Studies of proliferation and pathogenesis of extracellular gram-negative bacterial pathogens
Project Area | Matrix of Infection Phenomena |
Project/Area Number |
18073003
|
Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
|
Research Institution | The University of Tokyo |
Principal Investigator |
SASAKAWA Chihiro The University of Tokyo, 医科学研究所, 教授 (70114494)
|
Co-Investigator(Kenkyū-buntansha) |
IIDA Tetsuya 大阪大学, 微生物病研究所, 特任教授 (90221746)
|
Project Period (FY) |
2006 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥174,000,000 (Direct Cost: ¥174,000,000)
Fiscal Year 2010: ¥34,800,000 (Direct Cost: ¥34,800,000)
Fiscal Year 2009: ¥34,800,000 (Direct Cost: ¥34,800,000)
Fiscal Year 2008: ¥34,800,000 (Direct Cost: ¥34,800,000)
Fiscal Year 2007: ¥34,800,000 (Direct Cost: ¥34,800,000)
Fiscal Year 2006: ¥34,800,000 (Direct Cost: ¥34,800,000)
|
Keywords | 赤痢菌 / 腸炎ビブリオ / III型分泌機構 / エフェクター / 感染 / 病原性 / III型分泌装置 / 3型分泌装置 / III型分子機構 |
Research Abstract |
(1) We have identified the interaction between Shigella effectors secreted via the type III secretion system (T3SS) and their targeting host factors, and elucidated their roles in promoting bacterial infection of intestinal epithelium. Based on our results, we have proposed the bacterial infection strategy involving in promoting the initial stage of infection. (2) We have identified the effector proteins secreted via T3SS of Vibrio parahaemolyticus, and revealed their intracellular functions. Also, the analysis of the regulation mechanism of the T3SS genes revealed a possibility of a novel therapeutic means against bacterial diarrhea.
|
Report
(7 results)
Research Products
(160 results)
-
-
[Journal Article] A tecpr1-dependent selective autophagy pathway targets bacterial pathogens.2011
Author(s)
Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C.
-
Journal Title
Cell Host Microbe. 9
Pages: 376-389
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Listeria monocytogenes ActA-mediated escape from autophagic recognition.2009
Author(s)
Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim M, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, Kakizuka A, Sztul E, Chakraborty T, Sasakawa C.
-
Journal Title
Nat Cell Biol. 11
Pages: 1233-1240
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] A bacterial Effector Targets Mad2L2, an APC Inhibitor, to Modulate Host Cell Cycling.2007
Author(s)
Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson P.K, Kotani S.Sasakawa C.
-
Journal Title
Related Report
Peer Reviewed
-
-
-
[Journal Article] A Bacterial Effector Targets Mad2L2, an APC Inhibitor2007
Author(s)
Iwai, H., Kim, M., Yoshikawa, Y., Ashida, H., Ogawa, M., Fujita, Y., Muller, D., Kirikae, T., Jackson, P.K., Kotani, S., Sasakawa, C.
-
Journal Title
Modulate Host Cell Cycling. Cell 130
Pages: 611-623
Related Report
Peer Reviewed
-
[Journal Article] Identification and characterization of VopT, a novel ADP-ribosyltransferase effector protein secreted via the Vibrio parahaemolyticus Type III secretion system 2.2007
Author(s)
Kodama, T., Rokuda, M., Park, K.-S., Cantarelli, V.V., Matsuda, S., Iida, T., Honda, T.
-
Journal Title
Cell. Microbiol. 9
Pages: 2598-2609
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article] Shigella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery.2006
Author(s)
Handa, Y., Suzuki, M., Ohya, K., Iwai, H., Ishijima, N., Koleske, A.J., Fukui Y., Sasakawa, C.
-
Journal Title
Nat. Cell Biol. 9
Pages: 121-128
Related Report
Peer Reviewed
-
-
-
[Journal Article] High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin.2006
Author(s)
Suzuki, T., Yoshikawa, Y., Ashia, H., Iwai, H., Toyotome, T., Matsui, H., Sasakawa, C.
-
Journal Title
J. Immunol. 177
Pages: 4709-4717
Related Report
-
-
-
-
[Journal Article] Cuortactin is essential for F-actin assembly in enteropathogenic Escherichia coli (EPEC)- and enterohaemorrhagic E. coli (EHEC)-induced pedestals and the α -helical region is involved in the localization of cortactin to bacterial attachment sites.2006
Author(s)
Cantarelli, V.V., Kodama, T., Nijstad, N., Abolghait, S.K., Iida, T., Honda, T.
-
Journal Title
Cell. Microbiol. 8
Pages: 769-780
Related Report
-
[Journal Article] Two type IV pili of Vibrio parahaemolyticus play different roles in biofilm formation.2006
Author(s)
Shime-Hattori, A., Iida, T., Arita, M., Park, K.-S., Kodama, T., Honda, T.
-
Journal Title
FEMS Microbiol. Lett. 264
Pages: 89-97
Related Report
-
[Journal Article] VP1686, a Vibrio type III secretion protein, induces Toll-like receptor independent apoptosis in macrophage through NF-kB inhibition.2006
Author(s)
Bhattacharjee, B.N., Park, K.-S., Kumagai, Y., Okada, K., Yamamoto, M., Uematsu, S., Masui, K., Kumar, H., Kawai, T., Iida, T., Honda, T., Takeuchi, O., Akira, S.
-
Journal Title
J. Biol. Chem. 281
Pages: 36897-36904
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-