Infection/inflammation-assisted acceleration of the carcinogenic spiral and its alteration though vector conversion of the host response to tumors

• Project Area: Conversion of tumor-regulation vector to intercept oncogenic spiral accelerated by infection and inflammation
• Project/Area Number: 22114001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: HATAKEYAMA Masanori 東京大学, 医学(系)研究科(研究院), 教授 (40189551)
• Co-Investigator(Renkei-kenkyūsha): TANIGUCHI Tadatsugu 東京大学, 生産技術研究所, 特任教授 (50133616) ; SEYA Tsukasa 北海道大学, 大学院医学研究科, 教授 (10301805) ; OSHIMA Masanobu 金沢大学, がん進展制御研究所, 教授 (40324610) ; MATSUOKA Masao 京都大学, ウイルス研究所, 教授 (10244138) ; SHIMOTOHNO Kunitada 国立国際医療研究センター, 肝炎・免疫研究センター, 特任部長 (10000259) ; AZUMA Takeshi 神戸大学, 医学研究科, 教授 (60221040) ; AKIYOSHI Kazunari 京都大学, 工学研究科, 教授 (90201285)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥63,440,000 (Direct Cost: ¥48,800,000、Indirect Cost: ¥14,640,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000); Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2012: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2011: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000); Fiscal Year 2010: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
• Keywords: 癌 / 感染 / 炎症・免疫 / 発がんスパイラル / がん / 感染症 / 感染がん / 炎症 / 免疫 / ドラッグデリバリー / 細菌 / シグナル伝達

Outline of Annual Research Achievements

新学術領域研究「発がんスパイラル」は、単一の微生物感染による発がんを中心に、がんの発症・進展に関わる微生物側因子の役割を明らかにするとともに、発がん微生物感染が局所に誘起する炎症・免疫応答が発がんを加速する機構の本態を解明し、革新的ながん予防・がん治療法開発への道を拓くべく平成２２年度に開始された。本取り纏めでは、新学術領域研究「発がんスパイラル」の研究成果を以下のように取りまとめた。
１．領域研究報告書の作成
研究代表者ならびに連携研究者による会合を２回行い、過去4回にわたり発刊したNews Letterの集大成として、5年間の成果をまとめた領域研究報告書を発行した。報告書では、発がん微生物が保有するがんタンパク質の作用機構、微生物がんタンパク質と宿主生体応答系の相互作用ネットワーク、「発がんスパイラル」場形成を担う免疫系細胞の同定とゲノム不安定性を増強するエフェクター分子の作用機構、自然免疫系細胞のがん細胞認識とがん細胞破壊を促進する分子群の同定、など本領域研究から得られた多くの新たながん生物学的知見を記述するとともに、新規ナノゲルやDNAワクチンの開発を通して拓かれつつある「向がん」から「制がん」への宿主応答ベクトル変換を誘導する次世代のがん予防・治療法開発へのプロセスを記載した。インパクトの高い国際一流誌に報告された研究成果も報告書内に別刷として収集した。
２．領域公式ウェブサイトの運営：ウェブサイトを通じ、社会・国民に向けた積極的な情報公開を維持した。これまでに公開してきた情報に加え、新たに「研究成果」として過去5年間に進めてきた基礎研究の成果の社会への還元状況を発信した。さらに領域公式ウェブサイトから、各研究者個別のウェブサイトへ相互リンクを図り、利用者はリンク先からさらに詳細な情報を得ることが出来るように工夫した。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA (2016)
  • Author(s): Shimoda A, Ueda K, Nishiumi S, Murata-Kamiya N, Mukai SA, Sawada S, Azuma T, Hatakeyama M, Akiyoshi K
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 18346-18346
  • DOI: 10.1038/srep18346
  • NAID: 120005689168
  • Peer Reviewed / Open Access
• [Journal Article] Determination of the catalytic activity of LEOPARD syndrome- associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling (2016)
  • Author(s): Saori Noda, Atsushi Takahashi, Takeru Hayashi, Sei-ichi Tanuma and Masanori Hatakeyama
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 469 Issue: 4 Pages: 1133-1139
  • DOI: 10.1016/j.bbrc.2015.12.117
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Helicobacter pylori cytotoxin CagA is essential for suppressing host heat shock protein expression (2016)
  • Author(s): Lang, B.
  • Journal Title: Cell Stress Chaperones Volume: 21 Issue: 3 Pages: 1-11
  • DOI: 10.1007/s12192-016-0680-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Improvement of Helicobacter pylori CagA crystals by the multi-step soaking method (2016)
  • Author(s): Senda, M.
  • Journal Title: Cryst. Growth Des. Volume: 16 Issue: 3 Pages: 1565-1571
  • DOI: 10.1021/acs.cgd.5b01692
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] <i><b>Helicobacter pylori</b></i><b> induces IL-1β protein through the inflammasome activation in differentiated macrophagic </b><b>cells </b> (2016)
  • Author(s): Kameoka, S.
  • Journal Title: Biomedical Research Volume: 37 Issue: 1 Pages: 21-27
  • DOI: 10.2220/biomedres.37.21
  • NAID: 130005128374
  • ISSN: 0388-6107, 1880-313X
  • Peer Reviewed / Open Access
• [Journal Article] Formation and functional analysis of specific tRNA granules caused by low-dose X-ray irradiation (2016)
  • Author(s): Katano, A.
  • Journal Title: Bioimages Volume: 24
  • Peer Reviewed
• [Journal Article] Helicobacter pylori-mediated carcinogenesis and tyrosine phosphatases (2015)
  • Author(s): 畠山 昌則
  • Journal Title: 生化学 Volume: 87 Issue: 5 Pages: 554-559
  • DOI: 10.14952/SEIKAGAKU.2015.870554
  • ISSN: 0037-1017
  • Year and Date: 2015-10-25
• [Journal Article] Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein (2015)
  • Author(s): Suzuki, N.
  • Journal Title: Sci. Rep/ Volume: 5 Issue: 1 Pages: 10024-10024
  • DOI: 10.1038/srep10024
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis (2015)
  • Author(s): Nagase, L.
  • Journal Title: Sci. Rep. Volume: 5 Issue: 1 Pages: 15749-15749
  • DOI: 10.1038/srep15749
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 細菌エフェクター・細菌毒素の分子標的と疾病脆弱性 (2015)
  • Author(s): 清水 健
  • Journal Title: 日本細菌学雑誌 Volume: 70 Pages: 319-328
• [Journal Article] Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein. (2015)
  • Author(s): Suzuki, N., Murata-Kamiya, N., Yanagiya, K., Suda, W., Hattori, M., Hiroaki Kanda, H., Bingo, A., Yumiko Fujii, Y., Maeda, S., Koike, K. and Hatakeyama, M.
  • Journal Title: Sci Rep Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis. (2014)
  • Author(s): Hatakeyama, M.
  • Journal Title: Cell Host Microbe Volume: 15 Issue: 3 Pages: 306-316
  • DOI: 10.1016/j.chom.2014.02.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1 (2014)
  • Author(s): Hashi, K.
  • Journal Title: Cancer Sci. Volume: 105 Issue: 3 Pages: 245-251
  • DOI: 10.1111/cas.12342
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori generates cells with cancer stem cell properties via epithelial-mesenchymal transition-like changes (2014)
  • Author(s): Bessede, E.
  • Journal Title: Oncogene Volume: 33 Issue: 32 Pages: 4123-4131
  • DOI: 10.1038/onc.2013.380
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase (2013)
  • Author(s): Miura, K.
