2015 Fiscal Year Annual Research Report
Project Area | Quality of lipids in biological systems |
Project/Area Number |
15H05897
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
有田 誠 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (80292952)
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Co-Investigator(Kenkyū-buntansha) |
有田 正規 国立遺伝学研究所, 生命情報研究センター, 教授 (10356389)
瀬藤 光利 浜松医科大学, 医学部, 教授 (20302664)
反町 典子 国立研究開発法人国立国際医療研究センター, その他部局等, 分子炎症制御プロジェクト長 (30217468)
藤本 豊士 名古屋大学, 医学系研究科, 教授 (50115929)
佐々木 雄彦 秋田大学, 医学(系)研究科(研究院), 教授 (50333365)
矢冨 裕 東京大学, 医学部附属病院, 教授 (60200523)
横溝 岳彦 順天堂大学, 医学(系)研究科(研究院), 教授 (60302840)
岡村 康司 大阪大学, 医学系研究科, 教授 (80201987)
杉本 幸彦 熊本大学, 大学院生命科学研究部(薬), 教授 (80243038)
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Project Period (FY) |
2015-06-29 – 2020-03-31
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Keywords | 研究支援センター / 領域事務局 / 脂質データベース / 領域会議の開催 / 広報活動 |
Outline of Annual Research Achievements |
リポクオリティ領域全体の円滑な研究活動を支援するため、総括班として以下の活動を行った。 (1)領域事務局を理研IMS内に設置した。(2)本領域のホームページを開設し、領域概要、領域研究者紹介、研究内容紹介、研究成果、脂質研究実験法、脂質データベース、共有リソース、掲示板、などの項目を整備した。また、領域メイリングリストを整備し、班員間の連絡や共同研究に向けてのインフラを整備した。(3)研究支援センターの整備と利用:ノンターゲット解析用のQ-TOF型質量分析機器を理研IMS内に導入し、技術員の雇用とトレーニングを行うとともに、測定系の立ち上げと最適化を行った。また、他の研究支援センターについてもそれぞれ基盤整備を行ない、平成28年度から公募班員を含めたリポクオリティ領域研究を支援する準備体制を整えた。(4)リポクオリティデータベースの企画会議を3回開催し、領域内外の研究者に対して実用性の高いデータベースとして、早期の公開に向けた準備を行った。(5)第1回、第2回総括班会議を開催し、これからの総括班の運営方針について議論を重ねた。(6)2015年9月に一般公開のリポクオリティシンポジウム(三島)を開催した。(7)2016年2月に第1回領域会議(仙台)を開催した。(8)2016年3月に第1回領域ニュースレターを発行した。
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Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
各研究支援センターの準備状況も以下のように良好であり、当初想定したより早い時点からの研究サポートを行うことができる体制が整った。 (1)質量分析センター:新しいQ-TOF型質量分析機器を導入することで脂質ノンターゲット解析システムを確立し、支援センターとしての運用を開始した(有田班)リン脂質測定および技術指導について、既に2件実施した(佐々木班)(2)脂質イメージングセンター:支援センターとして、リゾリン脂質、エイコサノイド、コレステリルエステルなどのマスイメージング解析を行なった(瀬藤班)国際会議で電顕技術の研修を希望する研究者の受入が可能であることを広報し、既にチェコから研修生を受け入れている(藤本班)(3)膜機能解析センター:本格的なセンターの運用に向け、発現系細胞由来の膜断片からの急速還流によるパッチクランプ電流計測について、実践的なマニュアルを整備した(岡村班)PS結合プローブとしてevectin-2 PHドメインに2種類の蛍光タンパク質を融合させたプローブの配布準備が完了した。合わせてこれらの安定発現株の樹立を進め、配布が可能となるよう準備を進めている(反町班)(4)脂質データベース:スプレットシート形式で記録された脂質の生体サンプル、分子クラス情報、定量値を元データとし、これに対してウェブ上のインターフェースから検索をかけて結果をグラフィカルに表示するシステムを構築した(有田班)(5)臨床検体センター:研究倫理申請を進め、これまでに血清,血漿,髄液,眼房水を採取し,リゾリン脂質等の解析を開始した(矢冨班)皮膚炎症性疾患を中心とした種々の皮膚疾患の血清・病理組織を収集中である(本田班)(6)第1回領域会議を開催し(横溝班)、第1回領域ニュースレターを発行した(杉本班)
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Strategy for Future Research Activity |
現時点では本総括班は極めて順調に稼働していると考えられるため、とくに問題点はない。今後も計画班に公募班を加えて積極的な研究のサポートと、活発な班会議や情報発信を継続する。また、リポクオリティデータベースの早期の公開を目指す。
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Research Products
(231 results)
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[Journal Article] Maternal dietary balance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites.2016
Author(s)
Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, Osumi N.
