43

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites.2016

    • Author(s)
      Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, Osumi N.
    • Journal Title

      Stem Cells

      Volume: 34(2) Pages: 470-482

    • DOI

      10.1002/stem.2246

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cardioprotective mechanism of omega-3 polyunsaturated fatty acids.2016

    • Author(s)
      Endo J, Arita M.
    • Journal Title

      J Cardiol

      Volume: 67 Pages: 22-27

    • DOI

      10.1016/j.jjcc.2015.08.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 脂肪酸クオリティによる炎症性疾患の制御2016

    • Author(s)
      有田誠
    • Journal Title

      感染炎症免疫

      Volume: 46 Pages: 22-30

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Imaging Mass Spectrometry Reveals a Unique Distribution of Triglycerides in the Abdominal Aortic Aneurysmal Wall.2016

    • Author(s)
      Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Saito T, Hayasaka T, Goto-Inoue N, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
    • Journal Title

      J Vasc Res.

      Volume: 52 Pages: 127-135

    • DOI

      10.1159/000439169

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel organ culture model of aorta for vascular calcification.2016

    • Author(s)
      Akiyoshi T, Ota H, Iijima K, Son BK, Kahyo T, Setou M, Ogawa S, Ouchi Y, Akishita M.
    • Journal Title

      Atherosclerosis

      Volume: 244 Pages: 51-58

    • DOI

      10.1016/j.atherosclerosis.2015.11.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic Distribution Pattern of Lysophosphatidylcholine in Fibromuscular Dysplasia-Associated Visceral Artery Aneurysms Compared with Atherosclerotic Visceral Artery Aneurysms.2016

    • Author(s)
      Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Konno H, Urano T, Setou M, Unno N.
    • Journal Title

      J Atheroscler Thromb

      Volume: 印刷中

    • NAID

      130005154756

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia2016

    • Author(s)
      Miyawaki S, Imai H, Hayasaka T, Masaki N, Ono H, Ochi T, Ito A, Nakatomi H, Setou M, Saito.
    • Journal Title

      Neuroscience

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 質量顕微鏡の原理とその応用2016

    • Author(s)
      佐野圭吾、深野華、有久亘、瀬藤光利
    • Journal Title

      病理と臨床&nbsp;

      Volume: 34 Pages: 203-210

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脂質分析イメージングで脂質を「見る」2016

    • Author(s)
      堀川誠、武井史郎、瀬藤光利
    • Journal Title

      生体の科学

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Effects of unsaturated fatty acids on the kinetics of voltage-gated proton channels heterologously expressed in cultured cells.2016

    • Author(s)
      Kawanabe A., Okamura Y.
    • Journal Title

      J. Physiol.

      Volume: 594 Pages: 595-610

    • DOI

      10.1113/jp271274

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release2016

    • Author(s)
      Okochi Y, Aratani Y, Adissu HA, Miyawaki N, Sasaki M, Suzuki K, Okamura Y.
    • Journal Title

      J Microbiol Methods

      Volume: 99 Pages: 159-163

    • DOI

      10.1189/jlb.3hi0814-393r

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Structural basis for the membrane association of ankyrinG via palmitoylation2016

    • Author(s)
      Fujiwara Y, Kondo H, Shirota M, Kobayashi M, Takeshita K, Nakagawa A, Okamura Y, Kinoshita K
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 23981-23981

    • DOI

      10.1038/srep23981

    • NAID

      120006770875

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Direct Interaction between the Voltage-sensors Produces Cooperative Sustained Deactivation in Voltage-gated H+ Channel Dimers.2016

    • Author(s)
      Okuda H, Yonezawa Y, Takano Y, Okamura Y, Fujiwara Y.
    • Journal Title

      J BIOL CHEM

      Volume: 291 Pages: 5935-47

    • DOI

      10.1074/jbc.m115.666834

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 電位依存性プロトンチャネルにおけるプロトン透過の機構2016

    • Author(s)
      岡村康司
    • Journal Title

      Biophysics

      Volume: 56(3) Issue: 1 Pages: 001-001

    • DOI

      10.2142/biophys.56.001

    • NAID

      130005121653

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel imaging method revealed phosphatidylinositol 3,5-bisphosphate-rich domains in the endosome/lysosome membrane2016

