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Development of novel fluorescence probes and imaging technologies for elucidating the mechanism of cellular signaling and responses induced by ROS

Planned Research

Project AreaSignaling functions of reactive oxygen species
Project/Area Number 20117003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

URANO Yasuteru  東京大学, 大学院・医学系研究科, 教授 (20292956)

Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥71,630,000 (Direct Cost: ¥55,100,000、Indirect Cost: ¥16,530,000)
Fiscal Year 2012: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2011: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2010: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2009: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2008: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Keywords蛍光プローブ / 活性酸素種 / シグナル / 親電子性活性種 / イメージング / ルシフェラーゼ / アミノルシフェリン / 分子内電子移動 / 次亜塩素酸 / インビボ / 生物発光プローブ / 過酸化水素 / α-ジケトン / カルセイン / フルオレセイン / 細胞内滞留性 / 活性窒素種 / 長時間観測
Research Abstract

For elucidating the functions of ROS and RNS as intracellular signaling molecules, we aimed at developing novel optical imaging probes which afford their live-imaging in living biological samples. We have succeeded in developing fluorescence probes for hydrogen peroxide, acrolein, and the enzymatic activity of glutathione S-transferase, those for highly ROS and NO which has much desired property of intracellular retention for the long-period observation, that for hypochlorite with NIR emitting capability, and luminescence probes for detecting hROS. We also have succeeded to obtain various striking images of each ROS and RNS in living cells and animals.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (165 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (36 results) (of which Peer Reviewed: 36 results) Presentation (117 results) (of which Invited: 13 results) Book (11 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Rational Design of Highly Sensitive Fluorescence Probes For Protease and Glycosidase Based on Precisely Controlled Spirocyclization2013

    • Author(s)
      Sakabe M, Asanuma D, Kamiya M, Iwatate JR, Hanaoka K, Terai T, Nagano T, Urano Y
    • Journal Title

      J. Am. Chem. Soc

      Volume: 135 Issue: 1 Pages: 409-14

    • DOI

      10.1021/ja309688m

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of NIR-emitting Firefly Luciferins Available in vivo2013

    • Author(s)
      Ryosuke Kojima, Hideo Takakura, Takeaki Ozawa, Yukio Tada, Tetsuo Nagano, Yasuteru Urano
    • Journal Title

      Angwandte Chemie International Edition

      Volume: 52 Issue: 4 Pages: 1175-1179

    • DOI

      10.1002/anie.201205151

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TokyoGreen Derivatives as Specific and Practical Fluorescent Probes for UDP-Glucuronosyltransferase (UGT) 1A12013

    • Author(s)
      Takuya Terai, Rie Tomiyasu, Tomoe Ota, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Yasuteru Urano and Tetsuo Nagano
    • Journal Title

      Chem. Commun.

      Volume: 49 Issue: 30 Pages: 3101-3103

    • DOI

      10.1039/c3cc38810g

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rational Design of Highly Sensitive Fluorescence Probes For Protease and Glycosidase Based on Precisely Controlled Spirocyclization.2013

    • Author(s)
      Sakabe, M. et al.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 135 Pages: 409-414

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly Sensitive and Intraoperative Detection of Tiny Tumors with Novel “Activatable” Fluorescence Probes2012

    • Author(s)
      浦野泰照
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 132 Issue: 4 Pages: 397-406

    • DOI

      10.1248/yakushi.132.397

    • NAID

      130001872040

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2012-04-01
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel live imaging techniques of cellular functions and in vivo tumors based on precise design of small molecule-based 'Activatable' fluorescence probes2012

    • Author(s)
      Urano Y
    • Journal Title

      Current Opinion in Chemical Biology

      Volume: 16 Pages: 602-608

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly Activatable and Environment-insensitive Optical Highlighters for Selective Spatiotemporal Imaging of Target Proteins2012

    • Author(s)
      Kobayashi T, Komatsu T, Kamiya M, Campos C, Gonzalez-Gaitan M, Terai T, Hanaoka K, Nagano T, Urano Y
    • Journal Title

      J. Am. Chem. Soc

      Volume: 134 Issue: 27 Pages: 11153-11160

    • DOI

      10.1021/ja212125w

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of NIR fluorescent dyes based on Si-rhodamine for in vivo imaging2012

    • Author(s)
      Koide Y, Urano Y, Hanaoka K, Piao W, Kusakabe M, Saito N, Terai T, Okabe T, Nagano T
    • Journal Title

      J Am Chem Soc

      Volume: 134 Issue: 11 Pages: 5029-31

    • DOI

      10.1021/ja210375e

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of 5'- and 7'-substituted luciferin analogues as acid-toler ant substrates of firefly luciferase2012

    • Author(s)
      Hideo Takakura, Ryosuke Kojima, Yasuteru Urano, Kenjiro Hanaoka, Takuya Terai, and Tetsuo Nagano
    • Journal Title

      Chembiochem

      Volume: 13 Issue: 10 Pages: 1424-1427

    • DOI

      10.1002/cbic.201200142

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel live imaging techniques of cellular functions and in vivo tumors based on precise design of small molecule-based 'activatable' fluorescence probes2012

    • Author(s)
      Urano, Y.
    • Journal Title

      Curr. Opin. Chem. Biol.

      Volume: 16 Issue: 5-6 Pages: 602-608

    • DOI

      10.1016/j.cbpa.2012.10.023

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visible-Light-Triggered Release of Nitric Oxide from N-Pyramidal Nitrosamines2012

    • Author(s)
      Karaki, F., et al
    • Journal Title

      Chemistry-A European Journal

      Volume: 18 Issue: 4 Pages: 1127-1141

    • DOI

      10.1002/chem.201101427

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Practical Strategy to Create Near-Infrared Luminescent Probes : Conversion from Fluorescein-Based Sensors2012

    • Author(s)
      Terai, T., et al
    • Journal Title

      Chem.Commun.