  • Journal Title: Oncogene Volume: 32 Issue: 45 Pages: 5292-5301
  • DOI: 10.1038/onc.2012.571
  • Peer Reviewed
• [Journal Article] YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function. (2013)
  • Author(s): Tsutsumi, D., Masoodi, M., Takahashi, A., Fujii, Y., Hayashi, T, . Kikuchi, I., et al.
  • Journal Title: Developmental Cell Volume: 26(6) Issue: 6 Pages: 658-665
  • DOI: 10.1016/j.devcel.2013.08.013
  • Peer Reviewed
• [Journal Article] Bacterial EPIYA effectors - Where do they come from? What are they? Where are they going? (2013)
  • Author(s): Hayashi, T.
  • Journal Title: Cell. Microbiol. Volume: 15 Issue: 3 Pages: 377-385
  • DOI: 10.1111/cmi.12040
  • Peer Reviewed
• [Journal Article] PAR1b takes the stage in the morphogenetic and motogenetic activity of Helicobacter pylori CagA oncoprotein (2013)
  • Author(s): Yamahashi, Y.
  • Journal Title: Cell Adh. Migr. Volume: 7 Issue: 1 Pages: 11-17
  • DOI: 10.4161/cam.21936
  • Peer Reviewed
• [Journal Article] ピロリ菌由来胃がん発症因子CagAの立体構造解明 (2013)
  • Author(s): 畠山 昌則
  • Journal Title: Isotope News Volume: 707 Pages: 2-7
• [Journal Article] ヘリコバクター・ピロリ癌タンパク質CagA―その分子構造と機能― (2013)
  • Author(s): 畠山 昌則
  • Journal Title: 日本臨床 Volume: 72 (増刊号 1) Pages: 92-99
• [Journal Article] ヘリコバクター・ピロリ菌およびその胃炎や胃潰瘍における役割の発見 (2013)
  • Author(s): 畠山 昌則
  • Journal Title: Surgery Frontier Volume: 20 Pages: 15-18
• [Journal Article] H. pyloriによる腸上皮化生の誘導機構と発癌 (2013)
  • Author(s): 畠山 昌則
  • Journal Title: 消化器の臨床 Volume: 16 Pages: 351-356
• [Journal Article] 胃がん発症の基盤となる限定的細胞リプログラミング (2013)
  • Author(s): 藤井 裕美子
  • Journal Title: 実験医学 Volume: 31 Pages: 2095-2100
• [Journal Article] Bacterial EPIYA effectors-Where do they come from? What are they ? Where are they going? (2013)
  • Author(s): Hayashi, T.
  • Journal Title: Cell.Microbiol. Volume: 7 Pages: 377-385
  • Peer Reviewed
• [Journal Article] CDX1 directs gastric intestinal metaplasia via induction of stemness-associated reprogramming factors SALL4 and KLF5 (2012)
  • Author(s): Fujii, Y.
  • Journal Title: Proc. Natl. Acad. Sci.USA Volume: 109 Issue: 50 Pages: 20584-20589
  • DOI: 10.1073/pnas.1208651109
  • Peer Reviewed
• [Journal Article] Reactive oxygen species-induced autophagic degration of Helicobacter pylori CagA is species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells (2012)
  • Author(s): Tsugawa, H.
  • Journal Title: Cell Host Microbe Volume: 12 Pages: 764-777
  • Peer Reviewed
• [Journal Article] Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA (2012)
  • Author(s): Hayashi, T.
  • Journal Title: Cell Host Microbe Volume: 12 Pages: 20-33
  • Peer Reviewed
• [Journal Article] Helicobacter pulori CagA triggers expression of the bactericidal lectin REG3γ via gastric STAT3 activation (2012)
  • Author(s): Lee, K.S.
  • Journal Title: PLoS One Volume: 7 Issue: 2 Pages: e30786-e30786
  • DOI: 10.1371/journal.pone.0030786
  • Peer Reviewed
• [Journal Article] Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling (2012)
  • Author(s): Kikuchi, K.
  • Journal Title: Microbes Infect Volume: 14 Pages: 470-476
  • Peer Reviewed
• [Journal Article] H.pylori 癌タンパク質CagA (2012)
  • Author(s): 鈴木 伸三
  • Journal Title: 消化器内科 Volume: 54 Pages: 236-270
• [Journal Article] ピロリ菌CagAの発癌活性と細胞極性破壊 (2012)
  • Author(s): 畠山 昌則
  • Journal Title: 生体の科学 Volume: 63 Pages: 229-235
• [Journal Article] ピロリ菌による胃癌発症のメカニズム (2012)
  • Author(s): 畠山 昌則
  • Journal Title: Bios Volume: 17 Pages: 7-8
• [Journal Article] H.pylori癌タンパク質CagAと胃癌 (2012)
  • Author(s): 畠山 昌則
  • Journal Title: 日本臨床 Volume: 70 Pages: 1699-1704
• [Journal Article] Helicobacter pylori 感染症、そのメカニズムと病態生理 (2012)
  • Author(s): 畠山 昌則
  • Journal Title: 成人病と生活習慣病 Volume: 42 Pages: 1137-1144
• [Journal Article] Helicobacter pylori CagA-胃がん発症におけるその役割 (2012)
  • Author(s): 畠山 昌則
  • Journal Title: 成人病と生活習慣病 Volume: 42 Pages: 1151-1156
• [Journal Article] チロシンホスファターゼSHP2による核における基質タンパク質parafibrominを介したWnt経路の活性化 (2011)
  • Author(s): 高橋 昌史
  • Journal Title: First Author's Volume: 33 Pages: 123
  • DOI: 10.7875/first.author.2011.123
• [Journal Article] Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization (2011)
  • Author(s): Yamahashi, Y.
  • Journal Title: J.Biol.Chem.2 Volume: 286 Issue: 52 Pages: 44576-44584
  • DOI: 10.1074/jbc.m111.267021
  • Peer Reviewed
• [Journal Article] Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors (2011)
  • Author(s): Safari, F.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108 Issue: 36 Pages: 14938-14943
  • DOI: 10.1073/pnas.1107740108
  • Peer Reviewed
• [Journal Article] Potentiation of Helicobacter pylori CagA protein virulence through homodimerization (2011)
  • Author(s): Nagase, L.
  • Journal Title: J.Biol.Chem. Volume: 286 Issue: 38 Pages: 33622-33631
  • DOI: 10.1074/jbc.m111.258673
  • Peer Reviewed
• [Journal Article] Evolution of cagA oncogene of Helicobacter pylori through recombination (2011)
  • Author(s): Y Furuta, K Yahara, M Hatakeyama, I Kobayashi
  • Journal Title: PLoS ONE Volume: 6(8) Issue: 8 Pages: e23499-e23499
  • DOI: 10.1371/journal.pone.0023499
  • Peer Reviewed
• [Journal Article] SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver (2011)
  • Author(s): Takahashi A.、Tsutsumi R.、Kikuchi I.、 Obuse C.、Saito Y.、Seidi A.、Karisch R.、 Fernandez M.、Cho T.、Ohnishi N.、 Rozenblatt-Rosen O.、Meyerson M.、Neel B.G.、Hatakeyama M.
