Neuronal basis of prediction and decision in the basal ganglia and amygdala.

• Project Area: Elucidation of neural computation for prediction and decision making: toward better human understanding and applications
• Project/Area Number: 23120010
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Tamagawa University
• Principal Investigator: KIMURA Minoru 玉川大学, 脳科学研究所, 教授 (40118451)
• Co-Investigator(Kenkyū-buntansha): HARUNO Masahiko 国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報通信融合研究室, 主任研究員 (40395124)
• Co-Investigator(Renkei-kenkyūsha): SAMEJIMA Kazuyuki 玉川大学, 脳科学研究所, 教授 (30395131) ; ENOMOTO Kazuki 玉川大学, 脳科学研究所, 科研費研究員 (10585904)
• Research Collaborator: YAMANAKA Ko 順天堂大学, スポーツ健康科学部, 助教 (40551479)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥86,710,000 (Direct Cost: ¥66,700,000、Indirect Cost: ¥20,010,000); Fiscal Year 2015: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2014: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2013: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2012: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2011: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
• Keywords: 神経科学 / 生理学 / 意思決定 / 大脳基底核 / 扁桃体 / 意志決定

Outline of Final Research Achievements

We made new findings about neuronal basis of prediction and decision by conducting animal experiments and functional brain imaging of human subjects.
1.Japanese monkeys are able to make optimal decisions based on reward histories of their own as well as another monkey sitting side by side. 2.Activity of midbrain dopamine neurons and neurons in the striatum evaluate whether decision and action are rewarded or not and predict multiple future rewards through multi-step actions toward a goal. 3.Neurons in the centromedian (CM) nucleus of thalamus encode response bias to large-reward action, binding of response bias into action and unexpected change of behavioral state. 4.Activity of human amygdala and accumbens represents inequity in monetary resources delivered between oneself and another person.

Research Products

• [Journal Article] Characteristics of fast-spiking neurons in the striatum of behaving monkeys. (2016)
  • Author(s): Yamada H, Inokawa H, Hori Y, Pan X, Matsuzaki R, Nakamura K, Samejima K, Shidara M, Kimura M, Sakagami M, Minamimoto T.
  • Journal Title: Neuroscience research Volume: 105 Pages: 2-18
  • DOI: 10.1016/j.neures.2015.10.003
  • NAID: 120007135484
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Activity in the Nucleus Accumbens and Amygdala Underlies Individual Differences in Prosocial and Individualistic Economic Choices (2014)
  • Author(s): Masahiko Haruno, Minoru Kimura, Christopher D. Frith
  • Journal Title: J Cogn Neurosci. Volume: 0 Pages: 1-10
  • DOI: 10.1162/jocn_a_00589
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Enhancement of alcohol drinking in mice depends on alterations in RNA editing of serotonin 2C receptors. (2014)
  • Author(s): Watanabe Y, Yoshimoto K, Tatebe H, Kita M, Nishikura K, Kimura M, Tanaka M
  • Journal Title: Journal of Cognitive Neuroscience Volume: 17(5) Pages: 1861-1870
  • DOI: 10.1017/s1461145713001545
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Neural signal for counteracting pre-action bias in the centromedian thalamic nucleus (2014)
  • Author(s): Minamimoto T, Hori Y, Yamanaka K, Kimura M.