      Volume: 48 Issue: 23 Pages: 2840-2842

    • DOI

      10.1039/c2cc16553h

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly sensitive and intraoperative detection of tiny tumors with novel "activatable" fluorescence probes2012

    • Author(s)
      Urano Y.
    • Journal Title

      Yakugaku Zasshi

      Volume: 132(掲載確定)(印刷中)(未定)

    • NAID

      130001872040

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Cancer Detection by Topically Spraying a Gamma-glutamyltranspeptidase-activated Fluorescent Probe2011

    • Author(s)
      Urano Y, Sakabe M, Nobuyuki Kosaka, Ogawa M, Mitsunaga M, Asanuma D, Kamiya M, Young MR, Nagano T, Choyke PL, Kobayashi H
    • Journal Title

      Sci Transl Med

      Volume: 3 Issue: 110 Pages: 110-119

    • DOI

      10.1126/scitranslmed.3002823

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved Cellular Accumulation Based on Spirocyclized Rhodol Scaffold2011

    • Author(s)
      Kamiya M, Asanuma D, Kuranaga E, Takeishi A, Sakabe M, Miura M, Nagano T, Urano Y
    • Journal Title

      J. Am. Chem. Soc

      Volume: 133 Issue: 33 Pages: 12960-12963

    • DOI

      10.1021/ja204781t

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Highly Sensitive Fluorescence Probe for Hydrogen Peroxide2011

    • Author(s)
      Masahiro Abo, et al
    • Journal Title

      Journal of the American Chemical Society

      Volume: 133 Issue: 27 Pages: 10629-10637

    • DOI

      10.1021/ja203521e

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method2011

    • Author(s)
      Komatsu T, Johnsson K, Okuno H, Bito H, Inoue T, Nagano T, Urano Y
    • Journal Title

      J. Am. Chem. Soc

      Volume: 133 Issue: 17 Pages: 6745-6751

    • DOI

      10.1021/ja200225m

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an Si-rhodamine-based far-red to near-infrared fluorescence probe selective for hypochlorous acid and its applications for biological imaging2011

    • Author(s)
      Koide Y, Urano Y, Hanaoka K, Terai T, Nagano T
    • Journal Title

      J. Am. Chem. Soc

      Volume: 133 Issue: 15 Pages: 5680-5682

    • DOI

      10.1021/ja111470n

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolution of group 14 rhodamines as platforms for near-infrared fluorescence probes utilizing photoinduced electron transfer2011

    • Author(s)
      Koide, Y., et al
    • Journal Title

      ACS Chem.Biol.

      Volume: 6 Issue: 6 Pages: 600-608

    • DOI

      10.1021/cb1002416

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ evaluation of kinetic resolution catalysts for nitroaldol by using a rationally designed fluorescence probe2011

    • Author(s)
      Matsumoto T., et al
    • Journal Title

      J.Org.Chem.

      Volume: 76 Issue: 10 Pages: 3616-3625

    • DOI

      10.1021/jo1020344

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activatable Optical Imaging with a Silica-Rhodamine Based Near Infrared (SiR700) Fluorophore : A comparison with cyanine based dyes2011

    • Author(s)
      McCann, TE., et al
    • Journal Title

      Bioconjugate Chem

      Volume: 22 Issue: 12 Pages: 2531-2538

    • DOI

      10.1021/bc2003617

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an Si-rhodamine-based far-red to near-infrared fluorescence probe selective for hypochlorous acid and applications for biological imaging.2011

    • Author(s)
      Koide Y, Urano Y, Hanaoka K, Terai T, Nagano T
    • Journal Title

      J.Am.Chem.Soc. 133

      Pages: 5680-5682

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling (FAPL) method.2011

    • Author(s)
      Toru Komatsu
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 133((掲載確定)印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aminoluciferins as functional bioluminogenic substrates of firefly luciferase.2011

    • Author(s)
      Hideo Takakura
    • Journal Title

      Chem.Asian J.

      Volume: 6((掲載確定)印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an Si-rhodamine-based far-red to near-infrared fluorescence probe selective for hypochlorous acid and applications for biological imaging.2011

    • Author(s)
      Yuichiro Koide
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 133 Pages: 5680-5682

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive Detection of Acrolein in Serum Using Time-resolved Luminescence2010

    • Author(s)
      Togashi M, Urano Y, Kojima H, Terai T, Hanaoka K, Igarashi K, Hirata Y, Nagano T
    • Journal Title

      Org. Lett

      Volume: 12 Issue: 8 Pages: 1704-1707

    • DOI

      10.1021/ol1002219

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] I Development of luciferin analogues bearing an amino group and their application as BRET donors.2010

    • Author(s)
      Hideo Takakura
    • Journal Title

      Chem.Asian J.

      Volume: 5 Pages: 2053-2061

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of enzyme-activated photosensitizer based on intramolecular electron transfer.2010

    • Author(s)
      Takatoshi Yogo
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 4320-4323

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive detection of acrolein in serum using time-resolved luminescence2010

    • Author(s)
      Masataka Togashi
    • Journal Title

      Org.Lett. 12

      Pages: 1704-1707

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A simple and effective strategy to increase the sensitivity of fluorescence probes in living cells2009

    • Author(s)
      Izumi S, Urano Y, Hanaoka K, Terai T, Nagano T
    • Journal Title

      J. Am. Chem. Soc

      Volume: 131 Issue: 29 Pages: 10189-10200

    • DOI

      10.1021/ja902511p

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes2009

    • Author(s)
      Urano Y, Asanuma D, Hama Y, Koyama Y, Barrett T, Kamiya M, Nagano T, Watanabe T, Hasegawa A, Choyke PL, Kobayashi H
    • Journal Title