  • Journal Title: Molecular cell Volume: 43(1) Issue: 1 Pages: 45-56
  • DOI: 10.1016/j.molcel.2011.05.014
  • Peer Reviewed
• [Journal Article] ピロリ菌はいかにして胃の細胞をがん化するのでしょうか (2011)
  • Author(s): 畠山昌則
  • Journal Title: Gastro-Health Now Volume: 16 Pages: 1-3
• [Journal Article] Helicobacter pyloriの最近の話題 (2011)
  • Author(s): 畠山昌則
  • Journal Title: Medical Practice Volume: 28(基礎) Pages: 259-263
• [Journal Article] 細菌発がんの生物学的ロジック (2011)
  • Author(s): 畠山昌則
  • Journal Title: BIO Clinica Volume: 26 Pages: 875-875
• [Journal Article] 動物とヒトのピロリ菌感染 (2011)
  • Author(s): 畠山昌則
  • Journal Title: 日本医事新報 Volume: 4531 Pages: 96-97
• [Journal Article] ヘリコバクター・ピロリがんタンパク質CagA研究の新たな展開 (2011)
  • Author(s): 畠山昌則
  • Journal Title: 日本消化器病学会雑誌総説 Volume: 16(総説) Pages: 1505-1513
  • NAID: 10030298241
• [Journal Article] 胃がん発症におけるピロリ菌がんタンパク質CagAの役割 (2011)
  • Author(s): 畠山昌則
  • Journal Title: 感染・炎症・免疫 Volume: 41 Pages: 174-185
• [Journal Article] ピロリ菌がんタンパク質CagAが機能模倣する宿主蛋白質の発見 (2011)
  • Author(s): 畠山昌則
  • Journal Title: 医学のあゆみ Volume: 239 Pages: 855-856
• [Journal Article] Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein. (2011)
  • Author(s): Hatakeyama, M.
  • Journal Title: Cancer Sci. Volume: 102 Pages: 36-43
  • NAID: 10029288205
  • Peer Reviewed
• [Journal Article] Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. (2010)
  • Author(s): Saito, Y.
  • Journal Title: J.Exp.Med. Volume: 207 Pages: 2157-2174
  • Peer Reviewed
• [Journal Article] Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein. (2010)
  • Author(s): Murata-Kamiya, N.
  • Journal Title: Cell Host & Microb Volume: 7 Pages: 399-411
  • Peer Reviewed
• [Journal Article] Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis. (2010)
  • Author(s): Ding, S.Z.
  • Journal Title: Future Oncol. Volume: 6(5) Pages: 851-862
  • Peer Reviewed
• [Journal Article] Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. (2010)
  • Author(s): Ding, S.Z.
  • Journal Title: PLoS One. Volume: 1;5(4)
  • Peer Reviewed
• [Journal Article] The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice. (2010)
  • Author(s): Tanaka, H.
  • Journal Title: Arch.Biochem.Biophys. Volume: 498(1) Pages: 35-42
  • Peer Reviewed
• [Journal Article] Helicobacter pyloriの最近の話題 (2010)
  • Author(s): 畠山昌則
  • Journal Title: Medical Practic Volume: 28 Pages: 259-263
• [Journal Article] 上皮細胞極性に連動したヘリコバクター・ピロリCagAの発がん活性 (2010)
  • Author(s): 畠山昌則
  • Journal Title: 血液・腫瘍科 Volume: 61 Pages: 627-632
  • NAID: 40019064173
• [Journal Article] x.pylori感染と胃癌発生のメカニズム～H.pylori CagA癌蛋白質の胃上皮細胞侵入メカニズム (2010)
  • Author(s): 畠山昌則
  • Journal Title: Pharma Medica Volume: 28(No.8) Pages: 13-15
• [Journal Article] Helicobacter pylori CagA細胞内侵入機構の新展開 (2010)
  • Author(s): 畠山昌則
  • Journal Title: Helicobacter Research Volume: 14(No.4) Pages: 232-237
• [Presentation] ピロリ菌CagAの発がん活性を規定するSHP2結合能の非線形的変動 (2015)
  • Author(s): 畠山 昌則
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同年会
  • Place of Presentation: ポートピアホテル、神戸
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] Helicobacter pylori CagA oncoprotein and gastric cancer (2015)
  • Author(s): Hatakeyama, M.
  • Organizer: The 20th Korea-Japan Cancer Workshop
  • Place of Presentation: Royal Park Hotel The Shiodome, Tokyo
  • Year and Date: 2015-12-01
  • Int'l Joint Research / Invited
• [Presentation] ピロリ菌による胃がん発症機構 (2015)
  • Author(s): 畠山 昌則
  • Organizer: 昭和薬科大学・特別講演会
  • Place of Presentation: 昭和薬科大学、町田
  • Year and Date: 2015-11-26
  • Invited
• [Presentation] Role of Helicobacter pylori CagA oncoprotein in determining gastric caner risk (2015)
  • Author(s): Hatakeyama, M.
  • Organizer: 2015 International Symposium on Infectious Disease and Signal Transduction
  • Place of Presentation: National Cheng Kung University, Tainan, Taiwan
  • Year and Date: 2015-11-15
  • Int'l Joint Research / Invited
• [Presentation] Structural determinant for the oncogenic potential of the Helicobacter pylori CagA protein (2015)
  • Author(s): Hatakeyama, M.
  • Organizer: The 2015 Cold Spring Harbor Asia Conference on Bacterial Infection and Host Defense
  • Place of Presentation: CSHA Conference Centre, Jangsu, China
  • Year and Date: 2015-11-05
  • Int'l Joint Research / Invited
• [Presentation] The stomach microbiota and gastric cancer, (2015)
  • Author(s): Hatakeyama, M.
  • Organizer: The 74th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya Congress Center, Nagoya, Japan
  • Year and Date: 2015-10-09
  • Invited
• [Presentation] Function and regulation of the H. pylori CagA oncoprotein (2015)
  • Author(s): Hatakeyama, M.
  • Organizer: 16th FASEB Conference on Gastrointestinal Tract
  • Place of Presentation: Stemboat Springs, Colorado, USA
  • Year and Date: 2015-08-05
  • Int'l Joint Research / Invited
• [Presentation] ヘリコバクター・ピロリ菌による発がん機構 (2015)
  • Author(s): 畠山 昌則
  • Organizer: 第26回がん・エピゲノム研究会
  • Place of Presentation: 東北大学医学部艮陵会館記念ホール、仙台
  • Year and Date: 2015-07-29
  • Invited
• [Presentation] Function and Regulation of the Helicobacter pylori CagA oncoprotein (2015)
  • Author(s): Masanori Hatakeyama
  • Organizer: 10th International Symposium of the Institute Network
  • Place of Presentation: Frate Hall, Hokkaido University, Sapporo
  • Year and Date: 2015-07-24
  • Int'l Joint Research / Invited
• [Presentation] ヘリコバクター・ピロリがんタンパク質CagAと胃がん (2015)
  • Author(s): 畠山 昌則
  • Organizer: 第13回日本臨床腫瘍学会学術集会
  • Place of Presentation: ロイトン札幌／ホテルさっぽろ芸文館／札幌市教育文化会館、札幌
  • Year and Date: 2015-07-18
  • Invited
• [Presentation] ピロリ菌がんタンパク質CagAの機能とその制御 (2015)
  • Author(s): 畠山 昌則
  • Organizer: 第21回日本ヘリコバクター学会学術集会
  • Place of Presentation: 神戸ポートピアホテル、神戸
  • Year and Date: 2015-06-26
  • Invited
• [Presentation] ヘリコバクター・ピロリ病原因子 CagAの構造・機能とその制御 (2015)
  • Author(s): 畠山 昌則
  • Organizer: 第43回日本潰瘍学会・OIST合同シンポジウム
  • Place of Presentation: 沖縄科学技術大学院大学、沖縄
  • Year and Date: 2015-06-19
  • Invited
• [Presentation] ピロリ菌癌タンパク質CagAと炎症発癌 (2015)
  • Author(s): 畠山 昌則
  • Organizer: 日本プロバティクス学会プロバイオティクスシンポジウム 2015
  • Place of Presentation: 三井プラザホール (霞ヶ関ビル)、東京
  • Year and Date: 2015-05-22
  • Invited
• [Presentation] Helicobacter pylori and gastric cancer (2015)
  • Author(s): Hatakeyama, M.
