Immunological Self Recognition and its Disorders
Project Area | Immunological Self Recognition and its Disorders |
Project/Area Number |
19059009
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Kyoto University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
高浜 洋介 徳島大学, ゲノム機能研究センター, 教授 (20183858)
清野 宏 東京大学, 医科学研究所, 教授 (10271032)
松島 綱治 東京大学, 医学(系)研究科(研究院), 教授 (50222427)
山本 一彦 東京大学, 医学部・附属病院, 教授 (80191394)
渡邊 武 独立行政法人理化学研究所, 免疫組織再生研究ユニット, 教授 (40028684)
|
Project Period (FY) |
2007 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥62,100,000 (Direct Cost: ¥62,100,000)
Fiscal Year 2011: ¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2010: ¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2009: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2008: ¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2007: ¥12,700,000 (Direct Cost: ¥12,700,000)
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Keywords | 自己認識 / 免疫制御 / 胸腺 / 自己免疫病 / 炎症 / がん / 免疫系自己 / 自己識別 / 免疫病態 / 自己寛容 / 免疫組織 / がん免疫 / 獲得免疫 / 免疫老化 / 白血病 / T細胞 / アナジー / G蛋白 / 自己免疫 |
Research Abstract |
To understand the mechanisms of immunological self-recognition, we organized three research groups, (A01) basic immunological mechanisms, (A02) immunological diseases, (A03) new technological development for human immune system, and published over 1000 original scientific papers as a whole in the 5 year period. We also performed a series of educational courses for high school students to promote the interest and understanding of immunology as well as 4 open international symposia inviting world-leading immunologists. Ex post facto evaluation of the project by the MEXT biology committee was ranked “A”.
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Report
(7 results)
Research Products
(81 results)
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[Journal Article] E2A and CBP/p300 act in synergy topromote chromatin accessibility of the immunoglobulin κ locus2012
Author(s)
Sakamoto, S., Wakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Myyazaki, K.,Romanow, W.J., Ikawa, T., Kitamura, D.,Yanagihira, I., Minato, N., Murre, C., and Agata, Y
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Journal Title
J. Immunol
Volume: 188(11)
Pages: 5547-60
Related Report
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[Journal Article] Spa-1 (Sipa1) controlsthe invasion and metastasis of human prostatecancers via Rap signal2011
Author(s)
Shimizu Y, Hamazaki Y, Hattori M, Doi K,Terada Y, Kobayashi T, Toda Y, Yamasak T,Inoue T, Kajita Y, Atsushi M, Kamba T, MikamiY, Kamoto T, Yamada T, Ogawa O, Minato Nand Nakamura E
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Journal Title
Cancer Science
Volume: 102
Issue: 4
Pages: 828-836
DOI
Related Report
Peer Reviewed
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[Journal Article] Claudin-4 isinduced in thymocytes of late CD4/CD8 doublepositive stage by E2A and promotes abT cellreceptor.mediated positive selection2011
Author(s)
Kawai. K. Hamazaki, Y., Fujita, H., Fujita,A., Sato, T., Moriwaki, K., Furuse, M., Fujimoto,T., Agata, Y. and Minato, N
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Journal Title
Proc. Nat. Acad. Sci. USA
Volume: 108(10)
Issue: 10
Pages: 4075-4080
DOI
Related Report
Peer Reviewed
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[Journal Article] laudin-4 is induced in thymocytes of late CD4/CD8 double positive stage by E2A and promotes α βT cell receptor-mediated positive selection.2011
Author(s)
Kawai. K. Hamazaki, Y., Fujita, H., Fujita, A., Sato, T., Moriwaki, K., Furuse, M., Fujimoto, T., Agata, Y. Mi〓〓t〓〓, N
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Journal Title
Proc. Nat. Acad. Sci. USA
Volume: 108
Pages: 4075-4080
Related Report
Peer Reviewed
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[Journal Article] Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.2011
Author(s)
Lei Y, Mat Ripen A, Ishimaru N, Ohigashi I, Nagasawa T, Jeker L, Bosl M, Hollander GA, Hayashi Y, de Waal Malefyt R, Nitta T, 〓〓〓
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Journal Title
J Exp Med.