      Nat. Med

      Volume: 15 Issue: 1 Pages: 104-109

    • DOI

      10.1038/nm.1854

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A simple and effective strategy to increase the sensitivity of fluorescence probes in living cells.2009

    • Author(s)
      Izumi S, Urano Y, Hanaoka K, Terai T, Nagano T
    • Journal Title

      J.Am.Chem.Soc. 131

      Pages: 10189-10200

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A simple and effective strategy to increase the sensitivity of fluorescence probes in living cells2009

    • Author(s)
      Saki Izumi
    • Journal Title

      J.Am.Chem.Soc. 131

      Pages: 10189-10200

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase (GST) and application for activity imaging in living cells2008

    • Author(s)
      Fujikawa Y, Urano Y, Komatsu T, Hanaoka K, Kojima H, Terai T, Inoue H, Nagano T
    • Journal Title

      J. Am. Chem. Soc

      Volume: 130 Issue: 44 Pages: 14533-14543

    • DOI

      10.1021/ja802423n

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer2008

    • Author(s)
      Yogo T, Urano Y, Mizushima A, Sunahara H, Inoue T, Hirose K, Iino M, Kikuchi K, Nagano T
    • Journal Title

      Proc. Natl. Acad. Sci

      Volume: 105 Issue: 1 Pages: 28-32

    • DOI

      10.1073/pnas.0611717105

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling (FAPL)

    • Author(s)
      Komatsu T, Johnsson K, Okuno H, Bito H, Inoue T, Nagano T, Urano Y.
    • Journal Title

      method.J.Am.Chem.Soc. 印刷中(掲載決定)

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Presentation] 優れたactivation ratioを示すhROS検出生物発光プローブの開発2013

    • Author(s)
      小嶋 良輔
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      神奈川(パシフィコ横浜)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規グルタチオン感受性蛍光プローブによるin vivoがんイメージング2013

    • Author(s)
      吉田 昌史
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      神奈川(パシフィコ横浜)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分子内spiro環化平衡の精密制御に基づく蛍光・増感プローブの開発とがん医療への応用2013

    • Organizer
      日本化学会第93春季年会特別企画講演
    • Place of Presentation
      滋賀(立命館大学)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 分子内spiro環化平衡の精密制御に基づく蛍光・増感プローブの開発とがん医療への応用2013

    • Author(s)
      浦野 泰照
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀(立命館大学)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 細胞内タンパク質のライブセル超解像顕微鏡イメージングを可能とする近赤外蛍光プローブ2013

    • Author(s)
      梅澤 啓太郎
    • Organizer
      日本化学会 第93春季年会
    • Place of Presentation
      滋賀(立命館大学)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] BRETドナーとして利用可能なluciferin発光基質の開発2013

    • Author(s)
      高倉 栄男
    • Organizer
      日本化学会 第93春季年会
    • Place of Presentation
      滋賀(立命館大学)
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] In Vivo Rapid Cancer Detection by Topically Spraying a Novel -Glutamyltranspeptidase-activated Fluorescence Probe2013

    • Author(s)
      Yasuteru Urano
    • Organizer
      3rd Joint Symposium of the Max Planck Society and the University of Tokyo
    • Place of Presentation
      Tokyo (The University of Tokyo)
    • Year and Date
      2013-03-08
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 有機小分子蛍光プローブの精密設計とその応用 ~リアルタイム生細胞イメージングとin vivoがんイメージング~2013

    • Author(s)
      浦野 泰照
    • Organizer
      第6回The Heart研究会
    • Place of Presentation
      東京(コンファレンススクエア エムプラス)
    • Year and Date
      2013-03-02
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] In Vivo Rapid Cancer Detection by Topically Spraying a Novel γ-Glutamyltranspeptidase-activated Fluorescence Probe2013

    • Organizer
      VIPCA Chemical Biology: Methods and Progress
    • Place of Presentation
      Austria (Vienna)
    • Year and Date
      2013-02-12
    • Related Report
      2012 Final Research Report
  • [Presentation] In Vivo Rapid Cancer Detection by Topically Spraying a Novel -Glutamyltranspeptidase-activated Fluorescence Probe2013

    • Author(s)
      Yasuteru Urano
    • Organizer
      VIPCA Chemical Biology: Methods and Progress
    • Place of Presentation
      Austria (Vienna)
    • Year and Date
      2013-02-12
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 小分子蛍光プローブの開発による新たな細胞機能・疾患イメージング2013

    • Author(s)
      浦野 泰照
    • Organizer
      平成24年度次世代バイオナノ研究会
    • Place of Presentation
      香川(サンポートホール高松)
    • Year and Date
      2013-01-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] In Vivo Rapid Cancer Detection by Topically Spraying a Novel gamma-Glutamyltranspeptidase-activated Fluorescence Probe2012

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 43rd International Symposium of The Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      Tokyo (Hotel Grand Palace)
    • Year and Date
      2012-11-16
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Realtime imaging of ROS in living cells and tiny tumors in vivo by rationally designed novel fluorescence probes2012

    • Organizer
      Joint JSPS - Karolinska Institute Symposium
    • Place of Presentation
      Sweden (Karolinska Institute, Stockholm)
    • Year and Date
      2012-10-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Realtime imaging of ROS in living cells and tiny tumors in vivo by rationally designed novel fluorescence probes2012

    • Author(s)
      Yasuteru Urano
    • Organizer
      Joint JSPS –Karolinska Institute Symposium
    • Place of Presentation
      Sweden (Karolinska Institute, Stockholm)
    • Year and Date
      2012-10-23
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] スマート蛍光プローブの精密開発による新たな細胞・疾患イメージング2012

    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京(昭和大学旗の台キャンパス)
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] スマート蛍光プローブの精密開発による新たな細胞・疾患イメージング2012