  • Organizer: Academia Sinica Concerence of Frontiers in Biological Chemistry
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2015-04-18
  • Int'l Joint Research / Invited
• [Presentation] Linking inflammation and carcinogenesis by Helicobacter pylori CagA (2015)
  • Author(s): Hatakeyama, M.
  • Organizer: Seoul National University Cancer Research Institute Cancer Symposium 2015
  • Place of Presentation: Hwasun Kumho Resort, Korea
  • Year and Date: 2015-04-03
  • Int'l Joint Research / Invited
• [Presentation] Structural basis for the interaction of the Helicobacter pylori CagA oncoprotein with cellular targets (2015)
  • Author(s): 畠山 昌則
  • Organizer: 第5回 新学術領域研究 発がんスパイラル国際シンポジウム
  • Place of Presentation: 神戸ポートピアホテル、兵庫県
  • Year and Date: 2015-02-27
  • Invited
• [Presentation] ParafibrominはWnt-Notch経路間の協調的クロストークを担うシグナルハブタンパク質として機能する (2015)
  • Author(s): 菊地 逸平
  • Organizer: 平成26年度「がん研究分野等踏まえた支援活動」公開シンポジウム
  • Place of Presentation: 一橋講堂、東京都
  • Year and Date: 2015-01-28
• [Presentation] ピロリ菌がんタンパク質CagAと細菌EPIYAエフェクターファミリー (2015)
  • Author(s): 畠山 昌則
  • Organizer: 大阪大学微生物研究所アドバンストセミナー
  • Place of Presentation: 大阪大学微生物病研究所、吹田、大阪府
  • Year and Date: 2015-01-23
  • Invited
• [Presentation] Keynote Lecture “Infection, Inflammation and Cancer: the eternal triangle?” (2014)
  • Author(s): Masanori Hatakeyama
  • Organizer: Max Planck Society-The University of Tokyo Joint Meerting 2014
  • Place of Presentation: Max Planck Gesellschaft, Tagungsstatte harnack Hous, Gerlin, Germany
  • Year and Date: 2014-12-16
  • Invited
• [Presentation] Role of Helicobacter pylori CagA oncoprotein in gastric carcinogenesis. (2014)
  • Author(s): Masanori Hatakeyama
  • Organizer: VI Simposio Internacional Helicobacter pylori: Historia natural e implicaciones en ls salud humana.
  • Place of Presentation: Instituto de Investigaciones en Salud, INISA, Universidad de Costa Rica, San Jose, Costa Rica
  • Year and Date: 2014-12-05
  • Invited
• [Presentation] ピロリ菌感染による胃上皮細胞リプログラミングと発がん (2014)
  • Author(s): 畠山 昌則
  • Organizer: 第37回 日本分子生物学会MBSJ 2014）ワークショップ「サーフェスバリア・共生と感染」
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-11-25
  • Invited
• [Presentation] Protein tyrosine phosphatase SHP1 negatively regulates the oncogenic action of the Helicobacter pylori CagA protein (2014)
  • Author(s): 畠山 昌則
  • Organizer: 第4回 日仏がんワークショップ
  • Place of Presentation: 関西セミナーハウス、京都府
  • Year and Date: 2014-11-20
  • Invited
• [Presentation] 胃がん発症におけるピロリ菌がんタンパク質CagAの役割 (2014)
  • Author(s): 畠山 昌則
  • Organizer: 第5回 癌と炎症と抗酸化研究会（CIA研究会）
  • Place of Presentation: 大分県 別府コンベンションセンター
  • Year and Date: 2014-11-15
  • Invited
• [Presentation] Opposing roles for SHP1 and SHP2 phosphatases in the oncogenic action of Helicobacter pylori CagA protein (2014)
  • Author(s): 畠山 昌則
  • Organizer: 第11回日本プロテインホスファターゼ国際カンファレンス
  • Place of Presentation: 艮陵会館、東北大学、宮城県
  • Year and Date: 2014-11-13
  • Invited
• [Presentation] Structure and function of the Helicobacter pylori CagA oncoprotein (2014)
  • Author(s): Masanori Hatakeyama
  • Organizer: Department of Molecular Microbiology and Immunology Seminar at USC-Keck School of Medicine
  • Place of Presentation: Keck School of Medicinen of Southeren California, Los Angels, USA
  • Year and Date: 2014-11-06
  • Invited
• [Presentation] Structure and function of the Helicobacter pylori CagA oncoprotein (2014)
  • Author(s): Masanori Hatakeyama
  • Organizer: The Saban Research Institute at Children’s Hospital Los Angeles
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2014-11-05
  • Invited
• [Presentation] ピロリ菌による胃癌発症の分子機構 (2014)
  • Author(s): 畠山 昌則
  • Organizer: 平成２６年度日本医師会医学賞受賞講演
  • Place of Presentation: 日本医師会館、東京都
  • Year and Date: 2014-11-01
  • Invited
• [Presentation] ピロリ菌から胃の健康を守る～プロバイオティクスの可能性～ (2014)
  • Author(s): 畠山 昌則
  • Organizer: 四国新聞国際健康フォーラム
  • Place of Presentation: サンポート高松、香川県
  • Year and Date: 2014-10-25
  • Invited
• [Presentation] Instigation of carcinogenesis by mutual reinforcement of the Helicobacter pylori CagA oncoprotein and inflammation (2014)
  • Author(s): 畠山 昌則
  • Organizer: 5th Asian Pacific Topic Conference (APTC 2014) JSGE-APAGE Joint Conference
  • Place of Presentation: 神戸ポートピアホテル、兵庫県
  • Year and Date: 2014-10-22
  • Invited
• [Presentation] 胃がん発症におけるピロリ菌がんタンパク質CagAのリン酸化依存的活性化 (2014)
  • Author(s): 畠山 昌則
  • Organizer: 第87回日本生化学会大会「タンパク質リン酸化の破綻による、がんを中心とした疾患発症機構」
  • Place of Presentation: 国立京都国際会館 、京都府
  • Year and Date: 2014-10-18
  • Invited
• [Presentation] ピロリ菌由来のがんタンパク質CagAの構造-機能相関研究 (2014)
  • Author(s): 千田 俊哉
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館 、京都府
  • Year and Date: 2014-10-16
• [Presentation] ピロリ菌がんタンパク質CagAと炎症による発がんスパイラルの形成 (2014)
  • Author(s): 畠山 昌則
  • Organizer: 第73回癌学会学術総会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] ピロリ菌がんタンパク質CagAと標的分子Cskとの相互作用における生物物理化学的解析 (2014)
  • Author(s): 林 剛瑠
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] ピロリ菌CagAによる宿主分子撹乱機構の構造と機能 (2014)
  • Author(s): 林 剛瑠
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] ピロリ菌CagA発現マウス胃粘膜における粘液細胞化生(SPEM)の誘導 (2014)
  • Author(s): 柳谷 公平
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] SHP1 is a cytoplasmic tyrosine phosphatase that dephosphorylates the Helicobacter pylori CagA oncoprotein. (2014)
  • Author(s): Priya Saju
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] ParafibrominはWnt-Notch経路間の協調的クロストークを担うシグナルハブタンパク質として機能する (2014)
  • Author(s): 菊地 逸平
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Pragmin/C-terminal Srcキナーゼ (Csk) 複合体形成の機能的意義 (2014)
  • Author(s): 千田 淑惠
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Xenopus遺伝学を用いたヘリコバクター・ピロリがんタンパク質CagAの機能解析 (2014)
  • Author(s): 田尻 諒
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Functional collaboration between H. pylori CagA oncoprotein and inflammation (2014)
