The pathophysiological role of bioactive peptides regulating energy metabolism against obesity

• Project Area: Molecular Basis and Disorders of Control of Apetite and Fat Accumulation
• Project/Area Number: 22126009
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: University of Miyazaki
• Principal Investigator: NAKAZATO Masamitsu 宮崎大学, 医学部, 教授 (10180267)
• Co-Investigator(Kenkyū-buntansha): HIDEKI Yamaguchi 宮崎大学, 医学部, 講師 (10305097) ; HIROAKI Ueno 宮崎大学, 医学部, 助教 (00381062) ; KOJI Toshinai 宮崎大学, 医学部, 講師 (80381101) ; HIRONOBU Tsubouchi 宮崎大学, 医学部, 助教 (60573988) ; 土持 若葉 宮崎大学, 医学部, 医員 (90573303)
• Co-Investigator(Renkei-kenkyūsha): AKIKO Taguchi 国立研究開発法人国立長寿医療研究センター, 部長 (80517186)
• Research Collaborator: Waise Zaved T.M ; Naznin Farhana ; Moin Abu Saleh MD
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥93,730,000 (Direct Cost: ¥72,100,000、Indirect Cost: ¥21,630,000); Fiscal Year 2014: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2013: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2012: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2011: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2010: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
• Keywords: 内科 / 医療 / 生理活性 / 糖尿病 / トランスレーショナルリサーチ / 肥満 / インスリン分泌 / 膵β細胞 / 整理活性 / 視床下部 / ペプチド / 迷走神経 / 摂食 / 糖代謝

Outline of Final Research Achievements

The vagus nerve links between the visceral organs and central nervous system (CNS). Here we showed that mice fed high-fat diet (HFD) developed acute inflammatory responses in the distal colon then the inflammation was induced in the nodose ganglion and hypothalamus through the vagus afferent nerve. These inflammations in the CNS induced the disorder of autonomic efferent nerve and immune system to cause hyperphasia and obesity. Because only one day HFD induced inflammation in the CNS, it is important to reduce fat intake for prevention of obesity.
We identified a novel peptide that is coexpressed with insulin in the secretory granules of pancreatic β cells. This peptide enhanced glucose-induced insulin secretion both in vitro and in vivo and this effect was mediated by increasing intracellular Ca2+ influx in β cells. These findings will provide a new candidate for insulin secretagogues and peptide-based therapeutics for type 2 diabetes.

Research Products

• [Journal Article] Chronic effects of neuroendocrine regulatory peptide (NERP-1 and -2) on insulin secretion and gene expression in pancreatic beta-cells. (2015)
  • Author(s): Kim JW, Rhee M, Park JH, Yamaguchi H, Sasaki K, Minamino N, Nakazato M, Song DK, Yoon KH
  • Journal Title: Biochem Biophys Res Commun Volume: 457 Issue: 2 Pages: 148-153
  • DOI: 10.1016/j.bbrc.2014.12.067
  • Peer Reviewed / Open Access
• [Journal Article] Ghrelin Administration for Chronic Respiratory Failure: A Randomized Dose-Comparison Trial. Lung (2015)
  • Author(s): Matsumoto N, Miki K, Tsubouchi H, Sakamoto A, Arimura Y, Yanagi S, Iiboshi H, Yoshida M, Souma R, Ishimoto H, Yamamoto Y, Yatera K, Yoshikawa M, Sagara H, Iwanaga T, Mukae H, Maekura R, Kimura H, Nakazato M, Kangawa K
  • Journal Title: Lung Volume: 193 Issue: 2 Pages: 239-247
  • DOI: 10.1007/s00408-015-9685-y
  • Peer Reviewed / Open Access
• [Journal Article] Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients (2015)
  • Author(s): Tsuchimochi W, Ueno H, Yamashita E, Tsubouchi C, Sakoda H, Nakamura S, Nakazato M
  • Journal Title: Endocrine Journal Volume: 62 Issue: 1 Pages: 13-20
  • DOI: 10.1507/endocrj.EJ14-0393