    • Author(s)
      浦野 泰照
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京(昭和大学旗の台キャンパス)
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Specific Ablation of Cells Expressing b-galactosidase with a Novel Activatable Photosensitizer2012

    • Author(s)
      Yuki Ichikawa
    • Organizer
      EMBO Conference Series Chemical Biology 2012
    • Place of Presentation
      Heidelberg (Germany)
    • Year and Date
      2012-09-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] 光機能性プローブの精密開発によるin vivo生物学・医療の新展開2012

    • Organizer
      BMAS2012
    • Place of Presentation
      東京(慶應義塾大学薬学部)
    • Year and Date
      2012-08-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 光機能性プローブの精密開発によるin vivo生物学・医療の新展開2012

    • Author(s)
      浦野 泰照
    • Organizer
      BMAS2012
    • Place of Presentation
      東京(慶應義塾大学薬学部)
    • Year and Date
      2012-08-09
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 化学プローブの精密設計によるin vivo光診断・治療の新展開2012

    • Author(s)
      浦野 泰照
    • Organizer
      第8回日本脳神経外科光線力学学会
    • Place of Presentation
      茨城(つくば国際会議場)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Real-time functional imaging of living cells and animals with rationally designed fluorescence probes2012

    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Hokkaido (Chateraise Gateaux Kingdom Sapporo)
    • Year and Date
      2012-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Real-time functional imaging of living cells and animals with rationally designed fluorescence probes2012

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 33rd Naito Conference on Oxygen Biology
    • Place of Presentation
      Hokkaido (Châteraisé Gateaux Kingdom Sapporo)
    • Year and Date
      2012-06-28
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新規有機小分子蛍光プローブの開発に基づく生細胞・動物個体内レドックスシグナルイメージング2012

    • Organizer
      第65回日本酸化ストレス学会
    • Place of Presentation
      徳島(徳島県郷土文化会館)
    • Year and Date
      2012-06-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規有機小分子蛍光プローブの開発に基づく生細胞・動物個体内レドックスシグナルイメージング2012

    • Author(s)
      浦野 泰照
    • Organizer
      第65回日本酸化ストレス学会
    • Place of Presentation
      徳島(徳島県郷土文化会館)
    • Year and Date
      2012-06-08
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] スマート蛍光プローブの精密開発による新たな分子イメージング2012

    • Author(s)
      浦野 泰照
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      兵庫(神戸国際会議場)
    • Year and Date
      2012-05-26
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新規有機小分子蛍光プローブの開発に基づく生細胞・動物個体内レドックスシグナルイメージング2012

    • Organizer
      日本薬学会第132年会 シンポジウム「レドックス制御研究の最前線」
    • Place of Presentation
      北海道(北海道大学)
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規有機小分子蛍光プローブの開発に基づく生細胞・動物個体内レドックスシグナルイメージング2012

    • Author(s)
      浦野泰照
    • Organizer
      日本薬学会第131年会シンポジウム「レドックス制御研究の最前線」
    • Place of Presentation
      北海道(北海道大学)(招待講演)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 術中in vivo微小がんイメージングを可能とする有機小分子蛍光プローブの開発2012

    • Author(s)
      浦野泰照
    • Organizer
      日本化学会第92春季年会シンポジウム「生物無機化学の新たなる挑戦」
    • Place of Presentation
      神奈川(慶應義塾大学)(招待講演)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生細胞適用可能な光機能性分子の精密設計とその応用2012

    • Organizer
      日本化学会第92春季年会 シンポジウム「有機合成化学を起点とするものづくり戦略」
    • Place of Presentation
      神奈川(慶應義塾大学)
    • Year and Date
      2012-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 生細胞適用可能な光機能性分子の精密設計とその応用2012

    • Author(s)
      浦野泰照
    • Organizer
      日本化学会第92春季年会シンポジウム「有機合成化学を起点とするものづくり戦略」
    • Place of Presentation
      神奈川(慶應義塾大学)(招待講演)
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel Live Imaging Techniques of Cellular Functions and In Vivo Tumors Based on Precise Design of Small Molecule-based Fluorescence Probes2012

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 5th International Symposium for Future Technology Creating Better Human Health and Society
    • Place of Presentation
      Okayama (Okayama University)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 有機小分子蛍光プローブの精密設計によるin vivoがんイメージング2012

    • Author(s)
      浦野泰照
    • Organizer
      第22回癌ゲノムサイエンス研究会
    • Place of Presentation
      東京(東京ガーデンパレス)(招待講演)
    • Year and Date
      2012-02-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] オリジナル蛍光プローブの精密設計による新たな生体イメージングの実現2011

    • Organizer
      第26回日本酸化ストレス学会関東支部会
    • Place of Presentation
      東京(東京工科大学鎌田キャンパス)
    • Year and Date
      2011-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] オリジナル蛍光プローブの精密設計による新たな生体イメージングの実現2011

    • Author(s)
      浦野泰照
    • Organizer
      第26回日本酸化ストレス学会関東支部会
    • Place of Presentation
      東京(東京工科大学鎌田キャンパス)(招待講演)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛍光プローブの精密開発によるin vivo迅速がん部位診断の実現2011

    • Author(s)
      浦野泰照
    • Organizer
      日本がん分子標的治療学会(JAMTTC)・日本遺伝子診療学会(JSGDT)合同シンポジウム
    • Place of Presentation
      東京(都市センターホール)(招待講演)
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Frontier of Medicinal Science" (Invited), "Intraoperative Imaging of Tiny Tumor Sites with Rationally Designed Fluorescence Probes2011

    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Tokyo (Keio Plaza Hotel)
    • Year and Date
      2011-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Intraoperative Imaging of Tiny Tumor Sites with Rationally Designed Fluorescence Probes2011