  • Author(s): Masanori Hatakeyama
  • Organizer: European Helicobacter Study Group 27Ith International Workshop on Helicobacter & Microbiota in Inflammation & Cancer
  • Place of Presentation: Rome, Italy
  • Year and Date: 2014-09-12
  • Invited
• [Presentation] Structure and function of the CagA oncoprotein from Helicobacter pylori (2014)
  • Author(s): Toshiya Senda
  • Organizer: 23rd Congress of the IUCr
  • Place of Presentation: Montreal ,Canada
  • Year and Date: 2014-08-11
• [Presentation] ピロリ菌による上皮極性破壊と胃発がん (2014)
  • Author(s): 畠山 昌則
  • Organizer: 千里ライフサイエンスセミナー
  • Place of Presentation: 千里ライフサイエンスセンター、大阪府
  • Year and Date: 2014-07-28
  • Invited
• [Presentation] ピロリ菌感染と炎症・発がん (2014)
  • Author(s): 畠山 昌則
  • Organizer: 第38回 阿蘇シンポジウム
  • Place of Presentation: 阿蘇リゾートグランドヴィリオホテル、熊本県
  • Year and Date: 2014-07-25 – 2014-07-26
  • Invited
• [Presentation] Enhanced carcinogenesis by mutual reinforcement between Helicobacter pylori CagA and inflammation (2014)
  • Author(s): Masanori Hatakeyama
  • Organizer: Singapore Gastric Cancer Consortium 7th Annual Scientific Meeting
  • Place of Presentation: National University Health System, Singapore
  • Year and Date: 2014-07-22 – 2014-07-25
  • Invited
• [Presentation] Helicobacter pylori感染によるInterleukin-1β産生誘導機構の解析 (2014)
  • Author(s): 亀岡 章一郎
  • Organizer: 日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 札幌、北海道
  • Year and Date: 2014-06-23
• [Presentation] ピロリ菌による胃がん発症の分子機構 (2014)
  • Author(s): 畠山 昌則
  • Organizer: 第24回感染研シンポジウム“微生物が関与する悪性腫瘍”
  • Place of Presentation: 国立感染症研究所、東京都
  • Year and Date: 2014-05-21
  • Invited
• [Presentation] Role of Helicobacter pylori CagA in inflammation and carcinogenesis (2014)
  • Author(s): Masanori Hatakeyama
  • Organizer: AACR Annual Meeting 2014 AACR-JCA Joint Symposium: Inflamation in Gastric Cancer
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-08
  • Invited
• [Presentation] YAP1-mRNAの選択的スプライシングによるSHP2/YAP1相互作用の制御 (2014)
  • Author(s): 高橋 昌史
  • Organizer: がん研究分野の特性等を踏まえた支援活動 公開シンポジウム
  • Place of Presentation: 学術総合センタ－、東京
• [Presentation] LEOPARD症候群特異的変異型SHP2のチロシンホスファターゼ活性解析 (2014)
  • Author(s): 野田 沙織
  • Organizer: 第6回日本プロテインホスファターゼ研究会学術集会
  • Place of Presentation: 三重大学、津
• [Presentation] ピロリ菌がんタンパク質CagAによる胃がん発症機構 (2013)
  • Author(s): 畠山 昌則
  • Organizer: 第155回日本獣医学会学術総会特別講演
  • Place of Presentation: 東京大学駒場キャンパス、東京都
  • Year and Date: 2013-03-29
  • Invited
• [Presentation] Helicobacter pylori CagA, a bacterial protein acting as an oncogenic scaffold/hub in mammalian cells (2013)
  • Author(s): 畠山 昌則
  • Organizer: 3rd Max Planck Institutes-University of Tokyo/Med Joint Conference
  • Place of Presentation: Ito International Research Cencer, University of Tokyo,Tokyo
  • Year and Date: 2013-03-07
  • Invited
• [Presentation] Helicobacter pylori CagA, a bacterial oncoprotein that directs gastric carcinogenesis (2013)
  • Author(s): 畠山 昌則
  • Organizer: 19th International Charles Heidelberger Symposium on Cancer Research-Carcinogenesis and Chemotherapy: Cancer core challenge-
  • Place of Presentation: William Wills Hall, Kagoshima University, Faculty of Medicine, Kagoshima
  • Year and Date: 2013-02-15
  • Invited
• [Presentation] Mechanisms deterining subcellular localization of SHP2 tyrosine phosphatase (2013)
  • Author(s): 畠山 昌則
  • Organizer: 10th International Conference on Protein Phosphatase,Special Lecture
  • Place of Presentation: nternational Lecture Hall, Foundation for Promotion of Cancer Research,Tokyo
  • Year and Date: 2013-02-08
  • Invited
• [Presentation] ピロリ菌がんタンパク質CagAの3次元構造と機能 (2013)
  • Author(s): 畠山 昌則
  • Organizer: 平成24年度文部科学省 新学術領域研究 「がん支援」公開シンポジウム
  • Place of Presentation: 学術総合センター 一橋講堂、東京都
  • Year and Date: 2013-01-29
  • Invited
• [Presentation] Helicobacter pylori CagA, a bacterial protein acting as an concogenic scaffold/hub in mammalian cells (2013)
  • Author(s): 畠山 昌則
  • Organizer: 3rd International Symposium on Carcinogenic Spiral
  • Place of Presentation: 金沢エクセル東急ホテル、金沢市
  • Year and Date: 2013-01-24
  • Invited
• [Presentation] LEOPARD症候群由来変異型SHP2ホスファターゼのin vitro酵素活性解析 (2013)
  • Author(s): 野田 沙織
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] Helicobacter pyloriアメリンド株由来CagAの病態生理学的活性 (2013)
  • Author(s): 橋 香奈
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] 転写因子CDX1による幹細胞性リプログラミング因子の発現誘導を介した胃上皮細胞の腸上皮細胞様分化形質転換 (2013)
  • Author(s): 藤井 裕美子
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] ヘリコバクター・ピロリがんタンパク質CagAの分子多型と生物活性 (2013)
  • Author(s): 長瀬 里沙
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] EBウィルスによる上皮腫瘍化における癌幹細胞の存在について (2013)
  • Author(s): 吉山 裕規
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] Biochemical and Biophysical Analysis for the Oncogenic Interaction between H. pylori CagA and SHP2 (2013)
  • Author(s): 林 剛瑠
  • Organizer: The 3rd French-Japanese Cancer Meeting
  • Place of Presentation: Toulouse, France
• [Presentation] A Natural Variant of Helicobacter pylori Carrying CagA with a Reduced Oncogenic Potential (2013)
  • Author(s): 橋 香奈
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: 東京ベイ舞浜ホテル クラブリゾート, 舞浜
• [Presentation] Regulation of SHP2-YAP Interaction by Differential Splicing of YAP mRNA (2013)
  • Author(s): Mohammad Masoudi
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: 東京ベイ舞浜ホテル クラブリゾート, 舞浜
• [Presentation] Influence of EPIYA-C Repeat Number on the Interaction of Helicobacter pylori Oncoprotein CagA with SHP2 Phosphatase (2013)
  • Author(s): 長瀬 里沙
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: 東京ベイ舞浜ホテル クラブリゾート, 舞浜
• [Presentation] Involvement of Stemness Factors in the Intestinal Transdifferentiation of Gastric Epithelial Cells (2013)
  • Author(s): 藤井 裕美子