Volume: 208
Pages: 383-394
Related Report
Peer Reviewed
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[Journal Article] Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration.2011
Author(s)
Kurachi M, Kurachi J, Suenaga F, Tsukui T, Abe J, Ueha S, Tomura M, Sugihara K, Takamura S, Kakimi K, Matsushima K.
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Journal Title
J Exp Med
Volume: 208
Pages: 1605-1620
Related Report
Peer Reviewed
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[Journal Article] Claudin-4 is induced in thymocytes of late CD4/CD8 double positive stage by E2A and promotes αβT cell receptor-mediated positive selection2011
Author(s)
Kawai, K.Hamazaki, Y., Fujita, H., Fujita, A., Sato, T., Moriwaki, K., Furuse, M., Fujimoto, T., Agata, Y., Minato, N.
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Journal Title
Proc.Nat.Acad.Sci.USA
Volume: 108
Pages: 4075-4080
Related Report
Peer Reviewed
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[Journal Article] Expression and function of PD-1 in human gd T cell responses to tumor cells2011
Author(s)
Iwasaki, M., Tanaka, Y., Kobayashi, H., Hirai K., Sugie, T., Toi, M., Minato, N.
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Journal Title
Eur.J.Immunol.
Volume: 41
Pages: 345-4080
Related Report
Peer Reviewed
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[Journal Article] Regulation of T cell receptor Vg2 gene rearrangement by the helix-loop-helix protein E2A2011
Author(s)
Nozaki, M., Wakae, K., Tamaki, N., Sakamoto, S., Ohnishi, K., Uejima, T., Minato, N., Yanagihara, I., Agata, Y.
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Journal Title
Int.Immunol.
Volume: 23
Pages: 297-305
Related Report
Peer Reviewed
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[Journal Article] Anti-PD-1 antibody reduces CD4+ PD-1+ T cells and relieves the lupus-like nephritis of l NZB/W F1mice2010
Author(s)
Kasagi, S, Kawano, S, Okazaki, T, Honjo, T, Morinobu, A, Hatachi, S, Shimatani, K, Tanaka,Y, Minato, N, and Kumagai, S
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Journal Title
J.Immunol
Volume: 184
Issue: 5
Pages: 2337-2347
DOI
Related Report
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[Journal Article] Anti-PD-1 antibody reduces CD4+ PD-1+ T cells and relieves the lupus-like nephritis of INZB/W F1 mice2010
Author(s)
Kasagi, S, Kawano, S, Okazaki, T, Honjo, T, Morinobu, A, Hatachi, S, Shimatani, K, Tanaka, Y, Minato, N, Kumagai, S
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Journal Title
J.Immunol
Volume: 184
Pages: 2337-2347
Related Report
Peer Reviewed
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[Journal Article] Rapid αβ TCR mediated responses in γδ T cells transduced with cancer-specific TCR genes2009
Author(s)
Hiasa A, Nishikawa H, Hirasawa M, Kitano S, Chono H, Yu S S, Mineno J, Tanaka Y, Minato N, Kato I, Shiku H.
