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「リポクオリティ」領域研究の推進

Organizer

Project AreaQuality of lipids in biological systems
Project/Area Number 15H05897
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

有田 誠  国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー (80292952)

Co-Investigator(Kenkyū-buntansha) 有田 正規  国立遺伝学研究所, 情報研究系, 教授 (10356389)
瀬藤 光利  浜松医科大学, 国際マスイメージングセンター, センター長 (20302664)
反町 典子  国立研究開発法人国立国際医療研究センター, その他部局等, 分子炎症制御プロジェクト長 (30217468)
藤本 豊士  順天堂大学, 医学(系)研究科(研究院), 特任教授 (50115929)
佐々木 雄彦  東京医科歯科大学, 難治疾患研究所, 教授 (50333365)
矢冨 裕  東京大学, 医学部附属病院, 教授 (60200523)
横溝 岳彦  順天堂大学, 医学(系)研究科(研究院), 教授 (60302840)
岡村 康司  大阪大学, 医学系研究科, 教授 (80201987)
杉本 幸彦  熊本大学, 大学院生命科学研究部(薬), 教授 (80243038)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Granted (Fiscal Year 2019)
Budget Amount *help
¥260,650,000 (Direct Cost: ¥200,500,000、Indirect Cost: ¥60,150,000)
Fiscal Year 2019: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2018: ¥36,530,000 (Direct Cost: ¥28,100,000、Indirect Cost: ¥8,430,000)
Fiscal Year 2017: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2016: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Fiscal Year 2015: ¥111,020,000 (Direct Cost: ¥85,400,000、Indirect Cost: ¥25,620,000)
Keywords脂質 / 領域マネジメント / 研究支援センター / 領域事務局 / 脂質データベース / 広報活動 / 領域会議の開催
Outline of Annual Research Achievements

リポクオリティ領域全体の円滑な研究活動を支援するため、総括班として以下の活動を行った。
(1)本領域のホームページ(https://sites.google.com/site/lipoqualityjpn/)において、研究成果や研究内容紹介などについて随時情報のアップデートを行った。16件の公募班を新たに加えた領域ホームページの整備および領域メイリングリストなど相互の連絡体制を整えた。また、本領域の最終年度に開催する第60回国際脂質生物学会議(ICBL2019)の事務局を立ち上げた。(2)研究支援センターの整備と利用:理研IMS内に設置した質量分析センターは、ノンターゲット解析の技術開発および従来のターゲット解析と組み合わせて領域内外との共同研究を展開し、リポクオリティ領域研究の進展に大きく貢献した。また、他の研究支援センターについてもそれぞれ整備を行ない、公募班員を含めたリポクオリティ領域研究を支援する運用を行った。(3)リポクオリティ・データベースの企画会議を月一回開催し、公開内容の検討、および海外の研究拠点や外部データベースとの連携方法について議論した。(4)第6回総括班会議を開催し、領域の運営方針について議論を重ねた。(5)「実験医学増刊:脂質クオリティ-生命機能と健康を支える脂質の多様性-」を羊土社から出版いただき、国内向けの総説集としてリポクオリティ領域研究の周知を図った。また、第60回日本脂質生化学会(東京)、9月に第91回日本生化学会大会(京都)にて共催シンポジウムを開催し、公知を図った。(6)2018年6月に第4回領域会議(淡路)を開催した。(7)2019年3月に第4回領域ニュースレターを発行した。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

各研究支援センターの運営状況は以下のように良好である。
(1)質量分析センター:引き続きノンターゲット解析(Q-TOF)とターゲット解析(tripleQ)による脂質分析支援を領域内外の研究者に対して行った。また、得られた脂質分子の定量情報をリポクオリティ・データベースに登録する作業を進めた(有田班)主にイノシトールリン脂質測定支援を行った(佐々木班)(2)脂質イメージングセンター:イメージングデータの解析に機械学習による分子分布パターンの分類を行い、脳の白質、灰白質、小脳皮質など特異的な分布を示す脂質群を得る解析法を確立した(瀬藤班)ホスファチジルセリンおよびイノシトールリン脂質可視化解析法による共同研究を進めている(藤本班)(3)膜機能解析センター:筋小胞体膜に膜電位プローブをターゲットさせて膜電位の計測を行い、内膜からの蛍光シグナルをもちいて内膜電位の計測の可能性が見出された。またファゴソーム膜からの膜電位計測を行い、貪食にともなって膜電位が過分極することを見出された(岡村班)新規スフィンゴミエリンプローブの有用性および汎用性を高めるための材料を構築している。また、スフィンゴミエリンプローブ発現誘導型トランスジェニックマウスを作出した(反町班)(4)脂質データベース:45のグリセロ脂質とスフィンゴ脂質クラスに対し、鎖長や不飽和度を自由に設定して理論スペクトルを生成、ダウンロードできる機能を付与した(有田班)(5)臨床検体センター:倫理委員会の承認の下、血清、血漿、リポ蛋白、髄液、尿、ヒト組織検体などの臨床検体を収集し、領域内に提供した(矢冨班)(6)2018年6月17-19日に第4回領域会議を淡路夢舞台国際会議場にて開催した(横溝班)2019年2月に領域ニュースレター第4号を発行し、ホームページ上の業績を更新することにより、研究内容と成果の公知を図った(杉本班)。

Strategy for Future Research Activity

現時点では本総括班は極めて順調に稼働していると考えられるため、とくに問題点はない。今後も班員のサポートと、活発な班会議や情報発信を継続する。
(1)質量分析センター:引き続きリポクオリティ分析支援センターとしての運用を行うと同時に、データベースや脂質スペクトルライブラリの構築を進める(有田班)位置異性体の個別解析法と集約解析法を領域内外の研究者に提供して、引き続きリポクオリティ分析支援センターとしての運用を行う(佐々木班)(2)脂質イメージングセンター:引き続き、組織分解能レベルから細胞分解能レベルでのマスイメージング解析を推進していくと共に、イメージング解析に機械学習を取り入れる事で効率化を推進していく(瀬藤班)進行中のイノシトール4リン酸、ホスファチジン酸の可視化解析法開発を推進するほか、リン脂質の脂肪酸鎖を解析する方法の開発に着手する(藤本班)(3)膜機能解析センター:膜電位プローブの分子の改変をさらに進め、蛍光シグナルの向上とフォトブリーチングの解消、計測希望部位での安定な集積効率を向上させ、多様な実験系での膜電位計測へと拡張させていく(岡村班)引き続き脂質可視化プローブの開発および管理配布体制を整備する(反町班)(4)脂質データベース:リポクオリティの成果を既存のデータベースと連携させ、領域終了後もその成果が継続して利用され続ける工夫をする(有田班)(5)臨床検体センター:引き続き臨床検体の提供を通じた領域内貢献を果たしていく(矢冨班)(6)2019年6月17日に第2回リポクオリティ国際シンポジウム、6月17-21日に国際脂質生物学会議(ICBL)を開催する(横溝班)リポクオリティニュースレターの編集・刊行や領域ホームページ更新を通じて、本領域内外の有機的な連携と国際交流活動を加速させる(杉本班)。

Report

(4 results)
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(835 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Int'l Joint Research] National University of Singapore(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School/Univ. of California Davis/Johns Hopkins University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Laval University(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Imperial College London/Babraham Institute(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Mahidol University(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School/Univ. of California Davis/Johns Hopkins Univ. School of Med.(USA)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Shanghai Jiao Tong University(中国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Babraham Institute/Imperial College London(UK)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] チェコ科学アカデミー(チェコ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Univ. Groningen(Netherlands)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School/Univ. of California Davis/UC Irvine(USA)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University College London/Babraham Institute/Imperial College London(UK)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] IMBA(Austria)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Institute of Molecular Genetics, ASCR(Czech Republic)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Lyon/Claude Bernard Lyon 1 University(France)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Univ. of Colorado/Mayo Clinic Alizona,/Harvard Medical School(USA)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University College London/Cambridge/Babraham Inst(UK)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Univ. of Monash/Women's & Children's Hospital(Australia)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] I2MC, I.G.B.M.C./Institut Pasteur de Lille(France)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Università degli Studi di Torino/University of Milan/Università degli Studi di Milano(Italy)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A cheminformatics approach to characterize metabolomes in stable-isotope-labeled organisms2019

    • Author(s)
      Hiroshi Tsugawa, Ryo Nakabayashi, Tetsuya Mori, Yutaka Yamada, Mikiko Takahashi, Amit Rai, Ryosuke Sugiyama, Hiroyuki Yamamoto, Taiki Nakaya, Mami Yamazaki, Rik Kooke, Johanna A Bac-Molenaar, Nihal Oztolan-Erol, Joost JB Keurentjes, Masanori Arita, Kazuki Saito
    • Journal Title

      Nature Methods

      Volume: 16 Pages: 295-298

    • DOI

      10.1038/s41592-019-0358-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis2019

    • Author(s)
      Soltysik K., Ohsaki Y., Tatematsu T., Cheng J., Fujimoto T.
    • Journal Title

      Nature Communications

      Volume: 10 Pages: 473-473

    • DOI

      10.1038/s41467-019-08411-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Definition of phosphoinositide distribution in the nanoscale2019

    • Author(s)
      Tsuji Takuma、Takatori Sho、Fujimoto Toyoshi
    • Journal Title

      Current Opinion in Cell Biology

      Volume: 57 Pages: 33-39

    • DOI

      10.1016/j.ceb.2018.10.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases.2019

    • Author(s)
      Tsuge Kyoshiro、Inazumi Tomoaki、Shimamoto Akira、Sugimoto Yukihiko
    • Journal Title

      Int Immunol

      Volume: - Pages: 1-10

    • DOI

      10.1093/intimm/dxz021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of cyclooxygenase-2/prostaglandin E2/prostaglandin E receptor 4 signaling in cardiac reprogramming.2019

    • Author(s)
      Muraoka Naoto、Nara Kaori、Tamura Fumiya、Kojima Hidenori、Yamakawa Hiroyuki、Sadahiro Taketaro、Miyamoto Kazutaka、Isomi Mari、Haginiwa Sho、Tani Hidenori、Kurotsu Shota、Osakabe Rina、Torii Satoru、Shimizu Shigeomi、Okano Hideyuki、Sugimoto Yukihiko、Fukuda Keiichi、Ieda Masaki
    • Journal Title

      Nat Commun

      Volume: 10 Pages: 1-15

    • DOI

      10.1038/s41467-019-08626-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.2019

    • Author(s)
      Kitadate Y., Jorg DJ., Tokue M,. Maruyama A., Ishikawa R., Tsuchiya S., Segi-Nishida E., Nakagawa T., Uchida A., Kimura-Yoshida C., Mizuno S., Sugiyama F., Azami T., Ema M., Noda C., Kobayashi S., Matsuo I., Kanai Y., Nagasawa T., Sugimoto Y., Takahashi S., Simons BD., Yoshida S.
    • Journal Title

      Cell Stem Cell.

      Volume: 24 Pages: 1-2

    • DOI

      10.1016/j.stem.2018.11.013

    • NAID

      120006583050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ligand Binding to Human Prostaglandin E Receptor EP4 at the Lipid-Bilayer Interface2019

    • Author(s)
      Toyoda Y, Morimoto K, Suno R, et al.
    • Journal Title

      Journal of Chemical Physics

      Volume: 15 Pages: 18-26

    • DOI

      10.1038/s41589-018-0131-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency.2019

    • Author(s)
      Nishio Miki、Miyachi Yousuke、Otani Junji、Tane Shoji、Omori Hirofumi、Ueda Fumihito、Togashi Hideru、Sasaki Takehiko、Mak Tak Wah、Nakao Kazuwa、Fujita Yasuyuki、Nishina Hiroshi、Maehama Tomohiko、Suzuki Akira
    • Journal Title

      FASEB J

      Volume: 33 Pages: 5548-5560

    • DOI

      10.1096/fj.201802005r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lysophosphatidylinositol‐acyltransferase‐1 is involved in cytosolic Ca 2+ oscillations in macrophages2019

    • Author(s)
      Takemasu Shinya、Ito Masaki、Morioka Shin、Nigorikawa Kiyomi、Kofuji Satoshi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Matsuoka Isao、Sasaki Junko、Sasaki Takehiko、Hazeki Kaoru
    • Journal Title

      Genes to Cells

      Volume: - Pages: 1-11

    • DOI

      10.1111/gtc.12681

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autotaxin and soluble IL-2 receptor concentrations in cerebrospinal fluids are useful for the diagnosis of central nervous system invasion caused by haematological malignancies2019

    • Author(s)
      Shimura Takuya、Kurano Makoto、Morita Yoshifumi、Yoshikawa Naoyuki、Nishikawa Masako、Igarashi Koji、Shimamoto Satoshi、Aoki Junken、Yatomi Yutaka
    • Journal Title

      Annals of Clinical Biochemistry: International Journal of Laboratory Medicine

      Volume: 56 Pages: 240-246

    • DOI

      10.1177/0004563218818197

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein M suppresses the phenotypes of IgA nephropathy in hyper-IgA mice2019

    • Author(s)
      Kurano Makoto、Tsuneyama Koichi、Morimoto Yuki、Nishikawa Masako、Yatomi Yutaka
    • Journal Title

      The FASEB Journal

      Volume: 33 Pages: 5181-5195

    • DOI

      10.1096/fj.201801748r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum autotaxin levels are associated with Graves’ disease2019

    • Author(s)
      Nojiri Takahiro、Kurano Makoto、Araki Osamu、Nakawatari Kazuki、Nishikawa Masako、Shimamoto Satoshi、Igarashi Koji、Kano Kuniyuki、Aoki Junken、Kihara Shinji、Murakami Masami、Yatomi Yutaka
    • Journal Title

      Endocr J

      Volume: - Issue: 5 Pages: 409-422

    • DOI

      10.1507/endocrj.ej18-0451

      10.1507/endocrj.EJ18-0451

    • NAID

      130007655267

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time functional analysis of Hv1 channel in neutrophils: a new approach from zebrafish model2019

    • Author(s)
      Ratanayotha Adisorn、Kawai Takafumi、Okamura Yasushi
    • Journal Title

      American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

      Volume: -

    • DOI

      10.1152/ajpregu.00326.2018

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Molecular mechanisms of coupling to voltage sensors in voltage-evoked cellular signals2019

    • Author(s)
      OKAMURA Yasushi、OKOCHI Yoshifumi
    • Journal Title

      Proc. Jpn. Acad., Ser. B

      Volume: 95 Issue: 3 Pages: 111-135

    • DOI

      10.2183/pjab.95.010

    • NAID

      130007610041

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dynamic structural rearrangements and functional regulation of voltage-sensing phosphatase2019

    • Author(s)
      Sakata S and Okamura Y
    • Journal Title

      The Journal of Physiology

      Volume: 597 Pages: 29-40

    • DOI

      10.1113/jp274113

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NaV チャネル全史-細菌からヒトまで-2019

    • Author(s)
      西野 敦雄,岡村 康司
    • Journal Title

      生化学

      Volume: 91 Pages: 1-14

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis2019

    • Author(s)
      Ishihara Tomoaki、Yoshida Mio、Arita Makoto
    • Journal Title

      International Immunology

      Volume: in press

    • DOI

      10.1093/intimm/dxz001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis2019

    • Author(s)
      Miyata Jun、Fukunaga Koichi、Kawashima Yusuke、Watanabe Takashi、Saitoh Akina、Hirosaki Tomomi、Araki Yasutomo、Kikawada Toru、Betsuyaku Tomoko、Ohara Osamu、Arita Makoto
    • Journal Title

      Allergy

      Volume: in press

    • DOI

      10.1111/all.13726

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー性好酸球における脂質代謝異常のメタボローム解析2019

    • Author(s)
      宮田純、有田誠
    • Journal Title

      臨床免疫・アレルギー科(科学評論社)

      Volume: 71 Pages: 34-40

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Discovery of lipid biomarkers correlated with disease progression in clear cell renal cell carcinoma using desorption electrospray ionization imaging mass spectrometry2019

    • Author(s)
      Tamura Keita、Horikawa Makoto、Sato Shumpei、Miyake Hideaki、Setou Mitsutoshi
    • Journal Title

      Oncotarget

      Volume: 10 Pages: 1688-1703

    • DOI

      10.18632/oncotarget.26706

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MALDI imaging mass spectrometry revealed atropine distribution in the ocular tissues and its transit from anterior to posterior regions in the whole-eye of rabbit after topical administration2019

    • Author(s)
      Mori Naoto、Mochizuki Takaharu、Yamazaki Fumiyoshi、Takei Shiro、Mano Hidetoshi、Matsugi Takeshi、Setou Mitsutoshi
    • Journal Title

      PLOS ONE

      Volume: 14 Pages: 0211376-0211376

    • DOI

      10.1371/journal.pone.0211376

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysophosphatidic acid precursor levels decrease and an arachidonic acid-containing phosphatidylcholine level increases in the dorsal root ganglion of mice after peripheral nerve injury2019

    • Author(s)
      Mihara Yuki、Horikawa Makoto、Sato Shumpei、Eto Fumihiro、Hanada Mitsuru、Banno Tomohiro、Arima Hideyuki、Ushirozako Hiroki、Yamada Tomohiro、Xu Dongmin、Okamoto Ayako、Yamazaki Fumiyoshi、Takei Shiro、Omura Takao、Yao Ikuko、Matsuyama Yukihiro、Setou Mitsutoshi
    • Journal Title

      Neuroscience Letters

      Volume: 698 Pages: 69-75

    • DOI

      10.1016/j.neulet.2018.12.035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses2019

    • Author(s)
      Hirakata T., Lee H. C., Ohba M., Saeki K., Okuno T., Murakami A., Matsuda A., Yokomizo T.
    • Journal Title

      The FASEB Journal

      Volume: 33 Pages: 3392-3403

    • DOI

      10.1096/fj.201801805r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing.2019

    • Author(s)
      Matsuda Akira、Asada Yosuke、Suita Naomasa、Iwamoto Satoshi、Hirakata Toshiaki、Yokoi Norihiko、Ohkawa Yasuyuki、Okada Yukinori、Yokomizo Takehiko、Ebihara Nobuyuki
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 143 Pages: 1610-1614

    • DOI

      10.1016/j.jaci.2018.11.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autophagy regulates lipid metabolism through selective turnover of NCoRl2019

    • Author(s)
      Saito Tetsuya、Kuma Akiko、Sugiura Yuki、Ichimura Yoshinobu、Obata Miki、Kitamura Hiroshi、Okuda Shujiro、Lee Hyeon-Cheol、Ikeda Kazutaka、Kanegae Yumi、Saito Izumu、Auwerx Johan、Motohashi Hozumi、Suematsu Makoto、Soga Tomoyoshi、Yokomizo Takehiko、Waguri Satoshi、Mizushima Noboru、Komatsu Masaaki
    • Journal Title

      Nat. Commun.

