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Identification of diseases harboring abnormalities in LipoQuality and clarification of molecular mechanisms therein

Planned Research

Project AreaQuality of lipids in biological systems
Project/Area Number 15H05905
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKumamoto University

Principal Investigator

Sugimoto Yukihiko  熊本大学, 大学院生命科学研究部(薬), 教授 (80243038)

Co-Investigator(Kenkyū-buntansha) 村上 誠  東京大学, 大学院医学系研究科(医学部), 教授 (60276607)
Project Period (FY) 2015-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥152,620,000 (Direct Cost: ¥117,400,000、Indirect Cost: ¥35,220,000)
Fiscal Year 2019: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2018: ¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
Fiscal Year 2017: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2016: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2015: ¥35,880,000 (Direct Cost: ¥27,600,000、Indirect Cost: ¥8,280,000)
Keywordsプロスタグランジン / ホスホリパーゼA2 / プロスタノイド / 脂質メディエーター / GPCR / ω3脂肪酸 / 脂肪分解 / 疾患マーカー / ホスホリパーゼA2 / プロスタノイド受容体 / 炎症マーカー
Outline of Final Research Achievements

In this study, in order to elucidate the roles of phospholipase A2 (PLA2) and prostaglandin (PG) receptors in diseases and the molecular mechanisms therein, we analyzed disease-like phenotypes in PLA2- or PG receptor-knockout mice. 1) We clarified the crystal structure of human EP4 and found that EP4 has a ligand access pocket opening toward plasma membrane. 2) We found that particular PG receptors are involved in myocyte reprogramming and gut microbiota-related responses in a lipoquality-dependent manner. 3) In white adipose tissues, PGE2 produced via PNPLA2/COX-1 by acting on EP4 receptor facilitates basal lipolysis and fat accumulation in liver.

Academic Significance and Societal Importance of the Research Achievements

各PG受容体がⅡ型糖尿病や肝がんなど、従来知られていなかった疾患発症に関わること、またその作用機序を同定したことは、医学・生理学の広範な研究分野に大きなインパクトを与えた。またPG受容体の結晶構造を世界で初めて明らかにし、ω鎖をはじめPG骨格認識部位を同定することで受容体を標的とした創薬を加速するものである。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(279 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (5 results) Journal Article (94 results) (of which Int'l Joint Research: 24 results,  Peer Reviewed: 53 results,  Open Access: 46 results,  Acknowledgement Compliant: 16 results) Presentation (160 results) (of which Int'l Joint Research: 45 results,  Invited: 60 results) Book (7 results) Remarks (7 results) Patent(Industrial Property Rights) (3 results) Funded Workshop (3 results)

  • [Int'l Joint Research] Rockfeller University/Columbia University/Icahn School of Medicine at Mount Sinai(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Cambridge(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Toronto(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] A*STAR/SRIS/SIgN(シンガポール)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ワシントン大学/バンダビルト大学/オハイオ州立大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition.2020

    • Author(s)
      Ishihara E, Nagaoka Y, Okuno T, Kofuji S, Ishigami-Yuasa M, Kagechika H, Kamimura K, Terai S, Yokomizo T, Sugimoto Y, Fujita Y, Suzuki A, Nishina H.
    • Journal Title

      FASEB J

      Volume: 25(3) Pages: 14528-14541

    • DOI

      10.1111/gtc.12750

    • NAID

      120006873037

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Induced Prostanoid Synthesis Regulates the Balance between Th1- and Th2-Producing Inflammatory Cytokines in the Thymus of Diet-Restricted Mice2020

    • Author(s)
      Razali N, Hohjoh H, Inazumi T, Maharjan BD, Nakagawa K, Konishi M, Sugimoto Y, Hasegawa H.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 43 Issue: 4 Pages: 649-662

    • DOI

      10.1248/bpb.b19-00838

    • NAID

      130007825267

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the selective EP2 receptor agonist omidenepag on adipocyte differentiation in 3T3-L1 cells2020

    • Author(s)
      Yamamoto Y, Taniguchi T, Inazumi T, Iwamura R, Yoneda K, Odani-Kawabata N, Matsugi T, Sugimoto Y, Shams NK.
    • Journal Title

      J. Ocul. Pharmacol. Ther.

      Volume: 36 Pages: 162-169

    • DOI

      10.1089/jop.2019.0079

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] プロスタグランジンD2レセプターのシグナル伝達2020

    • Author(s)
      稲住知明, 杉本幸彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 73 (13) Pages: 58-63

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Secreted phospholipase PLA2G2D contributes to metabolic health by mobilizing omega3 polyunsaturated fatty acids in WAT2020

    • Author(s)
      Sato H, Taketomi Y, Miki Y, Murase R, Yamamoto K, Murakami M.
    • Journal Title

      Cell Rep.

      Volume: 31 Pages: 10757-10757

    • DOI

      10.1016/j.celrep.2020.107579

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface2019

    • Author(s)
      Toyoda Y, Morimoto K, Suno R, et al.
    • Journal Title

      Nature chemical biology

      Volume: 15 Pages: 18-26

    • DOI

      10.1038/s41589-018-0131-3

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche2019

    • Author(s)
      Kitadate Y., Jorg DJ., Tokue M,. Maruyama A., Ishikawa R., Tsuchiya S., Segi-Nishida E., Nakagawa T., Uchida A., Kimura-Yoshida C., Mizuno S., Sugiyama F., Azami T., Ema M., Noda C., Kobayashi S., Matsuo I., Kanai Y., Nagasawa T., Sugimoto Y., Takahashi S., Simons BD., Yoshida S.
    • Journal Title

      Cell Stem Cell.

      Volume: 24 Pages: 1-2

    • DOI

      10.1016/j.stem.2018.11.013

    • NAID

      120007128265

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming2019

    • Author(s)
      Muraoka Naoto、Nara Kaori、Tamura Fumiya、Kojima Hidenori、Yamakawa Hiroyuki、Sadahiro Taketaro、Miyamoto Kazutaka、Isomi Mari、Haginiwa Sho、Tani Hidenori、Kurotsu Shota、Osakabe Rina、Torii Satoru、Shimizu Shigeomi、Okano Hideyuki、Sugimoto Yukihiko、Fukuda Keiichi、Ieda Masaki
    • Journal Title

      Nat Commun

      Volume: 10 Pages: 1-15

    • DOI

      10.1038/s41467-019-08626-y

    • NAID

      120007128245

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Essential role of prostaglandin E2 and the EP3 receptor in lymphatic vessel development during zebrafish embryogenesis2019

    • Author(s)
      Iwasaki R, Tsuge K, Kishimoto K, Hayashi Y, Iwaana T, Hohjoh H, Inazumi T, Kawahara A, Tsuchiya S, Sugimoto Y.
    • Journal Title

      Sci. Rep.

      Volume: 9 Pages: 7650-7650

    • DOI

      10.1038/s41598-019-44095-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases.2019

    • Author(s)
      Tsuge K, Inazumi T, Shimamoto A, Sugimoto Y.
    • Journal Title

      International immunology

      Volume: 印刷中 Pages: 1-10

    • DOI

      10.1093/intimm/dxz021

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis.2019

    • Author(s)
      Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, Nakajima S, Matsumoto R, Nakano Y, Otsuka M, Iwakura Y, Grinberg-Bleyer Y, Ghosh S, Sugimoto Y, Guttman-Yassky E, Krueger JG, Kabashima K.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 144(4) Pages: 1036-1049

    • DOI

      10.1016/j.jaci.2019.06.019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids2019

    • Author(s)
      Miyamoto J, Igarashi M, Watanabe K, Karaki SI, Mukouyama H, Kishino S, Li X, Ichimura A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Miki T, Ogawa J, Drucker DJ, Arita M, Itoh H, Kimura I
    • Journal Title

      Nat Commun.