    • Author(s)
      Takatori S, Fujimoto T
    • Journal Title

      Communicative & Integrative Biology

      Volume: 9

    • DOI

      10.1080/19420889.2016.1145319

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PML isoform II plays a critical role in nuclear lipid droplet formation.2016

    • Author(s)
      Ohsaki Y, Kawai T, Yoshikawa Y, Cheng J, Jokitalo E, Fujimoto T.
    • Journal Title

      J Cell Biol

      Volume: 212 Pages: 29-38

    • DOI

      10.1083/jcb.201507122

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phosphatidylinositol 3,5-bisphosphate-rich membrane domains in endosomes and lysosomes2016

    • Author(s)
      Takatori S, Tatematsu T, Cheng J, Matsumoto J, Akano T, Fujimoto T
    • Journal Title

      Traffic

      Volume: 17 Pages: 154-167

    • DOI

      10.1111/tra.12346

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ROR1 sustains caveolae and survival signaling as a scaffold of cavin-1 and caveolin-12016

    • Author(s)
      Yamaguchi T, Lu C, Yanagisawa K, Can Lu, Usukura J, Cheng J, Hotta N, Shimada Y, Ida R, Isomura H, Suzuki M, Fujimoto T, Takahashi T
    • Journal Title

      Nature Communication

      Volume: 7 Pages: 10060-10060

    • DOI

      10.1038/ncomms10060

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphatidic acid induces EHD3-containing membrane tubulation and is required for receptor recycling. Exp. Cell Res. 342, 1-10.2016

    • Author(s)
      Henmi, Y., Oe, N., Kono, N., Taguchi, T., Takei, K., and Tanabe, K.
    • Journal Title

      Exp Cell Res

      Volume: 342 Pages: 1-10

    • DOI

      10.1016/j.yexcr.2016.02.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes.2016

    • Author(s)
      Chiba, T., Nakahara, T., Hashimoto-Hachiya, A., Yokomizo, T., Uchi, H., Furue, M.
    • Journal Title

      Exp Dermatol I

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ロイコトリエン受容体2016

    • Author(s)
      市木貴子, 古賀友紹, 横溝岳彦.
    • Journal Title

      医学のあゆみ

      Volume: 256 Pages: 554-560

    • NAID

      10025740562

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior.2016

    • Author(s)
      Yabuki, Y., Koide, T., Miyasaka, N., Wakisaka, N., Masuda, M., Ohkura, M., Nakai, J., Tsuge, K., Tsuchiya, S., Sugimoto, Y., Yoshihara, Y.
    • Journal Title

      Nature Neurosci.

      Volume: 19

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] プロスタノイド受容体を介した免疫・炎症応答亢進の分子機構2016

    • Author(s)
      告恭史郎, 杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 256(5) Pages: 561-566

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats.2015

    • Author(s)
      M. Katakura, M. Hashimoto, T. Inoue, A. Mamun, Y. Tanabe, M. Arita, O. Shido.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0140884

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.2015

    • Author(s)
      Sawada Y, Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A, Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, Kabashima K.
    • Journal Title

      Journal of Experimental medicine

      Volume: 212 Pages: 1921-1930

    • DOI

      10.1084/jem.20150381

    • NAID

      120005733188

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aspirin and Eicosapentaenoic Acid May Arrest Progressive IgA Nephropathy: A Potential Alternative to Immunosuppression2015

    • Author(s)
      Hirahashi J, Hanafusa N, Wada T, Arita M, Hishikawa K, Hayashi M, Nangaku M
    • Journal Title

      Intern. Med.

      Volume: 54 Issue: 18 Pages: 2377-2382

    • DOI

      10.2169/internalmedicine.54.4623

    • NAID

      130005099678

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurite outgrowth stimulation by n3 and n6 polyunsaturated fatty acids of phospholipids in apolipoprotein E containing lipoproteins secreted from glial cells.2015

    • Author(s)
      Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, Ueda K.
    • Journal Title

      J Lipid Res.