    • Author(s)
      Yasuteru Urano
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
    • Place of Presentation
      Tokyo (Keio Plaza Hotel)(招待講演)
    • Year and Date
      2011-11-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] オリジナル蛍光プローブ開発によるin vivoがんイメージングの新展開2011

    • Author(s)
      浦野泰照
    • Organizer
      第22回日本消化器癌発生学会
    • Place of Presentation
      佐賀(ホテルニューオータニ佐賀)(招待講演)
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rational development of activatable fluorescence probes for in vivo medical imaging ~ Small molecule-based sensors for cancer detection ~2011

    • Organizer
      US-Japan Workshop on Bio-inspired Engineering of Next-generation Sensors and Actuators
    • Place of Presentation
      UC Berkeley (USA)
    • Year and Date
      2011-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Rational development of activatable fluorescence probes for in vivo medical imaging~Small molecule-based sensors for cancer detection~2011

    • Author(s)
      Yasuteru Urano
    • Organizer
      US-Japan Workshop on Bio-inspired Engineering of Next-generation Sensors and Actuators
    • Place of Presentation
      UC Berkeley (USA)(招待講演)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] オリジナル蛍光プローブの精密設計による新たな生体イメージングの実現2011

    • Organizer
      第31回キャピラリー電気泳動研究会
    • Place of Presentation
      山形(慶応義塾大学鶴岡キャンパス)
    • Year and Date
      2011-11-09
    • Related Report
      2012 Final Research Report
  • [Presentation] オリジナル蛍光プローブの精密設計による新たな生体イメージングの実現2011

    • Author(s)
      浦野泰照
    • Organizer
      第31回キャピラリー電気泳動研究会
    • Place of Presentation
      山形(慶應義塾大学鶴岡キャンパス)(招待講演)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛍光プローブの精密開発によるin vivoがん部位診断と治療効果の可視化2011

    • Author(s)
      浦野泰照
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      愛知(名古屋国際会議場)(招待講演)
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] オリジナル蛍光プローブの開発に基づく、生細胞応答・in vivoがんイメージングの新展開2011

    • Author(s)
      浦野泰照
    • Organizer
      日本消化器外科総会in JDDW2011
    • Place of Presentation
      福岡(福岡国際会議場)(招待講演)
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo Tumor Imaging with Rationally Designed Fluorescence Probes2011

    • Author(s)
      Yasuteru Urano
    • Organizer
      第10回日中合同組織細胞化学セミナー
    • Place of Presentation
      Beijing, Capital Medical University (China)(招待講演)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Intraoperative imaging of tumor with originally designed fluorescence probes2011

    • Author(s)
      浦野泰照
    • Organizer
      第70回日本癌学会学術総会Symposium : Seeing the unseen : Live imaging technologies in cancer research
    • Place of Presentation
      愛知(名古屋国際会議場)(招待講演)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] ROS蛍光プローブを活用した新たな生細胞応答イメージング~ 画期的なイメージングを実現するためのTipsと注意点~2011

    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都(京都国際会議場)
    • Year and Date
      2011-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] ROS蛍光プローブを活用した新たな生細胞応答イメージング~画期的なイメージングを実現するためのTipsと注意点~2011

    • Author(s)
      浦野泰照
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都(京都国際会議場)(招待講演)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光機能性プローブによるがんの検出・診断・治療2011

    • Author(s)
      浦野泰照
    • Organizer
      日本分析化学会第60年会シンポジウム「最先端医学を支える分析化学」
    • Place of Presentation
      愛知(名古屋大学)(招待講演)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel functional bioimaging techniques with rationally designed fluorescence probes2011

    • Organizer
      IUMS International Congress of bacteriology and Applied Microbiology
    • Place of Presentation
      Hokkaido (Sapporo Convention Center)
    • Year and Date
      2011-09-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel functional bioimaging techniques with rationally designed fluorescence probes2011

    • Author(s)
      Yasuteru Urano
    • Organizer
      IUMS International Congress of bacteriology and Applied Microbiology
    • Place of Presentation
      Hokkaido (Sapporo Convention Center)(招待講演)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Live imaging of ROS, RNS and in vivo tiny tumors with rationally designed fluorescence probes2011

    • Organizer
      Joint Meeting of 5th Biennial Meeting of Society for Free Radical Research-Asia(SFRR-Asia), 8th Conference of Asian Society for Mitochondrial Research and Medicine(ASMRM), and 11th Conference of Japanese Society of Mitochondrial Research and Medicine(J-mit)
    • Place of Presentation
      Kagoshima (Kagoshima Citizens' Culture Hall)
    • Year and Date
      2011-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Live imaging of ROS, RNS and in vivo tiny tumors with rationally designed fluorescence probes2011

    • Author(s)
      Yasuteru Urano
    • Organizer
      Joint Meeting of 5th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia), 8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM), and 11th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit)
    • Place of Presentation
      Kagoshima (Kagoshima Citizens' Culture Hall)(招待講演)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel functional bioimaging techniques with rationally designed fluorescence probes2011

    • Author(s)
      Yasuteru Urano
    • Organizer
      1st International Symposium on Molecular Imaging and Nanomedicine
    • Place of Presentation
      Lijiang (China)(招待講演)
    • Year and Date
      2011-08-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計によるin vivo迅速がんイメージングの実現2011

    • Author(s)
      浦野泰照
    • Organizer
      新学術研究領域がん支援班ミニシンポジウム「癌の蛍光生体イメージング」
    • Place of Presentation
      大阪(千里ライフセンター)(招待講演)
    • Year and Date
      2011-08-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel in vivo functional bioimaging with rationally designed fluorescence probes2011

    • Author(s)
      浦野泰照
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      北海道(ロイトン札幌)(招待講演)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計による新たな生細胞応答観測の実現2011