      Volume: 10 Pages: 1-15

    • DOI

      10.1038/s41467-019-11978-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional Hierarchy of Uterotonics Required for Successful Parturition in Mice2019

    • Author(s)
      Yoshida M, Takayanagi Y, Ichino-Yamashita A, Sato K, Sugimoto Y, Kimura T, Nishimori K.
    • Journal Title

      Endocrinology

      Volume: 160 Pages: 2800-2810

    • DOI

      10.1210/en.2019-00499

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] シクロオキシゲナーゼ経路によるリポクオリティ認識2019

    • Author(s)
      稲住知明, 杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 269 (1) Pages: 1002-1007

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Novel functions of Phospholipase A2s: Overview.2019

    • Author(s)
      Murakami M.
    • Journal Title

      Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

      Volume: 1864 Pages: 763-765

    • DOI

      10.1016/j.bbalip.2019.02.005

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Group IID, IIE, IIF and III secreted phospholipase A2s.2019

    • Author(s)
      Murakami M, Miki Y, Sato H, Murase R, Taketomi Y, Yamamoto K.
    • Journal Title

      Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

      Volume: 1864 Pages: 803-818

    • DOI

      10.1016/j.bbalip.2018.08.014

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function2019

    • Author(s)
      Hirabayashi Tetsuya、Murakami Makoto、Kihara Akio
    • Journal Title

      Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

      Volume: 1864 Pages: 803-818

    • DOI

      10.1016/j.bbalip.2018.09.010

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling.2019

    • Author(s)
      Mori A, Hatano T, Inoshita T, Shiba-Fukushima K, Koinuma T, Meng H, Kubo SI, Spratt S, Cui C, Yamashita C, Miki Y, Yamamoto K, Hirabayashi T, Murakami M, Takahashi Y, Shindou H, Nonaka T, Hasegawa M, Okuzumi A, Imai Y, Hattori N.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 116(41) Pages: 20689-20699

    • DOI

      10.1073/pnas.1902958116

    • NAID

      120007132272

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The orphan nuclear receptor NR4A1 promotes FcepsilonRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.2019

    • Author(s)
      Jin F, Li X. Deng Y, Timilshina M. Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW
    • Journal Title

      Allergy

      Volume: 74 Pages: 1145-1156

    • DOI

      10.1111/all.13702

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 脂質メディエーターとイムノメタボリズム2019

    • Author(s)
      佐藤弘泰、村上誠
    • Journal Title

      The Lipid

      Volume: 30 (2) Pages: 61-71

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 脂質メディエーターが繋ぐ臓器連関と動的恒常性2019

    • Author(s)
      村上誠
    • Journal Title

      実験医学

      Volume: 37 (7) Pages: 149-155

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 脂質メディエーターとアレルギー2019

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      実験医学

      Volume: 37 (10) Pages: 88-95

    • Related Report
      2019 Annual Research Report
  • [Journal Article] ホスホリパーゼA2 による代謝と疾患の制御2019

    • Author(s)
      村上誠
    • Journal Title

      医学のあゆみ

      Volume: 269 (13) Pages: 1024-1028

    • Related Report
      2019 Annual Research Report
  • [Journal Article] リピドミクスから見えてきた酸化脂肪酸によるマスト細胞の制御機構2019

    • Author(s)
      嶋中雄太、村上誠
    • Journal Title

      医学のあゆみ

      Volume: 270 (5) Pages: 401-407

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Epithelial TRAF6 drives IL-17?mediated psoriatic inflammation2018

    • Author(s)
      Matsumoto Reiko、Dainichi Teruki、Tsuchiya Soken、Nomura Takashi、Kitoh Akihiko、Hayden Matthew S.、Ishii Ken J.、Tanaka Mayuri、Honda Tetsuya、Egawa Gyohei、Otsuka Atsushi、Nakajima Saeko、Sakurai Kenji、Nakano Yuri、Kobayashi Takashi、Sugimoto Yukihiko、Kabashima Kenji
    • Journal Title

      JCI Insight.

      Volume: 3 Pages: 1-14

    • DOI

      10.1172/jci.insight.121175

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preventive effect of <i>Dioscorea japonica</i> on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E<sub>2</sub> synthetic pathway2018

    • Author(s)
      Tsukayama I, Toda K, Takeda Y, Mega T, Tanaka M, Kawakami Y, Takahashi Y, Kimoto M, Yamamoto K, Miki Y, Murakami M, Suzuki-Yamamoto T.
    • Journal Title

      J. Clin. Biochem. Nutr.

      Volume: 62 Issue: 2 Pages: 139-147

    • DOI

      10.3164/jcbn.17-54

    • NAID

      130006407477

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phospholipase A2 in skin biology: New insights from gene-manipulatied mice and lipidomics2018

    • Author(s)
      Murakami M, Yamamoto K, Taketomi Y
    • Journal Title

      Inflammation and Regeneration

      Volume: 38 Pages: 31-31

    • DOI

      10.1186/s41232-018-0089-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] プロスタグランジンE2による炎症病態制御機構2018

    • Author(s)
      稲住知明, 杉本幸彦
    • Journal Title

      細胞.

      Volume: 50 Pages: 118-121

    • Related Report
      2018 Annual Research Report
  • [Journal Article] リポクオリティの違いに基づくプロスタノイドのがん疾患制御2018

    • Author(s)
      土屋創健, 杉本幸彦.
    • Journal Title

      実験医学

      Volume: 36 Pages: 1675-1680

    • Related Report
      2018 Annual Research Report
  • [Journal Article] プロスタグランジンE2による炎症,免疫調節機構.2018

    • Author(s)
      稲住知明, 杉本幸彦.
    • Journal Title

      臨床免疫・アレルギー科.

      Volume: 70 Pages: 216-220

    • Related Report
      2018 Annual Research Report
  • [Journal Article] プロスタノイド受容体を介した免疫・炎症応答亢進機構.2018

    • Author(s)
      土屋創健, 杉本幸彦
    • Journal Title

      炎症と免疫.

      Volume: 26 Pages: 375-379

    • Related Report
      2018 Annual Research Report
  • [Journal Article] ホスホリパーゼA2と代謝性疾患2018

    • Author(s)
      村上誠
    • Journal Title

      糖尿病学2018

      Volume: ー Pages: 56-65

    • Related Report
      2018 Annual Research Report
  • [Journal Article] ホスホリパーゼA2ファミリーによるリポクオリティ制御2018

    • Author(s)
      村上誠,佐藤弘泰,武富芳隆,平林哲也
    • Journal Title

      実験医学増刊

      Volume: 36 Pages: 53-60

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 脂質による皮膚バリア形成と疾患制御2018

    • Author(s)
      村上誠,木原章雄
    • Journal Title

      実験医学増刊

      Volume: 36 Pages: 1730-1737

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 脂質によるマスト細胞の制御とアレルギー2018

    • Author(s)
      村上誠,武富芳隆
    • Journal Title

      医学のあゆみ

      Volume: 265 Pages: 773-778

    • Related Report
      2018 Annual Research Report
  • [Journal Article] ホスホリパーゼA2ファミリーの多様性と生命応答における役割2018

    • Author(s)
      村上誠
    • Journal Title

      生化学

      Volume: 90 Pages: 348-360

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] sPLA2と炎症・免疫2018

    • Author(s)
      村上誠
    • Journal Title

      炎症と免疫

      Volume: 26 Pages: 362-367

    • Related Report
      2018 Annual Research Report
  • [Journal Article] ホスホリパーゼA2群による免疫制御2018

    • Author(s)
      村上誠
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 70 Pages: 193-199

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Cross-talk between prostaglandin and retinoic acid signaling.2018

    • Author(s)
      Inazumi, T., and Sugimoto, Y.
    • Journal Title

      Carotenoid Science

      Volume: 23

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ゼブラフィッシュにおけるプロスタグランジンシステム2018

    • Author(s)
      土屋創健、杉本幸彦
    • Journal Title

      生化学

      Volume: 89 Pages: 445-445

    • NAID

      40021265217

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プロスタグランジンE2による炎症病態制御機構2018

    • Author(s)
      稲住知明、杉本幸彦
    • Journal Title

      細胞

      Volume: 50 Pages: 118-121

    • Related Report
      2017 Annual Research Report
  • [Journal Article] リポクオリティの違いに基づくプロスタノイドのがん疾患制御2018

    • Author(s)
      土屋創健、杉本幸彦
    • Journal Title

      実験医学

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 脂質代謝と喘息2018

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      分子呼吸器病

      Volume: 22 Pages: 18-21

    • Related Report
      2017 Annual Research Report
  • [Journal Article] PLA2とアレルギー2018

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      アレルギー・免疫

      Volume: 25 Pages: 44-53

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 分泌性ホスホリパーゼA2と炎症性疾患2018

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      医学のあゆみ

      Volume: 264 Pages: 137-143

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts2017

    • Author(s)
      Kato Hikaru、Kai Aika、Kawabata Tetsuro、Sunderhaus James D.、McAfoos Timothy J.、Finefield Jennifer M.、Sugimoto Yukihiko、Williams Robert M.、Tsukamoto Sachiko
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Pages: 4975-4978

    • DOI

      10.1016/j.bmcl.2017.10.017

    • NAID

      120006897984

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways2017

    • Author(s)
      Aikawa Shizu、Kano Kuniyuki、Inoue Asuka、Wang Jiao、Saigusa Daisuke、Nagamatsu Takeshi、Hirota Yasushi、Fujii Tomoyuki、Tsuchiya Soken、Taketomi Yoshitaka、Sugimoto Yukihiko、Murakami Makoto、Arita Makoto、Kurano Makoto、Ikeda Hitoshi、Yatomi Yutaka、Chun Jerold、Aoki Junken
    • Journal Title

      EMBO Journal

      Volume: 36 Pages: 2146-2160

    • DOI

      10.15252/embj.201696290

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gαs.2017

    • Author(s)
      Yano A, Takahashi Y, Moriguchi H, Inazumi T, Koga T, Otaka A, Sugimoto Y.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

      Volume: 1862 Pages: 615-622

    • DOI

      10.1016/j.bbalip.2017.03.006

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gut microbiota promotes obesity-associated liver cancer throug PGE2-mediated suppression of antitumor immunity2017

    • Author(s)
      Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N
    • Journal Title

      Cancer Discovery

      Volume: in press Pages: 522-538

    • DOI

      10.1158/2159-8290.cd-16-0932

    • Description
      Epub ahead of print
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.2017

    • Author(s)
      Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Mu&ntilde;oz-Garcia A, Brash A, Ikeda K, Arita M, Akiyama M, Murakami M.
    • Journal Title

      Nat. Commun.