      Volume: 56 Pages: 1880-1890

    • DOI

      10.1194/jlr.m058164

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Total synthesis of four stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-dihydroxy-4,7,10,12,16,18-docosahexaenoic acid and their anti-inflammatory activities.2015

    • Author(s)
      Goto T, Urabe D, Masuda K, Isobe Y, Arita M, Inoue M.
    • Journal Title

      J. Org. Chem,

      Volume: 80 Pages: 7713-7726

    • DOI

      10.1021/acs.joc.5b01461

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut2015

    • Author(s)
      J. Kunisawa, M. Arita, T. Hayasaka, T. Harada, R. Iwamoto, R. Nagasawa, S. Shikata, T. Nagatake, H. Suzuki, E. Hashimoto, Y. Kurashima, Y. Suzuki, H. Arai, M. Setou, and H. Kiyono
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 9750-9750

    • DOI

      10.1038/srep09750

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Eosinophil-mediated signaling attenuates inflammatory responses in experimental colitis.2015

    • Author(s)
      Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT.
    • Journal Title

      Gut

      Volume: 64 Pages: 1236-1247

    • DOI

      10.1136/gutjnl-2014-306998

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis.2015

    • Author(s)
      Hiroshi Tsugawa, Tomas Cajka, Tobias Kind, Yan Ma, Brendan Higgins, Kazutaka Ikeda, Mitsuhiro Kanazawa, Jean VanderGheynst, Oliver Fiehn, Masanori Arita
    • Journal Title

      Nat Methods

      Volume: 12 Pages: 523-526

    • DOI

      10.1038/nmeth.3393

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ω3脂肪酸の分子栄養学2015

    • Author(s)
      有田誠
    • Journal Title

      アンチエイジング医学(メディカルレビュー社)

      Volume: 11 Pages: 845-851

    • NAID

      40020717239

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ω3脂肪酸のメタボローム解析と心臓リモデリング抑制作用2015

    • Author(s)
      有田誠
    • Journal Title

      内分泌・糖尿病・代謝内科(科学評論社)

      Volume: 41 Pages: 380-384

    • NAID

      40020676046

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 多価不飽和脂肪酸の代謝と炎症の制御2015

    • Author(s)
      有田誠
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 254 Pages: 1127-1130

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ω3脂肪酸の代謝と疾患制御のメタボロミクス2015

    • Author(s)
      有田誠
    • Journal Title

      実験医学増刊号「脂質疾患学」(羊土社)

      Volume: 33 Pages: 2361-2366

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 炎症の収束に関わる脂肪酸代謝系とその機能2015

    • Author(s)
      有田誠
    • Journal Title

      別冊BIO Clinica「慢性炎症と疾患」(北隆館)

      Volume: 4 Pages: 27-31

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脂肪酸代謝と炎症のメタボロミクス2015

    • Author(s)
      有田誠
    • Journal Title

      臨床免疫・アレルギー科(科学評論社)

      Volume: 63 Pages: 118-124

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ω3脂肪酸の代謝と心臓保護作用2015

    • Author(s)
      有田誠
    • Journal Title

      別冊BIO Clinica「慢性炎症と疾患」(北隆館)

      Volume: 4 Pages: 99-110

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ω3系多価不飽和脂肪酸による心臓リモデリング抑制2015

    • Author(s)
      有田誠、遠藤仁
    • Journal Title

      循環plus(メディカルトリビューン社)

      Volume: 15 Pages: 7-9

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.2015

    • Author(s)
      Ip, LR., Poulogiannis, G., Viciano, FC., Sasaki, J., Kofuji, S., Spanswick, VJ., Hochhauser, D., Hartley, JA., Sasaki, T., Gewinner, CA.
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 10548-10562

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] INPP4B Is a PtdIns (3,4,5) P3 Phosphatase That Can Act as a Tumor Suppressor.2015

    • Author(s)
      Kofuji, S., Kimura, H., Nakanishi, H., Nanjo, H., Takasuga, S., Liu, H., Eguchi, S., Nakamura, R., Itoh, R., Ueno, N., Asanuma, K., Huang, M., Koizumi, A., Habuchi, T., Yamazaki, M., Suzuki, A., Sasaki, J., Sasaki, T.
    • Journal Title

      Cancer Discov.

