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Development of a large scale analysis platform for ncRNA neotaxonomy

Planned Research

Project AreaNeo-taxonomy of noncoding RNAs
Project/Area Number 26113008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ASAHARA Hiroshi  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70294460)

Research Collaborator CHIBA Tomoki  
MATSUSHIMA Takahide  
KURIMOTO Ryota  
KATAOKA Kensuke  
YANO Yuki  
UCHIDA Yutaro  
ITO Yoshiaki  
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥103,350,000 (Direct Cost: ¥79,500,000、Indirect Cost: ¥23,850,000)
Fiscal Year 2018: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2017: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2016: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2015: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2014: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
KeywordsノンコーディングRNA / マイクロRNA / 関節炎 / 遺伝子編集 / 細胞内構造体 / ncRNA / 大規模解析
Outline of Final Research Achievements

We developed and introduced new technologies and strategies such as high-content microscopy systems, gene libraries, genome editing technologies to extend known ncRNA taxon, and further complex that each ncRNA taxon makes We aimed to identify and analyze their behavior, and search for new ncRNA taxons. In addition, we have optimized the genome editing technology for functional analysis of ncRNA, and developed a method to analyze the function of newly identified ncRNA at high speed and genetically, accelerating research on ncRNA neotaxonomy.

Academic Significance and Societal Importance of the Research Achievements

本研究においては、ハイコンテンツ顕微鏡、GFPタグ遺伝子ライブラリー、遺伝子編集での個体作成などの新しい技術、戦略を開発あるいは導入し、これらシステムを複合的に用いることで、新規ノンコ―ディングRNAの同定とその機能解析による分類を細胞・個体レベルで進めることができた。結果、関節炎、骨系統疾患や白血病の病態解明や治療法の開発に貢献することができた。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (96 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (25 results) (of which Int'l Joint Research: 16 results,  Peer Reviewed: 22 results,  Open Access: 18 results,  Acknowledgement Compliant: 3 results) Presentation (64 results) (of which Int'l Joint Research: 9 results,  Invited: 23 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] スクリプス研究所(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] スクリプス研究所(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] カリフォルニア大学 サンディエゴ校(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ゲノム編集のヒトへの応用の展望と問題点2019

    • Author(s)
      松島 隆英, 淺原 弘嗣
    • Journal Title

      リウマチ科

      Volume: 61 Pages: 191-196

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Ablation of miR-146b in mice causes hematopoietic malignancy2018

    • Author(s)
      Mitsumura Takahiro、Ito Yoshiaki、Chiba Tomoki、Matsushima Takahide、Kurimoto Ryota、Tanaka Yoko、Kato Tomomi、Uchida Keisuke、Ito Takashi、Yamamoto Kouhei、Eishi Yoshinobu、Kitagawa Masanobu、Miyazaki Yasunari、Inase Naohiko、Asahara Hiroshi
    • Journal Title

      Blood Advances

      Volume: 2 Issue: 23 Pages: 3483-3491

    • DOI

      10.1182/bloodadvances.2018017954

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combinatorial CRISPR/Cas9 Approach to Elucidate a Far-Upstream Enhancer Complex for Tissue-Specific Sox9 Expression2018

    • Author(s)
      Mochizuki Yusuke、Chiba Tomoki、Kataoka Kensuke、Yamashita Satoshi、Sato Tempei、Kato Tomomi、Takahashi Kenji、Miyamoto Takeshi、Kitazawa Masashi、Hatta Tomohisa、Natsume Tohru、Takai Shinro、Asahara Hiroshi
    • Journal Title

      Developmental Cell

      Volume: 46 Issue: 6 Pages: 794-806

    • DOI

      10.1016/j.devcel.2018.07.024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Essential role of Mohawk for tenogenic tissue homeostasis including spinal disc and periodontal ligament2018

    • Author(s)
      Nakamichi Ryo、Kataoka Kensuke、Asahara Hiroshi
    • Journal Title

      Modern Rheumatology

      Volume: 28 Issue: 6 Pages: 933-940

    • DOI

      10.1080/14397595.2018.1466644

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dissecting the roles of miR-140 and its host gene2018