      Volume: 8 Pages: 14609-14609

    • DOI

      10.1038/ncomms14609

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phosphatidylethanolamine dynamics are required for osteoclast fusion.2017

    • Author(s)
      Irie, A., Yamamoto, K., Miki, Y., and Murakami, M.
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 46715-46715

    • DOI

      10.1038/srep46715

    • NAID

      120006534988

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Group III phospholipase A2 promotes colitis and colorectal cancer2017

    • Author(s)
      Murase R, Taketomi Y, Miki Y, Nishito Y, Saito M, Fukami K, Yamamoto K, Murakami M.
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 12261-12261

    • DOI

      10.1038/s41598-017-12434-z

    • NAID

      120006535021

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lipoquality control by phospholipase A<sub>2</sub> enzymes2017

    • Author(s)
      Makoto Murakami
    • Journal Title

      Proc. Jpn. Acad., Ser. B

      Volume: 93 Issue: 9 Pages: 677-702

    • DOI

      10.2183/pjab.93.043

    • NAID

      130006199317

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation2017

    • Author(s)
      Shimanaka Yuta、Kono Nozomu、Taketomi Yoshitaka、Arita Makoto、Okayama Yoshimichi、Tanaka Yuki、Nishito Yasumasa、Mochizuki Tatsuki、Kusuhara Hiroyuki、Adibekian Alexander、Cravatt Benjamin F、Murakami Makoto、Arai Hiroyuki
    • Journal Title

      Nat Med

      Volume: 23 Pages: 1287-1297

    • DOI

      10.1038/nm.4417

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 雌性生殖生理におけるプロスタグランジン受容体の役割2017

    • Author(s)
      杉本幸彦
    • Journal Title

      別冊BIO Clinica 慢性炎症と疾患

      Volume: 6 Pages: 16-21

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 皮膚バリア機能とアシルセラミド合成酵素2017

    • Author(s)
      平林哲也、村上誠
    • Journal Title

      BIO INDUSTRY

      Volume: 8 Pages: 9-17

    • Related Report
      2017 Annual Research Report
  • [Journal Article] リン脂質代謝酵素によるリポクオリティ制御と炎症・免疫2017

    • Author(s)
      村上誠、三木寿美、山本圭
    • Journal Title

      炎症と免疫

      Volume: 25 Pages: 28-35

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 脂質を基軸とした免疫調節2017

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      薬学雑誌

      Volume: 137 Pages: 503-515

    • NAID

      130005631393

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 生理活性脂質による自然免疫・アレルギーの制御2017

    • Author(s)
      武富芳隆、村上誠
    • Journal Title

      アレルギーの臨床

      Volume: 37 Pages: 58-62

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Secreted Phospholipase A2 Specificity on Natural Membrane Phospholipids2017

    • Author(s)
      Yamamoto K, Miki Y, Sato H, Murase R, Taketomi Y, Murakami M
    • Journal Title

      Methods in Enzymology

      Volume: 583 Pages: 101-117

    • DOI

      10.1016/bs.mie.2016.09.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostaglandin D2 elicits the reversible neurite retraction in hypothalamic cell line.2016

    • Author(s)
      Tsuchiya H, Hohjoh H, Fujiwara Y, Sugimoto Y, Koshimizu TA.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 470 Pages: 804-810

    • DOI

      10.1016/j.bbrc.2016.01.091

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior.2016

    • Author(s)
      Yabuki Y, Koide T, Miyasaka N, Wakisaka N, Masuda M, Ohkura M, Nakai J, Tsuge K, Tsuchiya S, Sugimoto Y, Yoshihara Y
    • Journal Title

      Nature Neurosci

      Volume: 19 Pages: 897-904

    • DOI

      10.1038/nn.4314

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.2016

    • Author(s)
      Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, Kobayashi T, Yamamoto T, Taketomi Y, Murakami M.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 291 Pages: 6895-6911

    • DOI

      10.1074/jbc.m116.715672

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer2016

    • Author(s)
      Miki Y, Kidoguchi Y, Sato M, Taketomi Y, Taya C, Muramatsu K, Gelb MH, Yamamoto K, Murakami M
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 291(30) Pages: 15588-15601

    • DOI

      10.1074/jbc.m116.734624

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Expression and Function of Group IIE Phospholipase A2 in Mouse Skin2016

    • Author(s)
      Yamamoto K, Miki Y, Sato H, Nishito Y, Gelb MH, Taketomi Y, Murakami M
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 291(30) Pages: 15602-13

    • DOI

      10.1074/jbc.m116.734657

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Roles of the Secreted Phospholipase A2 Gene Family in Immunology2016

    • Author(s)
      Murakami M, Yamamoto K, Miki Y, Murase R, Sato H, Taketomi Y
    • Journal Title

      Advances in Immunology

      Volume: 132 Pages: 91-134

    • DOI

      10.1016/bs.ai.2016.05.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] プロスタノイドクオリティと心血管系制御」血管医学2016

    • Author(s)
      告恭史郎、稲住知明、杉本幸彦
    • Journal Title

      血管医学

      Volume: 17(2) Pages: 37-43

    • Related Report
      2016 Annual Research Report
  • [Journal Article] プロスタノイド受容体を介した免疫・炎症応答亢進の分子機構2016

    • Author(s)
      告恭史郎、杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 256(5) Pages: 561-566

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior.2016

    • Author(s)
      Yabuki Y, Koide T, Miyasaki N, Wakisaka N, Masuda M, Ohkura M, Nakai J, Tsuge K, Tsuchiya S, Sugimoto Y, Yoshihara Y
    • Journal Title

      Nat Neurosci

      Volume: 19

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NecroX-5 suppresses IgE/Ag-stimulated anaphylaxis and mast cell activation by regulating the SHP-1-Syk signaling module2016

    • Author(s)
      Li X, Kwon O, Kim DY, Taketomi Y, Murakami M, Chang HW
    • Journal Title

      Allergy

      Volume: 71 Pages: 198-209

    • DOI

      10.1111/all.12786

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] プロスタノイド受容体を介した免疫・炎症応答亢進の分子機構2016

    • Author(s)
      告恭史郎, 杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 256(5) Pages: 561-566

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Roles of prostaglandin receptors in female reproduction.2015

    • Author(s)
      Sugimoto Y, Inazumi T, Tsuchiya S
    • Journal Title

      The Journal of Biochemistry

      Volume: 157 Pages: 73-80

    • DOI

      10.1093/jb/mvu081

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prostaglandin E2-induced inflammation: relevance of prostaglandin E receptors.2015

    • Author(s)
      Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1851 Pages: 414-421

    • DOI

      10.1016/j.bbalip.2014.07.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dermal Vγ4(+) γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8(+) T-Cell Activity through TNF-α Production.2015

    • Author(s)
      Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K.
    • Journal Title

      J. Invest. Dermatol.

      Volume: 135 Issue: 4 Pages: 1007-1015

    • DOI

      10.1038/jid.2014.516

    • NAID

      120005621945

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling that Drives Tumor Growth, Angiogenesis and Metastasis.2015

    • Author(s)
      Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C.
    • Journal Title

      J Biol Chem

      Volume: 290 Pages: 29781-29793

    • DOI

      10.1074/jbc.m115.669481

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A New Era of Secreted Phospholipase A2 (sPLA2).2015

    • Author(s)
      Murakami M, Sato H, Miki Y, Yamamoto K, Taketomi Y.
    • Journal Title

      J Lipid Res

      Volume: 印刷中 Pages: 1248-1261

    • DOI

      10.1194/jlr.r058123

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.2015

    • Author(s)
      Miyazaki, T., Taketomi, Y., Saito, Y., Hosono, T., Lei, X.F., Kim-Kaneyama, J.R., Arata, S., Takahashi, H., Murakami, M., and Miyazaki, A.
    • Journal Title

      Circ Res.