      Volume: 5 Pages: 730-739

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.2015

    • Author(s)
      Li, Chew C., Lunardi, A., Gulluni, F., Ruan, DT., Chen, M., Salmena, L., Nishino, M., Papa, A., Ng, C., Fung, J., Clohessy, JG., Sasaki, J., Sasaki, T., Bronson, RT., Hirsch, E., Pandolfi, PP.
    • Journal Title

      Cancer Discov.

      Volume: 5 Pages: 740-751

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inositol Polyphosphate-4-Phosphatase Type I Negatively2015

    • Author(s)
      Nigorikawa, K., Hazeki, K., Sasaki, J., Omori, Y., Miyake, M., Morioka, S., Guo, Y., Sasaki, T., Hazeki, O
    • Journal Title

      Cancer Discov.

      Volume: 10 Pages: 740-751

    • DOI

      10.1371/journal.pone.0142091

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells.2015

    • Author(s)
      Hammond GR, Takasuga S, Sasaki T, Balla T.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0139957

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Localizing the lipid products of PI3Kγ in neutrophils2015

    • Author(s)
      Norton L, Lindsay Y, Deladeriere A, Chessa T, Guillou H, Suire S, Lucocq J, Walker S, Andrews S, Segonds-Pichon A, Rausch O, Finan P, Sasaki T, Du CJ, Bretschneider T, Ferguson GJ, Hawkins PT, Stephens L.
    • Journal Title

      Adv Biol Regul

      Volume: 60 Pages: 36-45

    • DOI

      10.1016/j.jbior.2015.10.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] INPP4BはPTEN欠損による発がんへのフェイルセーフ機構を担う2015

    • Author(s)
      小藤智史,佐々木雄彦
    • Journal Title

      実験医学

      Volume: 34 Pages: 450-453

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Reductions of docosahexaenoic acid-containing phosphatidylcholine levels in the anterior horn of an ALS mouse model.2015

    • Author(s)
      Arima H, Omura T, Hayasaka T, Masaki N, Hanada M, Xu D, Banno T, Kobayashi K, Takeuchi H, Kadomatsu K, Matsuyama Y, Setou M.
    • Journal Title

      Neuroscience

      Volume: 印刷中 Pages: 127-136

    • DOI

      10.1016/j.neuroscience.2015.03.060

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Decreased level of phosphatidylcholine (16:0/20:4) in multiple myeloma cells compared to plasma cells: A single-cell MALDI-IMS approach.2015

    • Author(s)
      Hossen A, Nagata Y, Waki M, Ide Y, Takei S, Fukano H, Romero-Perez GA, Tajima S, Yao I, Ohnishi K,Setou M.
    • Journal Title

      Anal Bioanal Chem.

      Volume: 407 Pages: 5273-5280

    • DOI

      10.1007/s00216-015-8741-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Three-Dimensional Image of Cleavage Bodies in Nuclei Is Configured Using Gas Cluster Ion Beam with Time-of-Flight Secondary Ion Mass Spectrometry.2015

    • Author(s)
      Masaki N, Ishizaki I, Hayasaka T, Fisher GL, Sanada N, Yokota H, Setou M.
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 10000-10000

    • DOI

      10.1038/srep10000

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Variation of prostaglandin E2 concentrations in ovaries and its effects on ovarian maturation and oocyte proliferation in the giant fresh water prawn, Macrobrachium rosenbergii.2015

    • Author(s)
      Sumpownon C, Engsusophon A, Siangcham T, Sugiyama E, Soonklang N, Meeratana P, Wanichanon C, Hanna PJ, Setou M, Sobhon P.
    • Journal Title

      Gen Comp Endocrinol.

      Volume: 223 Pages: 129-138

    • DOI

      10.1016/j.ygcen.2015.04.019

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Collection: Expression of Human Gaucher Disease Gene GBA Generates Neurodevelopmental Defects and ER Stress in Drosophila Eye.2015

    • Author(s)
      Suzuki T, Shimoda M, Ito K, Hanai S, Aizawa H, Kato T, Kawasaki K, Yamaguchi T, Ryoo HD, Goto-Inoue N, Setou M, Tsuji S, Ishida N.
    • Journal Title

      PLoS One.