  • Journal Title: Front Syst Neurosci Volume: 8(3) Pages: 1-11
  • DOI: 10.3389/fnsys.2014.00003
  • Peer Reviewed / Open Access
• [Journal Article] Coding of the long-term value of multiple future rewards in the primate striatum (2013)
  • Author(s): Yamada H, Inokawa H, Matsumoto N, Ueda Y, Enomoto K, Kimura M
  • Journal Title: J Neurophysiol. Volume: 109(4) Pages: 1140-1151
  • DOI: 10.1152/jn.00289.2012
  • Peer Reviewed
• [Journal Article] Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior (2012)
  • Author(s): Yoshimoto K, Watanabe Y, Tanaka M, Kimura M
  • Journal Title: Eur. J. Neurosci. Volume: vol 35 Pages: 1368-1380
  • DOI: 10.1111/j.1460-9568.2012.08037.x
  • Peer Reviewed
• [Journal Article] Dopamine neurons learn to encode the long-term value of multiple future rewards (2011)
  • Author(s): Enomoto K.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 108(37) Pages: 15462-15467
  • DOI: 10.1073/pnas.1014457108
  • Peer Reviewed
• [Journal Article] Neuronal basis for evaluating selected action in the primate striatum (2011)
  • Author(s): Yamada H, Inokawa H, Matsumoto N, Ueda Y, Kimura M
  • Journal Title: Eur.J.Neurosci Volume: 34 (3) Pages: 489-506
  • DOI: 10.1111/j.1460-9568.2011.07771.x
  • Peer Reviewed
• [Journal Article] Thalamic Contributions to Basal Ganglia-Related Behavioral Switching and Reinforcement (2011)
  • Author(s): Smith Y
  • Journal Title: J Neurosci. Volume: 31(45) Pages: 16102-16106
  • DOI: 10.1523/jneurosci.4634-11.2011
  • Peer Reviewed
• [Presentation] Roles of nigrostriate and thalamostriate systems in motivation and learning. (2016)
  • Author(s): Minoru Kimura
  • Organizer: The Third CiNet Conference Neural mechanisms of decision making: Achievements and new directions
  • Place of Presentation: NICT,Center for information and Neural Networks(CiNet/NICT)(大阪府吹田市）
  • Year and Date: 2016-02-05
  • Int'l Joint Research / Invited
• [Presentation] Roles of the centromedian nucleus of thalamus and its projection to the striatum in cognitive and behavioral biases. (2015)
  • Author(s): Kimura, M., Yamanaka, K., Minamimoto, T., Hori, Y. and Ueda, Y.
  • Organizer: Neuroscience 2015, SfN's 45th annual meeting
  • Place of Presentation: McCormic Place, Chicago, Illinois, USA
  • Year and Date: 2015-10-21
  • Int'l Joint Research / Invited
• [Presentation] 大脳基底核による行動選択と学習機能 (2015)
  • Author(s): 木村 實
  • Organizer: 第30回日本大脳基底核研究会
  • Place of Presentation: 名鉄犬山ホテル（愛知県犬山市）
  • Year and Date: 2015-07-19
  • Invited
• [Presentation] Neural basis of congnitive control of behavior in the centromedian nucleus of thalamus and its projection to the striatum. (2015)
  • Author(s): Kimura M.,Yamanaka K., Minamimoto T., Hori T., Ueda Y.
  • Organizer: Thalamus and Corticithalamic Interactions
  • Place of Presentation: Janelia Research Campus, Virginia, USA
  • Year and Date: 2015-04-27
  • Int'l Joint Research / Invited