    • Author(s)
      浦野泰照
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      新潟(長岡リリックホール)(招待講演)
    • Year and Date
      2011-07-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛍光プローブの論理的設計に基づくin vivoがんイメージング2011

    • Author(s)
      浦野泰照
    • Organizer
      第10回国際バイオEXPO「若手研究者が牽引する再生医療とがん診断・治療の最先端」
    • Place of Presentation
      東京(東京ビックサイト)(招待講演)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛍光プローブの論理的開発に基づく、新たな生体応答観測・in vivoがんイメージングの実現2011

    • Author(s)
      浦野泰照
    • Organizer
      第97回日本消化器病九州支部例会
    • Place of Presentation
      福岡(久留米)(招待講演)
    • Year and Date
      2011-06-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光機能性プローブの精密設計による、高選択的in vivoがんイメージング・治療の実現2011

    • Author(s)
      浦野泰照
    • Organizer
      第27回日本DDS学会学術集会「ワークショップ7:診断と治療の一体化-Theranostics」
    • Place of Presentation
      東京(東京大学理学部小柴記念ホール)(招待講演)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗がん剤創薬に向けて~生体イメージング、合成化学の観点から~2011

    • Author(s)
      浦野泰照
    • Organizer
      がん支援・化学療法基盤支援活動拡大班会議
    • Place of Presentation
      静岡(熱海)(招待講演)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小分子蛍光プローブの精密開発に基づく生細胞・動物個体内ROS・RNSイメージング2011

    • Organizer
      第11回日本NO学会学術集会
    • Place of Presentation
      東京(昭和薬科大学)
    • Year and Date
      2011-05-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 小分子蛍光プローブの精密開発に基づく生細胞・動物個体内ROS・RNSイメージング2011

    • Author(s)
      浦野泰照
    • Organizer
      第11回日本NO学会学術集会
    • Place of Presentation
      東京(昭和薬科大学)(招待講演)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] オリジナル化学プローブの開発に基づく、in vivoがんイメージングの新展開2011

    • Author(s)
      浦野泰照
    • Organizer
      第70回日本医学放射線学会総会
    • Place of Presentation
      神奈川(パシフィコ横浜)(招待講演)
    • Year and Date
      2011-04-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] "Activatable"蛍光プローブの開発に基づく高感度迅速術中がん診断の実現2011

    • Author(s)
      浦野泰照
    • Organizer
      日本薬学会第131年会特別シンポジウム「生体反応・細胞挙動のセンシング-光を使って何ができるのか?-」
    • Place of Presentation
      グランシップ、静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル化学プローブの開発による、新たな生細胞観測、in vivoがんイメージングの実現2011

    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川(神奈川大学)
    • Year and Date
      2011-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] オリジナル化学プローブの開発による、新たな生細胞観測、in vivoがんイメージングの実現2011

    • Author(s)
      浦野泰照
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学、神奈川
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel chemical fluorescence sensors for visualization of various ROS in living cells and animals2011

    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      神奈川(パシフィコ横浜)
    • Year and Date
      2011-03-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel chemical fluorescence sensors for visualization of various ROS in living cells and animals2011

    • Author(s)
      浦野泰照
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナルプローブの精密設計による、術中迅速がん蛍光イメージングの実現2011

    • Author(s)
      浦野泰照
    • Organizer
      第7回ナノバイオ国際シンポジウム
    • Place of Presentation
      東京ビッグサイト、東京
    • Year and Date
      2011-02-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル蛍光プローブの開発による、細胞応答観測・in vivoがんイメージングの最前線2011

    • Author(s)
      浦野泰照
    • Organizer
      第40回日本心脈管作動物質学会
    • Place of Presentation
      香川国際会議場、香川
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 有機小分子蛍光プローブの開発による、細胞応答観測・in vivoがんイメージングの新展開2011

    • Author(s)
      浦野泰照
    • Organizer
      第38回千葉ベイシティカンファレンス
    • Place of Presentation
      オリエンタルホテル東京ベイ、千葉
    • Year and Date
      2011-02-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光機能性分子プローブの開発に基づく新しいin vivoがんイメージング2011

    • Author(s)
      浦野泰照
    • Organizer
      レーザー学会第31回年次大会
    • Place of Presentation
      電気通信大学、東京
    • Year and Date
      2011-01-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo cancer imaging with rationally designed fluorescence probes2010

    • Author(s)
      Yasuteru Urano
    • Organizer
      2010 International Chemical Congress of Pacific Basin Societies, Fluorescent Sensors by Design (#181)
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-12-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo Tumor Imaging with Rationally Designed Fluorescence Probes2010

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 16th Takeda Science Foundation Symposium on Bioscience
    • Place of Presentation
      The Miyako hotel in Tokyo, Tokyo
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの論理的開発に基づく術中がん診断の実現2010

    • Author(s)
      浦野泰照
    • Organizer
      GlycoTOKYOシンポジウム2010
    • Place of Presentation
      東京大学薬学部講堂、東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル蛍光プローブの開発に基づく、生細胞応答・in vivoがんイメージングの新展開2010

    • Author(s)
      浦野泰照
    • Organizer
      第4回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      東京大学武田先端知ビル、東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル蛍光プローブの論理的開発による新しい細胞応答観測・in vivoがんイメージングの実現2010

    • Author(s)
      浦野泰照
    • Organizer
      視る生物学5
    • Place of Presentation
      奈良先端科学技術大学院大学 ミレニアムホール、奈良
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計によるin vivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第56回秋期特別総会病理学会
    • Place of Presentation
      北九州西日本総合展示場、福岡
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル化学プローブの開発による、新たな生細胞観測、in vivoがんイメージングの実現2010

    • Organizer
      第35回日本薬学会関東支部学術講演会
    • Place of Presentation
      東京(日本薬学会長井記念ホール)
    • Year and Date
      2010-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] オリジナル化学プローブの開発による、新たな生細胞観測、in vivoがんイメージングの実現2010