      Volume: 10 Issue: 1 Pages: 1567-1567

    • DOI

      10.1038/s41467-019-08829-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lipids and lipid domains of the yeast vacuole.2018

    • Author(s)
      Tsuji Takuma、Fujimoto Toyoshi
    • Journal Title

      Biochemical Society transactions

      Volume: 46 Pages: 1047-1054

    • DOI

      10.1042/bst20180120

    • NAID

      120006554476

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient RNA polymerase II-dependent transcription.2018

    • Author(s)
      Sobol Margarita、Krausova Alzbeta、Yildirim Sukriye、Kalasova Ilona、Faberova Veronika、Vrkoslav Vladimir、Philimonenko Vlada、Marasek Pavel、Pastorek Lukas、Capek Martin、Lubovska Zuzana、Ulicna Livia、Tsuji Takuma、Lisa Miroslav、Cvacka Josef、Fujimoto Toyoshi、Hozak Pavel
    • Journal Title

      Journal of cell science

      Volume: 131

    • DOI

      10.1242/jcs.211094

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 32018

    • Author(s)
      Kimura H, Arasaki K, Ohsaki Y, Fujimoto T, Ohtomo T, Yamada J, Tagaya M.
    • Journal Title

      J. Lipid Res.

      Volume: in press Pages: 805-819

    • DOI

      10.1194/jlr.m081679

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UBXN3B positively regulates STING-mediated antiviral immune responses2018

    • Author(s)
      Yang Long、Wang Leilei、Ketkar Harshada、Ma Jinzhu、Yang Guang、Cui Shuang、Geng Tingting、Mordue Dana G.、Fujimoto Toyoshi、Cheng Gong、You Fuping、Lin Rongtuan、Fikrig Erol、Wang Penghua
    • Journal Title

      Nature Communications

      Volume: 9 Pages: 2329-2329

    • DOI

      10.1038/s41467-018-04759-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy.2018

    • Author(s)
      Sugo Masashi、Kimura Hana、Arasaki Kohei、Amemiya Toshiki、Hirota Naohiko、Dohmae Naoshi、Imai Yuzuru、Inoshita Tsuyoshi、Shiba‐Fukushima Kahori、Hattori Nobutaka、Cheng Jinglei、Fujimoto Toyoshi、Wakana Yuichi、Inoue Hiroki、Tagaya Mitsuo
    • Journal Title

      EMBO J.

      Volume: 37

    • DOI

      10.15252/embj.201798899

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunoelectron Microscopy of Gangliosides2018

    • Author(s)
      Tsuji Takuma、Fujita Akikazu、Fujimoto Toyoshi
    • Journal Title

      Methods in Molecular Biology

      Volume: 1804 Pages: 231-239

    • DOI

      10.1007/978-1-4939-8552-4_11

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膜リン脂質クオリティの可視化2018

    • Author(s)
      辻琢磨、藤本豊士
    • Journal Title

      実験医学

      Volume: 36 Pages: 89-96

    • Related Report
      2018 Annual Research Report
  • [Journal Article] プロスタグランジンE2による炎症病態制御機構2018

    • Author(s)
      稲住知明, 杉本幸彦.
    • Journal Title

      細胞.

      Volume: 50 Pages: 118-121

    • Related Report
      2018 Annual Research Report
  • [Journal Article] リポクオリティの違いに基づくプロスタノイドのがん疾患制御2018

    • Author(s)
      土屋創健, 杉本幸彦.
    • Journal Title

      実験医学

      Volume: 36 Pages: 1675-1680

    • Related Report
      2018 Annual Research Report
  • [Journal Article] プロスタグランジンE2による炎症,免疫調節機構.2018

    • Author(s)
      稲住知明, 杉本幸彦.
    • Journal Title

      臨床免疫・アレルギー科. 炎症と免疫.

      Volume: 70 Pages: 216-220

    • Related Report
      2018 Annual Research Report
  • [Journal Article] プロスタノイド受容体を介した免疫・炎症応答亢進機構.2018

    • Author(s)
      土屋創健, 杉本幸彦
    • Journal Title

      炎症と免疫.

      Volume: 26 Pages: 375-379

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation.2018

    • Author(s)
      Matsumoto Reiko、Dainichi Teruki、Tsuchiya Soken、Nomura Takashi、Kitoh Akihiko、Hayden Matthew S.、Ishii Ken J.、Tanaka Mayuri、Honda Tetsuya、Egawa Gyohei、Otsuka Atsushi、Nakajima Saeko、Sakurai Kenji、Nakano Yuri、Kobayashi Takashi、Sugimoto Yukihiko、Kabashima Kenji
    • Journal Title

      JCI Insight.

      Volume: 3 Pages: 1-14

    • DOI

      10.1172/jci.insight.121175

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preventive effect of <i>Dioscorea japonica</i> on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E<sub>2</sub> synthetic pathway2018

    • Author(s)
      Tsukayama I, Toda K, Takeda Y, Mega T, Tanaka M, Kawakami Y, Takahashi Y, Kimoto M, Yamamoto K, Miki Y, Murakami M, Suzuki-Yamamoto T.
    • Journal Title

      J. Clin. Biochem. Nutr.

      Volume: 62 Issue: 2 Pages: 139-147

    • DOI

      10.3164/jcbn.17-54

    • NAID

      130006407477

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] イノシトールリン脂質におけるリン酸化クオリティ制御の病態生理学的意義2018

    • Author(s)
      高須賀俊輔、佐々木雄彦
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36 Pages: 1591-1607

    • Related Report
      2018 Annual Research Report
  • [Journal Article] TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis2018

    • Author(s)
      Morioka Shin、Nigorikawa Kiyomi、Okada Eri、Tanaka Yoshimasa、Kasuu Yoshihiro、Yamada Miho、Kofuji Satoshi、Takasuga Shunsuke、Nakanishi Hiroki、Sasaki Takehiko、Hazeki Kaoru
    • Journal Title

      Journal of Cell Science

      Volume: 131 Pages: 213272-213272

    • DOI

      10.1242/jcs.213272

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma2018

    • Author(s)
      Makinoshima H et al.
    • Journal Title

      Cancer Res

      Volume: - Pages: 2179-2190

    • DOI

      10.1158/0008-5472.can-17-2109

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PIKfyve regulates melanosome biogenesis2018

    • Author(s)
      Liggins Marc C.、Flesher Jessica L.、Jahid Sohail、Vasudeva Priya、Eby Victoria、Takasuga Shunsuke、Sasaki Junko、Sasaki Takehiko、Boissy Raymond E.、Ganesan Anand K.
    • Journal Title

      PLOS Genetics

      Volume: 14

    • DOI

      10.1371/journal.pgen.1007290

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 脂肪酸クオリティに着目した新しい臨床検査への可能性.2018

    • Author(s)
      蔵野 信,矢冨 裕.
    • Journal Title

      医学のあゆみ

      Volume: 264 Pages: 979-983

    • Related Report
      2018 Annual Research Report
  • [Journal Article] リゾリン脂質と病態2018

    • Author(s)
      蔵野 信,矢冨 裕.
    • Journal Title

      細胞

      Volume: 50 Pages: 132-135

    • Related Report
      2018 Annual Research Report
  • [Journal Article] リポクオリティに注目した臨床検査の可能性2018

    • Author(s)
      蔵野 信,矢冨 裕.
    • Journal Title

      実験医学

      Volume: 36 Pages: 1767-1772

    • Related Report
      2018 Annual Research Report
  • [Journal Article] ヒト疾患におけるリゾリン脂質メディエーター.2018

    • Author(s)
      蔵野 信,矢冨 裕.
    • Journal Title

      生化学

      Volume: 90 Pages: 643-650

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P 2 and S1P 3 Expression in Colon?Cancer2018

    • Author(s)
      Uranbileg B, Nishikawa T, Ikeda H, Kurano M, Sato M, Saigusa D, Aoki J, Watanabe T, Yatomi Y.
    • Journal Title

      Clinical Colorectal Cancer

      Volume: Nov 21. pii: Pages: 30369-9

    • DOI

      10.1016/j.clcc.2017.11.004

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma2018

    • Author(s)
      Kurano Makoto、Miyagaki Tomomitsu、Miyagawa Takuya、Igarashi Koji、Shimamoto Satoshi、Ikeda Hitoshi、Aoki Junken、Sato Shinichi、Yatomi Yutaka
    • Journal Title

      The Journal of Dermatology

      Volume: - Pages: 571-579

    • DOI

      10.1111/1346-8138.14278

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay.2018

    • Author(s)
      Ohkawa Ryunosuke、Kurano Makoto、Sakai Noboru、Kishimoto Tatsuya、Nojiri Takahiro、Igarashi Koji、Hosogaya Shigemi、Ozaki Yukio、Dohi Tomotaka、Miyauchi Katsumi、Daida Hiroyuki、Aoki Junken、Okubo Shigeo、Ikeda Hitoshi、Tozuka Minoru、Yatomi Yutaka
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 1-12

    • DOI

      10.1038/s41598-018-23009-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury2018

    • Author(s)
      Kurano M, Tsuneyama K, Morimoto Y, Shimizu T, Jona M, Kassai H, Nakao K, Aiba A, Yatomi Y
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 印刷中 Pages: 1021-1035

    • DOI

      10.1055/s-0038-1641750

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the metabolism of apolipoprotein M and sphingosine 1-phosphate by hepatic PPARγ activity2018

    • Author(s)
      Kurano Makoto、Ikeda Hitoshi、Iso-O Naoyuki、Hara Masumi、Tsukamoto Kazuhisa、Yatomi Yutaka
    • Journal Title

      Biochemical Journal

      Volume: 475 Pages: 2009-2024

    • DOI

      10.1042/bcj20180052

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased aqueous autotaxin and lysophosphatidic acid levels are potential prognostic factors after trabeculectomy in different types of glaucoma2018

    • Author(s)
      Igarashi Nozomi、Honjo Megumi、Kurano Makoto、Yatomi Yutaka、Igarashi Koji、Kano Kuniyuki、Aoki Junken、Aihara Makoto
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 11304-11304

    • DOI

      10.1038/s41598-018-29649-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dihydro-sphingosine 1-phosphate interacts with carrier proteins in a manner distinct from that of sphingosine 1-phosphate2018

    • Author(s)
      Mishima Yuko、Kurano Makoto、Kobayashi Tamaki、Nishikawa Masako、Ohkawa Ryunosuke、Tozuka Minoru、Yatomi Yutaka
    • Journal Title

      Bioscience Reports

      Volume: 38

    • DOI

      10.1042/bsr20181288

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study2018

    • Author(s)
      Kuwajima Ken、Sumitani Masahiko、Kurano Makoto、Kano Kuniyuki、Nishikawa Masako、Uranbileg Baasanjav、Tsuchida Rikuhei、Ogata Toru、Aoki Junken、Yatomi Yutaka、Yamada Yoshitsugu
    • Journal Title

      PLOS ONE

      Volume: 13 Pages: 0207310-0207310

    • DOI

      10.1371/journal.pone.0207310

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysophospholipids in laboratory medicine2018

    • Author(s)
      YATOMI Yutaka、KURANO Makoto、IKEDA Hitoshi、IGARASHI Koji、KANO Kuniyuki、AOKI Junken
    • Journal Title

      Proc. Jpn. Acad., Ser. B

      Volume: 94 Issue: 10 Pages: 373-389

    • DOI

      10.2183/pjab.94.025

    • NAID

      130007529097

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リポクオリティ認識プローブの開発と応用2018

    • Author(s)
      田口友彦,小林俊彦,反町典子,仁木隆裕
    • Journal Title

      実験医学

      Volume: 36 Pages: 217-221

    • Related Report
      2018 Annual Research Report
  • [Journal Article] エンドリソソーム環境に依存した自然免疫応答偏向2018

    • Author(s)
      反町典子、小林俊彦
    • Journal Title

      医学のあゆみ

      Volume: 265 Pages: 1094-1100

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 炎症・感染応答を担うオルガネラ2018

    • Author(s)
      小林俊彦、向井康治朗、田口友彦、反町典子
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 69 Pages: 99-106

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice.2018

    • Author(s)
      Watanabe-Takahashi, M., Yamasaki, S., Murata, M., Kano, F., Motoyama, J., Yamate, J., Omi, J., Sato, W., Ukai, H., Shimasaki, K., Ikegawa, M., Tamura-Nakano, M., Yanoshita, R., Nishino, Y., Miyazawa, A., Natori, Y., Toyama-Sorimachi, N., Nishikawa, N.
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 10776-10776

    • DOI

      10.1038/s41598-018-29128-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolutionary History of Voltage-Gated Sodium Channels2018

    • Author(s)
      Nishino Atsuo, Okamura Yasushi
    • Journal Title

      Handbook of Experimental Pharmacology, Springer

      Volume: Epub ahead of print Pages: 1-30

    • DOI

      10.1007/164_2017_70

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of divalent cation permeability by heterologous expression of a voltage sensor domain2018

    • Author(s)
      Arima Hiroki、Tsutsui Hidekazu、Sakamoto Ayako、Yoshida Manabu、Okamura Yasushi
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Biomembranes

      Volume: 1860 Pages: 981-990

    • DOI

      10.1016/j.bbamem.2018.01.004

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Conservation of the Ca2+-permeability through the voltage sensor domain of mammalian CatSper subunit2018

    • Author(s)
      Arima Hiroki、Tsutsui Hidekazu、Okamura Yasushi
    • Journal Title

      Channels

      Volume: 12 Pages: 240-248

    • DOI

      10.1080/19336950.2018.1476791

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tracking the sarcoplasmic reticulum membrane voltage in muscle with a FRET biosensor2018

    • Author(s)
      Sanchez Colline、Berthier Christine、Allard Bruno、Perrot Jimmy、Bouvard Cl?ment、Tsutsui Hidekazu、Okamura Yasushi、Jacquemond Vincent
    • Journal Title

      The Journal of General Physiology

      Volume: 150 Pages: 1163-1177

    • DOI

      10.1085/jgp.201812035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Zn2+-Binding to the Voltage-Gated Proton Channel Hv1/VSOP2018

    • Author(s)
      Iwaki Masayo、Takeshita Kohei、Kondo Hiroko X.、Kinoshita Kengo、Okamura Yasushi、Takano Yu、Nakagawa Atsushi、Kandori Hideki
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 122 Pages: 9076-9080

    • DOI

      10.1021/acs.jpcb.8b04890

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase2018

    • Author(s)
      Kawanabe A, Hashimoto M, Mishizawa M, Nishizawa N, Narita H, Yonezawa T, Jinno Y, Sakata S, Nakawaga A and Okamura Y
    • Journal Title

      eLife

      Volume: 7 Pages: 2097-2131

    • DOI

      10.7554/elife.41653

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Voltage-Sensing Phosphatases: Biophysics, Physiology, and Molecular Engineering2018

    • Author(s)
      Okamura Yasushi、Kawanabe Akira、Kawai Takafumi
    • Journal Title

      Physiological Reviews

      Volume: 98 Pages: 2097-2131

    • DOI

      10.1152/physrev.00056.2017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 脂質-イオンチャネル相互連関2018

    • Author(s)
      岡村康司、大澤匡範
    • Journal Title

      「脂質クオリティ」実験医学増刊

      Volume: 36 Pages: 97-104

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent2018

    • Author(s)
      Kawashima Yusuke、Miyata Jun、Watanabe Takashi、Shioya Juri、Arita Makoto、Ohara Osamu
    • Journal Title

      Journal of Proteome Research

      Volume: 18 Pages: 301-308

    • DOI

      10.1021/acs.jproteome.8b00609

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reelin deficiency leads to aberrant lipid composition in mouse brain2018

    • Author(s)
      Mizukami T, Ikeda K, Shimanaka Y, Korogi K, Zhou C, Takase H, Tsuiji H, Kono N, Kohno T, Arai H, Arita M, Hattori M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 505 Pages: 81-86

    • DOI

      10.1016/j.bbrc.2018.09.089

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An omega-3 polyunsaturated fatty acid derivative, 18-HEPE, protects against CXCR4-associated melanoma metastasis2018

    • Author(s)
      Li Jieping、Chen Chih-Yu、Arita Makoto、Kim Kuijin、Li Xiangyong、Zhang Hongman、Kang Jing X
    • Journal Title

      Carcinogenesis

      Volume: 39 Pages: 1380-1388

    • DOI

      10.1093/carcin/bgy117

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines2018

    • Author(s)
      Burla Bo、Arita Makoto、Arita Masanori et al.
    • Journal Title

      Journal of Lipid Research

      Volume: 59 Pages: 2001-2017

    • DOI

      10.1194/jlr.s087163

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thromboxane A 2 facilitates IL-17A production from Vγ4 + γδ T cells and promotes psoriatic dermatitis in mice2018

    • Author(s)
      Ueharaguchi Y, Honda T, Kusuba N, Hanakawa S, Adachi A, Sawada Y, Otsuka A, Kitoh A, Dainich T, Egawa G, Nakachima C, Nakajima S, Murata T, Ono S, Arita M, Narumiya S, Miyachi Y, Kabashima K
    • Journal Title

      J Allergy Clin Immunol.

      Volume: in press

    • DOI

      10.1016/j.jaci.2018.01.054

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The 17,18-EpETE-GPR 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques2018

    • Author(s)
      Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J
    • Journal Title

      J Allergy Clin Immunol

      Volume: S0091-6749 Pages: 32949-32944

    • DOI

      10.1016/j.jaci.2017.09.053

    • NAID

      40021650879

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling.2018

    • Author(s)
      Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, Yamazaki K
    • Journal Title

      Sci Rep

      Volume: 8 Pages: 1-12

    • DOI

      10.1038/s41598-018-27408-y

    • NAID

      120006546008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid2018

    • Author(s)
      Isobe Yosuke、Itagaki Mai、Ito Yuko、Naoe Satoko、Kojima Kotoe、Ikeguchi Mitsunori、Arita Makoto
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 7954-7954

    • DOI

      10.1038/s41598-018-26325-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Facile determination of sphingolipids under alkali condition using metal-free column by LC-MS/MS2018

    • Author(s)
      B. Gowda Siddabasave Gowda、Ikeda Kazutaka、Arita Makoto
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 410 Pages: 4793-4803

    • DOI

      10.1007/s00216-018-1116-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of lipid accumulation rescues Bietti's crystalline dystrophy phenotypes.2018

    • Author(s)
      Hata Masayuki、Ikeda Hanako O.、Iwai Sachiko、Iida Yuto、Gotoh Norimoto、Asaka Isao、Ikeda Kazutaka、Isobe Yosuke、Hori Aya、Nakagawa Saori、Yamato Susumu、Arita Makoto、Yoshimura Nagahisa、Tsujikawa Akitaka
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 115 Pages: 3936-3941

    • DOI

      10.1073/pnas.1717338115

    • NAID

      120006416205

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid.2018

    • Author(s)
      Isobe Yosuke、Kawashima Yusuke、Ishihara Tomoaki、Watanabe Kenji、Ohara Osamu、Arita Makoto
    • Journal Title

      ACS Chem Biol.