      Volume: 116 Pages: 1170-1181

    • DOI

      10.1161/circresaha.116.305363

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever2015

    • Author(s)
      Berry E, Hernandez-Anzaldo S, Ghomashchi F, Lehner R, Murakami M, Gelb MH, Kassiri Z, Wang X, Fernandez-Patron C
    • Journal Title

      J Am Heart Assoc

      Volume: 4

    • DOI

      10.1161/jaha.115.001868

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G32015

    • Author(s)
      Gijs HL, Willemarck N, Vanderhoydonc F, Khan NA, Dehairs J, Derua R, Waelkens E, Taketomi Y, Murakami M, Agostinis P, Annaert W, Swinnen JV
    • Journal Title

      Mol Biol Cell

      Volume: 26 Pages: 2321-2332

    • DOI

      10.1091/mbc.e14-10-1472

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phospholipase A2 group III and group X have opposing associations with prognosis in colorectal cancer2015

    • Author(s)
      Kazama S, Kitayama J, Hiyoshi M, Taketomi Y, Murakami M, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Yamaguchi H, Nozawa H, Ishihara S, Sunami E, Watanabe T
    • Journal Title

      Anticancer Res

      Volume: 35 Pages: 2983-2990

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical role of Phospholipase A2 group IID in age-related susceptibility to Severe Acute Respiratory Syndrome-CoV infection.2015

    • Author(s)
      Vijay, R., Hua, X., Meyerholz, D.K., Miki, Y., Yamamoto, K., Gelb, M.H., Murakami, M., and Perlman, S.
    • Journal Title

      J Exp Med

      Volume: 212 Pages: 1851-1868

    • DOI

      10.1084/jem.20150632

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of group IIF secreted phospholipase A2 in epidermal homeostasis and hyperplasia.2015

    • Author(s)
      Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi, R., Kambe, N., Kabashima, K., Lambeau, G., Gelb, M.H., and Murakami, M
    • Journal Title

      J Exp Med

      Volume: 212 Pages: 1901-19

    • DOI

      10.1084/jem.20141904

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] プロスタグランジンによる皮膚マスト細胞の成熟と活性化2015

    • Author(s)
      杉本幸彦
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 62-67

    • NAID

      40020330437

    • Related Report
      2015 Annual Research Report
  • [Journal Article] プロスタグランジンによる神経機能の調節機構2015

    • Author(s)
      杉本幸彦
    • Journal Title

      日薬理誌

      Volume: 145 Pages: 237-242

    • NAID

      130005067370

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 炎症反応におけるプロスタグランジンE2の役割2015

    • Author(s)
      岩崎亮, 北條寛典, 杉本幸彦
    • Journal Title

      細胞

      Volume: 47 Pages: 266-269

    • Related Report
      2015 Annual Research Report
  • [Journal Article] プロスタグランジンによる女性生殖制御の意義2015

    • Author(s)
      告恭史郎, 杉本幸彦
    • Journal Title

      実験医学

      Volume: 33(15) Pages: 164-169

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 急性炎症にかかわるプロスタグランジンとその働き2015

    • Author(s)
      杉本幸彦
    • Journal Title

      医学のあゆみ

      Volume: 254(12) Pages: 1091-1096

    • Related Report
      2015 Annual Research Report
  • [Journal Article] PLA2メタボロームによる疾患脂質代謝マップの創成と生活習慣病解析2015

    • Author(s)
      村上 誠
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 41 (5) Pages: 361-369

    • Related Report
      2015 Annual Research Report
  • [Journal Article] sPLA2と炎症2015

    • Author(s)
      武富芳隆, 村上 誠
    • Journal Title

      炎症と免疫

      Volume: 23 (6) Pages: 22-28

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ホスホリパーゼA2と循環器疾患2015

    • Author(s)
      久木山清貴, 村上 誠
    • Journal Title

      実験医学

      Volume: 33 (15) Pages: 80-84

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ホスホリパーゼA2と神経疾患2015

    • Author(s)
      平林哲也, 村上 誠
    • Journal Title

      実験医学

      Volume: 33 (15) Pages: 134-139

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ホスホリパーゼA2による代謝シグナル制御2015

    • Author(s)
      村上 誠
    • Journal Title

      BioClinica

      Volume: 30 (9) Pages: 33-38

    • Related Report
      2015 Annual Research Report
  • [Journal Article] アレルギーと脂質代謝2015

    • Author(s)
      武富芳隆、村上 誠
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 585-592

    • NAID

      40020505111

    • Related Report
      2015 Annual Research Report
  • [Journal Article] アレルギーを制御するsPLA2の役割2015

    • Author(s)
      村上 誠
    • Journal Title

      細胞

      Volume: 47 (6) Pages: 4-7

    • Related Report
      2015 Annual Research Report
  • [Presentation] プロスタグランジン受容体による脂質恒常性の調節機構2020

    • Author(s)
      稲住知明, 杉本幸彦
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 多価不飽和脂肪酸としてのω3脂肪酸摂取が雌性生殖と母性行動に与える影響2020

    • Author(s)
      橋本美穂, 大窪喜丸, 稲住知明, 杉本聡子, 土屋創健, 杉本幸彦
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リン脂質代謝異常と循環器疾患2020

    • Author(s)
      村上誠
    • Organizer
      第80回BLOOD VESSEL CLUB
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] リン脂質とエピゲノムを結ぶ新規脂質代謝酵素の解析2020

    • Author(s)
      原田沙夜可,佐藤弘康, 武富芳隆,曽我朋義, 相葉俊樹, 大迫誠一郎,村上誠
    • Organizer
      第23回日本栄養病態学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Roles of prostaglandin EP4 receptor axis in adipocytes: relevance of LipoQuality2019

    • Author(s)
      Sugimoto Y.
    • Organizer
      2nd International Conference on Lipoquality
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of multiple prostanoid receptors in embryo implantation and spacing2019

    • Author(s)
      Inazumi T, Okubo K, Xiaoyen Ma, Otsuka T, Hirai Y, Sugimoto T, Tsuchiya S, Takeo T, Nakagata N, Sugimoto Y.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of dietary omega-3 fatty acids on female reproduction and nursing behavior2019

    • Author(s)
      Hashimoto M, Okubo K, Inazumi T, Sugimoto T, Tsuchiya S, Yamashita A, Suhara Y, Arita M, Sugimoto Y.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ゼブラフィッシュ腎臓形成におけるプロスタグランジンの役割2019

    • Author(s)
      岩穴拓也, 告恭史郎, 岸本幸一朗, 岩崎亮, 稲住知明, 川原敦雄, 土屋創健, 杉本幸彦
    • Organizer
      第61回日本脂質生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高ω3脂肪酸含有食が母性行動に与える影響とその分子機構の解析2019

    • Author(s)
      橋本美穂, 大窪喜丸, 稲住知明, 杉本聡子, 土屋創健, 杉本幸彦
    • Organizer
      第18回次世代を担う若手ファーマ・バイオフォーラム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 子宮内膜症におけるプロスタグランジンE受容体機能の解析2019

    • Author(s)
      前田ひかる, 大窪喜丸, 橋本美穂, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第18回次世代を担う若手ファーマ・バイオフォーラム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 複数の受容体を介したプロスタグランジンの着床制御機構2019

    • Author(s)
      稲住知明, 大窪喜丸, 馬驍彦, 大塚友絵, 杉本聡子, 土屋創健, 竹尾透, 中潟直己, 杉本幸彦
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食事由来ω3脂肪酸含有食が雌性生殖と母性行動に与える影響2019

    • Author(s)
      橋本美穂, 大窪喜丸, 稲住知明, 杉本聡子, 土屋創健, 杉本幸彦
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 子宮内膜症におけるプロスタグランジンE受容体の役割2019

    • Author(s)
      前田ひかる, 大窪喜丸, 橋本美穂, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 複数のプロスタグランジン受容体による着床調節機構2019

    • Author(s)
      大塚友絵, 稲住知明, 大窪喜丸, 馬驍彦, 杉本聡子, 土屋創健, 廣田泰, 竹尾透, 中潟直己, 杉本幸彦
    • Organizer
      第36回日本薬学会九州支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] プロスタグランジンI2受容体によるマスト細胞の炎症応答の制御機構2019

    • Author(s)
      佐々木諒也, 中尾優子, 村上里穂, 宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第36回日本薬学会九州支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification of a novel metabolic pathway that links phospholipids to methionine metabolism2019

    • Author(s)
      川口舞, 平林哲也, 村上誠
    • Organizer
      第19回東京大学生命科学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脂質とアレルギー疾患2019

    • Author(s)
      村上誠
    • Organizer
      第68回日本アレルギー学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] LipoQuality regulation by the phospholipase A2 family2019

    • Author(s)
      Murakami M.
    • Organizer
      2nd International Conference on Lipoquality
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Group IIF phospholipase A2/lysoplasmalogen axis is a novel drug target for epidermal-hyperplasic disease2019

    • Author(s)
      Yamamoto K, Hakoi H, Miki Y, Murakami M.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of arachidonate 5-lipoxygenase and improvement in psoriasis by red rice proanthocyanidin2019

    • Author(s)
      Toda K, Nagasaki Y, Tsukayama I, Tamenobu A, Konoike Y, Ganeko N, Ito H, Kawakami Y, Takahashi Y, Miki Y, Yamamoto K, Murakami M, Suzuki-Yamamoto T.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exosome could be the source of lipid mediator in cancer platform2019