      Volume: 10

    • DOI

      10.1371/journal.pone.0135619

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm.2015

    • Author(s)
      Tanaka H, Zaima N, Sasaki T, Sano M, Yamamoto N, Saito T, Inuzuka K, Hayasaka T, Goto-Inoue N, Sugiura Y, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
    • Journal Title

      PLoS One.

      Volume: 10

    • DOI

      10.1371/journal.pone.0134386

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct profiling of the phospholipid composition of adult Caenorhabditis elegans using whole-body imaging mass spectrometry.2015

    • Author(s)
      Hameed S, Ikegami K, Sugiyama E, Matsushita S, Kimura Y, Hayasaka T, Sugiura Y, Masaki N, Waki M, Ohta I, Hossen MA, Setou M
    • Journal Title

      Anal Bioanal Chem.

      Volume: 407 Pages: 7589-7602

    • DOI

      10.1007/s00216-015-8932-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mode of bioenergetic metabolism during B cell differentiation in the intestine determines the distinct requirement for vitamin B12015

    • Author(s)
      J. Kunisawa, Y. Sugiura, T. Wake, T. Nagatake, H. Suzuki, R. Nagasawa, S. Shikata, K. Honda, E. Hashimoto, Y. Suzuki, M. Setou, M. Suematsu, H. Kiyono
    • Journal Title

      Cell Reports

      Volume: 13 Pages: 122-131

    • DOI

      10.1016/j.celrep.2015.08.063

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ammonium sulfate improves detection of hydrophilic quaternary ammonium compounds through decreased ion suppression in matrix-assisted laser desorption/ionization imaging mass spectrometry.2015

    • Author(s)
      Sugiyama E, Masaki N, Matsushita S, Setou M.
    • Journal Title

      Anal Chem.

      Volume: 87 Pages: 11176-11181

    • DOI

      10.1021/acs.analchem.5b02672

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Alzheimer’s disease is associated with disordered localization of ganglioside GM1 molecular species in the human dentate gyrus.2015

    • Author(s)
      Hirano-Sakamaki W, Sugiyama E, Hayasaka T, Ravid R, Setou M, Taki T.
    • Journal Title

      FEBS Lett.

      Volume: 589 Pages: 3611-3616

    • DOI

      10.1016/j.febslet.2015.09.033

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decrease in Sphingomyelin (d18:1/16:0) in Stem Villi and Phosphatidylcholine (16:0/20:4) in Terminal Villi of Human Term Placentas with Pathohistological Maternal Malperfusion.2015

    • Author(s)
      Yamazaki K, Masaki M, Kohmura-Kobayashi Y, Chizuko Y, Hayasaka T, Itoh H, Setou M, Kanayama N.
    • Journal Title

      PLoS One

      Volume: 10 Pages: 1-14

    • DOI

      10.1371/journal.pone.0142609

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle.2015

    • Author(s)
      Senoo N, Miyoshi N, Goto-Inoue N, Minami K, Yoshimura R, Morita A, Sawada N, Matsuda J, Ogawa Y, Setou M, Kamei Y, Miura S.
    • Journal Title

      J Lipid Res

      Volume: 56 Pages: 2286-2296

    • DOI

      10.1194/jlr.m060533

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mechanical Stimulation by Postnasal Drip Evokes Cough.2015

    • Author(s)
      Iwata T, Ito I, Niimi A, Ikegami K, Marumo S, Tanabe N, Nakaji H, Kanemitsu Y, Matsumoto H, Kamei J, Setou M, Mishima M.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0141823

    • NAID

      120005749926

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 質量分析イメージング法による病理組織解析2015

    • Author(s)
      山崎文義、瀬藤光利
    • Journal Title

      臨床病理

      Volume: 63 Pages: 472-480

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 質量顕微鏡法による脂質解析2015

    • Author(s)
      佐藤智仁、杉山栄二、松下祥子、武井史郎、瀬藤光利
    • Journal Title

      実験医学増刊

      Volume: 33 Pages: 2521-2527

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 電位依存性プロトンチャネルVSOPの結晶構造から考察するプロトン漏洩制御機構2015