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Journal Title
Stem Cells
Volume: 34
Pages: 470-482
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] ROR1 sustains caveolae and survival signaling as a scaffold of cavin-1 and caveolin-12016
Author(s)
Yamaguchi T, Lu C, Yanagisawa K, Can Lu, Usukura J, Cheng J, Hotta N, Shimada Y, Ida R, Isomura H, Suzuki M, Fujimoto T, Takahashi T
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Journal Title
Nat Commun
Volume: 7
Pages: 10060
DOI
Peer Reviewed / Open Access
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[Journal Article] Phosphatidic acid induces EHD3-containing membrane tubulation and is required for receptor recycling. Exp. Cell Res. 342, 1-10.2016
Author(s)
Henmi, Y., Oe, N., Kono, N., Taguchi, T., Takei, K., and Tanabe, K.
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Journal Title
Exp. Cell Res.
Volume: 342
Pages: 1-10
DOI
Peer Reviewed
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[Journal Article] Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins.2016
Author(s)
Ishii, Y., Saeki, K., Liu, M., Sasaki, F., Koga, T., Kitajima, K., Meno, C., Okuno, T., Yokomizo, T.
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Journal Title
Faseb J
Volume: 30
Pages: 933-947
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Ichiki, T., Koga, T., Okuno, T., Saeki, K., Yamamoto, Y., Yamamoto, H., Sakaguchi, M., Yokomizo, T.2016
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[Journal Article] The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes.2016
Author(s)
Chiba, T., Nakahara, T., Hashimoto-Hachiya, A., Yokomizo, T., Uchi, H., Furue, M.
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Journal Title
Exp Dermatol I
Volume: 印刷中
Pages: 印刷中
Peer Reviewed
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[Journal Article] Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior.2016
Author(s)
Yabuki, Y., Koide, T., Miyasaka, N., Wakisaka, N., Masuda, M., Ohkura, M., Nakai, J., Tsuge, K., Tsuchiya, S., Sugimoto, Y., Yoshihara, Y.
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Journal Title
Nature Neurosci.
Volume: 19
Pages: 印刷中
Peer Reviewed / Open Access
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[Journal Article] Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence2016
Author(s)
Uranbileg B, Ikeda H, Kurano M, Enooku K, Sato M, Saigusa D, Aoki J, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y
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Journal Title
PLoS One
Volume: 11
Pages: e0149462
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.2015
Author(s)
Sawada Y, Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A, Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, Kabashima K.
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Journal Title
J Exp Med
Volume: 212
Pages: 1921-1930
DOI
Peer Reviewed / Open Access
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[Journal Article] Total synthesis of four stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-dihydroxy-4,7,10,12,16,18-docosahexaenoic acid and their anti-inflammatory activities.2015
Author(s)
Goto T, Urabe D, Masuda K, Isobe Y, Arita M, Inoue M.
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Journal Title
J Org Chem
Volume: 80
Pages: 7713-7726
DOI
Peer Reviewed / Open Access
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[Journal Article] Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicostetraenoic acid in the gut.2015
Author(s)
Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H.
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Journal Title
Sci Rep
Volume: 5
Pages: 9750
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Eosinophil-mediated signaling attenuates inflammatory responses in experimental colitis.2015
Author(s)
Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT.
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Journal Title
Gut
Volume: 64
Pages: 1236-1247
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.2015
Author(s)
Ip, LR., Poulogiannis, G., Viciano, FC., Sasaki, J., Kofuji, S., Spanswick, VJ., Hochhauser, D., Hartley, JA., Sasaki, T., Gewinner, CA.
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Journal Title
Oncotarget
Volume: 6
Pages: 10548-10562
Peer Reviewed / Int'l Joint Research
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[Journal Article] INPP4B Is a PtdIns (3,4,5) P3 Phosphatase That Can Act as a Tumor Suppressor.2015
Author(s)
Kofuji, S., Kimura, H., Nakanishi, H., Nanjo, H., Takasuga, S., Liu, H., Eguchi, S., Nakamura, R., Itoh, R., Ueno, N., Asanuma, K., Huang, M., Koizumi, A., Habuchi, T., Yamazaki, M., Suzuki, A., Sasaki, J., Sasaki, T.