    • Author(s)
      Kudou K, Miki Y, Higuchi H, Yamamoto K, Murakami M, Kotani A.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Group III phospholipase A2 promotes atherosclerosis2019

    • Author(s)
      Taketomi Y, Miyazaki T, Sato H, Miki Y, Murakami M.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Group IID phospholipase A2 promotes browning of white adipose tissue and limits diet-induced obesity2019

    • Author(s)
      Sato H, Taketomi Y, Miki Y, Yamamoto K, Makoto Murakami
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distinct Roles of phospholipase A2s in colitis and colonic cancer2019

    • Author(s)
      Murase R, Taketomi Y, Miki Y, Yamamoto K, Murakami M.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Group IIA phospholipase A2 regulates gut microbiome2019

    • Author(s)
      Miki Y, Taketomi Y, Yamamoto K, Hosomi K, Kunisawa J, Siddabasave GB, Ikeda K, Arita M, Murakami M.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Group IVE phospholipase A2 (cPLA2ε) mobilizes the non-canonical lipid mediator N-acylethanolamine in mouse skin2019

    • Author(s)
      Liang L, Heike K, Kobayashi T, Hirabayashi T, Miki Y, Yamamoto K, Taketomi Y, Murakami M.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phosphatidylcholine catabolism mediated by PNPLA8 and PNPLA7 has an important role in supplying methyl groups in the liver2019

    • Author(s)
      Kawaguchi M, Hirabayashi T, Murakami M.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The lysophospholipase PNPLA7 is induced by methionine depletion and is linked to epigenetic regulation2019

    • Author(s)
      Harada S, Taketomi Y, Kawaguchi M, Hirabayashi T, Murakami M.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PLA2G3-driven lysophospholipid pathway protects against allergic asthma2019

    • Author(s)
      Takagi K, Taketomi Y, Tanoue A, Matsuyama T, Sakaue K, Machida K, Murakami M, Inoue H.
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IIF型分泌性ホスホリパーゼA2/リゾプラズマローゲン経路は表皮肥厚性疾患の新規創薬ターゲットである2019

    • Author(s)
      山本圭, 箱井春香, 三木寿美, 村上誠
    • Organizer
      第61回日本脂質生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] PNPLA8、PNPLA7を介した内因性コリン産生経路は肝臓のメチル基供給に寄与する2019

    • Author(s)
      川口舞, 平林哲也, 笠原浩二, 村上誠
    • Organizer
      第61回日本脂質生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] PLA2分子群と皮膚疾患2019

    • Author(s)
      村上誠
    • Organizer
      第61回日本脂質生化学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] PLA2と炎症・再生2019

    • Author(s)
      村上誠
    • Organizer
      第40回日本炎症・再生医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] sPLA2ファミリーと代謝疾患2019

    • Author(s)
      村上誠
    • Organizer
      第40回日本炎症・再生医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Phospholipid metabolism and lipid mediators in health and diseases2019

    • Author(s)
      Murakami M.
    • Organizer
      Asia Pacific Society for Biology and Medical Sciences (APSBMS) 2019 Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] PLA2分子ファミリーによるリポクオリティ調節と疾患制御2019

    • Author(s)
      村上誠
    • Organizer
      第17回レドックス・ライフイノベーションシンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] リゾホスホリパーゼPNPLA7はメチオニン欠乏により誘導されエピゲノム制御に関わる2019

    • Author(s)
      原田沙夜可,武富芳隆,川口舞,平林哲也,大迫誠一郎,村上誠
    • Organizer
      フォーラム2019衛生薬学・環境トキシコロジー
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脂肪細胞のベージュ化に関わる2種類のThermogenic sPLA2sの同定2019

    • Author(s)
      佐藤弘泰, 武富芳隆, 三木寿美, 村上誠
    • Organizer
      第91回日本生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 皮膚における新規細胞質型ホスホリパーゼA2(cPLA2δ, cPLA2ε)の機能解析2019

    • Author(s)
      梁陸伊韻, 三木寿美, 平林哲也, 平家圭奈子, 小林哲幸, 山本圭, 武富芳隆, 高宮里奈, 村上誠
    • Organizer
      第91回日本生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 乾癬におけるXIIA型ホスホリパーゼA2(sPLA2-XIIA)の役割2019

    • Author(s)
      望月茅可, 高宮里奈, 杉本奈央, 三木寿美, 武富芳隆, 村上誠
    • Organizer
      第91回日本生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒトとウシの乳汁中脂質プロファイル解析2019

    • Author(s)
      長崎祐樹, 川井恵梨佳, 田中充樹, 戸田圭祐, 津嘉山泉, 川上祐生, 高橋吉孝, 岡_愉加, 三木寿美, 山本圭, 村上誠, 山本登志子
    • Organizer
      第91回日本生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ホスホリパーゼA2を起点としたリゾリン脂質経路とアレルギー2019

    • Author(s)
      武富芳隆, 村上誠
    • Organizer
      第91回日本生化学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] PLA2ファミリーによる代謝調節2019

    • Author(s)
      村上誠
    • Organizer
      第91回日本生化学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] アシルセラミド代謝を介した皮膚バリア形成機構2019

    • Author(s)
      平林哲也, 武市拓也, 笠原浩二, Alan R. Brash, 村上誠, 秋_真志
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] プロスタグランジンI2は、マスト細胞の障害性炎症応答を抑制する2019

    • Author(s)
      中尾優子, 村上里穂, 宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 成宮周, 杉本幸彦
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胎盤形成期におけるプロスタグランジンの機能解析2019

    • Author(s)
      坂本理紗, 稲住知明, 藤原拓司, 河野佑子, 土屋創健, 杉本幸彦,
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PNPLAファミリーによる膜リン脂質分解経路の破綻は肝臓の機能異常を導く2019

    • Author(s)
      村上誠
    • Organizer
      第129回日本薬学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] プロスタノイドクオリティによる生体制御2018

    • Author(s)
      杉本幸彦
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] マスト細胞炎症性応答に対するプロスタサイクリンIP受容体の役割2018

    • Author(s)
      村上里穂, 中尾優子,宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 成宮周, 杉本幸彦,
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マスト細胞のIL-33誘導性サイトカイン産生に対するPGI2-IP受容体シグナルの抑制機構2018

    • Author(s)
      中尾優子, 村上里穂, 宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 成宮周, 杉本幸彦
    • Organizer
      平成30年度日本生化学会九州支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Stimulation and modulation of inflammatory mast cell responses by prostaglandin receptors2018

    • Author(s)
      Yukihiko Sugimoto
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology (WCP2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マスト細胞炎症性応答におけるプロスタサイクリンIP受容体の役割2018

    • Author(s)
      村上里穂, 中尾優子,宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 成宮周, 杉本幸彦
    • Organizer
      第17回次世代を担う若手ファーマ・バイオフォーラム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Stimulation and modulation of inflammatory mast cell responses by prostaglandin receptors2018

    • Author(s)
      Yukihiko Sugimoto
    • Organizer
      7th European Workshop on Lipid Mediators
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 初期発生におけるプロスタグランジンの役割,2018

    • Author(s)
      土屋創健, 杉本幸彦
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジンEP4受容体は生理的な脂肪細胞機能を調節する2018

    • Author(s)
      稲住知明, 山田清隆, 土屋創健, 猿渡淳二,成宮周,杉本幸彦
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] プロスタグランジンとその受容体による脂質代謝の恒常性調節2018

    • Author(s)
      杉本幸彦
    • Organizer
      第40回生体膜と薬物の相互作用シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジンEP4受容体による脂肪細胞機能の調節機構2018

    • Author(s)
      稲住知明, 山田清隆, 土屋創健, 猿渡淳二, 成宮周, 杉本幸彦
    • Organizer
      第40回生体膜と薬物の相互作用シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 子宮内膜症に関与するプロスタグランジンE受容体の解析2018

    • Author(s)
      前田ひかる, 大窪喜丸, 橋本美穂, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第40回生体膜と薬物の相互作用シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス視索前野神経の突起伸長に対するプロスタグランジンE2-EP4受容体の役割2018

    • Author(s)
      衛藤勝喜, 北條寛典, 吉岡美樹, 土屋裕義, 稲住知明, 土屋創健, 杉本幸彦.
    • Organizer
      第35回日本薬学会九州支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] III型分泌性ホスホリパーゼA2は動脈硬化の新規増悪因子であるる腸管恒常性維持機構の解析2018

    • Author(s)
      武富芳隆, 佐藤弘泰, 宮崎拓郎, 三木寿美, 山崎文義, 瀬藤光利, 村上誠
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 白色脂肪細胞のベージュ化に関わるThermogenic sPLA2の同定2018

    • Author(s)
      佐藤弘泰, 武富芳隆, 三木寿美, 村上誠
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞内II型PAFアセチルハイドロラーゼによる新規脂肪酸メディエーター産生機構2018