      Volume: 13 Pages: 887-893

    • DOI

      10.1021/acschembio.7b01092

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脂肪酸代謝バランスによるマクロファージの機能制御2018

    • Author(s)
      青木秀憲、有田誠
    • Journal Title

      実験医学(羊土社)

      Volume: 36 Pages: 2353-2357

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 「脂質クオリティ」生命機能と健康を支える脂質の多様性(企画・編集)2018

    • Author(s)
      有田誠
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 概論/リポクオリティから解き明かす生命現象2018

    • Author(s)
      有田誠
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36 Pages: 1580-1584

    • Related Report
      2018 Annual Research Report
  • [Journal Article] リポクオリティを識別するリピドミクス解析技術2018

    • Author(s)
      池田和貴、青柳良平、有田誠
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36 Pages: 1797-1803

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 脂質クオリティを捉える解析手法とデータベース2018

    • Author(s)
      津川裕司、池田和貴、有田誠、有田正規
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36 Pages: 1804-1811

    • Related Report
      2018 Annual Research Report
  • [Journal Article] UBL3 modification influences protein sorting to small extracellular vesicles.2018

    • Author(s)
      Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
    • Journal Title

      Nature Communications

      Volume: 9 Pages: 1-14

    • DOI

      10.1038/s41467-018-06197-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of caveolin-1 in hepatocellular carcinoma arising from non-alcoholic fatty liver disease2018

    • Author(s)
      Takeda Makoto、Sakaguchi Takanori、Hiraide Takanori、Shibasaki Yasushi、Morita Yoshifumi、Kikuchi Hirotoshi、Ikegami Koji、Setou Mitsutoshi、Konno Hiroyuki、Takeuchi Hiroya
    • Journal Title

      Cancer Science

      Volume: 109 Pages: 2401-2411

    • DOI

      10.1111/cas.13659

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis2018

    • Author(s)
      Sato Shumpei、Horikawa Makoto、Kondo Takeshi、Sato Tomohito、Setou Mitsutoshi
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 10315-10315

    • DOI

      10.1038/s41598-018-28667-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] リポクオリティの可視化と操作2018

    • Author(s)
      堀川誠、武井史郎、瀬藤光利
    • Journal Title

      実験医学増刊(羊土社)

      Volume: 36 Pages: 103-210

    • Related Report
      2018 Annual Research Report
  • [Journal Article] The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer2018

    • Author(s)
      Ishimine M, Lee HC, Nakaoka H, Orita H, Kobayashi T, Mizuguchi K, Endo M, Inoue I, Sato K, Yokomizo T
    • Journal Title

      Dis Markers

      Volume: - Pages: 1-7

    • DOI

      10.1155/2018/5280736

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Urinary prostaglandin D2 metabolite excretion during the first six months of life was significantly lower in breast-fed than formula-fed infants.2018

    • Author(s)
      Shoji Hiromichi、Ikeda Naho、Kitamura Tomohiro、Suganuma Hiroki、Ohba Mai、Okuno Toshiaki、Yokomizo Takehiko、Shimizu Toshiaki
    • Journal Title

      Acta Paediatr

      Volume: 107 Pages: 95-100

    • DOI

      10.1111/apa.14068

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle.2018

    • Author(s)
      Kawanishi Noriaki、Takagi Kana、Lee Hyeon-Cheol、Nakano Daiki、Okuno Toshiaki、Yokomizo Takehiko、Machida Shuichi
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 印刷中

    • DOI

      10.1152/ajpregu.00371.2017

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Na(+)-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1.2018

    • Author(s)
      Hori Tetsuya、Okuno Toshiaki、Hirata Kunio、Yamashita Keitaro、Kawano Yoshiaki、Yamamoto Masaki、Hato Masakatsu、Nakamura Motonao、Shimizu Takao、Yokomizo Takehiko、Miyano Masashi、Yokoyama Shigeyuki
    • Journal Title

      Nat Chem Biol

      Volume: 14 Pages: 262-269

    • DOI

      10.1038/nchembio.2547

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered eicosanoid production and phospholipid remodeling during cell culture.2018

    • Author(s)
      Okuno Toshiaki、Gij?n Miguel A.、Zarini Simona、Martin Sarah A.、Barkley Robert M.、Johnson Christopher A.、Ohba Mai、Yokomizo Takehiko、Murphy Robert C.
    • Journal Title

      J Lipid Res

      Volume: 59 Pages: 542-549

    • DOI

      10.1194/jlr.m083030

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Leukotriene B4 receptor 2 regulates the proliferation, migration, and barrier integrity of bronchial epithelial cells.2018

    • Author(s)
      M Liu J Shen H Yuan F Chen H Song H Qin Y Li J Xu Q Ye S Li K Saeki T Yokomizo
    • Journal Title

      Journal of Cellular Physiology

      Volume: 印刷中 Pages: 6117-6124

    • DOI

      10.1002/jcp.26455

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stepwise phosphorylation of leukotriene B4receptor 1 defines cellular responses to leukotriene B42018

    • Author(s)
      Nakanishi,Y., Tan,M., Ichiki,T., Inoue,A. Yoshihara,J., Maekawa,N., Takenoshita.I., Yanagida,K., Yamahira,S., Yamaguchi,S., Aoki,J. Nagamune,T., Yokomizo,T., Shimizu,T., and Nakamura,M
    • Journal Title

      Science Signaling

      Volume: 11 (544) Pages: 5390-5390

    • DOI

      10.1126/scisignal.aao5390

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method2018

    • Author(s)
      Ohba M., Saeki K., Koga T., Okuno T., Kobayashi Y., Yokomizo T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 504 Pages: 562-568

    • DOI

      10.1016/j.bbrc.2018.06.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models2018

    • Author(s)
      Sasaki F., Koga T., Ohba M., Saeki K., Okuno T., Ishikawa K., Nakama T., Nakao S., Yoshida S., Ishibashi T., Ahmadieh H., Kanavi M. R., Hafezi-Moghadam A., Penninger J. M., Sonoda K. H., Yokomizo T.
    • Journal Title

      JCI Insight

      Volume: 3 Pages: 96902-96902

    • DOI

      10.1172/jci.insight.96902

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Applications of mass spectrometry-based targeted and non-targeted lipidomics2018

    • Author(s)
      Lee Hyeon-Cheol、Yokomizo Takehiko
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 504 Pages: 576-581

    • DOI

      10.1016/j.bbrc.2018.03.081

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 22018

    • Author(s)
      Okuno T., Yokomizo T.
    • Journal Title

      Inflammation and Regeneration

      Volume: 38 Pages: 29-29

    • DOI

      10.1186/s41232-018-0087-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Leukotriene receptors as potential therapeutic targets2018

    • Author(s)
      Yokomizo,T., Nakamura,M., and Shimizu,T
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128 Pages: 2691-2701

    • DOI

      10.1172/jci97946

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生理活性脂質ロイコトリエンB4とその受容体による免疫調節機構2018

    • Author(s)
      古賀友紹, 佐伯和子, 横溝岳彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 70 Pages: 209-215

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 【生理活性脂質研究の最前線】 BLT2受容体の上皮保護作用2018

    • Author(s)
      岩本 怜., 横溝 岳彦
    • Journal Title

      炎症と免疫

      Volume: 26 Pages: 380-383

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 脂肪酸由来の脂質メディエーターによるアレルギー炎症の制御2018

    • Author(s)
      平形寿彬, 李賢喆, 横溝岳彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 69 Pages: 569-575

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 【脂質クオリティ 生命機能と健康を支える脂質の多様性】 (第3章)リポクオリティによる疾患制御 ロイコトリエン受容体の生理・病態における役割2018

    • Author(s)
      横溝 岳彦
    • Journal Title

      実験医学

      Volume: 36

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B42018

    • Author(s)
      Nosaka T, Baba T, Tanabe Y, Sasaki S, Nishimura T, Imamura Y, Yurino H, Hashimoto S, Arita M, Nakamoto Y, Mukaida N.
    • Journal Title

      J Immunol.

      Volume: 200 Pages: 1839-1852

    • DOI

      10.4049/jimmunol.1700544

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 12-OH-17,18-epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs.2018

    • Author(s)
      Mochimaru T.、Fukunaga K.、Miyata J.、Matsusaka M.、Masaki K.、Kabata H.、Ueda S.、Suzuki Y.、Goto T.、Urabe D.、Inoue M.、Isobe Y.、Arita M.、Betsuyaku T.
    • Journal Title

      Allergy

      Volume: 73 Pages: 369-378

    • DOI

      10.1111/all.13297

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stereoselective total synthesis of macrophage-produced prohealing 14,21-dihydroxydocosahexaenoic acids.2018

    • Author(s)
      Nishimura Keita、Sakaguchi Tsuyoshi、Nanba Yutaro、Suganuma Yuta、Morita Masao、Hong Song、Lu Yan、Jun Bokkyoo、Bazan Nicolas G.、Arita Makoto、Kobayashi Yuichi
    • Journal Title

      J Org Chem

      Volume: 83 Pages: 154-166

    • DOI

      10.1021/acs.joc.7b02510

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection.2018

    • Author(s)
      Codagnone M, Cianci E, Lamolinara A, Mari VC, Nespoli A, Isopi E, Mattoscio D, Arita M, Bragonzi A, Iezzi M, Romano M, Recchiuti A.
    • Journal Title

      Mucosal Immunology

      Volume: in press Pages: 35-49

    • DOI

      10.1038/mi.2017.36

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 脂肪酸クオリティの多様性と病態(企画・編集)2018

    • Author(s)
      有田誠
    • Journal Title

      医学のあゆみ (医歯薬出版)

      Volume: 264

    • Related Report
      2017 Annual Research Report
  • [Journal Article] ω3脂肪酸由来脂質メディエーターと炎症制御2018

    • Author(s)
      吉田美桜、礒部洋輔、石原知明、有田誠
    • Journal Title

      細胞(ニューサイエンス社)

      Volume: 50 Pages: 8-12

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics2018

    • Author(s)
      Lai Z, Tsugawa H, Wohlgemuth G, Mehta S, Mueller M, Zheng Y, Ogiwara A, Meissen J, Showalter M, Takeuchi K, Kind T, Beal P, Arita M, Fiehn O
    • Journal Title

      Nat Methods

      Volume: 15 Pages: 53-56

    • DOI

      10.1038/nmeth.4512

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Leukotriene receptors as potential therapeutic target.2018

    • Author(s)
      Yokomizo, T Nakamura, M Shimizu, T
    • Journal Title

      J Clin Invest

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method.2018

    • Author(s)
      Ohba, M Saeki, K Koga, T Okuno, T Konbayashi, Y Yokomizo, T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚保護作用を有する脂質メディエーター12-HHT2018

    • Author(s)
      石井由美子 劉珉 佐伯和子 横溝岳彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 67 Pages: 106-114

    • NAID

      40021064298

    • Related Report
      2017 Annual Research Report
  • [Journal Article] The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis2018

    • Author(s)
      Kimura Hirotaka、Matsuyama Yasushi、Araki Sachiko、Koizumi Atsushi、Kariya Yumi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Sasaki Junko、Sasaki Takehiko
    • Journal Title

      Modern Rheumatology

      Volume: 28 Pages: 1-12

    • DOI

      10.1080/14397595.2017.1367116

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice2018

    • Author(s)
      Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 2094-2094

    • DOI

      10.1038/s41598-018-21120-7

    • NAID

      120006551757

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Profiling and Imaging of Phospholipids in Brains of Abcd1-Deficient Mice2018

    • Author(s)
      Hama K, Fujiwara Y, Morita M, Yamazaki F, Nakashima Y, Takei S, Takashima S, Setou M, Shimozawa N, Imanaka T, Yokoyama K.
    • Journal Title

      Lipids

      Volume: 53 Pages: 85-102

    • DOI

      10.1002/lipd.12022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of local phosphatidylcholine synthesis within hippocampal neurons using a compartmentalized culture system and imaging mass spectrometry2018

    • Author(s)
      Sugiyama Eiji、Yao Ikuko、Setou Mitsutoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Pages: 1048-1054

    • DOI

      10.1016/j.bbrc.2017.11.108

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms2018

    • Author(s)
      Ikedo Taichi、Minami Manabu、Kataoka Hiroharu、Hayashi Kosuke、Nagata Manabu、Fujikawa Risako、Yamazaki Fumiyoshi、Setou Mitsutoshi、Yokode Masayuki、Miyamoto Susumu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Pages: 332-338

    • DOI

      10.1016/j.bbrc.2017.10.133

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cross-talk between prostaglandin and retinoic acid signaling.2018

    • Author(s)
      Inazumi, T., and Sugimoto, Y.
    • Journal Title

      Carotenoid Sci

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ゼブラフィッシュにおけるプロスタグランジンシステム2018

    • Author(s)
      土屋創健、杉本幸彦
    • Journal Title

      生化学

      Volume: 89 Pages: 445-445

    • NAID

      40021265217

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プロスタグランジンE2による炎症病態制御機構2018

    • Author(s)
      稲住知明、杉本幸彦
    • Journal Title

      細胞

      Volume: 50 Pages: 118-121

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Sitosterol prevents obesity-related chronic inflammation2018

    • Author(s)
      Kurano Makoto、Hasegawa Koji、Kunimi Motoei、Hara Masumi、Yatomi Yutaka、Teramoto Tamio、Tsukamoto Kazuhisa
    • Journal Title

      Biochim Biophys Acta

      Volume: 1863 Pages: 191-198

    • DOI

      10.1016/j.bbalip.2017.12.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphingosine 1-Phosphate and Atherosclerosis2018

    • Author(s)
      Kurano Makoto、Yatomi Yutaka
    • Journal Title

      J Atheroscler Thromb

      Volume: 25 Issue: 1 Pages: 16-26

    • DOI

      10.5551/jat.rv17010

      10.5551/jat.RV17010

    • NAID

      130006301107

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚疾患と脂質メディエーター2018

    • Author(s)
      本田哲也, 椛島健治
    • Journal Title

      アレルギー・免疫 医薬ジャーナル社

      Volume: 25 Pages: 30-37

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 炎症・感染応答を担うオルガネラ2018

    • Author(s)
      小林俊彦、向井康治朗、田口友彦、反町典子
    • Journal Title

      臨床免疫アレルギー科

      Volume: 63 Pages: 99-106

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Voltage-Sensing Phosphatases: Biophysics, Physiology and Engineering2018

    • Author(s)
      Okamura Y, Kawanabe A, Kawai T.
    • Journal Title

      Physiological reviews

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels(VSOP/Hv1)2018

    • Author(s)
      Kawai T, Tatsumi S, Kihara S, Sakimura K, Okamura Y.
    • Journal Title

      Channels

      Volume: 12 Issue: 1 Pages: 43108-43108

    • DOI

      10.1080/19336950.2017.1385684

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The importance of bioinformatics for connecting data-driven lipidomics and biological insights2017

    • Author(s)
      Tsugawa H, Ikeda K, Arita M.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

      Volume: 1862 Pages: 762-765

    • DOI

      10.1016/j.bbalip.2017.05.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library.2017

    • Author(s)
      Aoyagi Ryohei、Ikeda Kazutaka、Isobe Yosuke、Arita Makoto
    • Journal Title

      J Lipid Res

      Volume: 58 Pages: 2229-2237

    • DOI

      10.1194/jlr.d077123

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut microbiota promotes obcsity-associatcd liver cancer through PGE2-mediated suppression of antitumor immunity2017

    • Author(s)
      Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N, et al.
    • Journal Title

      Cancer Discovery

      Volume: 7 Pages: 522-538

    • DOI

      10.1158/2159-8290.cd-16-0932

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.2017

    • Author(s)
      Shimanaka Yuta、Kono Nozomu、Taketomi Yoshitaka、Arita Makoto、Okayama Yoshimichi、Tanaka Yuki、Nishito Yasumasa、Mochizuki Tatsuki、Kusuhara Hiroyuki、Adibekian Alexander、Cravatt Benjamin F、Murakami Makoto、Arai Hiroyuki
    • Journal Title

      Nat Med

      Volume: 23 Pages: 1287-1297

    • DOI

      10.1038/nm.4417

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation.2017

    • Author(s)
      Yotsumoto Satoshi、Muroi Yuito、Chiba Tatsuya、Ohmura Rio、Yoneyama Maki、Magarisawa Megumi、Dodo Kosuke、Terayama Naoki、Sodeoka Mikiko、Aoyagi Ryohei、Arita Makoto、Arakawa Satoko、Shimizu Shigeomi、Tanaka Masato
    • Journal Title

      Journal, Scientific Reports

      Volume: 7 Pages: 16026-16026

    • DOI

      10.1038/s41598-017-15668-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo‐epithelial boundary controls decidualization pathways2017

    • Author(s)
      Aikawa Shizu、Kano Kuniyuki、Inoue Asuka、Wang Jiao、Saigusa Daisuke、Nagamatsu Takeshi、Hirota Yasushi、Fujii Tomoyuki、Tsuchiya Soken、Taketomi Yoshitaka、Sugimoto Yukihiko、Murakami Makoto、Arita Makoto、Kurano Makoto、Ikeda Hitoshi、Yatomi Yutaka、Chun Jerold、Aoki Junken
    • Journal Title

      EMBO Journal

      Volume: 36 Pages: 2146-2160

    • DOI

      10.15252/embj.201696290

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] リポクオリティと炎症・免疫の制御(企画・編集)2017

    • Author(s)
      有田誠
    • Journal Title

      炎症と免疫(先端医学社)

      Volume: 25

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 脂肪酸クオリティと炎症・アレルギーの制御2017

    • Author(s)
      永沼達郎、有田誠
    • Journal Title

      炎症と免疫(先端医学社)

      Volume: 25 Pages: 265-270

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Identification of small molecules using accurate mass MS/MS search2017

    • Author(s)
      Kind T, Tsugawa H, Cajka T, Ma Y, Lai Z, Mehta SS, Wohlgemuth G, Barupal DK, Showalter MR, Arita M, Fiehn O
    • Journal Title

      Mass Spectrom Rev

      Volume: -

    • DOI

      10.1002/mas.21535

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 化学とメタボロミクス2017

    • Author(s)
      有田正規、津川裕司
    • Journal Title

      化学

      Volume: 72 Pages: 26-30

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid a ligand for leukotriene B4 receptor 22017

    • Author(s)
      Iwamoto Satoshi、Koga Tomoaki、Ohba Mai、Okuno Toshiaki、Koike Masato、Murakami Akira、Matsuda Akira、Yokomizo Takehiko
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 1-10

    • DOI

      10.1038/s41598-017-13122-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification signaling and functions of LTB4 receptors2017

    • Author(s)
      Saeki K, Yokomizo T
    • Journal Title

      Seminars in Immunology

      Volume: 33 Pages: 30-36

    • DOI

      10.1016/j.smim.2017.07.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical and immunological characterization of a novel monoclonal antibody against mouseleukotriene B4 receptor 1.2017

    • Author(s)
      Sasaki F, Koga T, Saeki K, Okuno T, Kazuno S, Fujimura T, Ohkawa Y, Yokomizo T
    • Journal Title

      PLoS One.