    • Author(s)
      Inui Masafumi、Mokuda Sho、Sato Tempei、Tamano Moe、Takada Shuji、Asahara Hiroshi
    • Journal Title

      Nature Cell Biology

      Volume: 20 Issue: 5 Pages: 516-518

    • DOI

      10.1038/s41556-018-0077-4

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ~運動器から健康と加齢を俯瞰する~2018

    • Author(s)
      浅原弘嗣
    • Journal Title

      月刊誌 CLINICAL CALCIUM

      Volume: 28 Pages: 3-3

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Identification of targets of tumor suppressor microRNA-34a using a reporter library system.2017

    • Author(s)
      Ito Y, Inoue A, Seers T, Hato Y, Igarashi A, Toyama T, Taganov KD, Boldin MP, Asahara H.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: - Issue: 15 Pages: 3927-3932

    • DOI

      10.1073/pnas.1620019114

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Analysis of transcription factors expressed at the anterior mouse limb bud2017

    • Author(s)
      Yokoyama Shigetoshi、Furukawa Soichi、Kitada Shoya、Mori Masaki、Saito Takeshi、Kawakami Koichi、Belmonte Juan Carlos Izpisua、Kawakami Yasuhiko、Ito Yoshiaki、Sato Tempei、Asahara Hiroshi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 5 Pages: e0175673-e0175673

    • DOI

      10.1371/journal.pone.0175673

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis2017

    • Author(s)
      Asahara Hiroshi、Inui Masafumi、Lotz Martin K
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 32 Issue: 9 Pages: 1773-1782

    • DOI

      10.1002/jbmr.3199

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bhlha9 regulates apical ectodermal ridge formation during limb development.2017

    • Author(s)
      Kataoka K, Matsushima T, Ito Y, Sato T, Yokoyama S, Asahara H*.
    • Journal Title

      JBMM.

      Volume: 印刷中 Issue: 1 Pages: 1-9

    • DOI

      10.1007/s00774-017-0820-0

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analysis of transcription factors expressed at the anterior mouse limb bud.2017

    • Author(s)
      Yokoyama S, Furukawa S, Kitada S, Mori M, Saito T, Kawakami K, Izpisua Belmonte JC, Kawakami Y, Ito Y, Sato T, AsaharaH*.
    • Journal Title

      PLoS One.

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
  • [Journal Article] TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes.2017

    • Author(s)
      Hasei J, Teramura T, Takehara T, Onodera Y, Horii T, Olmer M, Hatada I, Fukuda K, Ozaki T, Lotz M, Asahara H*.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 42990-42990

    • DOI

      10.1038/srep42990

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Complementary critical functions of Zfy1 and Zfy2 in mouse spermatogenesis and reproductiontran .2017

    • Author(s)
      Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, Tanaka H, Kondo T, Miyado K, Miyasaka N, Kubota T, Ogura A, Asahara H*.
    • Journal Title

      PLoS Genetics.

      Volume: 13 Issue: 1 Pages: e1006578-e1006578

    • DOI

      10.1371/journal.pgen.1006578

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mohawk transcription factor regulates homeostasis of the periodontal ligament2017

    • Author(s)
      Koda N, Sato T, Shinohara M, Ichinose S, Ito Y, Nakamichi R, Kayama T, Kataoka K, Suzuki H, Moriyama K, Asahara H
    • Journal Title

      Development

      Volume: 144 Pages: 313-320

    • DOI

      10.1242/dev.135798

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2.2016

    • Author(s)
      Masashi Naito, Masaki Mori, Inagawa M, Miyata K, Hashimoto N, Tanaka S, Asahara H.
    • Journal Title

      PLOS Genetics

      Volume: 12 Issue: 7 Pages: e1006167-e1006167

    • DOI

      10.1371/journal.pgen.1006167

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.2016

    • Author(s)
      Rho Nakamichi, Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz M, Sakai D, Masuda K, Ozaki T, Asahara H.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 12503-12503