  • NAID: 130004690934
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Ghrelin. (2015)
  • Author(s): Muller T.D., Kojima M, Bloom S, Bowers C.Y, Casanueva F, Cowley M, Dickson S, Inui A, Nakazato M, Nass R, Perez-Tilve D, Pfluger, P.T., Schwartz T, Seeley R, Sleeman M, Smith R.G., Sun Y, Sussel L, Tong J, Thorner M.O., van der Lely A.J., van der Ploeg L, Zigman J, Kangawa K, Horvath T, Tschop M.H, et al
  • Journal Title: Molecular Metabolism Volume: 未定 Issue: 6 Pages: 437-460
  • DOI: 10.1016/j.molmet.2015.03.005
  • Peer Reviewed / Open Access
• [Journal Article] Neuroendocrine regulatory peptide-1 and -2 (NERPs) inhibit the excitability of magnocellular neurosecretory cells in the hypothalamus. (2014)
  • Author(s): Toshinai K, Saito T, Yamaguchi H, Sasaki K, Tsuchimochi W, Minamino N, Ueta Y, Nakazato M
  • Journal Title: Brain Res Volume: 1563 Pages: 52-60
  • DOI: 10.1016/j.brainres.2014.03.038
  • Peer Reviewed / Open Access
• [Journal Article] Exploratory trial of intranasal administration of glucagon-like peptide-1 in Japanese patients with type 2 diabetes. (2014)
  • Author(s): Ueno H, Mizuta M, Shiiya T, Tshuchimochi W, Noma K, Nakashima N, Fujihara M, Nakazato M
  • Journal Title: Diabetes Care Volume: 37 Issue: 7 Pages: 2024-2027
  • DOI: 10.2337/dc13-0690
  • Peer Reviewed
• [Journal Article] Ghrelin relieves cancer cachexia associated with the development of lung adenocarcinoma in mice (2014)
  • Author(s): Tsubouchi H, Yanagi S, Miura A, Matsumoto N, Kangawa K, Nakazato M
  • Journal Title: Eur J Pharmacol Volume: 743 Pages: 1-10
  • DOI: 10.1016/j.ejphar.2014.09.025
  • Peer Reviewed
• [Journal Article] Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner. (2014)
  • Author(s): Tsubouchi H, Yanagi S, Miura A, Iizuka S, Mogami S, Yamada C, Hattori T, Nakazato M
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 306 Issue: 3 Pages: 233-245
  • DOI: 10.1152/ajplung.00096.2013
  • Peer Reviewed
• [Journal Article] Circulating Des-acyl Ghrelin Improves Cardiovascular Risk Prediction in Older Hypertensive Patients (2014)
  • Author(s): Yano Y, Nakazato M, Toshinai K, Inokuchi T, Matsuda S, Hidaka T, Hayakawa M, Kangawa K, Shimada K, Kario K
  • Journal Title: Am J Hypertens Volume: 27 Issue: 5 Pages: 723-733
  • DOI: 10.1093/ajh/hpt232
  • Peer Reviewed
• [Journal Article] Rikkunshito ameliorates cachexia associated with bleomycin-induced lung fibrosis in mice by stimulating ghrelin secretion. (2014)
  • Author(s): Tsubouchi H, , Yanagi S, Miura A, Mogami S, Yamada C, Iizuka S, Hattori T, Nakazato M
  • Journal Title: Nutr Res Volume: 34 Issue: 10 Pages: 876-885
  • DOI: 10.1016/j.nutres.2014.08.014
  • Peer Reviewed
• [Journal Article] Exploratory trial of intranasal administration of glucagon-like peptide-1 in Japanese patients with type 2 diabetes (2014)
  • Author(s): Ueno H, Mizuta M, Shiiya T, Tshuchimochi W, Noma K, Nakashima N, Fujihara M, Nakazato M.
  • Journal Title: Diabetes Care, Volume: in press
  • Peer Reviewed
• [Journal Article] Ghrelin prevents the development of experimental diabetic neuropathy in rodents (2013)
  • Author(s): Tsuchimochi W, Kyoraku I, Yamaguchi H, Toshinai K, Shiomi K, Kangawa K, Nakazato M.
  • Journal Title: Eur J Pharmacol, Volume: 702 Pages: 187-193
  • Peer Reviewed
• [Journal Article] Elevation of muscle temperature stimulates muscle glucose uptake in vivo and in vitro. (2013)
  • Author(s): Koshinaka K, Kawamoto E, Abe N, Toshinai K, Nakazato M, Kawanaka K.