      Volume: 12 Pages: 0185133-0185133

    • DOI

      10.1371/journal.pone.0185133

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.2017

    • Author(s)
      Takeda Tomoki、Komiya Yukiko、Koga Takayuki、Ishida Takumi、Ishii Yuji、Kikuta Yasushi、Nakaya Michio、Kurose Hitoshi、Yokomizo Takehiko、Shimizu Takao、Uchi Hiroshi、Furue Masutaka、Yamada Hideyuki
    • Journal Title

      J Biol Chem

      Volume: 292 Pages: 10586-10599

    • DOI

      10.1074/jbc.m116.764332

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vacuolar protein sorting 34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy2017

    • Author(s)
      Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T
    • Journal Title

      JCI insight

      Volume: 2(1) Pages: 89462-89478

    • DOI

      10.1172/jci.insight.89462

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia2017

    • Author(s)
      Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 7 Pages: 1-11

    • DOI

      10.1038/srep45050

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis.2017

    • Author(s)
      Iizuka-Hishikawa Yoshiko、Hishikawa Daisuke、Sasaki Junko、Takubo Keiyo、Goto Motohito、Nagata Katsuyuki、Nakanishi Hiroki、Shindou Hideo、Okamura Tadashi、Ito Chizuru、Toshimori Kiyotaka、Sasaki Takehiko、Shimizu Takao
    • Journal Title

      J Biol Chem

      Volume: 292 Pages: 12065-12076

    • DOI

      10.1074/jbc.m117.791277

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells.2017

    • Author(s)
      Shindou Hideo、Koso Hideto、Sasaki Junko、Nakanishi Hiroki、Sagara Hiroshi、Nakagawa Koh M.、Takahashi Yoshikazu、Hishikawa Daisuke、Iizuka-Hishikawa Yoshiko、Tokumasu Fuyuki、Noguchi Hiroshi、Watanabe Sumiko、Sasaki Takehiko、Shimizu Takao
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 292 Pages: 1205412064-1205412064

    • DOI

      10.1074/jbc.m117.790568

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.2017

    • Author(s)
      Malek M、Kielkowska A、Chessa T、Anderson K E.、Barneda D、Pir P、Nakanishi H、Eguchi S、Koizumi A、Sasaki J、Juvin V、Kiselev VY.、Niewczas I、Gray A、Valayer A、Spensberger D、Imbert M、Felisbino S、Habuchi T、Beinke S、Cosulich S、Le Novere N、Sasaki T、Clark J、Hawkins PT.、Stephens LR.
    • Journal Title

      Mol Cell

      Volume: 68 Pages: 566-580

    • DOI

      10.1016/j.molcel.2017.09.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production2017

    • Author(s)
      Huang Mingguo、Narita Shintaro、Inoue Takamitsu、Koizumi Atsushi、Saito Mitsuru、Tsuruta Hiroshi、Numakura Kazuyuki、Satoh Shigeru、Nanjo Hiroshi、Sasaki Takehiko、Habuchi Tomonori
    • Journal Title

      Oncotarget

      Volume: 8 Pages: 111780-111794

    • DOI

      10.18632/oncotarget.22908

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A New Electron Microscopic Method to Observe the Distribution of Phosphatidylinositol 3,4-bisphosphate2017

    • Author(s)
      Aktar S, Takatori S, Tsuji T, Orii M, Ohsaki Y, Cheng J, Fujimoto T
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 50(5) Issue: 5 Pages: 141-147

    • DOI

      10.1267/ahc.17025

    • NAID

      130006179489

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatocyte-specific depletion of ubiquitin regulatory X domain containing protein 8 accelerates fibrosis in a mouse non-alcoholic steatohepatitis model2017

    • Author(s)
      Imai Norihiro、Suzuki Michitaka、Ishizu Yoji、Kuzuya Teiji、Honda Takashi、Hayashi Kazuhiko、Ishigami Masatoshi、Hirooka Yoshiki、Ishikawa Tetsuya、Goto Hidemi、Fujimoto Toyoshi
    • Journal Title

      Histochem Cell Biol

      Volume: 148 Pages: 219-227

    • DOI

      10.1007/s00418-017-1572-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for ESCRT- and clathrin-dependent microautophagy2017

    • Author(s)
      Masahide Oku, Yuichiro Maeda, Yoko Kagohashi, Takeshi Kondo, Mai Yamada, Toyoshi Fujimoto, Yasuyoshi Sakai
    • Journal Title

      The Journal of Cell Biology

      Volume: 216 Pages: 3263-3274

    • DOI

      10.1083/jcb.201611029

    • NAID

      120006454716

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole2017

    • Author(s)
      Tsuji T, Fujimoto M, Tatematsu T, Cheng J, Orii M, Takatori S, Fujimoto T
    • Journal Title

      eLife

      Volume: 6

    • DOI

      10.7554/elife.25960

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Freeze-fracture-etching Electron Microscopy for Facile Analysis of Yeast Ultrastructure2017

    • Author(s)
      Tsuji Takuma、Fujimoto Toyoshi
    • Journal Title

      BIO-PROTOCOL

      Volume: 7

    • DOI

      10.21769/bioprotoc.2556

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The lipid droplet and the endoplasmic reticulum2017

    • Author(s)
      Ohsaki, Y., Soltysik, K., and Fujimoto, T
    • Journal Title

      Adv Exp Med Biol

      Volume: 997 Pages: 111-120

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency2017

    • Author(s)
      Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.
    • Journal Title

      Frontiers in Genetics

      Volume: 8 Pages: 113-113

    • DOI

      10.3389/fgene.2017.00113

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues2017

    • Author(s)
      Hosokawa Yuko、Masaki Noritaka、Takei Shiro、Horikawa Makoto、Matsushita Shoko、Sugiyama Eiji、Ogura Hiroyuki、Shiiya Norihiko、Setou Mitsutoshi
    • Journal Title

      PLOS ONE

      Volume: 12

    • DOI

      10.1371/journal.pone.0183724

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical expression analysis of leucine-rich PPR-motif-containing protein (LRPPRC), a candidate colorectal cancer biomarker identified by shotgun proteomics using iTRAQ2017

    • Author(s)
      Nishio Tomohisa、Kurabe Nobuya、Goto-Inoue Naoko、Nakamura Toshio、Sugimura Haruhiko、Setou Mitsutoshi、Maekawa Masato
    • Journal Title

      Clinica Chimica Acta

      Volume: 471 Pages: 276-282

    • DOI

      10.1016/j.cca.2017.06.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts.2017

    • Author(s)
      Kato Hikaru、Kai Aika、Kawabata Tetsuro、Sunderhaus James D.、McAfoos Timothy J.、Finefield Jennifer M.、Sugimoto Yukihiko、Williams Robert M.、Tsukamoto Sachiko
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Pages: 4975-4978

    • DOI

      10.1016/j.bmcl.2017.10.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gαs2017

    • Author(s)
      Yano A, Takahashi Y, Moriguchi H, Inazumi T, Koga T, Otaka A, Sugimoto Y.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

      Volume: 1862 Pages: 615-622

    • DOI

      10.1016/j.bbalip.2017.03.006

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 雌性生殖生理におけるプロスタグランジン受容体の役割2017

    • Author(s)
      杉本幸彦
    • Journal Title

      別冊BIO Clinica 慢性炎症と疾患

      Volume: 6 Pages: 16-21

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Involvement of Band 3 in the efflux of sphingosine 1-phospate from erythrocytes2017

    • Author(s)
      Kurano M, Nishikawa M, Kuma H, Jona M, Yatomi Y.
    • Journal Title

      PLos One

      Volume: 12

    • DOI

      10.1371/journal.pone.0177543

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.2017

    • Author(s)
      Nakamizo Satoshi、Honda Tetsuya、Adachi Akimasa、Nagatake Takahiro、Kunisawa Jun、Kitoh Akihiko、Otsuka Atsushi、Dainichi Teruki、Nomura Takashi、Ginhoux Florent、Ikuta Koichi、Egawa Gyohei、Kabashima Kenji
    • Journal Title

      Sci. Rep.

      Volume: 7 Pages: 14076-14076

    • DOI

      10.1038/s41598-017-14292-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Advances in atopic dermatitis and urticarial in 20162017

    • Author(s)
      Honda Tetsuya、Nomura Takashi、Kabashima Kenji
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 140 Pages: 369-376

    • DOI

      10.1016/j.jaci.2017.06.005

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.2017

    • Author(s)
      Kobayashi Toshihiko、Tsutsui Hidemitsu、Shimabukuro-Demoto Shiho、Yoshida-Sugitani Reiko、Karyu Hitomi、Furuyama-Tanaka Kaori、Ohshima Daisuke、Kato Norihiro、Okamura Tadashi、Toyama-Sorimachi Noriko
    • Journal Title

      Int Immunol.

      Volume: 29 Pages: 551-566

    • DOI

      10.1093/intimm/dxx063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel role for PHT1 in the disposition of l -histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice2017

    • Author(s)
      Wang XX, Hu Y, Keep RF, Toyama-Sorimachi N, Smith DE.
    • Journal Title

      Biochemical Pharmacology

      Volume: 15 Pages: 94-102

    • DOI

      10.1016/j.bcp.2016.11.012

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 炎症抑制に関わる電位依存性プロトンチャネルHv1/VSOPの機能(リポクオリティによる膜タンパク質の機能制御と炎症・免疫)2017

    • Author(s)
      大河内善史、川鍋陽、岡村康司
    • Journal Title

      炎症と免疫 2017年7月号

      Volume: 25 Pages: 17-22

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Domain-to-domain coupling in voltage-sensing phosphatase2017

    • Author(s)
      Sakata S, Matsuda M, Kawanabe A, Okamura Y.
    • Journal Title

      BIOPHYSICS

      Volume: 1 Issue: 0 Pages: 85-97

    • DOI

      10.2142/biophysico.14.0_85

    • NAID

      130007041363

    • ISSN
      2189-4779
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production.2017

    • Author(s)
      Kawai T, Okochi Y, Ozaki T, Imura Y, Koizumi S, Yamazaki M, Abe M, Sakimura K, Yamashita T, Okamura Y.
    • Journal Title

      J Neurochem.

      Volume: 142 Issue: 5 Pages: 686-699

    • DOI

      10.1111/jnc.14106

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular and functional characterization of the voltage-gated proton channel in zebrafish neutrophils2017

    • Author(s)
      Ratanayotha Adisorn、Kawai Takafumi、Higashijima Shin-ichi、Okamura Yasushi
    • Journal Title

      Physiol Rep

      Volume: 5

    • DOI

      10.14814/phy2.13345

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 増大特集 細胞多様性解明に資する光技術─見て,動かす Ⅱ.見えなかったものを視る 電位センサードメインを用いた膜電位プローブの進歩2017

    • Author(s)
      河合 喬文、筒井 秀和、岡村 康司
    • Journal Title

      生体の科学

      Volume: 68 Issue: 5 Pages: 444-445

    • DOI

      10.11477/mf.2425200686

    • ISSN
      0370-9531, 1883-5503
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library2017

    • Author(s)
      Tsugawa H, Ikeda K, Tanaka W, Senoo Y, Arita M, Arita M.
    • Journal Title

      Journal of cheminformatics

      Volume: 9 Pages: 19-19

    • DOI

      10.1186/s13321-017-0205-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis2017

    • Author(s)
      Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Mu&ntilde;oz-Garcia A, Brash A, Ikeda K, Arita M, Akiyama M, Murakami M.
    • Journal Title

      Nat. Commun.

      Volume: 8 Pages: 14609-14609

    • DOI

      10.1038/ncomms14609

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ω3脂肪酸の代謝と抗炎症作用に関する研究2017

    • Author(s)
      有田誠
    • Journal Title

      脂質栄養学(日本脂質栄養学会)

      Volume: 26 Pages: 27-34

    • NAID

      130006894081

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different desmin peptides are distinctly deposited in cytoplasmic aggregations and cytoplasm of desmin-related cardiomyopathy patients2017

    • Author(s)
      Shintani-Domoto Y, Hayasaka T, Maeda D, Masaki N, Ito TK, Sakuma K, Tanaka M, Kabashima K, Takei S, Setou M, Fukayama M.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

      Volume: S1570-9639 Pages: 30048-1

    • DOI

      10.1016/j.bbapap.2017.03.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside.2017

    • Author(s)
      Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N.
    • Journal Title

      Gene.

      Volume: S0378-1119 Pages: 30139-7

    • DOI

      10.1016/j.gene.2017.03.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proper cytoskeletal architecture beneath the plasma membrane of red blood cells requires Ttll4.2017

    • Author(s)
      Ijaz F, Hatanaka Y, Hatanaka T, Tsutsumi K, Iwaki T, Umemura K, Ikegami K, Setou M.
    • Journal Title

      Mol Biol Cell.

      Volume: 28 Pages: 535-544

    • DOI

      10.1091/mbc.e16-02-0089

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Selective improvement of peptides imaging on tissue by supercritical fluid wash of lipids for matrix-assisted laser desorption/ionization mass spectrometry2017

    • Author(s)
      Matsushita S, Masaki N, Sato K, Hayasaka T, Sugiyama E, Hui SP, Chiba H, Mase N, Setou M.
    • Journal Title

      Anal. Bioanal. Chem.

      Volume: 409 Pages: 1475-1475

    • DOI

      10.1007/s00216-016-0119-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.2017

    • Author(s)
      Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T
    • Journal Title

      Cell

      Volume: 168 Pages: 264-279

    • DOI

      10.1016/j.cell.2016.12.032

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Organelle Contact Sites2017

    • Author(s)
      Ohsaki Y, Soltysik K, Fujimoto T
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 997 Pages: 121-133

    • DOI

      10.1007/978-981-10-4567-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 電子顕微鏡による脂肪滴と膜脂質の探索2017

    • Author(s)
      藤本豊士、大﨑雄樹、辻琢磨
    • Journal Title

      Proc. Clin. Electron Microsc

      Volume: 35 Pages: 1-3

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Interleaflet coupling, pinning and leaflet asymmetry -major players in plasma membrane nanodomain formation2017

    • Author(s)
      Fujimoto T, Parmryd I
    • Journal Title

      Frontier Cell Dev Biol

      Volume: 4 Pages: 155-155

    • DOI

      10.3389/fcell.2016.00155

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Homology analysis detects topological changes of Iba1 localization accompanied by microglial activation.2017

    • Author(s)
      Inagaki S, Tsutsui H, Suzuki K, Agetsuma M, Arai Y, Jinno Y, Bai G, Daniels M, Okamura Y, Matsuda M, and Nagai T
    • Journal Title

      Neuroscience

      Volume: 7 Pages: 42398-42398

    • DOI

      10.1038/srep42398

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate2017

    • Author(s)
      Shinobu Hirai, Kohji Hotta, Yoshihiro Kubo, Atsuo Nishino, Shigeo Okabe, Yasushi Okamura, Haruo Okado
    • Journal Title

      PNAS

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Domain-to-domain coupling in voltage-sensing phosphatase2017

    • Author(s)
      Souhei Sakata, Makoto Matsuda, Akira Kawanabe, Yasushi Okamura
    • Journal Title

      Biophysics and Physiobiology

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 炎症抑制に関わる電位依存性プロトンチャネルHv1/VSOPの機能(リポクオリティによる膜タンパク質の機能制御と炎症・免疫2017

    • Author(s)
      大河内善史、川鍋陽、岡村康司
    • Journal Title

      炎症と免疫

      Volume: in press

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Analysis of glycero-lysophospholipids in gastric cancerous ascites2017

    • Author(s)
      Emoto, S., Kurano, M., Kano, K., Matsusaki, K., Yamashita, H., Nishikawa, M., Igarashi, K., Ikeda, H., Aoki, J., Kitayama, J., and Yatomi, Y.
    • Journal Title

      Journal of Lipid Research

      Volume: 58 Pages: 763-771

    • DOI

      10.1194/jlr.p072090

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions.2017

    • Author(s)
      Kurano, M., Hara, M., Ikeda, H., Tsukamoto, K., and Yatomi, Y
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 37 Pages: 506-514

    • DOI

      10.1161/atvbaha.116.308692

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome.2017

    • Author(s)
      Kurano, M., Kano, K., Dohi, T., Matsumoto, H., Igarashi, K., Nishikawa, M., Ohkawa, R., Ikeda, H., Miyauchi, K., Daida, H., Aoki, J., and Yatomi, Y.
    • Journal Title

      J Lipid Res.

      Volume: 58 Pages: 433-442

    • DOI

      10.1194/jlr.p071803

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression2017

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
    • Journal Title

      J Atheroscler Thromb

      Volume: in press Issue: 9 Pages: 954-969

    • DOI

      10.5551/jat.37663

    • NAID

      130006038432

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury.2017

    • Author(s)
      Shigematsu, M., Koga, T., Ishimori, A., Saeki, K., Ishii, Y., Taketomi, Y., Ohba, M., Jo-Watanabe, A., Okuno, T., Harada, N., Harayama, T., Shindou, H., Li, J. D., Murakami, M., Hoka, S.,Yokomizo, T.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 34560-34560

    • DOI

      10.1038/srep34560

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inhibition of leukotriene B4 action mitigates intracerebral hemorrhage-associated pathological events in mice2017

    • Author(s)
      Hijioka, M., Anan, J., Ishibashi, H., Kurauchi, Y., Hisatsune, A., Seki, T., Koga, T., Yokomizo, T., Shimizu, T.,Katsuki, H.
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 360 Pages: 399-406

    • DOI

      10.1124/jpet.116.238824

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prolonged exposure to volatile anesthetic isoflurane worsens the outcome of polymicrobial abdominal sepsis.2017

    • Author(s)
      Koutsogiannaki, S., Schaefers, M. M., Okuno, T., Ohba, M., Yokomizo, T., Priebe, G. P., DiNardo, J. A., Sulpicio, S. G.,Yuki, K.
    • Journal Title

      Toxicol Sci

      Volume: in press Pages: 402-411

    • DOI

      10.1093/toxsci/kfw261

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes2017

    • Author(s)
      Luo, L., Tanaka, R., Kanazawa, S., Lu, F., Hayashi, A., Yokomizo, T.,Mizuno, H.
    • Journal Title

      Journal of Diabetes and its Complications

      Volume: 31 Pages: 13-20

    • DOI

      10.1016/j.jdiacomp.2016.09.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ntravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production.2017

    • Author(s)
      Okuno, T., Koutsogiannaki, S., Ohba, M., Chamberlain, M., Bu, W., Lin, F. Y., Eckenhoff, R. G., Yokomizo, T.,Yuki, K.
    • Journal Title

      The FASEB Journal

      Volume: 31 Pages: 1584-1594

    • DOI

      10.1096/fj.201601095r

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 皮膚保護作用を有する脂質メディエーター12-HHT2017

    • Author(s)
      石井由美子, 劉珉, 佐伯和子,横溝岳彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 67 Pages: 106-114

    • NAID

      40021064298

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy2016

    • Author(s)
      Arita M
    • Journal Title

      Allergol. Int.