    • DOI

      10.1038/ncomms12503

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gene targeting of the transcription factor Mohawk in rats causes heterotropic ossification of Achilles tendon via failed tenogenesis2016

    • Author(s)
      Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 113 Issue: 28 Pages: 7840-7845

    • DOI

      10.1073/pnas.1522054113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gtf2ird1-dependent Mohawk (Mkx) expression regulates mechanosensing properties of tendon2016

    • Author(s)
      Kayama T, Mori M, Ito Y, Matsushima T, Nakamichi R, Suzuki H, Ichinose S, Saito M, Marumo K, Asahara H
    • Journal Title

      Mol Cell Biol

      Volume: 36 Issue: 8 Pages: 1297-309

    • DOI

      10.1128/mcb.00950-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MicroRNAs in Chronic Inflammation2016

    • Author(s)
      Y. Ito, S. Mokuda, K. Miyata, T. Matsushima and H. Asahara
    • Journal Title

      Chronic Inflammation

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation analysis of human myoblasts during in vitro myogenic differentiation: de novo methylation of promoters of muscle-related genes and its involvement in transcriptional down-regulation2015

    • Author(s)
      Miyata K, Miyata T, Nakabayashi K, Okamura K, Naito M, Kawai T, Takada S, Kato K, Miyamoto S, Hata K, Asahara H
    • Journal Title

      Hum. Mol. Genet.

      Volume: 24 Issue: 2 Pages: 410-423

    • DOI

      10.1093/hmg/ddu457

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo.2015

    • Author(s)
      Otabe K, Nakahara H, Hasegawa A, Matsukawa T, Ayabe F, Onizuka N, Inui M, Takada S, Ito Y, Sekiya I, Muneta T, Lotz M, Asahara H.
    • Journal Title

      J Orthop Res.

      Volume: 33 Issue: 1 Pages: 1-8

    • DOI

      10.1002/jor.22750

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis2015

    • Author(s)
      Matsubara Yohei, Kato Tomoko, Kashimada Kenichi, Tanaka Hiromitsu, Zhi Zhou, Ichinose Shizuko, Mizutani Shuki, Morio Tomohiro, Chiba Tomoki, Ito Yoshiaki, Saga Yumiko, Takada Shuji, and Asahara Hiroshi
    • Journal Title

      Stem Cells and Development

      Volume: 24 Issue: 10 Pages: 1164-1170

    • DOI

      10.1089/scd.2014.0466

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA 140 Promotes Expression of Long Noncoding RNA NEAT1 in Adipogenesis2015

    • Author(s)
      Gernapudi R, Wolfson B, Zhang Y, Yao Y, Yang P, Asahara H, Zhou Q
    • Journal Title

      Mol Cell Biol

      Volume: 36 Issue: 1 Pages: 30-8

    • DOI

      10.1128/mcb.00702-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 骨・関節を守るmiRNA2015

    • Author(s)
      森 雅樹、浅原 弘嗣
    • Journal Title

      実験医学増刊 ノンコーディングRNAテキストブック

      Volume: 33 Pages: 126-131

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRISPR/Cas9によるゲノム編集2015

    • Author(s)
      千葉 朋希、浅原 弘嗣
    • Journal Title

      実験医学増刊 ノンコーディングRNAテキストブック

      Volume: 33 Pages: 200-205

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] miRNAs in arthritis pathogenesis and therapy2019

    • Author(s)
      淺原弘嗣
    • Organizer
      The 20th Takeda Science Foundation Symposium on BioSciences
    • Related Report
      2018 Annual Research Report
  • [Presentation] ncRNA ネオタクソノミのための?規模解析基盤の開発2019

    • Author(s)
      淺原弘嗣
    • Organizer
      RNAタクソノミ領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] Genome dynamics for chondrogenesis and miRNAs for cartilage homeostasis via Sox92019

    • Author(s)
      Hiroshi Asahara
    • Organizer
      Cartilage GRC 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechano-property of tendon/ligament and its application to regenerative medicine2019

    • Author(s)
      Hiroshi Asahara
    • Organizer
      FAOPS2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ゲノム編集技術によって初めて露わにされる生命科学2018