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Journal Title
Cancer Discov.
Volume: 5
Pages: 730-739
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.2015
Author(s)
Li, Chew C., Lunardi, A., Gulluni, F., Ruan, DT., Chen, M., Salmena, L., Nishino, M., Papa, A., Ng, C., Fung, J., Clohessy, JG., Sasaki, J., Sasaki, T., Bronson, RT., Hirsch, E., Pandolfi, PP.
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Journal Title
Cancer Discov.
Volume: 5
Pages: 740-751
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P22015
Author(s)
Nigorikawa, K., Hazeki, K., Sasaki, J., Omori, Y., Miyake, M., Morioka, S., Guo, Y., Sasaki, T., Hazeki, O
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Journal Title
PLoS One
Volume: 10
Pages: e0142091
DOI
Peer Reviewed / Open Access
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[Journal Article] Localizing the lipid products of PI3Kγ in neutrophils2015
Author(s)
Norton L, Lindsay Y, Deladeriere A, Chessa T, Guillou H, Suire S, Lucocq J, Walker S, Andrews S,Segonds-Pichon A, Rausch O, Finan P, Sasaki T, Du CJ, Bretschneider T, Ferguson GJ, Hawkins PT,Stephens L
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Journal Title
Adv Biol Regul
Volume: 60
Pages: 36-45
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Reductions of docosahexaenoic acid-containing phosphatidylcholine levels in the anterior horn of an ALS mouse model.2015
Author(s)
Arima H, Omura T, Hayasaka T, Masaki N, Hanada M, Xu D, Banno T, Kobayashi K, Takeuchi H,Kadomatsu K, Matsushita Y, Setou M.
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Journal Title
Neuroscience
Volume: 297
Pages: 127-136
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Decreased level of phosphatidylcholine (16:0/20:4) in multiple myeloma cells compared to plasma cells: A single-cell MALDI-IMS approach.2015
Author(s)
Hossen MA, Nagata Y, Waki M, Ide Y, Takei S, Fukano H, Romero-Perez GA, Tajima S, Yao I, Ohnishi K, Setou M.
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Journal Title
Anal Bioanal Chem
Volume: 407
Pages: 5273-5280
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Variation of prostaglandin E2 concentrations in ovaries and its effects on ovarian maturation and oocyte proliferation in the giant fresh water prawn, Macrobrachium rosenbergii.2015
Author(s)
Sumpownon C, Engsusophon A, Siangcham T, Sugiyama E, Soonklang N, Meeratana P, Wanichanon C, Hanna PJ, Setou M, Sobhon P.
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Journal Title
Gen Comp Endocrinol.
Volume: 223
Pages: 129-138
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Collection: Expression of Human Gaucher Disease Gene GBA Generates Neurodevelopmental Defects and ER Stress in Drosophila Eye.2015
Author(s)
Suzuki T, Shimoda M, Ito K, Hanai S, Aizawa H, Kato T, Kawasaki K, Yamaguchi T, Ryoo HD, Goto-Inoue N, Setou M, Tsuji S, Ishida N.
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Journal Title
PLos One
Volume: 10
Pages: e0135619
DOI
Peer Reviewed
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[Journal Article] Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm.2015
Author(s)
Tanaka H, Zaima N, Sasaki T, Sano M, Yamamoto N, Saito T, Inuzuka K, Hayasaka T,Goto-Inoue N, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
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Journal Title
PLos One
Volume: 10
Pages: e0134386
DOI
Peer Reviewed
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[Journal Article] Direct profiling of the phospholipid composition of adult Caenorhabditis elegans using whole-body imaging mass spectrometry.2015
Author(s)
Hameed S, Ikegami K, Sugiyama E, Matsushita S, Kimura Y, Hayasaka T, Sugiura Y, Masaki N, Waki M, Ohta I, Hossen MA, Setou M.
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Journal Title
Anal Bioanal Chem
Volume: 407
Pages: 7589-7602
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Imaging mass spectrometry reveals a unique distribution of triglycerides in abdominal aortic aneurysmal wall.2015
Author(s)
Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Saito T, Hayasaka T, Goto-Inoue N, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
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Journal Title
J Vasc Res
Volume: 52
Pages: 127-135
DOI
Peer Reviewed
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[Journal Article] Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1.2015
Author(s)
Kunisawa J, Sugiura Y, Wake T, Nagatake T, Suzuki H, Nagasawa R, Shikata S, Honda K, Hashimoto E, Suzuki Y, Setou M, Suematsu M, Kiyono H.
