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2015 Fiscal Year Final Research Report

Organ malformations as results of accumulated polarity disruptions in epithelial tubular structures during organogenesis and histogenesis

Planned Research

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Project AreaRegulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure
Project/Area Number 23112006
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionShimane University

Principal Investigator

Otani Hiroki  島根大学, 医学部, 教授 (20160533)

Co-Investigator(Kenkyū-buntansha) HATTA Toshihisa  金沢医科大学, 医学部, 教授 (20238025)
UDAGAWA Jun  滋賀医科大学, 医学部, 教授 (10284027)
Research Collaborator HASHIMOTO Ryuju  
NAITO Kanta  
MATSUMOTO Akihiro  
FURUYA Motohide  
OGAWA Noriko  
INOUE Takayuki  
RAFIQ Ashiq Mahmood  
JAHAN Esrat  
MOTOYA Tomoyuki  
NITTA Tetsuya  
KURAMOTO Junko  
HIRANO Satoru  
ZHANG Qinghua  
LIANG Shuai  
DEREJE Getachew Regassa  
KANEDA Ryo  
SAEKI Yuko  
TAKEDA Yumiko  
Project Period (FY) 2011-04-01 – 2016-03-31
Keywords上皮管腔組織 / 極性 / 器官形成 / 組織形成 / 形態学 / 数理解析
Outline of Final Research Achievements

Basic morphological data on developing epithelial tubular structures were obtained applying mathematical methods as standards to evaluate abnormal development, and findings including those in Ror2 knockout mice were reported. We proved interkinetic nuclear migration (INM), a regulatory mechanism of stem cell proliferation/differentiation reported in the neural epithelium, in the developing epithelium of multiple organs of three germ-layer origins. We showed that INM is a general strategy for the regulated proliferation/differentiation of progenitor cells in the epithelial tubular structures, and also suggested a link between INM defects and malformation of organs.
We improved the exo-utero development method, an experimental analysis of organ histogenesis, and published the report and review papers. We also developed a kit for producing cleared biological specimens and method for producing cleared biological specimens for fine and effective 3-D observation.

Free Research Field

発生生物学、先天異常学、解剖学

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Published: 2017-05-10  

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