    • Author(s)
      浦野泰照
    • Organizer
      第35回日本薬学会関東支部学術講演会
    • Place of Presentation
      日本薬学会長井記念ホール、東京
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電子移動の精密制御による新たな生体応答観測・先進医療の実現2010

    • Organizer
      第43回酸化反応討論会
    • Place of Presentation
      東京(東京大学医学部鉄門講堂)
    • Year and Date
      2010-11-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 電子移動の精密制御による新たな生体応答観測・先進医療の実現2010

    • Author(s)
      浦野泰照
    • Organizer
      第43回酸化反応討論会
    • Place of Presentation
      東京大学医学部鉄門講堂、東京
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル化学プローブの開発による新しい生体分子イメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第6回「学際領域における分子イメージングフォーラム」
    • Place of Presentation
      宇宙航空研究開発機構 調布航空宇宙センター、東京
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計に基づく先進的がんイメージング技術の創製2010

    • Author(s)
      浦野泰照
    • Organizer
      創剤フォーラム第16回シンポジウム
    • Place of Presentation
      アルカディア市ヶ谷、東京
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Selective Molecular Imaging of Viable Cancer Cells with Rationally Designed "Activatable" Fluorescence Probes2010

    • Organizer
      SPACC17
    • Place of Presentation
      Kagoshima (Kagoshima University)
    • Year and Date
      2010-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Selective Molecular Imaging of Viable Cancer Cells with Rationally Designed "Activatable" Fluorescence Probes2010

    • Author(s)
      Yasuteru Urano
    • Organizer
      SPACC 17
    • Place of Presentation
      Kagoshima University, Kagoshima
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計による抗がん先進医療技術の創出2010

    • Author(s)
      浦野泰照
    • Organizer
      バイオジャパン2010
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル化学プローブの開発による新しい生体分子イメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      生化学夏の学校2010
    • Place of Presentation
      箱根高原ホテル、神奈川
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光機能性プローブの精密設計によるがん医療の新展開2010

    • Author(s)
      浦野泰照
    • Organizer
      第32回日本光医学・光生物学会年会
    • Place of Presentation
      東京慈恵会医科大学、東京
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計に基づく、新たな生細胞応答観測・in vivoがんイメージング2010

    • Organizer
      第21回日本生体防御学会シンポジウム「活性酸素の生体防御シグナルとバイオイメージング」
    • Place of Presentation
      宮城(仙台市戦災復興記念館)
    • Year and Date
      2010-07-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 蛍光プローブの精密設計に基づく、新たな生細胞応答観測・in vivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第21回日本生体防御学会シンポジウム「活性酸素の生体防御シグナルとバイオイメージング」
    • Place of Presentation
      宮城(仙台市戦災復興記念館)(招待講演)
    • Year and Date
      2010-07-24
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 蛍光プローブの精密設計に基づく、新たな生細胞応答観測・in vivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第21回日本生体防御学会シンポジウム「活性酸素の生体防御シグナルとバイオイメージング」
    • Place of Presentation
      仙台市戦災復興記念館、宮城
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル蛍光プローブ開発による新しい生体分子イメージング2010

    • Organizer
      第23回バイオメディカル分析科学シンポジウム シンポジウム 「in vivoイメージングと分析科学」
    • Place of Presentation
      宮城(ホテル松島大観荘)
    • Year and Date
      2010-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] オリジナル蛍光プローブ開発による新しい生体分子イメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第23回バイオメディカル分析科学シンポジウム シンポジウム「in vivoイメージングと分析科学」
    • Place of Presentation
      ホテル松島大観荘、宮城
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 有機小分子蛍光プローブの精密設計に基づく、新たな生細胞応答観測・in vivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第22回生体機能関連若手の会サマースクール
    • Place of Presentation
      国民宿舎「関ロッジ」、三重
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 化学蛍光プローブの精密設計による、新たな標的分子イメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      レーザ顕微鏡研究会第36回講演会
    • Place of Presentation
      理化学研究和光本所 鈴木梅太郎ホール、埼玉
    • Year and Date
      2010-07-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計による生細胞・生体内計測の実現2010

    • Author(s)
      浦野泰照
    • Organizer
      岡山大&理研ジョイントシンポジウム「最先端計測のトレンド2010」
    • Place of Presentation
      岡山大学創立50周年記念館、岡山
    • Year and Date
      2010-06-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Real-time imaging of various ROS, RNS and related enzymatic activities in living cells by using precisely designed novel fluorescence probes2010

    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto (Kyoto International Conference Center)
    • Year and Date
      2010-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Real-time imaging of various ROS, RNS and related enzymatic activities in living cells by using precisely designed novel fluorescence probes2010

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto (Kyoto International Conference Center)(Invited)
    • Year and Date
      2010-06-15
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Real-time imaging of various ROS, RNS and related enzymatic activities in living cells by using precisely designed novel fluorescence probes2010

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Year and Date
      2010-06-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] オリジナル蛍光プローブの開発による、生細胞応答・in vivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      第21回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      東京大学小柴ホール、東京
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計による、新たな生細胞イメージング・in vivoがんイメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      日本顕微鏡学会第66回学術講演会シンポジウム
    • Place of Presentation
      名古屋国際会議場、愛知
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Selective and Sensitive in vivo Tumor Imaging with Rationally Developed Novel Fluorescence Probes2010

    • Author(s)
      浦野泰照
    • Organizer
      日本血栓止血学会第33回学術集会シンポジウム「Innovation of Technology」
    • Place of Presentation
      鹿児島城山観光ホテル、鹿児島
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 化学プローブの精密設計による、医学生物解析の新展開2010