  • Journal Title: J Physiol Sci Volume: 63 Issue: 6 Pages: 409-418
  • DOI: 10.1007/s12576-013-0278-3
  • Peer Reviewed
• [Journal Article] Ghrelin prevents the development of experimental diabetic neuropathy in rodents. (2013)
  • Author(s): Tsuchimochi W, Kyoraku I, Yamaguchi H, Toshinai K, Shiomi K, Kangawa K, Nakazato M
  • Journal Title: Eur J Pharmacol Volume: 702 Issue: 1-3 Pages: 187-193
  • DOI: 10.1016/j.ejphar.2013.01.035
  • Peer Reviewed
• [Journal Article] Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial. (2012)
  • Author(s): Miki K, Maekura R, Nagaya N, Nakazato M, Kimura H, Murakami S, Ohnishi S, Hiraga T, Miki M, Kitada S, Yoshimura K, Tateishi Y, Arimura Y, Matsumoto N, Yoshikawa M, Yamahara K, Kangawa K
  • Journal Title: PLoS ONE Volume: 7 Issue: 5 Pages: e35708-e35708
  • DOI: 10.1371/journal.pone.0035708
  • Peer Reviewed
• [Journal Article] Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro. (2012)
  • Author(s): Moin AS, Yamaguchi H, Rhee M, Kim JW, Toshinai K, Waise TM, Naznin F, Matsuo T, Sasaki K, Minamino N, Yoon KH, Nakazato M
  • Journal Title: Biochem Biophys Res Commun Volume: 428 Issue: 4 Pages: 512-517
  • DOI: 10.1016/j.bbrc.2012.10.073
  • Peer Reviewed
• [Journal Article] Therapeutic potential of ghrelin treatment for unloading-induced muscle atrophy in mice (2011)
  • Author(s): Koshinaka K, Toshinai K, Mohammad A, Noma K, Oshikawa M, Ueno H, Yamaguchi H, Nakazato M
  • Journal Title: Biochem Biophys Res Commun Volume: 412 Pages: 296-301
  • Peer Reviewed
• [Journal Article] Glucagon-like peptide-1 and candesartan additively improve glucolipotoxicity in pancreatic β-cells (2011)
  • Author(s): Wang H, Mizuta M, Saitoh Y, Noma K, Ueno H, Nakazato M
  • Journal Title: Metabolism Volume: 60 Issue: 8 Pages: 1081-1089
  • DOI: 10.1016/j.metabol.2010.11.004
  • Peer Reviewed
• [Journal Article] Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men (2011)
  • Author(s): Shiiya T, Ueno H, Toshinai K, Kawagoe T, Naito S, Tobina T, Nishida Y, Shindo M, Kangawa K, Tanaka H, Nakazato M
  • Journal Title: Endocrine Journal Volume: 58 Issue: 5 Pages: 335-342
  • DOI: 10.1507/endocrj.K11E-021
  • NAID: 130004443692
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Localization of neuroendocrine regulatory peptide-1 and-2 in human tissues. (2010)
  • Author(s): Matsuo T, Yamaguchi H, Kageyama H, Sasaki K, Shioda S, Minamino N, Nakazato M.
  • Journal Title: Regul Pept Volume: 163 Pages: 43-48
  • Peer Reviewed
• [Journal Article] Neuropeptide W : an anorectic peptide regulated by leptin and metabolic state. (2010)
  • Author(s): Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M.
  • Journal Title: Endocrinology Volume: 151 Pages: 2200-2210
  • Peer Reviewed
• [Journal Article] Distribution of neuroendocrine regulatory peptide-1 and-2, and proteolytic processing of their precursor VGF protein in the rat. (2010)
  • Author(s): Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Yoshizawa-Kumagaye K, Satomi Y, Takao T, Shioda S, Nakazato M, Minamino N.