    • Author(s)
      嶋中雄太, 河野望, 村上誠, 新井洋由
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Lipoquality control by the phospholipase A2 family in the skin2018

    • Author(s)
      Murakami M
    • Organizer
      Tokyo 2018 Cell and Developmental Biology Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リン脂質代謝酵素による炎症・再生の制御2018

    • Author(s)
      村上誠
    • Organizer
      第39回日本炎症再生医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞外リン脂質代謝酵素(sPLA2)と動脈硬化2018

    • Author(s)
      村上誠
    • Organizer
      第50回日本動脈硬化学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 代謝調節におけるホスホリパーゼの役割2018

    • Author(s)
      村上誠
    • Organizer
      The 5th Diabetes Research Innovation Symposium,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Long-lasting sPLA2 research with Mike Gelb2018

    • Author(s)
      Murakami M
    • Organizer
      Gelb Research Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脂質によるアレルギー制御の新機軸質代謝系の網羅的解析2018

    • Author(s)
      村上誠
    • Organizer
      城南サマーセミナー2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Phosphatidylcholine catabolism by PNPLA7 provides a source of hepatic methyl groups and controls energy homeostasis2018

    • Author(s)
      Hirabayashi T, Murakami M
    • Organizer
      The 59th International Conference on the Bioscience of Lipids
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] w3 Fatty acid epoxides are autocrine mediators that control the magniture of IgE-mediated mast cell activation2018

    • Author(s)
      Shimanaka Y, Kono N, Murakami M, Arai H.
    • Organizer
      The 59th International Conference on the Bioscience of Lipids,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phosphatidylcholine catabolism mediated by PNPLAs plays an important role in liver function and energy homeostasis2018

    • Author(s)
      Hirabayashi T, Murakami M
    • Organizer
      The 2nd Japan-Korea Lipid Joint Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脂質によるアレルギー制御の新機軸2018

    • Author(s)
      村上誠
    • Organizer
      アレルギー・好酸球研究会2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ホスホリパーゼA2ファミリーによる健康と疾病の制御2018

    • Author(s)
      武富芳隆, 村上誠
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] IIA型ホスホリパーゼA2は腸内細菌叢を制御する2018

    • Author(s)
      三木寿美, 武富芳隆, 山本圭, 細見晃司, 國澤純, Siddabasavegowda Bommegowda, 有田誠, 村上誠
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PNPLA8とPNPLA7によるホスファチジルコリンの分解は肝臓のメチル基供給に重要である2018

    • Author(s)
      川口舞, 平林哲也, 村上誠
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] エポキシ化ω3脂肪酸はIgE依存的なマスト細胞の活性化を制御するオートクリンメディエーターである2018

    • Author(s)
      嶋中雄太, 河野望, 村上誠, 新井洋由
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Phospholipid metabolism in healthy and maladaptive aging2018

    • Author(s)
      Murakami M
    • Organizer
      The 2nd Stockholm-Tokyo Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生命応答における脂質の新機能:リン脂質代謝酵素群の網羅的ノックアウトからわかったこと2018

    • Author(s)
      村上誠
    • Organizer
      千里ライフサイエンスセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脂質代謝とアレルギー疾患2018

    • Author(s)
      村上誠
    • Organizer
      第5回総合アレルギー講習会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Updating the PLA2 knockout studies: immunity, metabolic diseases, and beyond.2018

    • Author(s)
      Makoto Murakami
    • Organizer
      Bioactive Lipids Conference. 2018 (BIPLIP2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 着床ならびに胎児のスペーシングにおけるプロスタグランジンの役割2017

    • Author(s)
      大窪喜丸,馬驍彦,稲住知明,杉本聡子,土屋創健,竹尾透,中潟直己,成宮周,杉本幸彦.
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] マスト細胞の炎症性応答に対するプロスタサイクリン受容体IPの抑制機構2017

    • Author(s)
      宮本卓馬,鈴木佑治,渡辺真由帆,森本和志,村上里穂,稲住知明,土屋創健,成宮周,○杉本幸彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] オス特異的神経回路形成におけるPGE2-EP受容体の役割2017

    • Author(s)
      北條寛典,吉岡美樹,平川昌樹,土屋裕義,土屋創健,瀬木-西田恵里,杉本幸彦
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脂質代謝におけるプロスタグランジンEP4受容体の生理機能解析2017

    • Author(s)
      稲住知明,山田清隆,土屋創健,成宮周,杉本幸彦
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] プロスタグランジンEP4受容体による脂質代謝調節機構2017

    • Author(s)
      杉本幸彦
    • Organizer
      第90回日本内分泌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 旧くて新しいプロスタグランジンの生理機能2017

    • Author(s)
      杉本幸彦
    • Organizer
      第41回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジン受容体による生理と病態の調節機構2017

    • Author(s)
      杉本幸彦
    • Organizer
      第31回カロテノイド研究談話会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Prostaglandin E2 regulates physiological lipid storage status2017

    • Author(s)
      Yukihiko Sugimoto
    • Organizer
      15th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of adipocyte functions by the prostaglandin EP4 receptor -Lipid regulates the lipid storage balance-2017

    • Author(s)
      Yukihiko Sugimoto
    • Organizer
      The 1st International Conference on Lipoquality
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 雌性生殖生理におけるプロスタグランジンの役割2017

    • Author(s)
      杉本幸彦
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] PLA2ファミリーによる皮膚のリポクオリティ制御2017

    • Author(s)
      村上誠
    • Organizer
      第42回日本医用マススペクトル学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 脂質代謝酵素PLA2ファミリーによるリポクオリティ制御の新機軸2017

    • Author(s)
      村上誠
    • Organizer
      第55回日本生物物理学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] New aspects of lipoquality control by the phospholipase A2 family2017

    • Author(s)
      Makoto Murakami
    • Organizer
      International Conference on Lipoquality
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Lipoquality control by the phospholipase A2 family in the skin.2017

    • Author(s)
      Makoto Murakami
    • Organizer
      The 15th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ホスホリパーゼA2分子群と生殖2017

    • Author(s)
      村上誠, 佐藤弘泰, 武富芳隆
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュ初期発生におけるプロスタグランジンI2受容体IPの生理的意義の探索2016

    • Author(s)
      岸本幸一朗,告恭史郎,岩崎亮,川原敦雄,稲住知明,土屋創健,杉本幸彦
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学(鹿児島県・鹿児島市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] プロスタグランジン受容体のGタンパク質ならびにβ-arrestinシグナル検出系の確立とバイアス型作動薬の探索2016

    • Author(s)
      沼田さおり,告恭史郎,江口幸臣,松永拓子,北條寛典,杉本聡子,稲住知明,土屋創健,杉本幸彦
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学(鹿児島県・鹿児島市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高ω3脂肪酸含有食が雌マウスの生殖生理・養育行動に与える影響2016

    • Author(s)
      橋本美穂,大窪喜丸,稲住知明,杉本聡子,土屋創健,杉本幸彦
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学(鹿児島県・鹿児島市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] プロスタサイクリンIP受容体がマスト細胞炎症性応答に与える影響2016

    • Author(s)
      村上里穂,宮本卓馬,鈴木佑治,渡辺真由帆,森本和志,稲住知明,土屋創健,成宮周,杉本幸彦
    • Organizer
      第33回日本薬学会九州支部大会
    • Place of Presentation
      鹿児島大学(鹿児島県・鹿児島市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 皮膚の恒常性と疾患における脂質代謝の新機軸2016

    • Author(s)
      村上誠
    • Organizer
      日本皮膚科学会大阪地方会
    • Place of Presentation
      大阪科学技術センター(大阪府・大阪市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] A unique plasmalogen pathway driven by secreted phospholipase A2 regulates skin homeostasis and disease2016

    • Author(s)
      Murakami, M., Yamamoto, K
    • Organizer
      The 1st Plasmalogen Symposium
    • Place of Presentation
      九州大学(福岡県福岡市)
    • Year and Date
      2016-11-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] PGE2-EP3 receptor signaling induces inflammatory swelling by mast cell activation2016

    • Author(s)
      Sugimoto Y
    • Organizer
      PSK-PSJ joint-international symposium in 2016
    • Place of Presentation
      The K Hotel (Seoul, Korea)
    • Year and Date
      2016-10-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] プロスタグランジンE受容体による脳のオス化の分子機構2016

    • Author(s)
      北條寛典,吉岡美樹,平川昌樹,土屋裕義,土屋創健,三隅将吾,瀬木-西田恵里,杉本幸彦
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] ゼブラフィッシュ初期発生におけるプロスタグランジンI2受容体IPの役割2016

    • Author(s)
      岸本幸一朗,告恭史郎,岩崎亮,川原敦雄,稲住知明,土屋創健,杉本幸彦
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] プロスタグランジンEP4受容体を介した脂質代謝調節機構2016

    • Author(s)
      山田清隆,稲住 知明,土屋創健,杉本幸彦
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] sPLA2と慢性炎症2016