• [Presentation] 大脳基底核の機能におけるドーパミンの役割 (2014)
  • Author(s): 木村 實
  • Organizer: エビリファイ発売8周年記念講演会
  • Place of Presentation: 京王プラザホテル（北海道札幌市）
  • Year and Date: 2014-11-29
• [Presentation] 大脳基底核の機能におけるドーパミンの役割 (2014)
  • Author(s): 木村 實
  • Organizer: エビリファイ発売8周年記念講演会 第2回ドーパミンシステムを再考する
  • Place of Presentation: 京王プラザホテル札幌（北海道）
  • Year and Date: 2014-11-29
  • Invited
• [Presentation] 強化学習に基づいた、サル線条体に存在する内因性エンドカンナビノイドの意志決定に関する役割 (2014)
  • Author(s): 上田 康雅，岡崎 哲，山中 航，鮫島 和行，榎本 一紀，狩野 方伸，木村 實
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2014-09-12
• [Presentation] サル中脳ドーパミン細胞によるオーバートレーニング時の部位特異的な将来報酬表現 (2014)
  • Author(s): 榎本 一紀、松本 直幸、春野 雅彦、木村 實
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-11
• [Presentation] 視床正中中心核における行動バイアスのモニター (2014)
  • Author(s): 山中 航、堀 由紀子、上田 康雅、南本 敬史、木村 實
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-11
• [Presentation] 視床正中中心核における行動バイアスのモニター (2014)
  • Author(s): 山中 航，堀 由紀子，上田 康雅，南本 敬史，木村 實
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2014-09-11
• [Presentation] サル中脳ドーパミン細胞によるオーバートレーニング時の部位特異的な将来報酬表現 (2014)
  • Author(s): 榎本 一紀，松本 直幸，春野 雅彦，木村 實
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2014-09-11
• [Presentation] Neural basis of congnitive control of behavior in the centromedian nucleus of thalamus and its projection to the striatum (2014)
  • Author(s): Kimura M, Yamanaka K., Minamimoto T., Hori Y., Ueda Y
  • Organizer: Thalamus and Cortico-Thalamic Interactions
  • Place of Presentation: Janelia Conference, Janelia Research Campus, VA, USA
  • Year and Date: 2014-04-27
  • Invited
• [Presentation] オーバートレーニング時のサルにおいてドーパミン細胞は課題ブロックを跨いだ超長期的な報酬情報を表現する (2013)
  • Author(s): 榎本 一紀，松本 直幸，木村 實
  • Organizer: Neuroscience 2013, SfN's 43nd annual meeting
  • Place of Presentation: San Diego（アメリカ）
  • Year and Date: 2013-11-13
• [Presentation] 過学習時においてサル中脳ドーパミン細胞は超長期的な報酬期待を表現する (2013)
  • Author(s): Enomoto K, Matsumoto N, Kimura M.
  • Organizer: 第36回日本神経科学学会大会 Neuro2013
  • Place of Presentation: 国立京都国際会館（京都府）
  • Year and Date: 2013-06-22
• [Presentation] 報酬に基づく行動のバイアスは視床CM核̶線条体投射によって最適化される (2013)
  • Author(s): Yamanaka K, Kimura M.
  • Organizer: 第36回日本神経科学学会大会 Neuro2013
  • Place of Presentation: 国立京都国際会館（京都府）
  • Year and Date: 2013-06-22
• [Presentation] 複数ステップ報酬課題における線条体の活動が時間割引率を反映する (2013)
  • Author(s): Tanaka S, Takaoka M, Yoneda H, Enomoto K, Samejima K, Haruno M Kimura M, Ohtake F.
  • Organizer: 第36回日本神経科学学会大会
  • Place of Presentation: 国立京都国際会館（京都府）
  • Year and Date: 2013-06-20
• [Presentation] 大脳基底核における意志決定の神経機構 (2013)
  • Author(s): 木村 實
  • Organizer: 京都府立医科大学生理学教室130周年記念シンポジウム
  • Place of Presentation: 京都府立医科大学、京都府
  • Invited
• [Presentation] 大脳基底核における意志決定の神経機構 (2013)
  • Author(s): 木村 實
  • Organizer: つくばブレインサイエンスセミナー第200回記念特別講演会
  • Place of Presentation: 筑波大学、茨城県
  • Invited
• [Presentation] Optimization of action selection by resetting response bias through CM-striatum projection (2013)
  • Author(s): Yamanaka K.
