|Budget Amount *help
¥96,330,000 (Direct Cost: ¥74,100,000、Indirect Cost: ¥22,230,000)
Fiscal Year 2015: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2013: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
|Outline of Final Research Achievements
Basic morphological data on developing epithelial tubular structures were obtained applying mathematical methods as standards to evaluate abnormal development, and findings including those in Ror2 knockout mice were reported. Ｗe proved interkinetic nuclear migration (INM), a regulatory mechanism of stem cell proliferation/differentiation reported in the neural epithelium, in the developing epithelium of multiple organs of three germ-layer origins. We showed that INM is a general strategy for the regulated proliferation/differentiation of progenitor cells in the epithelial tubular structures, and also suggested a link between INM defects and malformation of organs.
We improved the exo-utero development method, an experimental analysis of organ histogenesis, and published the report and review papers. We also developed a kit for producing cleared biological specimens and method for producing cleared biological specimens for fine and effective 3-D observation.