    • Author(s)
      村上誠
    • Organizer
      第89回日本生化学会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュ初期胚血管形成におけるプロスタノイドの役割2016

    • Author(s)
      岩崎亮,告恭史郎,岸本幸一朗,川原敦雄,稲住知明,土屋創健,杉本幸彦
    • Organizer
      第15回次世代を担う若手ファーマ・バイオフォーラム
    • Place of Presentation
      大阪大学(大阪府・吹田市)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 着床時子宮におけるプロスタグランジン受容体の役割2016

    • Author(s)
      大窪喜丸,馬驍彦,稲住知明,杉本聡子,土屋創健,竹尾透,中潟直己,成宮周,杉本幸彦
    • Organizer
      第15回次世代を担う若手ファーマ・バイオフォーラム
    • Place of Presentation
      大阪大学(大阪府・吹田市)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] マスト細胞の炎症性応答に対するプロスタサイクリン受容体IPの役割2016

    • Author(s)
      宮本卓馬,鈴木佑治,渡辺真由帆,森本和志,土屋創健,成宮周,杉本幸彦
    • Organizer
      第15回次世代を担う若手ファーマ・バイオフォーラム
    • Place of Presentation
      大阪大学(大阪府・吹田市)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 「あぶら」に秘められた生命応答制御の新しい仕組み2016

    • Author(s)
      村上誠
    • Organizer
      フォーラム2016衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学(東京都・品川区)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 着床時子宮におけるプロスタグランジン受容体の役割2016

    • Author(s)
      大窪喜丸,馬驍彦,稲住知明,杉本聡子,土屋創健,竹尾透,中潟直己,成宮周,杉本幸彦
    • Organizer
      第58回日本脂質生化学会
    • Place of Presentation
      秋田市にぎわい交流館AU(秋田県・秋田市)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Olfactory receptor for prostaglandin F2a mediates courtship behavior of male zebrafish2016

    • Author(s)
      Yabuki Y, Koide T, Miyasaka N, Wakisaka N, Masuda M, Ohkura M, Nakai J, Tsuge K, Tsuchiya S, Sugimoto Y, Yoshihara Y
    • Organizer
      第17回嗅覚・味覚国際シンポジウム
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel roles of the phospholipase A2 family in metabolic regulation2016

    • Author(s)
      Murakami, M
    • Organizer
      The 7th International Conference on Phospholipase A2 and Lipid Mediators(PLM2016)
    • Place of Presentation
      Scripps Seaside Forum (San Diego, USA)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Roles of prostaglandin EP4 receptor in adipose tissue2016

    • Author(s)
      Sugimoto Y, Inazumi T, Tsuchiya S, Narumiya S
    • Organizer
      The 7th International conference on phospholipase A2 and Lipid Mediators (PLM2016)
    • Place of Presentation
      Scripps Seaside Forum (San Diego, USA)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プロスタノイドIP受容体によるマスト細胞の炎症性応答の抑制機構2016

    • Author(s)
      宮本卓馬,鈴木佑治,渡辺真由帆,森本和志,土屋創健,成宮周,杉本幸彦
    • Organizer
      日本生化学会九州支部例会
    • Place of Presentation
      鹿児島大学(鹿児島県・鹿児島市)
    • Year and Date
      2016-05-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗体を用いたプロスタグランジン受容体のX線結晶構造解析2016

    • Author(s)
      豊田洋輔,森本和志,寿野良二,関口雄介,山下恵太郎,平田邦夫,安田賢司,白石充典,堀田韻虹,浅田秀基,中根崇智,椎村祐樹,中北智哉,稲住知明,告恭史郎,梶原佑太,清水朋子,漆畑祐司,吉田 優,栗原ともこ,細谷孝充,木下正弘,杉本幸彦,野村紀通,村田武士,高山喜好,山本雅貴,成宮 周,岩田 想,小林拓也
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      日本科学未来館(東京都・江東区)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 初期発生の血管形成におけるゼブラフィッシュ・プロスタノイド受容体の役割2016

    • Author(s)
      岩崎亮, 告恭史郎, 岸本幸一朗, 川原敦雄, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] IL-33によるマスト細胞の炎症性サイトカイン産生におけるプロスタサイクリン受容体IPの役割2016

    • Author(s)
      宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 成宮周, 杉本幸彦
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脂質メディエーターと免疫制御2016

    • Author(s)
      武富芳隆, 村上誠
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 脂質代謝の新しいパラダイム2016

    • Author(s)
      村上誠
    • Organizer
      脂質代謝の基礎と臨床研究会
    • Place of Presentation
      新潟
    • Year and Date
      2016-03-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 旧くて新しいプロスタグランジンの生理機能2016

    • Author(s)
      杉本幸彦
    • Organizer
      第165回東京脂質談話会
    • Place of Presentation
      東京
    • Year and Date
      2016-01-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 皮膚疾患における脂質代謝の新機軸2016

    • Author(s)
      村上誠
    • Organizer
      千葉アレルギークリニカルカンファレンス
    • Place of Presentation
      千葉
    • Year and Date
      2016-01-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 初期発生におけるプロスタグランジン受容体の新規機能:モデル生物としてゼブラフィッシュを用いた解析から2015

    • Author(s)
      土屋創健, 岩崎亮, 告恭史郎, 杉本幸彦
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] プロスタグランジンEP4受容体による脂肪細胞機能の調節2015

    • Author(s)
      稲住知明, 土屋創健, 猿渡淳二, 中川和子, 成宮周, 杉本幸彦
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] プロスタグランジンは複数の受容体を介して着床に必須の役割を果たす2015

    • Author(s)
      大窪喜丸, 馬驍彦, 稲住知明, 杉本聡子, 土屋創健, 堀越裕佳, 竹尾透, 中潟直己, 成宮周, 杉本幸彦
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] IL-33誘導性マスト細胞応答におけるプロスタサイクリン受容体IPの役割2015

    • Author(s)
      宮本卓馬, 鈴木佑治, 渡辺真由帆, 森本和志, 土屋創健, 成宮周, 杉本幸彦
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lipoquality regulation by the phospholipase A2 family2015

    • Author(s)
      Murakami M
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] リゾホスファチジン酸はマスト細胞の成熟に関わる2015

    • Author(s)
      武富芳隆, 可野邦行, 青木淳賢, 村上誠
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] ホスファチジルエタノールアミンは破骨細胞融合に関与する2015

    • Author(s)
      入江敦, 山本圭, 村上誠
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] PNPLA7を介した肝臓におけるコリン代謝経路の役割2015

    • Author(s)
      平林哲也, 毛利美紗, 平家圭奈子, 三田村涼美, 池田和貴, 中田理恵子, 北芳博, 村上誠
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] XIIA型分泌性ホスホリパーゼA2はIgE依存的な即時型アレルギーを増強する2015

    • Author(s)
      砂川アンナ, 武富芳隆, 佐藤弘泰, 小林哲幸, 村上誠
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 癌病態におけるIID型分泌性ホスホリパーゼA2の役割2015

    • Author(s)
      城戸口優, 山本圭, 三木寿美, 村上誠
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] III型分泌性ホスホリパーゼA2は大腸癌の進展に関わる2015

    • Author(s)
      斎藤萌, 村瀬礼美, 武富芳隆, 村上誠
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 皮膚バリア機能に重要なセラミド代謝経路におけるPNPLA1の役割2015

    • Author(s)
      金子亜里紗, 安城樹, 平林哲也, 妹尾勇弥, 柴田章貴, 直江綾乃, 石川准子, 池田和貴, 有田誠, 谷佳津子, 秋山真志, 村上誠
    • Organizer
      第88回日本生化学会大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Towards structure determination of the human prostanoid receptor bound to the antibody2015

    • Author(s)
      Toyoda Y, Morimoto K, Suno R, Sekiguchi Y, Yamashita K, Hirata K, Yasuda S, Asada H, Nakane T, Shiimura Y, Nakagita T, Inazumi T, Tsuge K, Kajiwara Y, Shimizu T, Urushibata Y, Yoshida S, Kuribara T, Hosoya T, Kinoshita M, Sugimoto Y, Nomura N, Murata T,Takayama K,Yamamoto M, Narumiya S, Iwata S, Kobayashi T
    • Organizer
      GPCR Workshop 2015
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ゼブラフィッシュ初期発生におけるプロスタグランジンI2受容体の機能探索2015

    • Author(s)
      岸本幸一朗, 告恭史郎, 岩崎亮, 川原敦雄, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第32回日本薬学会九州支部大会
    • Place of Presentation
      延岡
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] オス特有の脳構造構築におけるプロスタグランジンE2-EP4受容体の役割2015

    • Author(s)
      平川昌樹, 北條寛典, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第32回日本薬学会九州支部大会
    • Place of Presentation
      延岡
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 第一世代の脂質メディエーター・プロスタグランジンの生理病態作用2015