  • Journal Title: J Neurochem. Volume: 114 Pages: 1097-1106
  • Peer Reviewed
• [Journal Article] Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus. (2010)
  • Author(s): Toshinai K, Yamaguchi H, Kageyama H, Matsuo T, Koshinaka K, Sasaki K, Shioda S, Minamino N, Nakazato M
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 299
  • Peer Reviewed
• [Journal Article] Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats
  • Author(s): Ogawa N, Ito M, Yamaguchi H, Shiuchi T, Okamoto S, Wakitani K, Minokoshi Y, Nakazato M
  • Journal Title: Metabolism Volume: (in press)
  • Peer Reviewed
• [Presentation] エネルギー代謝調節中枢としての視床下部の機能とその破綻 (2015)
  • Author(s): 中里雅光
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-23 – 2015-04-25
• [Presentation] 自律神経・内分泌・免疫系を介するエネルギー代謝調節 (2015)
  • Author(s): 中里雅光
  • Organizer: 第52回日本臨床分子医学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-04-10 – 2015-04-11
• [Presentation] 臨床医が知っておくべき糖尿病の基礎 食欲調節のメカニズムからみた糖尿病 (2015)
  • Author(s): 中里雅光
  • Organizer: 第49回 糖尿病学の進歩
  • Place of Presentation: 岡山
  • Year and Date: 2015-02-20 – 2015-02-21
• [Presentation] エネルギー代謝調節におけるペプチドの役割と臨床応用 (2015)
  • Author(s): 中里雅光
  • Organizer: 第18回日本病態栄養学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-01-09 – 2015-01-10
  • Invited
• [Presentation] 摂食・エネルギー代謝における自律神経の重要性 (2014)
  • Author(s): 中里雅光
  • Organizer: 第67回日本自律神経学会総会
  • Place of Presentation: 埼玉
  • Year and Date: 2014-10-30 – 2014-10-31
  • Invited
• [Presentation] 会長講演 (2014)
  • Author(s): 中里雅光
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] グレリンの筋萎縮改善作用 (2014)
  • Author(s): 十枝内厚次，越中敬一，中里雅光
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] 高脂肪食による迷走神経機能障害の誘導 (2014)
  • Author(s): ナズニン ファーハナ，十枝内厚次，中里雅光
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] Localization of neuroendocrine regulatory peptide-4 (NERP-4) in mouse and human pancreas. (2014)
  • Author(s): Moin Abu Saleh Md., 十枝内厚次，山口秀樹，迫田秀之，山崎基生，佐々木一樹，上野浩晶，平子智史，塩田清二，南野直人，中里雅光
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] ブレオマイシン誘発肺線維症モデルにおけるグレリンを介した六君子湯の摂食調節作用 (2014)
  • Author(s): 飯塚正一，柳 重久，坪内拡伸，十枝内厚次，最上祥子，山田ちひろ，服部智久，中里雅光
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] イプラグリフロジンの抗糖尿病および抗肥満効果． (2014)
  • Author(s): 上野浩晶，山口秀樹，中里雅光
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] 食欲亢進ホルモン グレリンの呼吸器疾患への臨床応用 (2014)
  • Author(s): 中里雅光
  • Organizer: 第53回 日本肺癌学会中国・四国支部会
  • Place of Presentation: 米子
  • Year and Date: 2014-07-11
  • Invited
• [Presentation] Neuroendocrine regulatory peptide-4(nerp-4): A Vgf derived peptide that expresses in pancreatic β- cells and stimulate glucose-induced insulin secretion. (2014)
  • Author(s): Shimizu K, Moin AS Md, Ueno H, Toshinai K, Yamaguchi H, Yamasaki M, Hirako T, Shioda S, Sasaki K, Minamino N, Nakazato M
  • Organizer: American Diabetes Association 74th Scientific Sessions
  • Place of Presentation: San Francisco, California. USA
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] ブレオマイシン肺傷害モデルにおける六君子湯のグレリン分泌を介したcachexia改善効果 (2014)
  • Author(s): 坪内拡伸，柳 重久，松元信弘，中里雅光
  • Organizer: 第54回 日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] 消化管ホルモンと神経連関 (2014)
