| Budget Amount *help |
¥144,560,000 (Direct Cost: ¥111,200,000、Indirect Cost: ¥33,360,000)
Fiscal Year 2021: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2020: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2019: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2018: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2017: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
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| Outline of Final Research Achievements |
Starve treatment after hatching makes XX female medaka functional male. We revealed that the starvation causes a decrease of lipogenesis via a reduced activity of a CoA-producing pathway. The reduction of lipogenesis then leads to repression of dmrt1 expression that is a critical gene for testis development. This result is the first mechanistic demonstration that genetically determined vertebrate is affected by the change of metabolism induced by environment.
We also found genetic regulation on the spectrum of germ cell sex. After expression of germ cell sexual switch gene, foxl3, in germline stem cells, germ cells initiate oogenesis. However, germ cells remains feasible in sexual state and could develop into spermatogenesis. We found that feminization of germ cells establishes by pachytene stage. The mechanism underlying this spectrum demonstrates flexible sex that organisms originally possess and may ensure the base for creation of naturally sex reversed organism during evolution.
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