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Journal Title
Cell Rep
Volume: 13
Pages: 122-131
DOI
Peer Reviewed
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[Journal Article] PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle.2015
Author(s)
Senoo N, Miyoshi N, Goto-Inoue N, Minami K, Yoshimura R, Morita A, Sawada N, Matsuda J, Ogawa J, Setou M, Kamei Y, Miura S.
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Journal Title
J Lipid Res
Volume: 56
Pages: 2286-2296
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Mechanical Stimulation by Postnasal Drip Evokes Cough.2015
Author(s)
Iwata T, Ito I, Niimi A, Ikegami K, Marumo S, Tanabe N, Nakaji H, Kanemitsu Y, Matsumoto H, Kamei J, Setou M, Mishima M.
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Journal Title
PLos One
Volume: 10
Pages: e0141823
DOI
Peer Reviewed
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[Journal Article] A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division2015
Author(s)
Arasaki K, Shimizu H, Mogari H, Nishida N, Hirota N, Furuno A, Kudo Y, Baba M, Baba N, Cheng J, Fujimoto T, Ishihara N, Ortiz-Sandoval C, Barlow L, Raturi A, Dohmae N, Wakana Y, Inoue H, Tani K, Dacks J, Simmen T, Tagaya M
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Journal Title
Dev Cell
Volume: 32
Pages: 304-317
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-12015
Author(s)
Kagawa Y, Yasumoto Y, Sharifi K, Ebrahimi M, Islam A, Miyazaki H, Yamamoto Y, Sawada T, Tokuda N, Kobayashi S, Maekawa M, Yoshikawa T, Takaki E, Nakai A, Kogo H, Fujimoto T, Owada Y
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Journal Title
Glia
Volume: 63
Pages: 780-794
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay2015
Author(s)
Takeda H, Ogasawara T, Ozawa T, Muraguchi A, Jih P-J, Morishita R, Uchigashima M, Watanabe M, Fujimoto T, Iwasaki T, Endo Y, Sawasaki T
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Journal Title
Sci Rep
Volume: 5
Pages: -
DOI
Peer Reviewed / Open Access
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[Journal Article] Deficiency in the lipid exporter ABCA1 impairs retrograde sterol movement and disrupts sterol sensing at the endoplasmic reticulum2015
Author(s)
Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, and Yokoyama S
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Journal Title
J Biol Chem
Volume: 290
Pages: 23464-77
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury.2015
Author(s)
Asahara, M., Ito, N., Yokomizo, T., Nakamura, M., Shimizu, T., Yamada, Y.
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Journal Title
Mol Pain
Volume: 11
Pages: 11
DOI
Peer Reviewed / Open Access
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[Journal Article] ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration.2015
Author(s)
Zandi S,Nakao S,Chun K H,Fiorina P,Sun D,Arita R,Zhao M,Kim E,Schueller O,Campbell S,Taher M,Melhorn M I,Schering A,Gatti F,Tezza S,Xie F,Vergani A,Yoshida S,Ishikawa K,Yamaguchi M,Sasaki F,Schmidt-Ullrich R,Hata Y,Enaida H,Yuzawa M,Yokomizo T,Kim Y B,Sweetnam P,Ishibashi T,Hafezi-Moghadam A
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Journal Title
Cell Rep
Volume: 10
Pages: 1173-1186
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Dermal Vγ4+ γδ T cells possess a migratory potency to the draining lymph nodes and modulate CD8+ T cell activity through TNF-α production2015
Author(s)
Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K
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Journal Title
J Invest Dermatol
Volume: 135
Pages: 1007-1015
DOI
Peer Reviewed / Open Access
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[Journal Article] p13 overexpression in pancreatic ß-cells ameliorates type 2 diabetes in high-fat-fed mice2015
Author(s)
Higashi S, Katagi K, Shintani N, Ikeda K, Sugimoto Y, Tsuchiya S, Inoue N, Tanaka S, Koumoto M, Kasai A, Nakazawa T, Takano H A, Hamagami K, Tomimoto S, Yoshida T, Ohkubo T, Nagayasu K, Ago Y, Onaka Y, Hashimoto R, Ichikawa A, Baba A, Hashimoto H
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Journal Title