  • Author(s): 中里雅光
  • Organizer: 第87回日本内分泌学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-04-24 – 2014-04-26
  • Invited
• [Presentation] 消化管ホルモンから糖尿病治療戦略を考える (2014)
  • Author(s): 中里雅光
  • Organizer: 第23回臨床内分泌代謝Update
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 神経と内分泌の連関によるエネルギー代謝調節 (2014)
  • Author(s): 中里雅光
  • Organizer: 第23回臨床内分泌代謝Update
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 食欲調節のメカニズムからみた糖尿病 (2014)
  • Author(s): 中里雅光
  • Organizer: 第48回糖尿病学の進歩
  • Place of Presentation: 札幌
• [Presentation] 第5回福岡県病院薬剤師会学術大会ランチョンセミナー (2013)
  • Author(s): DPP-4阻害薬の登場で糖尿病治療が変わったこと．
  • Organizer: 中里雅光
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-03
• [Presentation] 高脂肪食負荷マウスにおけるグレリン抵抗性の解析． (2013)
  • Author(s): 中里雅光
  • Organizer: 第27回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-02-23
• [Presentation] 消化管ペプチドの神経を介した摂食調節連関およびその破綻 (2013)
  • Author(s): 中里雅光
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台
  • Invited
• [Presentation] 肥満症専門医に求められるもの (2013)
  • Author(s): 中里雅光
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Gut hormones regulating energy homeostasis (2013)
  • Author(s): Nakazato M
  • Organizer: APDO symposium 2013
  • Place of Presentation: 東京
  • Invited
• [Presentation] 迷走神経を介した消化管ペプチドによるエネルギー代謝調節機序 (2013)
  • Author(s): 十枝内厚次、中里雅光
  • Organizer: 第10回GPCR研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Functional interaction between ghrelin and GLP-1 for feeding and disruption of peripheral feeding regulation under obese condition. (2013)
  • Author(s): Toshinai K, Nakazato M
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本
  • Invited
• [Presentation] 迷走神経を介したグレリンとGLP-1の摂食調節連関 (2013)
  • Author(s): 十枝内厚次、Waise TM Zaved、中里雅光
  • Organizer: 第40回日本神経内分泌学会学術集会
  • Place of Presentation: 宮崎
  • Invited
• [Presentation] 消化管ホルモンから糖尿病治療戦略を考える～摂食調節機構を視野に入れて～ (2012)
  • Author(s): 中里雅光
  • Organizer: 第69回日本呼吸器学会・日本血管病学会九州支部・秋季学術講演会
  • Place of Presentation: 北九州
  • Year and Date: 2012-11-17
• [Presentation] 消化管ペプチドの発見によるエネルギー代謝調節の新たな理解とその臨床応用 (2012)
  • Author(s): 中里雅光
  • Organizer: 第20回西日本肥満研究会
  • Place of Presentation: 愛媛
  • Year and Date: 2012-07-15
• [Presentation] 摂食亢進ペプチド グレリンのトランスレーショナルリサーチ (2012)
  • Author(s): 中里雅光
  • Organizer: 第53回日本心身医学会 教育講演29
  • Place of Presentation: 鹿児島
  • Year and Date: 2012-05-26
• [Presentation] 中枢と末梢を結ぶエネルギー代謝調節機構 (2012)
  • Author(s): 中里雅光
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2012-04-21
• [Presentation] 消化管ホルモンから 糖尿病治療戦略を考える～摂食調節機構を視野にいれて～ (2012)
  • Author(s): 中里雅光
  • Organizer: 第85回日本内分泌学会学術総会 ランチョンセミナー18
  • Place of Presentation: 名古屋市
  • Year and Date: 2012-04-20
• [Presentation] Gut-Brain Network of Appetite Regulation in Obesity (2011)
  • Author(s): 中里雅光
  • Organizer: The Korea-Japan Joint Symposium in KSSO Meeting
  • Place of Presentation: 韓国(招待講演)
  • Year and Date: 2011-10-15
• [Presentation] 肥満研究の新たな展開と糖尿病への臨床応用 (2011)
  • Author(s): 中里雅光
  • Organizer: 第49回日本糖尿病学会九州地方会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-10-14
• [Presentation] 肥満症の内科的治療の展望 (2011)
  • Author(s): 中里雅光