      Volume: 65 Issue: Supplement.1 Pages: 2-5

    • DOI

      10.1016/j.alit.2016.05.010

    • NAID

      130005418951

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hydrogen rearrangement rules: computational MS/MS fragmentation and structure elucidation using MS-FINDER software2016

    • Author(s)
      Tsugawa H, Kind T, Nakabayashi R, Yukihira D, Tanaka W, Cajka T, Saito K, Fiehn O, Arita M
    • Journal Title

      Analytical Chemistry

      Volume: 88 Pages: 7946-7958

    • DOI

      10.1021/acs.analchem.6b00770

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Editorial: Metabolome Informatics and Statistics: Current State and Emerging Trends2016

    • Author(s)
      Carroll AJ, Salek RM, Arita M, Kopka J, Walther D
    • Journal Title

      Front Bioeng Biotechnol

      Volume: 4 Pages: 63-63

    • DOI

      10.3389/fbioe.2016.00063

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SPLASH, a hashed identifier for mass spectra2016

    • Author(s)
      Wohlgemuth G, Mehta SS, Mejia RF, Neumann S, Pedrosa D, Pluskal T, Schymanski EL, Willighagen EL, Wilson M, Wishart DS, Arita M, Dorrestein PC, Bandeira N, Wang M, Schulze T, Salek RM, Steinbeck C, Nainala VC, Mistrik R, Nishioka T, Fiehn O
    • Journal Title

      Nature Biotechnol

      Volume: 34 Pages: 1099-1101

    • DOI

      10.1038/nbt.3689

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 生体内の低分子代謝産物を網羅的に捉えるための新技術2016

    • Author(s)
      津川裕司、有田正規
    • Journal Title

      化学と生物

      Volume: 54 Pages: 151-153

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Overview/リポクオリティが制御する血管医学2016

    • Author(s)
      有田誠
    • Journal Title

      血管医学(メディカルレビュー社)

      Volume: 17 Pages: 115-117

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 脂肪酸クオリティ制御と血管医学2016

    • Author(s)
      遠藤仁、有田誠
    • Journal Title

      血管医学(メディカルレビュー社)

      Volume: 17 Pages: 137-143

    • Related Report
      2016 Annual Research Report
  • [Journal Article] リピドミクスによる脂肪酸代謝と疾患制御の解析2016

    • Author(s)
      有田誠
    • Journal Title

      生体の科学(医学書院)

      Volume: 67 Pages: 189-192

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model2016

    • Author(s)
      Morioka S, Nigorikawa K, Sasaki J, Hazeki K, Kasuu Y, Sasaki T, Hazeki O
    • Journal Title

      Innate Immun

      Volume: 6 Pages: 444-444

    • DOI

      10.1177/1753425916652714

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] イノシトールリン脂質のがん転移への関与 : "invadopodia"の形成機構2016

    • Author(s)
      坂東 倫行、佐々木 雄彦
    • Journal Title

      医学のあゆみ

      Volume: 257 Pages: 1211-1215

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Insufficient Lymph Drainage Causes Abnormal Lipid Accumulation and Vein Wall Degeneration2016

    • Author(s)
      Tanaka H, Yamamoto N, Suzuki M, Mano Y, Sano M, Zaima N, Sasaki T, Setou M, Unno N.
    • Journal Title

      AVD

      Volume: 9 Issue: 4 Pages: 277-284

    • DOI

      10.3400/avd.oa.16-00122

    • NAID

      130005252750

    • ISSN
      1881-641X, 1881-6428
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm.2016

    • Author(s)
      Kugo H, Zaima N, Tanaka H, Mouri Y, Yanagimoto K, Hayamizu K, Hashimoto K, Sasaki T, Sano M, Yata T, Urano T, Setou M, Unno N, Moriyama T.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 31268-31268

    • DOI

      10.1038/srep31268

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Accumulation of arachidonic acid-containing phosphatidylinositol at the outer edge of colorectal cancer2016

    • Author(s)
      Hiraide T, Ikegami K, Sakaguchi T, Morita Y, Hayasaka T, Masaki N, Waki M, Sugiyama E, Shinriki S, Takeda M, Shibasaki Y, Miyazaki S, Kikuchi H, Okuyama H, Inoue M, Setou M, Konno H.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 29935-29935

    • DOI

      10.1038/srep29935

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Increased arachidonic acid-containing phosphatidylcholine is associated with reactive microglia and astrocytes in the spinal cord after peripheral nerve injury.2016

    • Author(s)
      Xu D, Omura T, Masaki N, Arima H, Banno T, Okamoto A, Hanada M, Takei S, Matsushita S, Sugiyama E, Setou M, Matsuyama Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Pages: 26427-26427

    • DOI

      10.1038/srep26427

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of sphingolipids and phospholipids in the fundic gland mucosa of human stomach using imaging mass spectrometry.2016

    • Author(s)
      Kurabe N, Igarashi H, Ohnishi I, Tajima S, Inoue Y, Takahashi Y, Setou M, Sugimura H.
    • Journal Title

      World J Gastrointest Pathophysiol.

      Volume: 7 Pages: 235-41

    • DOI

      10.4291/wjgp.v7.i2.235

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protease-resistant modified human β-hexosaminidase B as a novel therapeutic enzyme for GM2 gangliosidosis.2016

    • Author(s)
      Kitakaze K, Mizutani Y, Sugiyama E, Tasaki C, Tsuji D, Maita N, Hirokawa T, Asanuma D, Kamiya M, Sato K, Setou M, Urano Y, Togawa T, Otaka A, Sakuraba H, Itoh K
    • Journal Title

      J. Clin. Invest.

      Volume: in press Pages: 16911703-16911703

    • DOI

      10.1172/jci85300

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Imaging mass spectrometry detects dynamic changes of2016

    • Author(s)
      Miyawaki S, Imai H, Hayasaka T, Masaki N, Ono H, Ochi T, Ito A, Nakatomi H, Setou M, Saito N.
    • Journal Title

      Neuroscience

      Volume: 322 Pages: 66-77

    • DOI

      10.1016/j.neuroscience.2016.02.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 質量顕微鏡法の開発とその応用2016

    • Author(s)
      瀬藤光利
    • Journal Title

      J Mass Spectrom. Soc. Jpn

      Volume: 64 Pages: 201-218

    • NAID

      130005421348

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 脂質分解イメージングで脂質を"見る"2016

    • Author(s)
      堀川誠、武井史郎、瀬藤光利
    • Journal Title

      生体の科学

      Volume: 67 Pages: 198-202

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18- dependent fusion of ER and lipid droplets in cultured human hepatocytes.2016

    • Author(s)
      Makino A, Hullin-Matsuda F, Murate M, Abe M, Tomishige N, Fukuda M, Yamashita S, Fujimoto T, Vidal H, Lagarde M, Delton I, Kobayashi T.
    • Journal Title

      Mol. Biol. Cell

      Volume: 27 Pages: 3293-3304

    • DOI

      10.1091/mbc.e15-10-0730

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death.2016

    • Author(s)
      Takabe W, Urano Y, Vo D-K H, Shibuya K, Tanno M, Kitagishi H, Fujimoto T, Noguchi N
    • Journal Title

      J Lipid Res.

      Volume: 57 Pages: 2005-2014

    • DOI

      10.1194/jlr.m068775

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison between mouse and sea urchin orthologs of voltage-gated proton channel suggests role of S3 segment in activation gating.2016

    • Author(s)
      Sakata S, Miyawaki N, McCormack TJ, Arima H, Kawanabe A, Ozkucur N, Kurokawa T, Jinno Y, Fujiwara Y, Okamura Y
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1858 Pages: 2972-2983

    • DOI

      10.1016/j.bbamem.2016.09.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Voltage-dependent motion of the catalytic region of voltage-sensing phosphatase monitored by a fluorescent amino acid2016

    • Author(s)
      Sakata S, Jinno Y, Kawanabe A, Okamura Y
    • Journal Title

      Proc Natil Acad Sci USA

      Volume: 113 Pages: 7521-7526

    • DOI

      10.1073/pnas.1604218113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Simple scheme of lipid enzyme can explain complex lives of phosphoinositides2016

    • Author(s)
      Okamura Y.
    • Journal Title

      PNAS

      Volume: 113 Pages: 7012-7014

    • DOI

      10.1073/pnas.1607427113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 細胞膜の機能的区画化におけるクラスターとドメインの概念とその制御2016

    • Author(s)
      反町典子
    • Journal Title

      生体の科学 特集号「脂質ワールド」

      Volume: 67 Pages: 220-226

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Resveratrol exerts a biphasic effect on apolipoprotein M2016

    • Author(s)
      Kurano M, Hara M, Nojiri T, Ikeda H, Tsukamoto K, Yatomi Y.
    • Journal Title

      Br. J. Pharmacol.

      Volume: 173 Pages: 222-233

    • DOI

      10.1111/bph.13360

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increased mRNA levels of sphingosine kinases and S1P lyase and reduced levels of S1P were observed in hepatocellular carcinoma in association with poorer differentiation and earlier recurrence.2016

    • Author(s)
      Uranbileg B, Ikeda H, Kurano M, Enooku K, Sato M, Saigusa D, Aoki J, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      PLOS ONE

      Volume: 11

    • DOI

      10.1371/journal.pone.0149462

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Higher LPA2 and LPA6 mRNA levels in hepatocellular carcinoma are associated with poorer differentiation, microvascular invasion and earlier recurrence with higher serum autotaxin levels2016

    • Author(s)
      Enooku K, Uranbileg B, Ikeda H, Kurano M, Sato M, Kudo H, Maki H, Koike K, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI

      10.1371/journal.pone.0161825

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction2016

    • Author(s)
      Nagura, Y., Tsuno, NH., Kano, K., Inoue, A., Aoki, J., Hirowatari, Y., Kaneko, M., Kurano, M., Matsuhashi, M., Ohkawa, R., Tozuka, M., Yatomi, Y., and Okazaki, H.
    • Journal Title

      Transfus Med

      Volume: 26 Pages: 365-372

    • DOI

      10.1111/tme.12326

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human2016

    • Author(s)
      Sato M, Ikeda H, Uranbileg B, Kurano M, Saigusa D, Aoki J, Maki H, Kudo H, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 32119-32119

    • DOI

      10.1038/srep32119

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 肝疾患による二次性脂質異常症.2016

    • Author(s)
      蔵野 信.
    • Journal Title

      臨床病理

      Volume: 64 Pages: 518-526

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 急性冠症候群の病態生理におけるマイナーリゾリン脂質の関与の可能性.2016

    • Author(s)
      蔵野 信.
    • Journal Title

      日本血栓止血学会誌

      Volume: 27 Pages: 460-465

    • Related Report
      2016 Annual Research Report
  • [Journal Article] HDLの抗血栓作用.2016

    • Author(s)
      蔵野 信.
    • Journal Title

      臨床病理

      Volume: 64 Pages: 66-71

    • Related Report
      2016 Annual Research Report
  • [Journal Article] スフィンゴシン1-リン酸とHDL.2016

    • Author(s)
      蔵野 信,矢冨 裕.
    • Journal Title

      医学のあゆみ

      Volume: 259 Pages: 878-879

    • Related Report
      2016 Annual Research Report
  • [Journal Article] he leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes2016

    • Author(s)
      Chiba, T., Nakahara, T., Hashimoto-Hachiya, A., Yokomizo, T., Uchi, H.,Furue, M.
    • Journal Title

      Exp Dermatol

      Volume: 25 Pages: 532-536

    • DOI

      10.1111/exd.12976

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] chiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Yamamoto H, Sakaguchi M, Yokomizo T. Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE).2016

    • Author(s)
      Ichiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Yamamoto H, Sakaguchi M, Yokomizo T
    • Journal Title

      FASEB Journal

      Volume: 30 Pages: 1811-1822

    • DOI

      10.1096/fj.201500117

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Receptor for Advanced Glycation End Products Regulates Leukotriene B4 Receptor 1 Signaling2016

    • Author(s)
      Ichiki, T., Koga, T.,Yokomizo, T.
    • Journal Title

      DNA and Cell Biology

      Volume: 35 Pages: 747-750

    • DOI

      10.1089/dna.2016.3552

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins. F2016

    • Author(s)
      Ishii Y, Saeki K, Liu M, Sasaki F, Koga T, Kitajima K, Meno C, Okuno T, Yokomizo T
    • Journal Title

      Faseb J

      Volume: 30 Pages: 933-47

    • DOI

      10.1096/fj.15-279653

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] BLT(1) signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils.2016

    • Author(s)
      Kojo, K., Ito, Y., Eshima, K., Nishizawa, N., Ohkubo, H., Yokomizo, T., Shimizu, T., Watanabe, M.,Majima, M.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 29650-29650

    • DOI

      10.1038/srep29650

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis2016

    • Author(s)
      Oba, J., Nakahara, T., Hashimoto-Hachiya, A., Liu, M., Abe, T., Hagihara, A., Yokomizo, T.,Furue, M.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI

      10.1371/journal.pone.0149285

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells.2016

    • Author(s)
      Tabe, Y., Hatanaka, Y., Nakashiro, M., Sekihara, K., Yamamoto, S., Matsushita, H., Kazuno, S., Fujimura, T., Ikegami, T., Nakanaga, K., Matsumoto, H., Ueno, T., Aoki, J., Yokomizo, T., Konopleva, M., Andreeff, M., Miida, T., Iwabuchi, K.,Sasai, K.
    • Journal Title

      Int J Radiat Biol.

      Volume: 92 Pages: 24-34

    • DOI

      10.3109/09553002.2015.1106021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 【脂質ワールド】 新規脂質メディエーターと受容体 古くて新しい脂質メディエーター・12-ヒドロキシヘプタデカトリエン酸の生理作用2016

    • Author(s)
      横溝岳彦
    • Journal Title

      生体の科学

      Volume: 67 Pages: 232-236

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 快人快説 最先端の研究テクノロジー紹介 微量サンプル中の微量脂質を定量化する驚異の質量分析技術2016

    • Author(s)
      横溝岳彦
    • Journal Title

      LiSA

      Volume: 23 Pages: 1179-1188

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 「脂質マシナリー」研究 脂質メディエーターの最新の研究成果2016

    • Author(s)
      横溝岳彦
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 4 Pages: 610-617

    • NAID

      40021041094

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Olfactory receptor for prostaglandin F2a mediates male fish courtship behavior.2016

    • Author(s)
      Yabuki Y, Koide T, Miyasaka N, Wakisaka N, Masuda M, Ohkura M, Nakai J, Tsuge K, Tsuchiya S, Sugimoto Y, Yoshihara Y
    • Journal Title

      Nature Neurosci

      Volume: 19 Pages: 897-904

    • DOI

      10.1038/nn.4314

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostaglandin D2 elicits the reversible neurite retraction in hypothalamic cell line2016

    • Author(s)
      Tsuchiya H, Hohjoh H, Fujiwara Y, Sugimoto Y, Koshimizu TA.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 470 Pages: 804-810

    • DOI

      10.1016/j.bbrc.2016.01.091

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] プロスタノイド受容体を介した免疫・炎症応答亢進の分子機構2016

    • Author(s)
      告恭史郎、杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 256 Pages: 561-566

    • Related Report
      2016 Annual Research Report
  • [Journal Article] プロスタノイドクオリティと心血管系制御」血管医学2016

    • Author(s)
      告恭史郎、稲住知明、杉本幸彦
    • Journal Title

      血管医学

      Volume: 17 Pages: 37-43

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites2016

    • Author(s)
      Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, Osumi N.
    • Journal Title

      Stem Cells

      Volume: 34(2) Pages: 470-482

    • DOI

      10.1002/stem.2246

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cardioprotective mechanism of omega-3 polyunsaturated fatty acids2016

    • Author(s)
      Endo J, Arita M.
    • Journal Title

      J Cardiol

      Volume: 67 Pages: 22-27

    • DOI

      10.1016/j.jjcc.2015.08.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 脂肪酸クオリティによる炎症性疾患の制御2016

    • Author(s)
      有田誠
    • Journal Title

      感染炎症免疫

      Volume: 46 Pages: 22-30

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Imaging mass spectrometry reveals a unique distribution of triglycerides in2016

    • Author(s)
      Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Saito T, Hayasaka T, Goto-Inoue N, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
    • Journal Title

      J Vasc Res.

      Volume: 52 Pages: 127-135

    • DOI

      10.1159/000439169

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel organ culture model of aorta for vascular calcification.2016

    • Author(s)
      Akiyoshi T, Ota H, Iijima K, Son BK, Kahyo T, Setou M, Ogawa S, Ouchi Y, Akishita M.
    • Journal Title

      Atherosclerosis

      Volume: 244 Pages: 51-58

    • DOI

      10.1016/j.atherosclerosis.2015.11.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic Distribution Pattern of Lysophosphatidylcholine in Fibromuscular Dysplasia-Associated Visceral Artery Aneurysms Compared with Atherosclerotic Visceral Artery Aneurysms.2016

    • Author(s)
      Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Konno H, Urano T, Setou M, Unno N.
    • Journal Title

      J Atheroscler Thromb

      Volume: 印刷中

    • NAID

      130005154756

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia2016

    • Author(s)
      Miyawaki S, Imai H, Hayasaka T, Masaki N, Ono H, Ochi T, Ito A, Nakatomi H, Setou M, Saito.
    • Journal Title

      Neuroscience

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 質量顕微鏡の原理とその応用2016

    • Author(s)
      佐野圭吾、深野華、有久亘、瀬藤光利
    • Journal Title

      病理と臨床&nbsp;

      Volume: 34 Pages: 203-210

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脂質分析イメージングで脂質を「見る」2016

    • Author(s)
      堀川誠、武井史郎、瀬藤光利
    • Journal Title

      生体の科学

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Effects of unsaturated fatty acids on the kinetics of voltage-gated proton channels heterologously expressed in cultured cells2016

    • Author(s)
      Kawanabe A., Okamura Y.
    • Journal Title

      J. Physiol.

      Volume: 594 Pages: 595-610

    • DOI

      10.1113/jp271274

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development and evaluation of immunochromatography to detect Gram-negative bacteria producing ArmA 16S rRNA methylase responsible for aminoglycoside resistance.2016

    • Author(s)
      Okochi Y, Aratani Y, Adissu HA, Miyawaki N, Sasaki M, Suzuki K, Okamura Y.
    • Journal Title

      J Microbiol Methods

      Volume: 99 Pages: 159-163

    • DOI

      10.1189/jlb.3hi0814-393r

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Structural basis for the membrane association of ankyrinG via palmitoylation.2016

    • Author(s)
      Fujiwara Y, Kondo H, Shirota M, Kobayashi M, Takeshita K, Nakagawa A, Okamura Y, Kinoshita K
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 23981-23981

    • DOI

      10.1038/srep23981

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Direct Interaction between the Voltage-sensors Produces Cooperative Sustained Deactivation in Voltage-gated H+ Channel Dimers2016

    • Author(s)
      Okuda H, Yonezawa Y, Takano Y, Okamura Y, Fujiwara Y.
    • Journal Title

      J BIOL CHEM

      Volume: 291 Pages: 5935-47

    • DOI

      10.1074/jbc.m115.666834

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 測定の名人2016

    • Author(s)
      岡村康司
    • Journal Title

      Biophysics

      Volume: 56(3) Issue: 1 Pages: 001-001

    • DOI

      10.2142/biophys.56.001

    • NAID

      130005121653

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel imaging method revealed phosphatidylinositol 3,5-bisphosphate-rich domains in the endosome/lysosome membrane2016

    • Author(s)
      Takatori S, Fujimoto T
    • Journal Title

      Communicative & Integrative Biology

      Volume: 9

    • DOI

      10.1080/19420889.2016.1145319

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PML isoform II plays a critical role in nuclear lipid droplet formation2016

    • Author(s)
      Ohsaki Y, Kawai T, Yoshikawa Y, Cheng J, Jokitalo E, Fujimoto T.
    • Journal Title

      J Cell Biol

      Volume: 212 Pages: 29-38

    • DOI

      10.1083/jcb.201507122

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phosphatidylinositol 3,5-Bisphosphate-Rich Membrane Domains in Endosomes and Lysosomes2016

    • Author(s)
      Takatori S, Tatematsu T, Cheng J, Matsumoto J, Akano T, Fujimoto T
    • Journal Title

      Traffic

      Volume: 17 Pages: 154-167

    • DOI

      10.1111/tra.12346

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-12016

    • Author(s)
      Yamaguchi T, Lu C, Yanagisawa K, Can Lu, Usukura J, Cheng J, Hotta N, Shimada Y, Ida R, Isomura H, Suzuki M, Fujimoto T, Takahashi T
    • Journal Title

      Nature Communication

      Volume: 7 Pages: 10060-10060

    • DOI

      10.1038/ncomms10060

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphatidic acid induces EHD3-containing membrane tubulation and is required for receptor recycling.2016

    • Author(s)
      Henmi, Y., Oe, N., Kono, N., Taguchi, T., Takei, K., and Tanabe, K.
    • Journal Title

      Exp Cell Res

      Volume: 342 Pages: 1-10

    • DOI

      10.1016/j.yexcr.2016.02.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes.2016

    • Author(s)
      Chiba, T., Nakahara, T., Hashimoto-Hachiya, A., Yokomizo, T., Uchi, H., Furue, M.
    • Journal Title

      Exp Dermatol I

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ロイコトリエン受容体2016

    • Author(s)
      市木貴子, 古賀友紹, 横溝岳彦.
    • Journal Title

      医学のあゆみ

      Volume: 256 Pages: 554-560

    • NAID

      10025740562

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior.2016

    • Author(s)
      Yabuki, Y., Koide, T., Miyasaka, N., Wakisaka, N., Masuda, M., Ohkura, M., Nakai, J., Tsuge, K., Tsuchiya, S., Sugimoto, Y., Yoshihara, Y.
    • Journal Title

      Nature Neurosci.