    • Author(s)
      杉本幸彦
    • Organizer
      第37回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 食道扁平上皮癌におけるプロスタノイドの機能解明2015

    • Author(s)
      小野明日香, 土屋創健, 杉本幸彦
    • Organizer
      第37回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 着床に関与するプロスタグランジン受容体の解析2015

    • Author(s)
      大窪喜丸, 馬驍彦, 橋本美穂, 稲住知明, 杉本聡子, 土屋創健, 堀越裕佳, 竹尾透, 中潟直己, 杉本幸彦
    • Organizer
      第37回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] プロスタグランジンI2によるマスト細胞応答の制御2015

    • Author(s)
      宮本卓馬, 鈴木佑治, 村上里穂, 渡辺真由帆, 森本和志, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第37回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] ホスホリパーゼA2分子群による大腸炎の制御2015

    • Author(s)
      村瀬礼美, 武富芳隆, 佐藤弘泰, 山本圭, 山元俊憲, 村上誠
    • Organizer
      第37回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Immune regulation by the sPLA2-driven lipid pathways in allergy2015

    • Author(s)
      Murakami M
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 脂質による免疫制御の新機軸2015

    • Author(s)
      村上誠
    • Organizer
      東京呼吸器フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジンE2による皮膚炎症惹起の分子機構2015

    • Author(s)
      杉本幸彦
    • Organizer
      第19回日本ヒスタミン学会
    • Place of Presentation
      仙台
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アシルセラミド生合成と皮膚バリア機能におけるPNPLA1の役割2015

    • Author(s)
      平林哲也, 安城樹, 妹尾勇弥, 池田和貴, 直江綾乃, 石川准子, 有田誠, 秋山真志, 村上誠
    • Organizer
      第8回セラミド研究会
    • Place of Presentation
      北海道
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] プロスタグランジンの炎症作用:生理と病態を繋ぐもの2015

    • Author(s)
      杉本幸彦
    • Organizer
      第22回日本血液代替物学会年次大会
    • Place of Presentation
      熊本
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Prostaglandin E2 contributes lipid homeostasis in adipose tissue2015

    • Author(s)
      Inazumi T, Tsuchiya S, Narumiya S, Sugimoto Y
    • Organizer
      International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)
    • Place of Presentation
      Kumamoto
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prostanoid receptor signaling is involved in vasculogenesis during early developmental stage of zebrafish2015

    • Author(s)
      Iwasaki R, Tsuge K, Inazumi T, Kawahara A, Tsuchiya S, Sugimoto Y
    • Organizer
      International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)
    • Place of Presentation
      Kumamoto
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ゼブラフィッシュにおけるプロスタノイド受容体の機能解析2015

    • Author(s)
      告恭史郎, 岩崎亮, 岸本幸一朗, 川原敦雄, 稲住知明, 土屋創健, 杉本幸彦
    • Organizer
      第14回次世代を担う若手ファーマ・バイオフォーラム2015
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] ホスホリパーゼA2分子ファミリーを起点とした脂質代謝の新しいパラダイム2015

    • Author(s)
      村上誠
    • Organizer
      第27回高遠シンポジウム
    • Place of Presentation
      比叡山
    • Year and Date
      2015-08-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ホスホリパーゼA2分子群を起点とした脂質代謝経路による大腸炎の制御2015

    • Author(s)
      村瀬礼美, 武富芳隆, 佐藤弘泰, 山本圭, 山元俊憲, 村上誠
    • Organizer
      第27回高遠シンポジウム
    • Place of Presentation
      比叡山
    • Year and Date
      2015-08-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] PNPLA7-mediated production of glycerophosphocholine from lysophoshatidylcholine has a pivotal role in hepatic choline metabolism and systemic energy homeostasis2015

    • Author(s)
      Hirabayashi T, Mouri M, Shimamura T, Ikeda K, Nakata R, Murakami M
    • Organizer
      FASEB Summer Research Conference on Lysophospholipids and Related Mediators
    • Place of Presentation
      Banff, Canada
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of prostaglandin E2 in acute inflammation of skin2015

    • Author(s)
      Sugimoto Y, Tsuchiya S, Inazumi T, Narumiya S
    • Organizer
      The 14th International conference on Bioactive Lipids in cancer, inflammation and related diseases
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prostanoid receptor signaling is involved in vasculogenesis during early development of zebrafish2015

    • Author(s)
      Iwasaki R, Tsuge K, Inazumi T, Kawahara A, Tsuchiya S, Sugimoto Y
    • Organizer
      The 14th International conference on Bioactive Lipids in cancer, inflammation and related diseases
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] sPLA2 in health and disease2015

    • Author(s)
      Murakami M
    • Organizer
      The 14th International conference on Bioactive Lipids in cancer, inflammation and related diseases
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Plasmalogen-lysophosphatidylethanolamine driven by group IIF sPLA2 underlies epidermal-hyperplasic disorders2015

    • Author(s)
      Yamamoto K, Miki Y, Taketomi Y, Kambe N, Kabashima K, Lambeau G, Gelb MH, Murakami M
    • Organizer
      The 14th International conference on Bioactive Lipids in cancer, inflammation and related diseases
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Group X sPLA2 mobilizes ω3 polyunsaturated fatty acid metabolites to protect from colitis2015

    • Author(s)
      Murase R, Taketomi Y, Sato H, Yamamoto K, Yamamoto T, Murakami M
    • Organizer
      The 14th International conference on Bioactive Lipids in cancer, inflammation and related diseases
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Skin abnormalities in group III secreted phospholipase A2-deficient mice2015

    • Author(s)
      Taketomi Y, Endo Y, Yamamoto K, Kobayashi T, Murakami M
    • Organizer
      The 14th International conference on Bioactive Lipids in cancer, inflammation and related diseases
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phospholipase A2-driven lipid networks in atherosclerosis and metabolic disease2015

    • Author(s)
      Murakami M, Sato H, Taketomi Y
    • Organizer
      第47回日本動脈硬化学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] エリオット生化学分子生物学第5版2016

    • Author(s)
      村上誠、原俊太郎、中村元直
    • Total Pages
      583
    • Publisher
      東京化学同人
    • Related Report
      2016 Annual Research Report
  • [Book] ホスホリパーゼA2と肥満. 糖尿病・代謝・内分泌 Annual Review 20162016

    • Author(s)
      佐藤弘泰, 村上 誠
    • Total Pages
      10
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 疾患モデルの作製と利用:脂質代謝異常と関連疾患・下巻(尾池雄一, 佐々木雄彦, 村上誠, 矢作直也編)2015

    • Author(s)
      北條寛典, 土屋創健, 杉本幸彦
    • Total Pages
      13
    • Publisher
      エル・アイ・シー
    • Related Report
      2015 Annual Research Report
  • [Book] Bioactive Lipid Mediators, Current Reviews and Protocols2015

    • Author(s)
      Inazumi T, Sugimoto Y
    • Total Pages
      10
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] 分泌性ホスホリパーゼA2:疾患モデルの作製と展開:脂質代謝異常と関連疾患(下巻), 尾池雄一, 佐々木雄彦, 村上 誠, 矢作直哉編2015

    • Author(s)
      武富芳隆, 村上 誠
    • Total Pages
      14
    • Publisher
      Life Science Information Center
    • Related Report
      2015 Annual Research Report
  • [Book] 細胞内ホスホリパーゼA2:疾患モデルの作製と展開:脂質代謝異常と関連疾患(下巻), 尾池雄一, 佐々木雄彦, 村上 誠, 矢作直哉編2015

    • Author(s)
      平林哲也, 村上 誠
    • Total Pages
      13
    • Publisher
      Life Science Information Center
    • Related Report
      2015 Annual Research Report
  • [Book] Phospholipase A2. Bioactive Lipid Mediators: Current Reviews and Protocols. eds. Yokomzo T, Murakami M2015

    • Author(s)
      Murakami M, Taketomi Y
    • Total Pages
      20
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Remarks] 熊本大学・杉本研ホームページ

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/seika/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学・村上研ホームページ

    • URL

      https://lmmhs.m.u-tokyo.ac.jp/home_j.html

    • Related Report
      2019 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/seika/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      https://lmmhs.m.u-tokyo.ac.jp/home_j.html

    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/seika/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://ebook.kumamoto-u.ac.jp/vol_68/

    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/seika/index.html

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 慢性特発性蕁麻疹の重症度マーカー、及びその使用2019

    • Inventor(s)
      村上誠
    • Industrial Property Rights Holder
      日本大学・東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-101289
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗がん剤2017

    • Inventor(s)
      土屋創健、村山裕海、杉本幸彦
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-193596
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗がん剤2017

    • Inventor(s)
      土屋創健、村山裕海、杉本幸彦
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-193597
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] 60th International Conference on the Bioscience of Lipid2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] 2nd International Conference on Lipoquality2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] The 1st International Conference on Lipoquality2017

    • Related Report
      2017 Annual Research Report

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Published: 2015-07-02   Modified: 2022-11-04  

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