    • Author(s)
      竹下浩平、岡村康司、中川敦史
    • Journal Title

      生化学

      Volume: 87(5) Pages: 625-628

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division2015

    • Author(s)
      Arasaki K, Shimizu H, Mogari H, Nishida N, Hirota N, Furuno A, Kudo Y, Baba M, Baba N, Cheng J, Fujimoto T, Ishihara N, Ortiz-Sandoval C, Barlow L, Raturi A, Dohmae N, Wakana Y, Inoue H, Tani K, Dacks J, Simmen T, Tagaya M
    • Journal Title

      Dev Cell

      Volume: 32 Pages: 304-317

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-1.2015

    • Author(s)
      Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki, Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto and Yuji Owada
    • Journal Title

      GLIA

      Volume: 63 Pages: 780-79

    • DOI

      10.1002/glia.22784

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hepatocyte-specific depletion of UBXD8 induces periportal steatosis in mice fed a high-fat diet2015

    • Author(s)
      Imai N, Suzuki M, Hayashi K, Ishigami M, Hirooka Y, Abe T, Shioi G, Goto H, Fujimoto T. (* co-first authors)
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0127114

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ELMOD2 is anchored to lipid droplets by palmitoylation and regulates ATGL recruitment2015

    • Author(s)
      Michitaka Suzuki, Tatsuro Murakami, Jinglei Cheng, Hiroyuki Kano, Masaki Fukata, and Toyoshi Fujimoto
    • Journal Title

      Molecular biology of the cell

      Volume: - Pages: 2333-2342

    • DOI

      10.1091/mbc.e14-11-1504

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay2015

    • Author(s)
      Takeda H, Ogasawara T, Ozawa T, Muraguchi A, Jih PJ, Morishita R, Uchigashima M, Watanabe M, Fujimoto T, Iwasaki T, Endo Y, Sawasaki T
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 11333-11333

    • DOI

      10.1038/srep11333

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum2015

    • Author(s)
      Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Pages: 23464-23477

    • DOI

      10.1074/jbc.m115.662668

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Microscopy of membrane lipids: how precisely can we define their distribution?2015

    • Author(s)
      Takatori S and Fujimoto T
    • Journal Title

      Essays in Biochemistry

      Volume: 57 Pages: 81-91

    • DOI

      10.1042/bse0570081

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Separation of Intracellular Vesicles for Immunoassays.2015

    • Author(s)
      Kobayashi T, Tanaka T, and Toyama-Sorimachi N.
    • Journal Title

      Bio-protocol

      Volume: 5(16)

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-62015

    • Author(s)
      Seto E, Yoshida-Sugitani R, Kobayashi T, Toyama-Sorimachi N
    • Journal Title

      PloS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0123223

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 学研メディカル秀潤社2015

    • Author(s)
      小林俊彦、反町典子
    • Journal Title

      細胞工学6月号

      Volume: 34 Pages: 557-561

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 羊土社2015

    • Author(s)
      小林俊彦、反町典子
    • Journal Title

      実験医学増刊号

      Volume: 33 Pages: 75-82

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury2015

    • Author(s)
      Asahara M, Ito N, Yokomizo T, Nakamura M, Shimizu T, Yamada Y.
    • Journal Title

      Mol Pain.

      Volume: 11 Pages: 11-11

    • DOI

      10.1186/s12990-015-0010-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The leukotriene B4 receptor BLT1 is stabilized by transmembrane helix capping mutations.2015

    • Author(s)
      Hori, T., Nakamura, M., Yokomizo, T., Shimizu, T., Miyano, M.
    • Journal Title

      Biochem. Biophys.

      Volume: 4 Pages: 243-249

    • DOI

      10.1016/j.bbrep.2015.09.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical characterization of three BLT receptors in zebrafish.2015

    • Author(s)
      Okuno T, Ishitani T, Yokomizo T.
    • Journal Title

      PLoS One

      Volume: 10 Pages: 0117888-0117888

    • DOI

      10.1371/journal.pone.0117888

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration2015

    • Author(s)
      Zandi S, Nakao S, Chun K H, Fiorina P, Sun D, Arita R, Zhao M, Kim E, Schueller O, Campbell S, Taher M, Melhorn M I, Schering A, Gatti F, Tezza S, Xie F, Vergani A, Yoshida S, Ishikawa K, Yamaguchi M, Sasaki F, Schmidt-Ullrich R, Hata Y, Enaida H, Yuzawa M, Yokomizo T, 4名
    • Journal Title

      Cell Rep.