      Volume: 19

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] プロスタノイド受容体を介した免疫・炎症応答亢進の分子機構2016

    • Author(s)
      告恭史郎, 杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 256(5) Pages: 561-566

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Chronic arachidonic acid administration decreases docosahexaenoic acid and eicosapentaenoic acid-derived metabolites in kidneys of aged rats2015

    • Author(s)
      M. Katakura, M. Hashimoto, T. Inoue, A. Mamun, Y. Tanabe, M. Arita, O. Shido.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0140884

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses2015

    • Author(s)
      Sawada Y, Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A, Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, Kabashima K.
    • Journal Title

      Journal of Experimental medicine

      Volume: 212 Pages: 1921-1930

    • DOI

      10.1084/jem.20150381

    • NAID

      120005733188

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aspirin and Eicosapentaenoic Acid May Arrest Progressive IgA Nephropathy: A Potential Alternative to Immunosuppression2015

    • Author(s)
      Hirahashi J, Hanafusa N, Wada T, Arita M, Hishikawa K, Hayashi M, Nangaku M
    • Journal Title

      Intern. Med.

      Volume: 54 Issue: 18 Pages: 2377-2382

    • DOI

      10.2169/internalmedicine.54.4623

    • NAID

      130005099678

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells.2015

    • Author(s)
      Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, Ueda K.
    • Journal Title

      J Lipid Res.

      Volume: 56 Pages: 1880-1890

    • DOI

      10.1194/jlr.m058164

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of Four Stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-Dihydroxy-4,7,10,12,16,18-docosahexaenoic Acid and Their Anti-inflammatory Activities2015

    • Author(s)
      Goto T, Urabe D, Masuda K, Isobe Y, Arita M, Inoue M.
    • Journal Title

      J. Org. Chem,

      Volume: 80 Pages: 7713-7726

    • DOI

      10.1021/acs.joc.5b01461

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut.2015

    • Author(s)
      J. Kunisawa, M. Arita, T. Hayasaka, T. Harada, R. Iwamoto, R. Nagasawa, S. Shikata, T. Nagatake, H. Suzuki, E. Hashimoto, Y. Kurashima, Y. Suzuki, H. Arai, M. Setou, and H. Kiyono
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 9750-9750

    • DOI

      10.1038/srep09750

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Eosinophil-mediated signaling attenuates inflammatory responses in experimental colitis2015

    • Author(s)
      Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT.
    • Journal Title

      Gut

      Volume: 64 Pages: 1236-1247

    • DOI

      10.1136/gutjnl-2014-306998

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis.2015

    • Author(s)
      Hiroshi Tsugawa, Tomas Cajka, Tobias Kind, Yan Ma, Brendan Higgins, Kazutaka Ikeda, Mitsuhiro Kanazawa, Jean VanderGheynst, Oliver Fiehn, Masanori Arita
    • Journal Title

      Nat Methods

      Volume: 12 Pages: 523-526

    • DOI

      10.1038/nmeth.3393

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ω3脂肪酸の分子栄養学2015

    • Author(s)
      有田誠
    • Journal Title

      アンチエイジング医学(メディカルレビュー社)

      Volume: 11 Pages: 845-851

    • NAID

      40020717239

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ω3脂肪酸のメタボローム解析と心臓リモデリング抑制作用2015

    • Author(s)
      有田誠
    • Journal Title

      内分泌・糖尿病・代謝内科(科学評論社)

      Volume: 41 Pages: 380-384

    • NAID

      40020676046

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 多価不飽和脂肪酸の代謝と炎症の制御2015

    • Author(s)
      有田誠
    • Journal Title

      医学のあゆみ(医歯薬出版)

      Volume: 254 Pages: 1127-1130

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ω3脂肪酸の代謝と疾患制御のメタボロミクス2015

    • Author(s)
      有田誠
    • Journal Title

      実験医学増刊号「脂質疾患学」(羊土社)

      Volume: 33 Pages: 2361-2366

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 炎症の収束に関わる脂肪酸代謝系とその機能2015

    • Author(s)
      有田誠
    • Journal Title

      別冊BIO Clinica「慢性炎症と疾患」(北隆館)

      Volume: 4 Pages: 27-31

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脂肪酸代謝と炎症のメタボロミクス2015

    • Author(s)
      有田誠
    • Journal Title

      臨床免疫・アレルギー科(科学評論社)

      Volume: 63 Pages: 118-124

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ω3脂肪酸の代謝と心臓保護作用2015

    • Author(s)
      有田誠
    • Journal Title

      別冊BIO Clinica「慢性炎症と疾患」(北隆館)

      Volume: 4 Pages: 99-110

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ω3系多価不飽和脂肪酸による心臓リモデリング抑制2015

    • Author(s)
      有田誠、遠藤仁
    • Journal Title

      循環plus(メディカルトリビューン社)

      Volume: 15 Pages: 7-9

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.2015

    • Author(s)
      Ip, LR., Poulogiannis, G., Viciano, FC., Sasaki, J., Kofuji, S., Spanswick, VJ., Hochhauser, D., Hartley, JA., Sasaki, T., Gewinner, CA.
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 10548-10562

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] INPP4B Is a PtdIns (3,4,5) P3 Phosphatase That Can Act as a Tumor Suppressor.2015

    • Author(s)
      Kofuji, S., Kimura, H., Nakanishi, H., Nanjo, H., Takasuga, S., Liu, H., Eguchi, S., Nakamura, R., Itoh, R., Ueno, N., Asanuma, K., Huang, M., Koizumi, A., Habuchi, T., Yamazaki, M., Suzuki, A., Sasaki, J., Sasaki, T.
    • Journal Title

      Cancer Discov.

      Volume: 5 Pages: 730-739

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K/AKT signaling at endosomes.2015

    • Author(s)
      Nigorikawa, K., Hazeki, K., Sasaki, J., Omori, Y., Miyake, M., Morioka, S., Guo, Y., Sasaki, T., Hazeki, O
    • Journal Title

      Cancer Discov.

      Volume: 10 Pages: 740-751

    • DOI

      10.1371/journal.pone.0142091

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The ML1Nx2 Phosphatidylinositol 3,5Bisphosphate Probe Shows Poor Selectivity in Cells.2015

    • Author(s)
      Hammond GR, Takasuga S, Sasaki T, Balla T.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0139957

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Localizing the lipid products of PI3Kγ in neutrophils2015

    • Author(s)
      Norton L, Lindsay Y, Deladeriere A, Chessa T, Guillou H, Suire S, Lucocq J, Walker S, Andrews S, Segonds-Pichon A, Rausch O, Finan P, Sasaki T, Du CJ, Bretschneider T, Ferguson GJ, Hawkins PT, Stephens L.
    • Journal Title

      Adv Biol Regul

      Volume: 60 Pages: 36-45

    • DOI

      10.1016/j.jbior.2015.10.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] INPP4BはPTEN欠損による発がんへのフェイルセーフ機構を担う2015

    • Author(s)
      小藤智史,佐々木雄彦
    • Journal Title

      実験医学

      Volume: 34 Pages: 450-453

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Reductions of docosahexaenoic acid-containing phosphatidylcholine levels in the anterior horn of an ALS mouse model.2015

    • Author(s)
      Arima H, Omura T, Hayasaka T, Masaki N, Hanada M, Xu D, Banno T, Kobayashi K, Takeuchi H, Kadomatsu K, Matsuyama Y, Setou M.
    • Journal Title

      Neuroscience

      Volume: 印刷中 Pages: 127-136

    • DOI

      10.1016/j.neuroscience.2015.03.060

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Decreased level of phosphatidylcholine (16:0/20:4) in multiple myeloma cells compared to plasma cells: A single-cell MALDI-IMS approach.2015

    • Author(s)
      Hossen A, Nagata Y, Waki M, Ide Y, Takei S, Fukano H, Romero-Perez GA, Tajima S, Yao I, Ohnishi K,Setou M.
    • Journal Title

      Anal Bioanal Chem.

      Volume: 407 Pages: 5273-5280

    • DOI

      10.1007/s00216-015-8741-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Three-Dimensional Image of Cleavage Bodies in Nuclei Is Configured Using Gas Cluster Ion Beam with Time-of-Flight Secondary Ion Mass Spectrometry.2015

    • Author(s)
      Masaki N, Ishizaki I, Hayasaka T, Fisher GL, Sanada N, Yokota H, Setou M.
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 10000-10000

    • DOI

      10.1038/srep10000

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Variation of prostaglandin E2 concentrations in ovaries and its effects on ovarian maturation and oocyte proliferation in the giant fresh water prawn, Macrobrachium rosenbergii2015

    • Author(s)
      Sumpownon C, Engsusophon A, Siangcham T, Sugiyama E, Soonklang N, Meeratana P, Wanichanon C, Hanna PJ, Setou M, Sobhon P.
    • Journal Title

      Gen Comp Endocrinol.

      Volume: 223 Pages: 129-138

    • DOI

      10.1016/j.ygcen.2015.04.019

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression of Human Gaucher Disease Gene GBA Generates Neurodevelopmental Defects and ER Stress in Drosophila Eye.2015

    • Author(s)
      Suzuki T, Shimoda M, Ito K, Hanai S, Aizawa H, Kato T, Kawasaki K, Yamaguchi T, Ryoo HD, Goto-Inoue N, Setou M, Tsuji S, Ishida N.
    • Journal Title

      PLoS One.

      Volume: 10

    • DOI

      10.1371/journal.pone.0135619

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm.2015

    • Author(s)
      Tanaka H, Zaima N, Sasaki T, Sano M, Yamamoto N, Saito T, Inuzuka K, Hayasaka T, Goto-Inoue N, Sugiura Y, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
    • Journal Title

      PLoS One.

      Volume: 10

    • DOI

      10.1371/journal.pone.0134386

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct profiling of the phospholipid composition of adult Caenorhabditis elegans using whole-body imaging mass spectrometry.2015

    • Author(s)
      Hameed S, Ikegami K, Sugiyama E, Matsushita S, Kimura Y, Hayasaka T, Sugiura Y, Masaki N, Waki M, Ohta I, Hossen MA, Setou M
    • Journal Title

      Anal Bioanal Chem.

      Volume: 407 Pages: 7589-7602

    • DOI

      10.1007/s00216-015-8932-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B12015

    • Author(s)
      J. Kunisawa, Y. Sugiura, T. Wake, T. Nagatake, H. Suzuki, R. Nagasawa, S. Shikata, K. Honda, E. Hashimoto, Y. Suzuki, M. Setou, M. Suematsu, H. Kiyono
    • Journal Title

      Cell Reports

      Volume: 13 Pages: 122-131

    • DOI

      10.1016/j.celrep.2015.08.063

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ammonium sulfate improves detection of hydrophilic quaternary ammonium compounds through decreased ion suppression in matrix-assisted laser desorption/ionization imaging mass spectrometry.2015

    • Author(s)
      Sugiyama E, Masaki N, Matsushita S, Setou M.
    • Journal Title

      Anal Chem.

      Volume: 87 Pages: 11176-11181

    • DOI

      10.1021/acs.analchem.5b02672

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Alzheimer’s disease is associated with disordered localization of ganglioside GM1 molecular species in the human dentate gyrus.2015

    • Author(s)
      Hirano-Sakamaki W, Sugiyama E, Hayasaka T, Ravid R, Setou M, Taki T.
    • Journal Title

      FEBS Lett.

      Volume: 589 Pages: 3611-3616

    • DOI

      10.1016/j.febslet.2015.09.033

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decrease in sphingomyelin (d18:1/16:0) in stem villi and phosphatidylcholine (16:0/20:4) in terminal villi of human term placentas with pathohistological maternal malperfusion2015

    • Author(s)
      Yamazaki K, Masaki M, Kohmura-Kobayashi Y, Chizuko Y, Hayasaka T, Itoh H, Setou M, Kanayama N.
    • Journal Title

      PLoS One

      Volume: 10 Pages: 1-14

    • DOI

      10.1371/journal.pone.0142609

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle.2015

    • Author(s)
      Senoo N, Miyoshi N, Goto-Inoue N, Minami K, Yoshimura R, Morita A, Sawada N, Matsuda J, Ogawa Y, Setou M, Kamei Y, Miura S.
    • Journal Title

      J Lipid Res

      Volume: 56 Pages: 2286-2296

    • DOI

      10.1194/jlr.m060533

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mechanical Stimulation by Postnasal Drip Evokes Cough2015

    • Author(s)
      Iwata T, Ito I, Niimi A, Ikegami K, Marumo S, Tanabe N, Nakaji H, Kanemitsu Y, Matsumoto H, Kamei J, Setou M, Mishima M.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0141823

    • NAID

      120005749926

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 質量分析イメージング法による病理組織解析2015

    • Author(s)
      山崎文義、瀬藤光利
    • Journal Title

      臨床病理

      Volume: 63 Pages: 472-480

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 質量顕微鏡法による脂質解析2015

    • Author(s)
      佐藤智仁、杉山栄二、松下祥子、武井史郎、瀬藤光利
    • Journal Title

      実験医学増刊

      Volume: 33 Pages: 2521-2527

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 電位依存性プロトンチャネルVSOPの結晶構造から考察するプロトン漏洩制御機構2015

    • Author(s)
      竹下浩平、岡村康司、中川敦史
    • Journal Title

      生化学

      Volume: 87(5) Pages: 625-628

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division2015

    • Author(s)
      Arasaki K, Shimizu H, Mogari H, Nishida N, Hirota N, Furuno A, Kudo Y, Baba M, Baba N, Cheng J, Fujimoto T, Ishihara N, Ortiz-Sandoval C, Barlow L, Raturi A, Dohmae N, Wakana Y, Inoue H, Tani K, Dacks J, Simmen T, Tagaya M
    • Journal Title

      Dev Cell

      Volume: 32 Pages: 304-317

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-12015

    • Author(s)
      Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki, Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto and Yuji Owada
    • Journal Title

      GLIA

      Volume: 63 Pages: 780-79

    • DOI

      10.1002/glia.22784

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hepatocyte-specific depletion of UBXD8 induces periportal steatosis in mice fed a high-fat diet2015

    • Author(s)
      Imai N, Suzuki M, Hayashi K, Ishigami M, Hirooka Y, Abe T, Shioi G, Goto H, Fujimoto T. (* co-first authors)
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0127114

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment2015

    • Author(s)
      Suzuki M, Murakami T, Cheng J, Kano H, Fukata M, Fujimoto T
    • Journal Title

      Molecular biology of the cell

      Volume: 26 Pages: 2333-2342

    • DOI

      10.1091/mbc.e14-11-1504

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay.2015

    • Author(s)
      Takeda H, Ogasawara T, Ozawa T, Muraguchi A, Jih PJ, Morishita R, Uchigashima M, Watanabe M, Fujimoto T, Iwasaki T, Endo Y, Sawasaki T
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 11333-11333

    • DOI

      10.1038/srep11333

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Deficiency in the lipid exporter ABCA1 Impairs retrograde sterol movement and disrupts Sterol Sensing at the endoplasmic reticulum.2015

    • Author(s)
      Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Pages: 23464-23477

    • DOI

      10.1074/jbc.m115.662668

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Microscopy of membrane lipids - how precisely can we define their distribution?2015

    • Author(s)
      Takatori S and Fujimoto T
    • Journal Title

      Essays in Biochemistry

      Volume: 57 Pages: 81-91

    • DOI

      10.1042/bse0570081

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Separation of Intracellular Vesicles for Immunoassays.2015

    • Author(s)
      Kobayashi T, Tanaka T, and Toyama-Sorimachi N.
    • Journal Title

      Bio-protocol

      Volume: 5(16)

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6.2015

    • Author(s)
      Seto E, Yoshida-Sugitani R, Kobayashi T, Toyama-Sorimachi N
    • Journal Title

      PloS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0123223

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 学研メディカル秀潤社2015

    • Author(s)
      小林俊彦、反町典子
    • Journal Title

      細胞工学6月号

      Volume: 34 Pages: 557-561

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 羊土社2015

    • Author(s)
      小林俊彦、反町典子
    • Journal Title

      実験医学増刊号

      Volume: 33 Pages: 75-82

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury.2015

    • Author(s)
      Asahara M, Ito N, Yokomizo T, Nakamura M, Shimizu T, Yamada Y.
    • Journal Title

      Mol Pain.

      Volume: 11 Pages: 11-11

    • DOI

      10.1186/s12990-015-0010-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The leukotriene B4 receptor BLT1 is stabilized by transmembrane helix capping mutations.2015

    • Author(s)
      Hori, T., Nakamura, M., Yokomizo, T., Shimizu, T., Miyano, M.
    • Journal Title

      Biochem. Biophys.

      Volume: 4 Pages: 243-249

    • DOI

      10.1016/j.bbrep.2015.09.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical Characterization of Three BLT Receptors in Zebrafish.2015

    • Author(s)
      Okuno T, Ishitani T, Yokomizo T.
    • Journal Title

      PLoS One

      Volume: 10 Pages: 0117888-0117888

    • DOI

      10.1371/journal.pone.0117888

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration. C2015

    • Author(s)
      Zandi S, Nakao S, Chun K H, Fiorina P, Sun D, Arita R, Zhao M, Kim E, Schueller O, Campbell S, Taher M, Melhorn M I, Schering A, Gatti F, Tezza S, Xie F, Vergani A, Yoshida S, Ishikawa K, Yamaguchi M, Sasaki F, Schmidt-Ullrich R, Hata Y, Enaida H, Yuzawa M, Yokomizo T, 4名
    • Journal Title

      Cell Rep.