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 兵庫
  • Year and Date: 2011-09-24
• [Presentation] 脳による摂食調節 (2011)
  • Author(s): 中里雅光
  • Organizer: 第29回日本肥満症治療学会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-06-10
• [Presentation] グレリンのトランスレーショナルリサーチ (2011)
  • Author(s): 中里雅光
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸(招待講演)
• [Presentation] 消化管ホルモンから糖尿病治療戦略を考える糖尿病治療の新時代～摂食調節機構を視野に入れて～ (2011)
  • Author(s): 中里雅光
  • Organizer: 消第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌(招待講演)
• [Presentation] Translational research of ghrelin. (2010)
  • Author(s): Nakazato M
  • Organizer: 5th International Peptide Symposium
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 2010-12-07
• [Presentation] 肥満と糖尿病の治療におけるパラダイムシフト (2010)
  • Author(s): 中里雅光
  • Organizer: 第42回日本内科学会九州支部主催生涯教育講演会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-11-14
• [Presentation] Nakazato M.: Clinical application of ghrelin and GLP-1 for the treatment of type 2 diabetes mellitus. (2010)
  • Author(s): 中里雅光
  • Organizer: 36^<th> Autumun Congress of Korean Diabetes Association
  • Place of Presentation: Korean
  • Year and Date: 2010-10-16
• [Presentation] 栄養-脳機能ネットワーク:食欲関連ペプチドの役割 (2010)
  • Author(s): 中里雅光
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] 加齢におけるアナボリックペプチドグレリンの意義とトランスレーショナルリサーチ (2010)
  • Author(s): 中里雅光
  • Organizer: 第32回日本臨床栄養学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-08-29
• [Presentation] Prevention and reversal of diabetic neuropathy by treatment with ghrelin. (2010)
  • Author(s): Nakazato M
  • Organizer: ENDO2010
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-06-20
• [Presentation] 機能性ペプチドの臨床応用の実際 (2010)
  • Author(s): 中里雅光
  • Organizer: 第122回日本薬理学会関東部会
  • Place of Presentation: 静岡
  • Year and Date: 2010-06-05
• [Book] Annual Review 2015呼吸器．（分担）呼吸器疾患におけるPTENの役割 (2015)
  • Author(s): 柳 重久、坪内拡伸、中里雅光
  • Total Pages: 248
  • Publisher: 中外医学社
• [Book] メディコピア55 栄養と食欲－病態と治療の進歩－．（分担）食欲を調節するホルモンと代謝 (2014)
  • Author(s): 中里雅光
  • Total Pages: 141
  • Publisher: 富士レビオ
• [Book] 最新 内分泌代謝学 (2013)
  • Author(s): 中尾一和 編集主幹. 中里雅光
  • Total Pages: 970
  • Publisher: 診断と治療社
• [Book] 糖尿病の分子標的と治療薬事典 (2013)
  • Author(s): 春日雅人 監修．上野浩晶、中里雅光
  • Total Pages: 342
  • Publisher: 羊土社
• [Book] Annual Review 糖尿病・代謝・内分泌 (2013)
  • Author(s): 山下英一郎、上野浩晶、中里雅光
  • Total Pages: 229
  • Publisher: 中外医学社
• [Book] 総編：今日の治療指針2013年版 (2013)
  • Author(s): 中里雅光
  • Total Pages: 1955
  • Publisher: 医学書院
• [Book] 今日の診療のためにガイドライン外来診療2013 (2013)
  • Author(s): 山下英一郎、中里雅光
  • Total Pages: 658
  • Publisher: 日経メディカル開発
• [Book] ペプチド医薬の最前線 (2012)
  • Author(s): 中里雅光
  • Total Pages: 240
  • Publisher: シーエムシー出版
• [Book] 次世代バイオ医薬品の製剤設計と開発戦略GLP-1の経鼻投与による2型糖尿病の治療開発150-154 (2011)
  • Author(s): 中里雅光
  • Total Pages: 245
  • Publisher: シーエムシー出版(東京)
• [Book] 今日の診断のために ガイドライン外来診療 (2010)
  • Author(s): 中里雅光
  • Total Pages: 610
  • Publisher: 内分泌・代謝性疾患 肥満症
• [Patent(Industrial Property Rights)] インスリン分泌促進剤 (2010)
  • Inventor(s): 山崎基生、中里雅光
  • Industrial Property Rights Holder: 宮崎大学,協和発酵
  • Industrial Property Number: 2010-296912
  • Filing Date: 2010-12-28