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: 東京ベイ舞浜ホテル クラブリゾート, 舞浜
• [Presentation] Tyrosine Phosphatase Activity of SHP2 Mutants Derived from LEOPARD Syndrome (2013)
  • Author(s): 野田 沙織
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: 東京ベイ舞浜ホテル クラブリゾート, 舞浜
• [Presentation] ピロリ菌CagAとチロシンホスファターゼSHP2の発がん複合体形成における生化学的解析 (2013)
  • Author(s): 林 剛瑠
  • Organizer: 2013年度CREST/さきがけ 合同キックオフミーティング
  • Place of Presentation: ホテルラフォーレ琵琶湖、滋賀
• [Presentation] Structure-function Analysis of Helicobacter pylori CagA oncoprotein(ヘリコバクター・ピロリがんタンパク質CagAの構造－機能解析) (2012)
  • Author(s): 林 剛瑠
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: マリンメッセ福岡、福岡市
  • Year and Date: 2012-12-13
• [Presentation] Helicobacter pylori CagA act as as an oncogenic scaffold/hub protein in mammalian cells (2012)
  • Author(s): 畠山 昌則
  • Organizer: 2nd Japanese-French Cancer Workship
  • Place of Presentation: Grand XIV Naruto,Tokushima
  • Year and Date: 2012-11-30
  • Invited
• [Presentation] Embryonic lethality in mice expressing H.pylori CagA oncoprotein (2012)
  • Author(s): Kohei Yanagiya
  • Organizer: 第７1回日本癌学会総会
  • Place of Presentation: 札幌文芸館、札幌市
  • Year and Date: 2012-09-20
• [Presentation] Projection from Basic Biology to Cancer Research Role of Helicobacter pylori CagA oncoprotein in gastric carcinogenesis (2012)
  • Author(s): 畠山 昌則
  • Organizer: 第71回日本癌学会総会コアシンポジウム
  • Place of Presentation: 札幌文芸館、札幌市
  • Year and Date: 2012-09-19
  • Invited
• [Presentation] Mechanism underlying cytoplasmic-nuclear shuttling of SHP2 (2012)
  • Author(s): Ryouhei Tsutsumi
  • Organizer: 第７１回日本癌学会総会
  • Place of Presentation: 札幌文芸館、札幌市
  • Year and Date: 2012-09-19
• [Presentation] Tertiary structure of the Helicobacter pylori CagA oncoprotein (2012)
  • Author(s): Takeru Hayashi
  • Organizer: 第７１回日本癌学会総会
  • Place of Presentation: 札幌文芸館、札幌市
  • Year and Date: 2012-09-19
• [Presentation] Estrogen-mediated enhancement of epithelial monolayer disruption by H.pylori CagA oncoprotein (2012)
  • Author(s): Naoko Kamiya
  • Organizer: 第７1回日本癌学会総会
  • Place of Presentation: 札幌文芸館、札幌市
  • Year and Date: 2012-09-19
• [Presentation] nvolvement of multiple tyrosine kinases in antagonizing parafibromin-mediated activation of Wnt signaling by SHP2 (2012)
  • Author(s): Atsushi Takahashi
  • Organizer: 第７１回日本癌学会総会
  • Place of Presentation: 札幌文芸館、札幌市
  • Year and Date: 2012-09-19
• [Presentation] 感染癌のエフェクター分子とその標的「ピロリ菌がんタンパク質CagAの三次元分子構造」 (2012)
  • Author(s): 畠山 昌則
  • Organizer: 平成24年度北海道大学遺伝子病制御研究所研究集会
  • Place of Presentation: 北海道大学医学部フラテ講堂、札幌市
  • Year and Date: 2012-09-18
  • Invited
• [Presentation] Three dimensional structure of the Helicobacter pylori CagA oncoprotein (2012)
  • Author(s): 畠山 昌則
  • Organizer: European Helicobacter Study Group 2012 Opening Lecture
  • Place of Presentation: リュブリアナ・スロベニア
  • Year and Date: 2012-09-11
  • Invited
• [Presentation] ピロリ菌がんタンパク質CagAの発がん活性 (2012)
  • Author(s): 畠山 昌則
  • Organizer: 第4回神戸大学次世代シグナル伝達医学グローバルCOE研究検討会・特別講演
  • Place of Presentation: 淡路夢舞台国際会議場、 兵庫県
  • Year and Date: 2012-07-09
  • Invited
• [Presentation] ピロリ菌と胃がん～細胞が仕掛けるトロイ戦争 (2012)
  • Author(s): 畠山 昌則
  • Organizer: 第12回東京大学生命科学シンポジウム(BIO UT)
  • Place of Presentation: 東京大学本郷キャンパス・安田講堂、東京都
  • Year and Date: 2012-06-30
  • Invited
• [Presentation] 細菌性がんタンパク質としてのピロリ菌CagAの作用機構 (2012)
  • Author(s): 畠山 昌則
  • Organizer: 第18回日本ヘリコバクター学会学術集会・特別講演
  • Place of Presentation: 岡山コンベンションセンター、岡山市
  • Year and Date: 2012-06-29
  • Invited
• [Presentation] 炎症・発がんにおけるピロリ菌CagAの役割 (2012)
  • Author(s): 畠山 昌則
  • Organizer: 平成24年度新学術領域「発がんスパイラル」研究進捗報告会
  • Place of Presentation: 東京大学伊藤国際学術センター、東京都
  • Year and Date: 2012-06-22
  • Invited
• [Presentation] ピロリ菌による胃がん発症機構 (2012)
  • Author(s): 畠山 昌則
  • Organizer: 金沢大学がん進展制御研究所セミナー
  • Place of Presentation: 金沢大学がん進展制御研究所、金沢市
  • Year and Date: 2012-05-17
  • Invited
• [Presentation] H.pylori-mediated gastric carcinogenesis; a new paradigm of cancer development (2012)
  • Author(s): 畠山 昌則
  • Organizer: 第98回日本消化器病学会総会 国際交流フォーラム
  • Place of Presentation: 京王プラザ、東京
  • Year and Date: 2012-04-20
  • Invited
• [Presentation] How does H.pylori cause gastric carcinoma? (2012)
  • Author(s): 畠山 昌則
  • Organizer: American Association for cancer Research (AACR)Annual Meeting 2012（招待講演）
  • Place of Presentation: McCormick Convention Center, Chicago,USA
  • Year and Date: 2012-04-01
  • Invited
• [Presentation] がんタンパク質SHP2によりCdc73/parafibromin脱リン酸化を介したWnt経路活性化機構 (2012)
  • Author(s): 高橋昌史、畠山昌則
  • Organizer: 第三次対がん10か年総合戦略・文科省がん支援活動合同シンポジウム
  • Place of Presentation: 学術総合センター・一橋記念講堂(東京都)
  • Year and Date: 2012-01-30
• [Presentation] Role of Helicobacter pylori CagA in gastric carcinogenesis (2011)
  • Author(s): 畠山昌則
  • Organizer: 9th China-Japan Joint Conference of Cancer
  • Place of Presentation: Oriental Riverside Hotel, Shanghai, (China)(招待講演)
  • Year and Date: 2011-12-22
• [Presentation] Parafibromin/CDC73 is a nuclear SHP2 substrate that connects RAs and Wnt signaling pathway (2011)
  • Author(s): 畠山昌則
  • Organizer: 1st Japan-Taiwan Bilateral Conference on Protein Phosphatase
  • Place of Presentation: National Institute for Basic Science(愛知県)(招待講演)
  • Year and Date: 2011-12-02
• [Presentation] Molecular mechanism of gastric carcinogenesis (2011)
  • Author(s): 畠山昌則
  • Organizer: France-Japan Cancer Meeting 2011
  • Place of Presentation: Montpellier (France)(招待講演)
  • Year and Date: 2011-11-24
• [Presentation] ピロリ菌がんタンパク質CagAが機能模倣するヒトタンパク質の同定 (2011)
  • Author(s): 畠山昌則
  • Organizer: 第56回日本人類遺伝学会・第11回東アジア人類遺伝学会共同大会シンポジウム9がん最近のトピックス
  • Place of Presentation: 幕張メッセ(千葉県)(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] Oncogenic Mechanism of Helicobacter pylori CagA (2011)
  • Author(s): 畠山昌則