Biochem Biophys Res Commun
Volume: 461
Pages: 612-617
DOI
Peer Reviewed / Open Access
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[Journal Article] Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice2015
Author(s)
Ikeda K, Tomimoto S, Tsuchiya S, Hamagami K, Shintani N, Sugimoto Y, Ichikawa A, Kasai A, Nakazawa T, Nagayasu K, Hayata-Takano A, Baba A, Hashimoto H
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Journal Title
Biochim Biophys Rep
Volume: 2
Pages: 179-183
DOI
Peer Reviewed / Open Access
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[Journal Article] Direct melanoma cell contact induces stromal cell autocrine prostaglandin E2-EP4 receptor signaling that drives tumor growth, angiogenesis and metastasis2015
Author(s)
Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C
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Journal Title
J Biol Chem
Volume: 290
Pages: 29781-29793
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Blood levels of serotonin are specifically correlated with plasma lysophosphatidylserine among the glycero-lysophospholipids2015
Author(s)
Kurano M, Dohi T, Nojiri T, Kobayashi T, Hirowatari Y, Inoue A, Kano K, Matsumoto H, Igarashi K, Nishikawa M, Miyauchi K, Daida H, Ikeda H, Aoki J, Yatomi Y
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Journal Title
BBA Clin
Volume: 4
Pages: 92-98
DOI
Peer Reviewed / Open Access
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[Journal Article] A New Enzyme Immunoassay for the Quantitative Determination of Classical Autotaxins (ATXα, ATXβ, and ATXγ) and Novel Autotaxins (ATXδ and ATXε)2015
Author(s)
Tokuhara Y, Kurano M, Shimamoto S, Igarashi K, Nojiri T, Kobayashi T, Masuda A, Ikeda H, Nagamatsu T, Fujii T, Aoki J, Yatomi Y
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Journal Title
PLoS One
Volume: 10
Pages: e0130074
DOI
Peer Reviewed / Open Access
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[Journal Article] Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects2015
Author(s)
Ohkawa R, Kurano M, Mishima Y, Nojiri T, Tokuhara Y, Kishimoto T, Nakamura K, Okubo S, Hosogaya S, Ozaki Y, Yokota H, Igarashi K, Ikeda H, Tozuka M, Yatomi Y
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Journal Title
Clin Biochem
Volume: 48
Pages: 690-7
DOI
Peer Reviewed
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[Journal Article] Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome2015
Author(s)
Kurano M, Suzuki A, Inoue A, Tokuhara Y, Kano K, Matsumoto H, Igarashi K, Ohkawa R, Nakamura K, Dohi T, Miyauchi K, Daida H, Tsukamoto K, Ikeda H, Aoki J, Yatomi Y
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 35
Pages: 463-70
DOI
Peer Reviewed / Open Access
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[Presentation] 核内に存在する脂肪滴の意義2016
Author(s)
大崎雄樹、程晶磊、川合毅、藤本豊士
Organizer
第121回日本解剖学会総会・全国学術集会
Place of Presentation
ビッグパレットふくしま(福島県郡山市)
Year and Date
2016-03-30
Invited
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[Presentation] 肝臓特異的UBXD8ノックアウトはNASHモデルにおける線維化形成を促進する2015
Author(s)
今井則博, 伊藤隆徳, 安田諭, 川口彩, 加藤幸一郎, 新家卓郎, 阿知波宏一, 石津洋二, 葛谷貞二, 本多隆, 林和彦, 石上雅敏, 廣岡芳樹, 石川哲也, 藤本豊士, 後藤秀実
Organizer
第41回日本肝臓学会西部会
Place of Presentation
名古屋国際会議場(名古屋市熱田区)
Year and Date
2015-12-03
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[Presentation] Towards structure determination of the human prostanoid receptor bound to the antibody2015
Author(s)
Toyoda Y, Morimoto K, Suno R, Sekiguchi Y, Yamashita K, Hirata K, Yasuda S, Asada H, Nakane T, Shiimura Y, Nakagita T, Inazumi T, Tsuge K, Kajiwara Y, Shimizu T, Urushibata Y, Yoshida S, Kuribara T, Hosoya T, Kinoshita M, Sugimoto Y, Nomura N, Murata T,Takayama K,Yamamoto M, Narumiya S, Iwata S, Kobayashi T
Organizer
GPCR Workshop 2015
Place of Presentation
Honolulu (USA)
Year and Date
2015-12-02
Int'l Joint Research
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[Presentation] 質量顕微鏡の世界2015
Author(s)
瀬藤光利
Organizer
第56回日本組織細胞化学会 総会・学術集会
Place of Presentation
関西医科大学 枚方新キャンパス(大阪府・枚方市)
Year and Date
2015-10-03
Invited
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