      Volume: 10 Pages: 1173-1186

    • DOI

      10.1016/j.celrep.2015.01.050

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two distinct leukotriene B4 receptors, BLT1 and BLT2.2015

    • Author(s)
      Yokomizo T.
    • Journal Title

      J Biochem

      Volume: 157 Pages: 65-71

    • DOI

      10.1093/jb/mvu078

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The role of leukotrienes in allergic diseases2015

    • Author(s)
      Liu M, Yokomizo T.
    • Journal Title

      Allergol. Int.

      Volume: 64 Issue: 1 Pages: 17-26

    • DOI

      10.1016/j.alit.2014.09.001

    • NAID

      130004873117

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 12-HHT 皮膚創傷治癒に働く新しいCOX代謝物.2015

    • Author(s)
      佐伯和子, 劉珉, 横溝岳彦.
    • Journal Title

      医学のあゆみ

      Volume: 254 Pages: 1121-1125

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 血小板由来の脂質メディエーター12-HHTは角化細胞の移動を亢進させ皮膚創傷治癒を促進する.2015

    • Author(s)
      佐伯和子, 劉珉, 横溝岳彦.
    • Journal Title

      血栓止血

      Volume: 26 Pages: 611-618

    • NAID

      130005113961

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脂質メディエーターによる免疫・炎症応答の制御2015

    • Author(s)
      李賢哲, 奥野利明, 横溝岳彦.
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 64 Pages: 386-390

    • NAID

      40020622928

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 第1世代脂質メディエーター エイコサノイド2015

    • Author(s)
      横溝岳彦
    • Journal Title

      実験医学

      Volume: 33 Pages: 2344-2348

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【アセトアミノフェン】 薬理学的側面から 古くて新しい謎だらけの薬2015

    • Author(s)
      横溝岳彦
    • Journal Title

      LiSA

      Volume: 22 Pages: 874-877

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Roles of prostaglandin receptors in female reproduction2015

    • Author(s)
      Sugimoto Y, Inazumi T, Tsuchiya S
    • Journal Title

      The Journal of Biochemistry

      Volume: 157 Pages: 73-80

    • DOI

      10.1093/jb/mvu081

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostaglandin E2-induced inflammation: relevance of prostaglandin E receptors2015

    • Author(s)
      Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1851 Pages: 414-421

    • DOI

      10.1016/j.bbalip.2014.07.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dermal Vγ4+ γδ T cells possess a migratory potency to the draining lymph nodes and modulate CD8+ T cell activity through TNF-α production2015

    • Author(s)
      Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K.
    • Journal Title

      J. Invest. Dermatol.

      Volume: 135 Issue: 4 Pages: 1007-1015

    • DOI

      10.1038/jid.2014.516

    • NAID

      120005621945

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] p13 overexpression in pancreaticβ-cells ameliorates type 2 diabetes in high-fat-fed mice2015

    • Author(s)
      Higashi, S. et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 461 Pages: 612-617

    • DOI

      10.1016/j.bbrc.2015.04.074

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice2015

    • Author(s)
      Ikeda K, Tomimoto S, Tsuchiya S, Hamagami K, Shintani N, Sugimoto Y, Ichikawa A, Kasai A, Nakazawa T, Nagayasu K, Hayata-Takano A, Baba A, Hashimoto H
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 2 Pages: 179-183

    • DOI

      10.1016/j.bbrep.2015.06.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct melanoma cell contact induces stromal cell autocrine prostaglandin E2-EP4 receptor signaling that drives tumor growth, angiogenesis and metastasis2015

    • Author(s)
      Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C.
    • Journal Title

      J Biol Chem

      Volume: 290 Pages: 29781-29793

    • DOI

      10.1074/jbc.m115.669481

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] プロスタグランジンによる皮膚マスト細胞の成熟と活性化2015

    • Author(s)
      杉本幸彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 62-67

    • NAID

      40020330437

    • Related Report
      2015 Annual Research Report
  • [Journal Article] プロスタグランジンによる神経機能の調節機構2015

    • Author(s)
      杉本幸彦
    • Journal Title

      日薬理誌

      Volume: 145 Pages: 237-242

    • NAID

      130005067370

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 炎症反応におけるプロスタグランジンE2の役割2015

    • Author(s)
      岩崎亮, 北條寛典, 杉本幸彦
    • Journal Title

      細胞

      Volume: 47 Pages: 266-269

    • Related Report
      2015 Annual Research Report
  • [Journal Article] プロスタグランジンによる女性生殖制御の意義2015

    • Author(s)
      告恭史郎, 杉本幸彦
    • Journal Title

      実験医学

      Volume: 33(15) Pages: 164-169

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 急性炎症にかかわるプロスタグランジンとその働き2015

    • Author(s)
      杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 254(12) Pages: 1091-1096

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Blood levels of serotonin are specifically correlated with plasma lysophosphatidylserine among the glycero-lysophospholipids2015

    • Author(s)
      Kurano M, Dohi T, Nojiri T, Kobayashi T, Hirowatari Y, Inoue A, Kano K, Matsumoto H, Igarashi K, Nishikawa M, Miyauchi K, Daida H, Ikeda H, Aoki J, Yatomi Y
    • Journal Title

      BBA Clin

      Volume: 4 Pages: 92-8

    • DOI

      10.1016/j.bbacli.2015.08.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A New Enzyme Immunoassay for the Quantitative Determination of Classical Autotaxins (ATXα, ATXβ, and ATXγ) and Novel Autotaxins (ATXδ and ATXε)2015

    • Author(s)
      Tokuhara Y, Kurano M, Shimamoto S, Igarashi K, Nojiri T, Kobayashi T, Masuda A, Ikeda H, Nagamatsu T, Fujii T, Aoki J, Yatomi Y
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0130074

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects2015

    • Author(s)
      Ohkawa R, Kurano M, Mishima Y, Nojiri T, Tokuhara Y, Kishimoto T, Nakamura K, Okubo S, Hosogaya S, Ozaki Y, Yokota H, Igarashi K, Ikeda H, Tozuka M, Yatomi Y
    • Journal Title

      Clin Biochem

      Volume: 48 Pages: 690-697

    • DOI

      10.1016/j.clinbiochem.2015.03.019

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lysophosphatidylserine has Bilateral Effects on Macrophages in the Pathogenesis of Atherosclerosis2015

    • Author(s)
      Nishikawa M, Kurano M, Ikeda H, Aoki J, Yatomi Y
    • Journal Title

      J Atheroscler Thromb

      Volume: 22 Issue: 5 Pages: 518-26

    • DOI

      10.5551/jat.25650

    • NAID

      130004704381

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome2015

    • Author(s)
      Kurano M, Suzuki A, Inoue A, Tokuhara Y, Kano K, Matsumoto H, Igarashi K, Ohkawa R, Nakamura K, Dohi T, Miyauchi K, Daida H, Tsukamoto K, Ikeda H, Aoki J, Yatomi Y
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol.

      Volume: 35 Pages: 463-470

    • DOI

      10.1161/atvbaha.114.304748

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] LDL receptor and ApoE are involved in the clearance of ApoM-associated sphingosine 1-phosphate2015

    • Author(s)
      Kurano M, Tsukamoto K, Hara M, Ohkawa R, Ikeda H, Yatomi Y.
    • Journal Title

      J Biol Chem

      Volume: 290 Pages: 2477-88

    • DOI

      10.1074/jbc.m114.596445

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] リゾリン脂質を標的とした診断と創薬2015

    • Author(s)
      蔵野 信,可野 邦行,矢冨 裕,青木 淳賢
    • Journal Title

      実験医学増刊号「脂質疾患学」(羊土社)

      Volume: 33 Pages: 178-185

    • Related Report
      2015 Annual Research Report
  • [Journal Article] リゾリン脂質と動脈硬化:虚血性心疾患予防への新たなアプローチとしての可能性2015

    • Author(s)
      蔵野 信,矢冨 裕
    • Journal Title

      呼吸と循環

      Volume: 63 Pages: 847-851

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脂質メディエーターの臨床検査2015

    • Author(s)
      矢冨 裕
    • Journal Title

      臨床病理

      Volume: 63 Pages: 1183-1186

    • Related Report
      2015 Annual Research Report
  • [Journal Article] リゾリン脂質と免疫制御 基礎から応用へ オートタキシン2015

    • Author(s)
      矢冨 裕
    • Journal Title

      炎症と免疫

      Volume: 23 Pages: 280-284

    • Related Report
      2015 Annual Research Report
  • [Presentation] スクランブラーゼによる細胞内ホスファチジルセリン分布の変化2019

    • Author(s)
      辻琢磨、藤本豊士
    • Organizer
      第124回日本解剖学会総会・学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脂肪滴:多様な機能を持つオルガネラ2019

    • Author(s)
      藤本豊士
    • Organizer
      第124回日本解剖学会総会・学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジンI2は、マスト細胞の障害性炎症応答を抑制する2019

    • Author(s)
      中尾優子, 村上里穂, 宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 成宮周, 杉本幸彦
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胎盤形成期におけるプロスタグランジンの機能解析2019

    • Author(s)
      坂本理紗, 稲住知明, 藤原拓司, 河野佑子, 土屋創健, 杉本幸彦,
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Molecular mechanisms of phosphoinositide signaling2019

    • Author(s)
      Junko Sasaki,Satoshi Eguchi,Hiroki Nakanishi,Takehiko Sasaki
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Controlling the innate immune signaling by the proton-coupled peptide transporters2019

    • Author(s)
      Kobayashi, T., Toyama-Sorimachi, N.
    • Organizer
      The 9th Federation of Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Zn2+ sensitivity of Hv1 channel: an evolutionary perspective2019

    • Author(s)
      Adisorn Ratanayotha, Takafumi Kawai, Yasushi Okamura
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019) , 第96回日本生理学会年会 合同大会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional analysis of voltage-sensing phosphatase in mouse sperm2019

    • Author(s)
      Takafumi Kawai, Haruhiko Miyata, Hiroki Nakanishi, Souhei Sakata, Yoshifumi Okochi, Masahiko Watanabe, Kenji Sakimura,Takehiko Sasaki, Masahito Ikawa, Yasushi Okamura
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019) , 第96回日本生理学会年会 合同大会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A new mechanism of Ca2+-independent voltage-dependent secretionin dorsal root ganglion neurons2019

    • Author(s)
      Zhuan Zhou, Yuan Wang, Hiroki Arima, Rong Huang, Yuqi Hang, Xingyu Du, Feipeng Zhu, Zuying Chai, Changhe Wang, Yasushi Okamura
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019) , 第96回日本生理学会年会 合同大会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hv1/VSOP voltage-gated proton channel inhibits migration in response to fMLF in neutrophils2019

    • Author(s)
      Yoshifumi Okochi, Yasushi Okamura
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019) , 第96回日本生理学会年会 合同大会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The comparison of sensitivity between NaPi-IIa and NaPi-IIb activity to phosphoinositides2019

    • Author(s)
      Natsuki Mizutani, Yoshifumi Okochi, Yasushi Okamura
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019) , 第96回日本生理学会年会 合同大会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cytoplasmic conformational changes of VSP detected by voltage clamp fluorescence spectroscopy2019

    • Author(s)
      Akira Kawanabe, Tomoko Yonezawa, Yasushi Okamura
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019) , 第96回日本生理学会年会 合同大会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of leukotriene A4 hydrolase in metabolism.2019

    • Author(s)
      Uzawa H., T. Yokomizo
    • Organizer
      Keystone Symposium, Obesity and Adipose Tissue Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体制御に関わる多彩なリポクオリティ2019

    • Author(s)
      有田誠
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] リピドミクス新技術による機能性脂質の探索研究2019

    • Author(s)
      有田誠
    • Organizer
      第10回記念JBFシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ω3脂肪酸が心臓を保護する仕組みと体内脂肪酸バランスの重要性2019

    • Author(s)
      有田誠
    • Organizer
      第5回東京心臓リハビリテーションセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞外微粒子の質量分析による分子解剖2019

    • Author(s)
      瀬藤光利
    • Organizer
      第124回日本解剖学会総会・全国学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Open genome analysis in the post-genomic era2018

    • Author(s)
      有田正規
    • Organizer
      International Workshop on Data Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Computational Metabolomics2018

    • Author(s)
      有田正規
    • Organizer
      6th Annual Korea Metabolomics Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 電子顕微鏡によるホスファチジルセリンの細胞内分布解析2018

    • Author(s)
      辻琢磨、藤本豊士
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] A new look at subcellular distribution of phosphatidylserine2018

    • Author(s)
      Toyoshi Fujimoto
    • Organizer
      Lipid Transporter Symposium 2018 “Flippases, Floppases and Scramblases”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nuclear lipid droplets: how they form and what they do in hepatocytes2018

    • Author(s)
      Toyoshi Fujimoto
    • Organizer
      59th International Conference on the Bioscience of Lipids
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Nuclear lipid droplets in hepatocytes: Implications for hepatic steatosis2018

    • Author(s)
      Toyoshi Fujimoto
    • Organizer
      FASEB Science Research Conference “Lipid Droplets on the Move from Health to Disease”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] プロスタノイドクオリティによる生体制御2018

    • Author(s)
      杉本幸彦
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] マスト細胞炎症性応答に対するプロスタサイクリンIP受容体の役割2018

    • Author(s)
      村上里穂, 中尾優子,宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 成宮周, 杉本幸彦,
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マスト細胞のIL-33誘導性サイトカイン産生に対するPGI2-IP受容体シグナルの抑制機構2018

    • Author(s)
      中尾優子, 村上里穂, 宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 成宮周, 杉本幸彦
    • Organizer
      平成30年度日本生化学会九州支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Stimulation and modulation of inflammatory mast cell responses by prostaglandin receptors2018

    • Author(s)
      Yukihiko Sugimoto
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology (WCP2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マスト細胞炎症性応答におけるプロスタサイクリンIP受容体の役割2018

    • Author(s)
      村上里穂, 中尾優子,宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 成宮周, 杉本幸彦
    • Organizer
      第17回次世代を担う若手ファーマ・バイオフォーラム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Stimulation and modulation of inflammatory mast cell responses by prostaglandin receptors2018

    • Author(s)
      Yukihiko Sugimoto
    • Organizer
      7th European Workshop on Lipid Mediators
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 初期発生におけるプロスタグランジンの役割,2018

    • Author(s)
      土屋創健, 杉本幸彦
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジンEP4受容体は生理的な脂肪細胞機能を調節する2018

    • Author(s)
      稲住知明, 山田清隆, 土屋創健, 猿渡淳二,成宮周,杉本幸彦
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] プロスタグランジンとその受容体による脂質代謝の恒常性調節2018

    • Author(s)
      杉本幸彦
    • Organizer
      第40回生体膜と薬物の相互作用シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジンEP4受容体による脂肪細胞機能の調節機構2018

    • Author(s)
      稲住知明, 山田清隆, 土屋創健, 猿渡淳二, 成宮周, 杉本幸彦
    • Organizer
      第40回生体膜と薬物の相互作用シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 子宮内膜症に関与するプロスタグランジンE受容体の解析2018

    • Author(s)
      前田ひかる, 大窪喜丸, 橋本美穂, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第40回生体膜と薬物の相互作用シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス視索前野神経の突起伸長に対するプロスタグランジンE2-EP4受容体の役割2018

    • Author(s)
      衛藤勝喜, 北條寛典, 吉岡美樹, 土屋裕義, 稲住知明, 土屋創健, 杉本幸彦.
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The lipid phosphatase INPP4B is a tumor suppressor in the context of PTEN insufficiency2018

    • Author(s)
      Takehiko Sasaki, Satoshi Kofuji, Shunsuke Takasuga, Junko Sasaki
    • Organizer
      Workshop on Frontiers in Phosphatase Research and Drug Discovery
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ホスホイノシタイドの異常と疾患2018

    • Author(s)
      佐々木雄彦
    • Organizer
      第176回 東京脂質談話会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞膜リン脂質動態の生理と病態:An overview2018

    • Author(s)
      佐々木雄彦
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] リポクオリティがプレクストリン相同ドメインと生体膜の相互作用に与える影響2018

    • Author(s)
      山本詠士、佐々木純子、Mark S.P. Sansom、佐々木雄彦
    • Organizer
      第60回 日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 癌性髄膜炎における髄液中リゾリン脂質の測定意義.2018

    • Author(s)
      森田 賢史,蔵野信,矢冨裕.
    • Organizer
      第65回 日本臨床検査医学会学術集会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] 造血器腫瘍の病態生理におけるオートタキシンの関与.2018

    • Author(s)
      西川 真子,蔵野 信,五十嵐 浩二,矢冨 裕.
    • Organizer
      第65回 日本臨床検査医学会学術集会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] オートタキシンはリンパ腫バイオマーカーとして可溶性IL-2レセプターと同等の診断能を有する.2018

    • Author(s)
      西川 真子,蔵野 信,小室 由佳,志村 拓也,五十嵐 浩二,矢冨 裕.
    • Organizer
      第19回 日本検査血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アラキドン酸またはDHA添加時の脂質メディエーターの解析:肝癌細胞株および大腸癌細胞株における検討.2018

    • Author(s)
      西川 尚子,蔵野 信,Baasanjav Uranbileg,池田 均,矢冨 裕
    • Organizer
      第65回 日本臨床検査医学会学術集会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] 髄液検体におけるsIL-2RとATX 造血器腫瘍の中枢神経浸潤バイオマーカーとしての有用性.2018

    • Author(s)
      志村 拓也,蔵野 信,森田 賢史,西川 真子,吉川 直之,田中 雅美,下坂 浩則,常名 政弘,島本 怜史,五十嵐 浩二,矢冨 裕.
    • Organizer
      第65回 日本臨床検査医学会学術集会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] 造血器腫瘍の髄膜浸潤におけるATX/LPA axisの関与 臨床検体を用いた検討.2018

    • Author(s)
      志村 拓也,蔵野 信,吉川 直之,森田 賢史,田中 雅美,西川 真子,常名 政弘,五十嵐 浩二,矢冨 裕
    • Organizer
      第19回 日本検査血液学会学術集会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] The importance of S1P lyase in the pathophysiology of hepatocellular carcinoma and colon cancer.2018

    • Author(s)
      Uranbileg, B., Ikeda, H., Kurano, M., Saigusa, D., Kano, K., Aoki, J., and Yatomi, Y.
    • Organizer
      The 15th Congress of the Asian Society for Clinical Pathology and Laboratory Medicine (ASCPaLM).
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The importance of S1P lyase in the pathophysiology of hepatocellular carcinoma and colon cancer.2018

    • Author(s)
      Uranbileg, B., Kurano, M., Nishikawa, T., Sato, M., IkedaH., and Yatomi, Y
    • Organizer
      第65回 日本臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Status of the Sphingolipid Metabolism in Rat Cauda Equina Compression Model.2018

    • Author(s)
      Uranbileg, B., Hasegawa, K., Ito, N., Kurano, M., Saigusa, D., Kano, K., Ikeda, H., Sumitani, M., Aoki, J., and Yatomi, Y.
    • Organizer
      第58回 日本臨床化学会年次学術集会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中枢神経系のアポ蛋白Mの役割.2018