  • Organizer: The 21^<st> Hiroshima Cancer Seminar (HCS)/The 5^<th> Three Universities' Consortium International Symposium "Recent Progress in Carcinogenesis, Progression and Management of Upper GI Cancers"
  • Place of Presentation: International Conference Center Hiroshima(広島県)(招待講演)
  • Year and Date: 2011-11-05
• [Presentation] The Role of Helicobacter pylori oncoprotein CagA in gastric carcinogenesis (2011)
  • Author(s): 畠山昌則
  • Organizer: Berlin Life Science Colloquium 2011
  • Place of Presentation: Paul Erlich Lecture Hall, Max Planck Institute fur Infektionsbiologie, Berlin (Germany)(招待講演)
  • Year and Date: 2011-10-20
• [Presentation] Infection, Inflammation and Cancer (2011)
  • Author(s): 畠山昌則
  • Organizer: 第70回日本癌学会総会(JCA2011)モーニングレクチャー15
  • Place of Presentation: 名古屋国際会議場(愛知県)(招待講演)
  • Year and Date: 2011-10-05
• [Presentation] SHP2 oncoprotein activates nuclear Wnt signaling via dephosphorylation of a novel substrate, parafibromin/Cdc73 (2011)
  • Author(s): Takahashi A
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] Cytoplasmic-nuclear shuttling of SHP2 oncoprotein (2011)
  • Author(s): Tsutsumi R
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] The impact of Helicobacter pylori CagA homodimerization on CagA virulence (2011)
  • Author(s): Nagase L
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] Crystal structure analysis of Helicobacter pylori CagA (2011)
  • Author(s): Hayashi T
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] Role of epithelial function in the oncogenic activity of Helicobacter pylori CagA (2011)
  • Author(s): Kashiba Y
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] Helicobacter pylori CagA oncoprotein targets epithelial polarity to elicit aberrant cell proliferation (2011)
  • Author(s): Saito Y
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] Pragmin is a human EPIYA-containinig protein targeted by H.pylori CagA oncoprotein (2011)
  • Author(s): Safari F
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] ピロリ菌感染による胃がん発症機構 (2011)
  • Author(s): 畠山昌則
  • Organizer: 第49回大分感染症研究会
  • Place of Presentation: 大分東洋ホテル(大分県)(招待講演)
  • Year and Date: 2011-09-01
• [Presentation] Searching for the origin of H.pylori CagA in mammalian proteome (2011)
  • Author(s): 畠山昌則
  • Organizer: CHRO 2011, Concurrent session A : Helicobacter pathogenesis
  • Place of Presentation: Vancouver (Canada)(招待講演)
  • Year and Date: 2011-08-29
• [Presentation] 感染発癌の分子機構 (2011)
  • Author(s): 畠山昌則
  • Organizer: 第50回日本婦人科腫瘍学会学術集会特別講演
  • Place of Presentation: 札幌コンベンションセンター(北海道)(招待講演)
  • Year and Date: 2011-07-23
• [Presentation] 胃がん原因菌としてのピロリ菌の最新知見 (2011)
  • Author(s): 畠山昌則
  • Organizer: 第238回ヘルスケア研究会
  • Place of Presentation: 日比谷星陵会館(東京都)(招待講演)
  • Year and Date: 2011-07-13
• [Presentation] ピロリ菌と胃がん (2011)
  • Author(s): 畠山昌則
  • Organizer: 第17回日本癌学会市民公開講座
  • Place of Presentation: 新潟市民プラザ(新潟県)(招待講演)
  • Year and Date: 2011-06-04
• [Presentation] In search for the origin of bacterial EPOIYA effectors in mammals (2011)
  • Author(s): 畠山昌則
  • Organizer: 1^<st> Joint Symposium of the Max-Planck Society and University of Tokyo Host Responses in Disease developmentent
  • Place of Presentation: ParkhotelSchlangenbad, (Germany)(招待講演)
  • Year and Date: 2011-05-18
• [Presentation] ヘリコバクター・ピロリ癌タンパク質CagAの作用機構 (2011)
  • Author(s): 畠山昌則
  • Organizer: 第97回日本消化器病学会総会シンポジウム7.ヘリコバクター・ピロリ感染症の徹底検証
  • Place of Presentation: 京王プラザホテル東京(東京都)(招待講演)
  • Year and Date: 2011-05-14
• [Presentation] 胃癌発症におけるピロリ菌の役割 (2011)
  • Author(s): 畠山昌則
  • Organizer: 第100回日本病理学会総会シンポジウム3.感染・炎症と胃癌
  • Place of Presentation: パシフィコ横浜、横浜(神奈川県)(招待講演)
  • Year and Date: 2011-04-29
• [Presentation] Carcinogenic mechanism of Helicobacter pylori (2011)
  • Author(s): 畠山昌則
  • Organizer: 9^<th> International Gastric Cancer Congress (IGCC 2011)
  • Place of Presentation: Coex Center, (Seoul, South Korea)(招待講演)
  • Year and Date: 2011-04-21
• [Presentation] 胃発癌の分子メカニズム (2011)
  • Author(s): 畠山昌則
  • Organizer: 第7回日本消化管学会総会学術総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-02-19
• [Presentation] Helicobacter pylori and Gastric Cancer (2011)
  • Author(s): 畠山昌則
  • Organizer: 第26回名古屋国際癌治療シンピジウム
  • Place of Presentation: 愛知県がんセンター(愛知県)
  • Year and Date: 2011-02-12
• [Presentation] Role of SHP2 Tyrosine Phosphatase in Gastric Carcinogenesis (2011)
  • Author(s): Hatakeyama, M.
  • Organizer: 1^<st> International Symposium on Carcinogenic Spiral & 9^<th> International Conference on Protein Phosphatase
  • Place of Presentation: 東京大学鉄門記念講堂(東京都)
  • Year and Date: 2011-02-02
• [Presentation] Role of Helicobacter pylori CagA oncoprotein in gastric carcinogenesis (2010)
  • Author(s): 畠山昌則
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市)
  • Year and Date: 2010-12-08
• [Presentation] Helicobacter pylori CagA oncoprotein in gastric carcinoma (2010)
  • Author(s): Hatakeyama, M.
  • Organizer: Frontiers in Cancer Science 2010
  • Place of Presentation: NUHS Auditorium (Singapore)
  • Year and Date: 2010-11-10
• [Presentation] Challenges facing mass eradication of H.pylolri (2010)
  • Author(s): Hatakeyama, M.
  • Organizer: 欧州消化器病学会/UEGW Barcelona 2010
  • Place of Presentation: CCIB (Barcelona, Spain)
  • Year and Date: 2010-10-25
• [Presentation] ヘリコバクター・ピロリ菌がんタンパク質CagAの胃上皮細胞内移行メカニズム (2010)
  • Author(s): 畠山昌則
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-23
• [Presentation] ピロリ菌がんタンパク質CagAによる胃がん発症の分子機構 (2010)
  • Author(s): 畠山昌則
  • Organizer: 第61回日本電気泳動学会総会
  • Place of Presentation: 北海道大学クラーク会館(北海道札幌市)
  • Year and Date: 2010-09-18
• [Presentation] ピロリ菌による胃発がんのメカニズム (2010)
  • Author(s): 畠山昌則
  • Organizer: 創薬薬理フォーラム第18回シンポジウム
  • Place of Presentation: 日本薬学会長井記念館(東京都)
  • Year and Date: 2010-09-16
• [Presentation] ピロリ菌癌タンパク質CagAの細胞内移行ならびに病原性発現機構 (2010)
  • Author(s): Hatakeyama, M.