    • Author(s)
      浦野泰照
    • Organizer
      日本顕微鏡学会関東支部第34回講演会
    • Place of Presentation
      帝京大学医学部医療技術学部棟、東京
    • Year and Date
      2010-03-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛍光プローブの精密設計による、新たな生細胞イメージング2010

    • Author(s)
      浦野泰照
    • Organizer
      日本顕微鏡学会バイオメディカルニューマイクロスコープ分科会平成21年度シンポジウム講演会
    • Place of Presentation
      帝京大学医学部臨床大講堂、東京
    • Year and Date
      2010-01-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 論理的分子設計に基づく、各種ROS、RNS選択的蛍光プローブの開発2009

    • Author(s)
      浦野泰照
    • Organizer
      大阪大学蛋白質研究所セミナー「活性酸素のシグナル伝達」
    • Place of Presentation
      大阪大学蛋白質研究所、大阪
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Precise design of small molecule-based fluorescence probes for elucidating biological events in living samples2009

    • Author(s)
      浦野泰照
    • Organizer
      第20回フォーラム・イン・ドージン「Fluorescence Biology」
    • Place of Presentation
      鶴屋ホール、熊本
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Novel Fluorescence Probes Based on Rational Design Strategies: Real-time Visualization of Various Cellular Responses and in vivo Tumor Imaging2009

    • Organizer
      ISBIE-2009
    • Place of Presentation
      Taipei
    • Year and Date
      2009-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Rational design of novel fluorescence probes for visualizing various cellular responses and in vivo tumor imaging2009

    • Organizer
      4th Cell Stress Society International Congress on Stress Responses
    • Place of Presentation
      Sapporo
    • Year and Date
      2009-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Rational design of novel fluorescence probes for visualizing various cellular responses and in vivo tumor imaging2009

    • Author(s)
      浦野泰照
    • Organizer
      4th Cell Stress Society International Congress on Stress Responses
    • Place of Presentation
      ガトーキングダムサッポロ、北海道
    • Year and Date
      2009-10-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rational design of novel fluorescence probes for visualizing various cellular responses and in vivo tumor imaging2009

    • Organizer
      European Conference on Chemistry for Life Sciences 2009
    • Place of Presentation
      Frankfurt, Germany
    • Year and Date
      2009-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Real-time imaging of various ROS and enzymatic activity in living cells by using precisely developed novel fluorescence probes2009

    • Organizer
      International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
    • Place of Presentation
      Kumamoto
    • Year and Date
      2009-07-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Real-time imaging of various ROS and enzymatic activity in living cells by using precisely developed novel fluorescence probes2009

    • Author(s)
      浦野泰照
    • Organizer
      International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
    • Place of Presentation
      阿蘇ビラパークホテル、熊本
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 活性酸素シグナル応答機構の解明を目指した新規蛍光プローブ・イメージング技法の開発2009

    • Organizer
      レドックス研究とケミカルバイオロジーシンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 蛍光プローブの論理的設計・開発に基づく生細胞レドックスイメージング2009

    • Author(s)
      浦野泰照
    • Organizer
      レドックス研究とケミカルバイオロジーシンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 蛍光プローブの精密開発に基づく、生細胞応答・in vivoがんイメージングの新展開2009

    • Author(s)
      浦野泰照
    • Organizer
      第2回創薬とイメージングに関するシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-09
    • Related Report
      2008 Annual Research Report
  • [Book] 種選択的高感度ROS・RNSイメージングを実現する有機小分子蛍光プローブ群の開発 細胞工学 312012

    • Author(s)
      浦野泰照
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2012 Final Research Report
  • [Book] 種選択的高感度ROS・RNSイメージングを実現する有機小分子蛍光プローブ群の開発2012

    • Author(s)
      浦野 泰照
    • Total Pages
      7
    • Publisher
      秀潤社
    • Related Report
      2012 Annual Research Report
  • [Book] 蛍光プローブの精密設計による新しい生細胞イメージング・in vivoがんイメージング2012

    • Author(s)
      浦野 泰照
    • Total Pages
      8
    • Publisher
      羊土社
    • Related Report
      2012 Annual Research Report
  • [Book] 実験医学2011年10月号2011

    • Author(s)
      浦野泰照
    • Publisher
      羊土社
    • Related Report
      2011 Annual Research Report
  • [Book] 呼吸と循環2011年12月号2011

    • Author(s)
      浦野泰照
    • Publisher
      医学書院
    • Related Report
      2011 Annual Research Report
  • [Book] 最新医学2011年10月号2011

    • Author(s)
      浦野泰照
    • Publisher
      最新医学社
    • Related Report
      2011 Annual Research Report
  • [Book] 化学と生物2011年9月号2011

    • Author(s)
      浦野泰照
    • Publisher
      日本農芸化学会
    • Related Report
      2011 Annual Research Report
  • [Book] がん分子標的治療2011年10月号2011

    • Author(s)
      浦野泰照
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Annual Research Report
  • [Book] 実験医学(論理的設計法に基づく種選択的ROS蛍光プローブの開発)272010

    • Author(s)
      浦野泰照
    • Related Report
      2010 Self-evaluation Report
  • [Book] 化学フロンティア22生命現象を理解する分子ツール2010

    • Author(s)
      浦野泰照
    • Total Pages
      174
    • Publisher
      化学同人
    • Related Report
      2010 Annual Research Report
  • [Book] 論理的設計法に基づく種選択的ROS蛍光プローブの開発 実験医学 27(15)2009

    • Author(s)
      浦野泰照
    • Publisher
      羊土社
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 活性酸素測定用試薬2009

    • Inventor(s)
      長野哲雄、和泉沙希、浦野泰照
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Filing Date
      2009-05-15
    • Related Report
      2010 Self-evaluation Report

URL: 

Published: 2008-04-01   Modified: 2018-03-28  

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