    • Author(s)
      蔵野 信,常山 幸一,矢冨 裕
    • Organizer
      第65回 日本臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アポ蛋白M/スフィンゴシン1-リン酸軸の糖尿病性腎症における役割2018

    • Author(s)
      蔵野 信,塚本 和久,原 眞純,矢冨 裕.
    • Organizer
      第33回 日本糖尿病合併症学会学術集会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規生理活性脂質リゾホスファチジルセリンの炎症への関与:分子種による作用の相違.2018

    • Author(s)
      蔵野 信,矢冨 裕 .
    • Organizer
      第58回 日本臨床化学会年次学術集会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肝臓NPC1L1は血漿スフィンゴシン1-リン酸を増加させる2018

    • Author(s)
      蔵野 信,塚本 和久,原 眞純,矢冨 裕.
    • Organizer
      第50回 日本動脈硬化学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糖代謝異常におけるスフィンゴシン1-リン酸/アポ蛋白M軸の役割.2018

    • Author(s)
      蔵野 信,塚本 和久,清水 知,矢冨 裕.
    • Organizer
      第60回 日本脂質生化学会.
    • Related Report
      2018 Annual Research Report
  • [Presentation] Regulation of the allergic inflammation by non-canonical type I interferon signaling2018

    • Author(s)
      Kobayashi, T., Toyama-Sorimachi, N.
    • Organizer
      6th Annual Meeting of the International Cytokine & Interferon
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of the allergic inflammation by non-canonical type I interferon signaling2018

    • Author(s)
      Kobayashi, T., Tsutsui, H., Toyama-Sorimachi, N.
    • Organizer
      第47回日本免疫学会学術集会・総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] リソソーム局在型アミノ酸トランスポーターに依存した炎症制御機構2018

    • Author(s)
      反町典子、小林俊彦
    • Organizer
      感覚免疫研究会2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 肺組織の炎症と修復におけるペプチドトランスポーターSLC15A3の役割2018

    • Author(s)
      小林俊彦、筒井俊充、反町典子
    • Organizer
      第13回トランスポーター研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Na-Pi cotransporter活性のPI(4,5)P2に対する感受性の解析2018

    • Author(s)
      水谷夏希、大河内善史、岡村康司
    • Organizer
      第111回 近畿生理学談話会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネルは肝臓の糖新生を調節する2018

    • Author(s)
      香山建斗、河合喬文、辰巳翔基、山本浩靖、崎村建司、木原進士、岡村康司
    • Organizer
      第111回 近畿生理学談話会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネルHv1/VSOPは、活性酸素の産生量の制御を介し て、好中球の走化性を抑制する2018

    • Author(s)
      大河内善史、岡村康司
    • Organizer
      第111回 近畿生理学談話会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電位依存性ホスファターゼVSP:14年を経て見えたこと、見えないこと2018

    • Author(s)
      岡村 康司、河合 喬文、川鍋 陽、筒井 秀和、坂田 宗平、佐々木 雄彦
    • Organizer
      心血管膜輸送研究会2018「心臓・血管系の頑健性と精緻な制御を支える分子基盤の統合的解明」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脊椎動物の稠密な脳の起源をホヤのNav チャネルから理解する2018

    • Author(s)
      江口 夏生、神野 有香、橋本 真宜、河合 喬文、西野 純子、大塚 幸雄、川鍋陽、西野 敦雄、笹倉 靖徳、岡村 康司
    • Organizer
      第4 回ホヤ研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電位依存性ホスファターゼにおける膜電位変化から脱リン酸化反応の変換機構2018

    • Author(s)
      岡村 康司, 川鍋 陽, 坂田 宗平, 神野 有香
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 電位依存性ホスファターゼVSPの疎水性膜界面の役割2018

    • Author(s)
      川鍋 陽, 橋本 真宜, 米澤 智子, 神野 有香, 岡村 康司
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Struvctural analysis of voltage-sensing phospharase (VSP) on the electrochemical coupling2018

    • Author(s)
      Hirotaka Narita, Makoto Matsuda, Yasushi Okamura, Atsushi Nakagawa
    • Organizer
      The 55th Annual Meeting of the Biophysical Society of Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The analysis of sensitivity of Na-Pi cotransporter activity to phosphoinositides2018

    • Author(s)
      Natsuki Mizutani, Yoshifumi Okochi, Yasushi Okamura
    • Organizer
      Europhysiology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ホヤ由来電位依存性ナトリウムチャネルの機能解析2018

    • Author(s)
      江口夏生, 橋本真宜, 神野有香, 川鍋陽,河合喬文,岡村康司
    • Organizer
      第41回日本神経科学学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Age-dependent regulatory function of microglial voltage-gated proton channels2018

    • Author(s)
      Takafumi Kawai, Keizo Takao, Kenji Sakimura, Tsuyoshi Miyakawa, Yasushi Okamura
    • Organizer
      第41回日本神経科学学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Ion-permeable voltage sensor domains2018

    • Author(s)
      Yasushi Okamura
    • Organizer
      WCP2018 KYOTO Satellite SymposiaNew Insights into Ion Channel Functions and Pharmacology
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 膜電位感受性イノシトールリン脂質ホスファターゼの動作原理とその応用2018

    • Author(s)
      岡村 康司
    • Organizer
      2018年 生理学研究所研究会 オルガネラ膜ナノドメインの機能と動態
    • Related Report
      2018 Annual Research Report
  • [Presentation] イノシトールリン脂質によるナトリウム依存性リン酸トランスポーターの活性制御2018

    • Author(s)
      水谷夏希、大河内善史、岡村康司
    • Organizer
      新学術領域研究「脂質クオリティが解き明かす生命現象」第4 回領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電位依存性脂質ホスファターゼにおける疎水性膜界面の役割2018

    • Author(s)
      川鍋陽、橋本真宜、米澤智子、神野有香、岡村康司
    • Organizer
      新学術領域研究「脂質クオリティが解き明かす生命現象」第4 回領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 膜の疎水領域でのリポクオリティ認識機構とナノ膜ドメインの解明2018

    • Author(s)
      岡村 康司、中川 敦史
    • Organizer
      新学術領域研究「脂質クオリティが解き明かす生命現象」第4 回領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] Metal binding to the voltage-gated proton channel Hv1/VSOP2018

    • Author(s)
      Masayo Iwaki, Kohei Takeshita, Hiroko X. Kondo, Kengo Kinoshita, Yasushi Okamura, Yu Takano, Atsushi Nakagawa, Hideki Kandori
    • Organizer
      The 49th NIPS International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rapid gating of sea squirt Nav1 channel does not require auxiliary subunit2018

    • Author(s)
      Takafumi Kawai, Natsuki Eguchi, Masaki Hashimoto, Yuki Yabuuchi, Yuka Jinno, Akira Kawanabe, Junko Nishino, Atsuo Nishino, Yasushi Okamura
    • Organizer
      The 49th NIPS International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Toward understanding of membrane potential in phagosomai membrane2018

    • Author(s)
      Yoshifumi Okochi, Hidekazu Tsutsui, Yasushi Okamura
    • Organizer
      The 49th NIPS International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of two-step cytoplasmic conformational changes of voltage sensing phosphatase2018

    • Author(s)
      Akira Kawanabe, Masaki Hashimoto, Tomoko Yonezawa, Yuka Jinno, Yasushi Okamura
    • Organizer
      The 49th NIPS International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrophysiological characterization of two types of Na-Pi cotransporters2018

    • Author(s)
      Natsuki Mizutani, Yoshifumi Okochi, Yasushi Okamura
    • Organizer
      The 49th NIPS International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisms and physiological roles of voltage-sensing phosphatase2018

    • Author(s)
      Yasushi Okamura, Akira Kawanabe, Kazuhisa Nishizawa, Takafumi Kawai
    • Organizer
      The 49th NIPS International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Protective role of leukotriene B4 receptor type 2 in pneumolysin-induced epithelial injury.2018

    • Author(s)
      Chi Y., Saeki K., Yokomizo T.
    • Organizer
      第41回日本分子生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 薬物代謝酵素カルボキシルエステラーゼの消化器癌における発現調節機構の解明2018

    • Author(s)
      折田創, 伊志嶺百々子, 李賢喆, 小泉明博, 村井勇太, 加藤永記, 山本陸, 上田脩平, 櫻庭駿介, 徳田智史, 朝倉孝延, 氷室貴規, 櫛田知志, 櫻田睦, 田中顕一郎, 前川博, 横溝岳彦, 佐藤浩一
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] An algal precursor rearranges in a new 1,8-diol forming reaction to bioactive LTB4 enantiomers2018

    • Author(s)
      Jagusch H, Werner M, Okuno T, Yokomizo T, Watz O, Pohnert G
    • Organizer
      European Lipid Meeting 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Phospholipid remodeling altered eicosanoid production during cell culture2018

    • Author(s)
      Okuno T, Gijon MA, Yokomizo T, Murphy RC
    • Organizer
      European Lipid Meeting 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生理活性脂質12-HHTのBLT2受容体を介した生体保護的役割2018

    • Author(s)
      佐伯和子, 重松美沙子, 古賀友紹, 奥野利明, 横溝岳彦
    • Organizer
      第91回日本生化学会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ロイコトリエンA4水解酵素の代謝における役割の解析2018

    • Author(s)
      鵜澤博嗣, 古賀友紹, 佐伯和子, 宮塚健, 綿田裕孝, 横溝岳
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウスアレルギー性結膜炎モデルにおけるオメガ3脂肪酸食効果の検証2018

    • Author(s)
      平形寿彬, 李賢哲, 大塲麻衣, 佐伯和子, 奥野利明, 松田彰, 村上晶, 横溝岳彦
    • Organizer
      第1回日本眼科アレルギー学会学術集会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Crystal structure of leukotriene B4 receptor 1 bound with an inverse agonist2018

    • Author(s)
      Okuno T, Hori T, Yokoyama S, Yokomizo T
    • Organizer
      International GPCR symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BLT1 and BLT2, two GPCRs for lipid mediators2018

    • Author(s)
      Yokomizo T
    • Organizer
      International GPCR symposium
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ロイコトリエンB4受容体BLT1発現が規定する単球・樹状細胞サブセット2018

    • Author(s)
      横溝岳彦
    • Organizer
      第28回日本樹状細胞研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生理活性脂質受容体の機能解析:ゼロから創薬への挑戦2018

    • Author(s)
      横溝岳彦
    • Organizer
      New Insight Crosstalk Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ロイコトリエンB4受容体に関する最近の知見2018

    • Author(s)
      横溝岳彦
    • Organizer
      Kobe Biological Science Forum
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ロイコトリエンA4水解酵素の代謝における解析2018

    • Author(s)
      鵜澤博嗣, 古賀友紹, 奥野利明, 佐伯和子, 横溝岳彦
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アレルギー性結膜炎におけるオメガ3脂肪酸の効果の検2018

    • Author(s)
      平形寿彬, 李賢哲, 大塲麻衣, 佐伯和子, 奥野利明, 松田彰, 村上晶, 横溝岳彦
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生理活性脂質受容体研究への質量分析計の応用2018

    • Author(s)
      横溝岳彦
    • Organizer
      第31回Future of Radiology
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Control of mouse allergic conjunctivitis by resolvins2018

    • Author(s)
      Iwamoto S., Yokomizo T., Murakami A., Matsuda A
    • Organizer
      ARVO 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dietary omega-3 fatty acids alleviate allergic conjunctivitis in a mouse model2018

    • Author(s)
      Hirakata T., Lee C. H., Ohba M., Okuno T., Murakami A., Matsuda A., Yokomizo T.
    • Organizer
      ARVO 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 12-hydroxyheptadecatrienoic acid accelerates epithelial wound healing through leukotriene B4 receptor 2, BLT22018

    • Author(s)
      Yokomizo T.
    • Organizer
      Keystone Symposium, the resolution of inflammation in health and disease
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Leukotriene B4 receptor type 2 protects against CysLT1 signaling-related acute lung injury2018

    • Author(s)
      Jo-Watanabe A., Shigematsu M., Saeki K., Koga T, Ohba M, Okuno T, Yokomizo T
    • Organizer
      Keystone Symposium, GPCR Structure and Function
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A fatty acid 12-hydroxyheptadecatrienoic acid accelerates corneal wound healing through leukotriene B4 receptor 2, BLT22018

    • Author(s)
      Yokomizo T., Iwamoto S., Koga T., Ohba M., Okuno T., Koike M., Murakami A., Matsuda A.
    • Organizer
      Keystone Symposium, GPCR Structure and Function
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The importance of LipoQuality in biological systems2018

    • Author(s)
      Makoto Arita
    • Organizer
      3rd McGill-RIKEN Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Genetics and lipidomics of omega-3 polyunsaturated fatty acid biology2018

    • Author(s)
      Makoto Arita
    • Organizer
      The 3rd International Symposium on Lipids Science and Health
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The importance of LipoQuality in biological systems (Keynote Lecture)2018

    • Author(s)
      Makoto Arita
    • Organizer
      8th Mind-Body Interface International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リピドミクス新技術による機能性脂質の探索研究2018

    • Author(s)
      有田誠
    • Organizer
      レドックス・ライフイノベーション第170委員会、日本におけるケミカルバイオロジーの新展開第189委員会合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] リピドミクス新技術による機能性脂質の探索研究2018

    • Author(s)
      有田誠
    • Organizer
      BioJapan2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] リポクオリティと脂質栄養(教育講演)2018

    • Author(s)
      有田誠
    • Organizer
      第40回日本臨床栄養学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生体制御に関わる多彩なリポクオリティ2018

    • Author(s)
      有田誠
    • Organizer
      Fatty Acids at the Cutting Edge (FACE)研究会2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ω3脂肪酸クオリティによる生体制御2018

    • Author(s)
      有田誠
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アトピー性皮膚炎マウスにおける脂質代謝異常の網羅的解析2018

    • Author(s)
      飯野雄大、永沼達郎、有田誠
    • Organizer
      第17回次世代を担う若手ファーマ・バイオフォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酸化脂肪酸の膜リン脂質アシル化を担う酵素の探索と機能解析2018

    • Author(s)
      橋本怜暉、青柳良平、永沼達郎、有田誠
    • Organizer
      第17回次世代を担う若手ファーマ・バイオフォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] ω3脂肪酸オキシゲナーゼの皮膚恒常性における役割2018

    • Author(s)
      吉田美桜、石原知明、有田誠
    • Organizer
      第17回次世代を担う若手ファーマ・バイオフォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] レチノイン酸産生酵素Aldh1a1による腸管恒常性維持機構の解析2018

    • Author(s)
      大泉建貴、岡橋伸幸、宣旭、磯部洋輔、有田誠
    • Organizer
      第17回次世代を担う若手ファーマ・バイオフォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Advanced lipidomics strategy to identify bioactive lipids2018

    • Author(s)
      Makoto Arita
    • Organizer
      ZPM-RIKEN Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リポクオリティ研究が解き明かすもの~ω3脂肪酸の代謝と抗炎症作用~2018

    • Author(s)
      有田誠
    • Organizer
      第50回日本動脈硬化学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] リポクオリティが解き明かす生命現象2018

    • Author(s)
      有田誠
    • Organizer
      第4回京都大学ウイルス・再生医科学研究所生命情報研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 健康維持における脂肪酸クオリティの重要性2018

    • Author(s)
      有田誠
    • Organizer
      第40回日本血栓止血学会サテライトシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脂質代謝とアレルギー(教育講演)2018

    • Author(s)
      有田誠
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脂肪酸クオリティによる生体制御2018

    • Author(s)
      有田誠
    • Organizer
      富山県創薬研究開発センター開所記念シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脂肪酸クオリティによる生体制御2018

    • Author(s)
      有田誠
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アトピー性皮膚炎発症に関わる脂質代謝系の網羅的解析2018

    • Author(s)
      飯野雄大、永沼達郎、有田誠
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酸化脂肪酸クオリティによる生体制御2018

    • Author(s)
      有田誠
    • Organizer
      第71回日本酸化ストレス学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脂肪酸クオリティを捉える最先端リピドミクスと生理的意義の解明2018

    • Author(s)
      有田誠
    • Organizer
      第91回日本内分泌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脂肪酸クオリティによる生体制御2018

    • Author(s)
      有田誠
    • Organizer
      第55回日本臨床分子医学会学術集会「エネルギー代謝研究の新しいアプローチ」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 顕微鏡技術と質量分析技術の融合で見えてくる新しい細胞間コミュニケーション2018

    • Author(s)
      瀬藤光利
    • Organizer
      京都大学大学院工学研究科
    • Related Report
      2018 Annual Research Report
  • [Presentation] 質量顕微鏡で見えてくるブレインサイエンス2018

    • Author(s)
      瀬藤光利
    • Organizer
      鹿児島ブレインサイエンスカンファレンス
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] DESIイメージングの実際2018

    • Author(s)
      瀬藤光利
    • Organizer
      Waters MS forum
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 質量イメージング2018

    • Author(s)
      瀬藤光利
    • Organizer
      AMED-CREST 質量分析講習会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mass Spectrometry Imaging for Metabolomics in diseases and translational research2018

    • Author(s)
      Mitsutoshi Setou
    • Organizer
      2018 Joint Meeting of 22nd International Symposium on MDO and 33rd JSSX Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 健康長寿を目指した光量子技術の開発2018

    • Author(s)
      瀬藤光利
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TC201/WG4:Surface Characterization of Biomaterials2018

    • Author(s)
      Mitsutoshi Setou
    • Organizer
      Meeting of TC201
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] WG4-Biomaterials Handing for Surface Analysis2018

    • Author(s)
      Mitsutoshi Setou
    • Organizer
      Meeting of TC201
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TOF-SIMSの医学・生物学応用の最前線2018

    • Author(s)
      瀬藤光利
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] イメージングと質量分析2018

    • Author(s)
      瀬藤光利
    • Organizer
      第43回日本医用マススペクトル学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 超臨界組織洗浄による高分子の組織内分布解析2018

    • Author(s)
      瀬藤光利
    • Organizer
      第3回日本医用マススペクトル学会西部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 質量顕微鏡とその老化関連疾患研究への応用2018

    • Author(s)
      瀬藤光利
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 分子の重さを可視化する:質量分析イメージングの最前線2018

    • Author(s)
      瀬藤光利
    • Organizer
      第31回Future of Radiology
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 病気の解明・診断や植物分野の研究への質量顕微鏡の活用2018

    • Author(s)
      瀬藤光利
    • Organizer
      医学生物学電子顕微鏡技術学会第34回学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 質量顕微鏡とその老化・内分泌代謝疾患研究への応用2018

    • Author(s)
      瀬藤光利
    • Organizer
      第22回日本心血管内分泌代謝学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Genetics and Lipidomics of Omega-3 Polyunsaturated Fatty Acid Biology2018

    • Author(s)
      Makoto Arita
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The Resolution of Inflammation in Health and Disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リピドミクス新技術による機能性脂質の探索研究2018

    • Author(s)
      有田誠
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The importance of LipoQuality in biological system2018

    • Author(s)
      Makoto Arita
    • Organizer
      7th International Singapore Lipid Symposium 2018 (iSLS7)
    • Related Report
      2017 Annual Research Report