  • Organizer: 第16回日本消化器病学会関東支部教育講演会
  • Place of Presentation: シェーンバッハ・サボー(東京都)
  • Year and Date: 2010-07-11
• [Presentation] 発がん性足場タンパク質としてのピロリ菌CagAの機能と構造
  • Author(s): 畠山 昌則
  • Organizer: 第50回日本臨床医学会学術集会
  • Place of Presentation: 東京国際フォーラム、東京
  • Invited
• [Presentation] ピロリ菌癌タンパク質CagAの構造と機能
  • Author(s): 畠山 昌則
  • Organizer: 第44回広島消化管研究会
  • Place of Presentation: ホテルグランヴィア広島、広島
  • Invited
• [Presentation] Structure and function of the H. pylori CagA oncoprotein
  • Author(s): 畠山 昌則
  • Organizer: 40th Institute of Medical Science, The University of Tokyo (IMSUT) Commemorative Symposium
  • Place of Presentation: 東京大学医科学研究所、東京
  • Invited
• [Presentation] ヘリコバクター・ピロリによる胃癌発症機構
  • Author(s): 畠山 昌則
  • Organizer: 第49回姫路市医師会夏期大会
  • Place of Presentation: 姫路市医師会館、姫路
  • Invited
• [Presentation] Helicobacter pylori and gastric cancer: recent development
  • Author(s): 畠山 昌則
  • Organizer: 6th Annual Scientific Meeting of Singapore Gastric Cancer Consortium
  • Place of Presentation: Singapore, Singapore
  • Invited
• [Presentation] ヘリコバクター・ピロリCagAによる胃がん発症機構
  • Author(s): 畠山 昌則
  • Organizer: 平成25年度文科省がん支援「がん若手研究者ワークショップ」
  • Place of Presentation: 蓼科グランドホテル、長野
  • Invited
• [Presentation] Helicobacter pylori CagA directs gastric intestinal metaplasia by inducing stemness-related reprogramming factors
  • Author(s): 畠山 昌則
  • Organizer: 26th European Helicobacter study group International Workshop
  • Place of Presentation: Madrid, Spain
  • Invited
• [Presentation] Oncogenic mechanism of Helicobacter pylori
  • Author(s): 畠山 昌則
  • Organizer: Seminar Series at Centro National de Investigaciones Onc&#243;lo&#289;icas (CNIO)
  • Place of Presentation: Madrid, Spain
  • Invited
• [Presentation] Function and regulation of SHP2 phosphatase, a cellular target of Helicobacter pylori oncoprotein CagA
  • Author(s): 畠山 昌則
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Invited
• [Presentation] ヘリコバクター・ピロリ菌による胃がん発症機構
  • Author(s): 畠山 昌則
  • Organizer: 第61回日本ウイルス学会学術集会・特別講演
  • Place of Presentation: 神戸国際会議場、神戸
  • Invited
• [Presentation] Role of Helicobacter pylori in gastric carcinogenesis
  • Author(s): 畠山 昌則
  • Organizer: UTokyo Forum in Brazil 2013
  • Place of Presentation: Sao Paulo, Brazil
  • Invited
• [Presentation] Mechanisms determining subcellular localization of the oncogenic protein tyrosine phosphatase SHP2
  • Author(s): 畠山 昌則
  • Organizer: The 3rd French-Japanese Cancer Meeting
  • Place of Presentation: Toulouse, France
  • Invited
• [Presentation] Function and regulation of SHP2 tyrosine phosphatase
  • Author(s): 畠山 昌則
  • Organizer: The 2rd Taiwan-Japan Bilateral Conference on Protein Phosphatases
  • Place of Presentation: Taipei, Taiwan
  • Invited
• [Presentation] Role of Helicobacter pylori CagA in Gastric Carcinogenesis
  • Author(s): 畠山 昌則
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: 東京ベイ舞浜ホテル クラブリゾート, 舞浜
  • Invited
• [Presentation] ピロリ菌がんタンパク質CagAの構造と機能
  • Author(s): 畠山 昌則
  • Organizer: 宮城県立がんセンターセミナー
  • Place of Presentation: 名取、宮城
  • Invited
• [Presentation] Role of Helicobacter pylori CagA in Gastric Carcinogenesis
  • Author(s): 畠山 昌則
  • Organizer: The 4th International Symposium on Carcinogenic Spiral
  • Place of Presentation: 京王プラザホテル札幌、札幌
  • Invited
• [Presentation] 胃発がんにおけるピロリ菌がんタンパク質CagAの役割
  • Author(s): 畠山 昌則
  • Organizer: 愛媛大学プロテオサイエンスセンター 第1回学術シンポジウム
  • Place of Presentation: 愛媛大学、松山
  • Invited
• [Presentation] Oncogenic mechanisms of the Helicobacter pylori CagA protein
  • Author(s): 畠山 昌則
  • Organizer: Seminar at the Institute of Biological Chemistry, Academia Sinica
  • Place of Presentation: Taipei, Taiwan
  • Invited
• [Presentation] Oncogenic mechanisms of the Helicobacter pylori CagA protein
  • Author(s): 畠山 昌則
  • Organizer: Tsu-Chi Hospital and University Seminar Series
  • Place of Presentation: Hua-Lien, Taiwan
  • Invited
• [Presentation] ピロリ菌エフェクターによる細胞がん化機構
  • Author(s): 畠山 昌則
  • Organizer: 第87回日本細菌学会総会
  • Place of Presentation: タワーホール船堀、東京
  • Invited
• [Book] Recent Advances in Gastrointestinal Carcinogenesis (2016)
  • Author(s): Senda, Y., Hatakeyama, M.
  • Total Pages: 14
  • Publisher: Springer
• [Book] ピロリ菌因子CagAの発癌病原性活性化機構 (2014)
  • Author(s): 畠山 昌則
  • Publisher: 感染・炎症・免疫
• [Book] Hippo経路のエフェクター分子YAPおよびTAZによるがんタンパク質SHP2の機能制御 (2014)
  • Author(s): 高橋 昌史、堤 良平、畠山 昌則
  • Publisher: 細胞工学
• [Book] ピロリ菌の発がんタンパク質CagAの構造と機能 (2014)
  • Author(s): 千田 俊哉、千田 美紀、林 剛瑠、畠山 昌則
  • Publisher: 実験医学
• [Book] Helicobacter pyloriがんタンパク質CagAとEPIYAエフェクターファミリー (2014)
  • Author(s): 畠山 昌則
  • Publisher: 生化学（総説）
• [Book] ピロリ菌による胃癌発症の分子機構 (2014)
  • Author(s): 畠山 昌則
  • Publisher: 日本医師会雑誌
• [Book] カラー版内科学 (2013)
  • Author(s): 門脇孝、永井良三
  • Total Pages: 2004
  • Publisher: 西村書店
• [Book] 看護学大辞典（第6版） (2013)
  • Author(s): 永井良三、田村やよひ
  • Total Pages: 2453
  • Publisher: メジカルフレンド社
• [Book] がん生物学イラストレイテッド(渋谷正史、湯浅保仁編) (2011)
  • Author(s): 畠山昌則
  • Publisher: 羊土社
• [Remarks] 東京大学大学院医学系研究科・医学部 微生物学研究室
  • URL: http://www.microbiol.m.u-tokyo.ac.jp/
• [Remarks] 医学系研究科 医学部 微生物学教室のホームページ
  • URL: http://www.microbiol.m.u-tokyo.ac.jp/
• [Remarks] 東京大学医学系研究科・医学部 微生物学研究室
  • URL: http://www.microbiol.m.u-tokyo.ac.jp/