      Volume: 10 Pages: 1173-1186

    • DOI

      10.1016/j.celrep.2015.01.050

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two distinct leukotriene B4 receptors, BLT1 and BLT22015

    • Author(s)
      Yokomizo T.
    • Journal Title

      J Biochem

      Volume: 157 Pages: 65-71

    • DOI

      10.1093/jb/mvu078

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The role of leukotrienes in allergic diseases2015

    • Author(s)
      Liu M, Yokomizo T.
    • Journal Title

      Allergol. Int.

      Volume: 64 Issue: 1 Pages: 17-26

    • DOI

      10.1016/j.alit.2014.09.001

    • NAID

      130004873117

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 12-HHT 皮膚創傷治癒に働く新しいCOX代謝物.2015

    • Author(s)
      佐伯和子, 劉珉, 横溝岳彦.
    • Journal Title

      医学のあゆみ

      Volume: 254 Pages: 1121-1125

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 血小板由来の脂質メディエーター12-HHTは角化細胞の移動を亢進させ皮膚創傷治癒を促進する.2015

    • Author(s)
      佐伯和子, 劉珉, 横溝岳彦.
    • Journal Title

      血栓止血

      Volume: 26 Pages: 611-618

    • NAID

      130005113961

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脂質メディエーターによる免疫・炎症応答の制御2015

    • Author(s)
      李賢哲, 奥野利明, 横溝岳彦.
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 64 Pages: 386-390

    • NAID

      40020622928

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 第1世代脂質メディエーター エイコサノイド2015

    • Author(s)
      横溝岳彦
    • Journal Title

      実験医学

      Volume: 33 Pages: 2344-2348

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【アセトアミノフェン】 薬理学的側面から 古くて新しい謎だらけの薬2015

    • Author(s)
      横溝岳彦
    • Journal Title

      LiSA

      Volume: 22 Pages: 874-877

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Roles of prostaglandin receptors in female reproduction.2015

    • Author(s)
      Sugimoto Y, Inazumi T, Tsuchiya S
    • Journal Title

      The Journal of Biochemistry

      Volume: 157 Pages: 73-80

    • DOI

      10.1093/jb/mvu081

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostaglandin E2-induced inflammation: relevance of prostaglandin E receptors.2015

    • Author(s)
      Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1851 Pages: 414-421

    • DOI

      10.1016/j.bbalip.2014.07.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dermal Vγ4(+) γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8(+) T-Cell Activity through TNF-α Production.2015

    • Author(s)
      Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K.
    • Journal Title

      J. Invest. Dermatol.

      Volume: 135 Issue: 4 Pages: 1007-1015

    • DOI

      10.1038/jid.2014.516

    • NAID

      120005621945

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] p13 overexpression in pancreatic b-cells ameliorates type 2 diabetes in high-fat-fed mice2015

    • Author(s)
      Higashi, S. et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 461 Pages: 612-617

    • DOI

      10.1016/j.bbrc.2015.04.074

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice2015

    • Author(s)
      Ikeda K, Tomimoto S, Tsuchiya S, Hamagami K, Shintani N, Sugimoto Y, Ichikawa A, Kasai A, Nakazawa T, Nagayasu K, Hayata-Takano A, Baba A, Hashimoto H
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 2 Pages: 179-183

    • DOI

      10.1016/j.bbrep.2015.06.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling that Drives Tumor Growth, Angiogenesis and Metastasis.2015

    • Author(s)
      Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C.
    • Journal Title

      J Biol Chem

      Volume: 290 Pages: 29781-29793

    • DOI

      10.1074/jbc.m115.669481

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] プロスタグランジンによる皮膚マスト細胞の成熟と活性化2015

    • Author(s)
      杉本幸彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 62-67

    • NAID

      40020330437

    • Related Report
      2015 Annual Research Report
  • [Journal Article] プロスタグランジンによる神経機能の調節機構2015