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Journal Title
Gene Therapy 16
Pages: 620-628
Related Report
Peer Reviewed
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[Journal Article] Development ofNotch-dependent T cell leukemia by deregulatedRap1 signaling2008
Author(s)
Wang, S-F, Aoki, M., Shinozuka, Y.,Nakashima, Y., Tanaka, H., Taniwaki, F., Hattori,M., and Minato, N
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Journal Title
Blood
Volume: 111
Issue: 5
Pages: 3011-3016
DOI
Related Report
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[Journal Article] Structureof the human programmed death (PD)-1 ligand and its complex with PD-1 that inhibits immune responses2008
Author(s)
Lin, D. Y., Tanaka, Y., Iwasaki, M., Gitttis, A. G., Su, H-P., Mikami, B., Okazaki, T., Honjo, T.,Minato, N., and Garboczi, D, N
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 105
Issue: 8
Pages: 3011-3016
DOI
Related Report
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[Journal Article] Essential role of Rapsignal in pre-TCR mediated b-selection in ab Tcell development2008
Author(s)
Kometani, K, Moriyama, M, Nakashima, Y,Katayama, Y, Wang, S-F, Saito, T, Hattori, Mand Minato, N
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Journal Title
Blood
Volume: 112
Issue: 12
Pages: 4565-4573
DOI
Related Report
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[Journal Article] Rap signaling is crucial for the competence ofIL-7 response and the development of B-lineagecells2008
Author(s)
Katayama, Y., Sekai, M., Hattori, M.,Miyoshi, I., Hamazaki, Y, and Minato, N
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Journal Title
Blood
Volume: 114
Issue: 9
Pages: 1768-1775
DOI
Related Report
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[Journal Article] Medullary thymic epithelial cells expressing Airerepresent a unique lineage derived from claudin-expressing cells2007
Author(s)
Hamazaki, Y, Fujita, H, Kobayashi, T, Choi, Y, H. Scott, Matsumoto, M, and Minato, N
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Journal Title
Nature Immunol
Volume: 8
Pages: 304-311
Related Report
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[Journal Article] Intestinal tumorsinactivated in TGF-b signaling secrete CCL9 andrecruit CCR1+ myeloid cells that help invasion2007
Author(s)
Kitamura, T., Kometani, K., Hashiba, H., Matsunaga, A., Miyoshi. H., Hosogi, H., Aoki, M.,Oshima, M., Hattori, M., Takabayashi, A., Minato,N., and Taketo, M
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Journal Title
Nature Gen
Volume: 39
Pages: 467-475
Related Report
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[Journal Article] PD-L1 and tumor-infiltrating CD8+ T lymphocytes are independent prognostic factors of human ovarian cancer2007
Author(s)
Hamanishi J., Mandai, M., Iwasaki, M., Okazaki. T., Tanaka, Y., Yamaguchi, K., Higuchi, T., Yagi, H., Takakura, K, Minato, N., Honjo, T., and Fujii, S
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 104
Pages: 3360-3365
Related Report
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[Journal Article] T cell lineage determination precedes the initiation of TCRb gene rearrangement2007
Author(s)
Masuda, K, Kakugawa, K, Nakayama, T, Minato, N, Katsura, Y, and Kawamoto, H
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Journal Title
J. Immunol
Volume: 179
Pages: 3699-3706
Related Report
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[Journal Article] PD-L1 and tumor-infiltrating CD8+ T lymphocytes are independent prognostic factors of human ovarian cancer.2007
Author(s)
Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, Yamaguchi K, Higuchi T, Yagi H, Takakura K, Minato N, Honjo T, Fujii S.
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Journal Title
Proc. Natl. Acad. Sci. USA. 104
Pages: 3360-3365
Related Report
Peer Reviewed
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[Journal Article] Intestinal tumors inactivated in TGF-b signaling secrete CCL9 and recruit CCR1+ myeloid cells that help invasion.2007
Author(s)
Kitamura T, Kometani K, Hashiba H, Matsunaga A, Miyoshi H, Hosogi H, Aoki M, Oshima M, Hattori M, Takabayashi A, Minato N, Taketo M.
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Journal Title
Nature Gen. 39
Pages: 467-475
Related Report
Peer Reviewed
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[Presentation] 免疫老化2010
Author(s)
Minato, N
Organizer
抗加齢医学学会シンポジウム
Place of Presentation
Kyoto(国立京都国際会館)(招待講演)
Year and Date
2010-06-11
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