  • Organizer: 11th International Basal Ganglia Society Meeting (IBAGS XI)
  • Place of Presentation: Princess Hotel Eilat, Taba Beach (Eilat), Israel
• [Presentation] カンナビノイド(CB1)受容体阻害剤の線条体注入による、試行錯誤学習課題に及ぼす影響 (2012)
  • Author(s): 岡崎哲
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本文化会館、長野県
  • Year and Date: 2012-03-31
• [Presentation] ドーパミンと脳報酬系のシステム神経科学 (2012)
  • Author(s): 木村實
  • Organizer: 第9回GPCR研究会
  • Place of Presentation: 日本科学未来館、東京都
  • Invited
• [Presentation] 5-HT2C受容体RNA編集のアルコール嗜好性への関与 (2012)
  • Author(s): 渡邊 義久
  • Organizer: 第9回GPCR研究会
  • Place of Presentation: 日本科学未来館、東京都
• [Presentation] Neuronal basis of decision, action and evaluation in the basal ganglia (2012)
  • Author(s): Kimura M.
  • Organizer: Striatum Workshop in London （Gatsby Computational Neuroscience Unit Striatum Meeting）
  • Place of Presentation: Gatsby Computational Neuroscience Unit, UK
  • Invited
• [Presentation] 試行錯誤学習課題遂行中の、サルの線条体CB1受容体が果たす役割について (2012)
  • Author(s): 上田 康雅
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場、愛知県
• [Presentation] 学習と意思決定課題におけるサルの中脳部位特異的なドーパミン細胞の活動 (2012)
  • Author(s): 榎本 一紀
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場、愛知県
• [Presentation] 視床CM核の非感覚性細胞による行動選択への関与 (2012)
  • Author(s): 山中 航
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場、愛知県
• [Presentation] Location-specific roles of dopamine neurons in the midbrain in learning and decision-making. (2012)
  • Author(s): Enomoto K.
  • Organizer: Neuroscience 2012, SfN's 42nd annual meeting
  • Place of Presentation: Ernest N. Morial Convention Center, New Orleans, LA, USA
• [Presentation] Activity in the nucleus accumbens and amygdala encodes prosocial and individualistic intuitions in social decision making. (2012)
  • Author(s): Haruno M.
  • Organizer: Neuroscience 2012, SfN's 42nd annual meeting
  • Place of Presentation: Ernest N. Morial Convention Center, New Orleans, LA, USA
• [Presentation] Impairment of reward-based adaptive choice of actions by local injection of cannabinoid CB1 receptor antagonist into the striatum of behaving monkeys (2012)
  • Author(s): Ueda Y.
  • Organizer: Neuroscience 2012, SfN's 42nd annual meeting
  • Place of Presentation: Ernest N. Morial Convention Center, New Orleans, LA, USA
• [Presentation] Signals projected from the centromedian nucleus of thalamus to the putamen during reward-based action selection in monkey (2012)
  • Author(s): Yamanaka K.
  • Organizer: Neuroscience 2012, SfN's 42nd annual meeting
  • Place of Presentation: Ernest N. Morial Convention Center, New Orleans, LA, USA
• [Presentation] スポーツにおける動機づけ ―その時脳はどう働くのか？― (2012)
  • Author(s): 木村 實
  • Organizer: 札幌スポーツ医科学セミナー'12
  • Place of Presentation: 札幌プリンスホテル国際館パミール、北海道
  • Invited
• [Presentation] Thalamic Contributions to Basal Ganglia-Related Behavioral Switching and Reinforcement (2011)
  • Author(s): Smith Y.
  • Organizer: The 41th annual meeting of Society for Neuroscience
  • Place of Presentation: Walter E.Washington Convention Center, USA
  • Year and Date: 2011-11-14
• [Presentation] 中脳ドーパミン細胞による、異なった時間スケールでの報酬価値とその誤差の表現 (2011)
  • Author(s): 榎本一紀
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2011-09-16
• [Book] Neuroeconomics: Decision-Making and the Brain (2013)
  • Author(s): Doya K. and Kimura M. (担当:共著, 範囲:The Basal Ganglia, Reinforcement Learning and the Encoding of Value)
  • Total Pages: 577
  • Publisher: Academic Press
• [Book] Annual Review 2013 神経 (2013)
  • Author(s): 山中航
  • Publisher: 中外医学社
• [Book] 分子精神医学 (2012)
  • Author(s): 山中航
  • Publisher: 先端医学社