    • Author(s)
      杉本幸彦
    • Journal Title

      日薬理誌

      Volume: 145 Pages: 237-242

    • NAID

      130005067370

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 炎症反応におけるプロスタグランジンE2の役割2015

    • Author(s)
      岩崎亮, 北條寛典, 杉本幸彦
    • Journal Title

      細胞

      Volume: 47 Pages: 266-269

    • Related Report
      2015 Annual Research Report
  • [Journal Article] プロスタグランジンによる女性生殖制御の意義2015

    • Author(s)
      告恭史郎, 杉本幸彦
    • Journal Title

      実験医学

      Volume: 33(15) Pages: 164-169

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 急性炎症にかかわるプロスタグランジンとその働き2015

    • Author(s)
      杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 254(12) Pages: 1091-1096

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Blood levels of serotonin are specifically correlated with plasma lysophosphatidylserine among the glycero-lysophospholipids2015

    • Author(s)
      Kurano M, Dohi T, Nojiri T, Kobayashi T, Hirowatari Y, Inoue A, Kano K, Matsumoto H, Igarashi K, Nishikawa M, Miyauchi K, Daida H, Ikeda H, Aoki J, Yatomi Y
    • Journal Title

      BBA Clin

      Volume: 4 Pages: 92-8

    • DOI

      10.1016/j.bbacli.2015.08.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A New Enzyme Immunoassay for the Quantitative Determination of Classical Autotaxins (ATXα, ATXβ, and ATXγ) and Novel Autotaxins (ATXδ and ATXε)2015

    • Author(s)
      Tokuhara Y, Kurano M, Shimamoto S, Igarashi K, Nojiri T, Kobayashi T, Masuda A, Ikeda H, Nagamatsu T, Fujii T, Aoki J, Yatomi Y
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0130074

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects2015

    • Author(s)
      Ohkawa R, Kurano M, Mishima Y, Nojiri T, Tokuhara Y, Kishimoto T, Nakamura K, Okubo S, Hosogaya S, Ozaki Y, Yokota H, Igarashi K, Ikeda H, Tozuka M, Yatomi Y
    • Journal Title

      Clin Biochem

      Volume: 48 Pages: 690-697

    • DOI

      10.1016/j.clinbiochem.2015.03.019

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lysophosphatidylserine has Bilateral Effects on Macrophages in the Pathogenesis of Atherosclerosis2015

    • Author(s)
      Nishikawa M, Kurano M, Ikeda H, Aoki J, Yatomi Y
    • Journal Title

      J Atheroscler Thromb

      Volume: 22 Issue: 5 Pages: 518-26

    • DOI

      10.5551/jat.25650

    • NAID

      130004704381

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome.2015

    • Author(s)
      Kurano M, Suzuki A, Inoue A, Tokuhara Y, Kano K, Matsumoto H, Igarashi K, Ohkawa R, Nakamura K, Dohi T, Miyauchi K, Daida H, Tsukamoto K, Ikeda H, Aoki J, Yatomi Y
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol.

      Volume: 35 Pages: 463-470

    • DOI

      10.1161/atvbaha.114.304748

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] LDL Receptor and ApoE are Involved in the Clearance of ApoM-associated Sphingosine 1-phosphate2015

    • Author(s)
      Kurano M, Tsukamoto K, Hara M, Ohkawa R, Ikeda H, Yatomi Y.
    • Journal Title

      J Biol Chem

      Volume: 290 Pages: 2477-88

    • DOI

      10.1074/jbc.m114.596445

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] リゾリン脂質を標的とした診断と創薬2015

    • Author(s)
      蔵野 信,可野 邦行,矢冨 裕,青木 淳賢
    • Journal Title

      実験医学増刊号「脂質疾患学」(羊土社)

      Volume: 33 Pages: 178-185

    • Related Report
      2015 Annual Research Report
  • [Journal Article] リゾリン脂質と動脈硬化:虚血性心疾患予防への新たなアプローチとしての可能性2015

    • Author(s)
      蔵野 信,矢冨 裕
    • Journal Title

      呼吸と循環

      Volume: 63 Pages: 847-851

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脂質メディエーターの臨床検査2015