    • Author(s)
      淺原弘嗣
    • Organizer
      日本オミックス医療学会シンポジウム「ゲノム編集に基づく医療の到来」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 遺伝子の織り成す旋律を採譜するには2018

    • Author(s)
      淺原弘嗣
    • Organizer
      東京医科歯科大学ピアノの会 第21回市民フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] RNA階層における炎症とがんの病態制御2018

    • Author(s)
      淺原弘嗣
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] マイクロRNAによる変形性関節症の病態解明と医療応用2018

    • Author(s)
      淺原弘嗣、伊藤義晃
    • Organizer
      第4回日本骨免疫学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 長鎖非コードRNAによる炎症性サイトカインの発現制御2018

    • Author(s)
      千葉朋希、淺原弘嗣
    • Organizer
      第4回日本骨免疫学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 骨と軟骨と腱・靭帯の織りなす生理と病理2018

    • Author(s)
      淺原弘嗣
    • Organizer
      第36回日本骨代謝学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腱マスター転写因子Mkxとメカニカルストレスに依存した人工腱様組織の作製2018

    • Author(s)
      片岡健輔、千葉朋希、伊藤義晃、中道亮、鈴木英嗣、嘉山智大、淺原弘嗣
    • Organizer
      日本筋学会第4回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腱・靭帯の分子ネットワークの解明と再生医療への応用2018

    • Author(s)
      淺原弘嗣
    • Organizer
      日本筋学会第4回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Transcriptional and translational regulation of musculoskeletal development and arthritis pathogenesis.2018

    • Author(s)
      Hiroshi Asahara
    • Organizer
      Marc Montminy's 62nd Birthday Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] miRNAs in arthritis pathogenesis and therapy2018

    • Author(s)
      Hiroshi Asahara
    • Organizer
      JAJ RNA 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechano-signal pathway regulating tendon and ligament via Mkx2018

    • Author(s)
      Hiroshi Asahara
    • Organizer
      ORS Tendon Section 2018 Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 骨と骨にまつわる組織の発生と保護と再生2018

    • Author(s)
      淺原弘嗣
    • Organizer
      第25回徳島骨代謝研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 腱マスター転写因子Mkxとメカニカルストレスによる人口腱様組織の作製2018

    • Author(s)
      片岡健輔、千葉朋希、伊藤義晃、加藤眞理子、河村峻太郎、中道亮、浅原弘嗣
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 軟骨恒常性維持に関わるmicroRNA-455の機能解析2018

    • Author(s)
      伊藤 義晃、松崎 時夫、綾部 文明、茂久田 翔、山下 聡、淺原弘嗣
    • Organizer
      第31回 日本軟骨代謝学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] RNA結合タンパク質による炎症性サイトカインの転写後制御2018

    • Author(s)
      千葉朋希
    • Organizer
      第4回病因研究会別府シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Mkxを介した腱・靱帯のメカノシグナルの調整機構2018

    • Author(s)
      淺原弘嗣
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ハイスルプットスクリーニング解析顕微鏡システムの開発と応用2018

    • Author(s)
      松島隆英
    • Organizer
      ライフイノベーションマテリアル公開討論会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The completely automated ChIP system performed by LabDroid ”Maholo”2018

    • Author(s)
      Hiroshi Asahara
    • Organizer
      Robotics and Semantic Systems for Biology (RSSB) 2
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] microRNA-455 の軟骨における機能解析、2017

    • Author(s)
      伊藤 義晃〔講演〕、綾部 文明、山下 聡、浅原 弘嗣
    • Organizer
      第30回日本軟骨代謝学会
    • Place of Presentation
      京都市勧業館みやこめっせ、京都市
    • Year and Date
      2017-03-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] The role of microRNA-455 in cartilage2017

    • Author(s)
      Hiroshi Asahara〔ポスター発表〕、Yoshiaki Ito
    • Organizer
      第19回武田科学振興財団生命科学シンポジウム
    • Place of Presentation
      吹田市、武田薬品研修所
    • Year and Date
      2017-01-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of targets of tumor suppressor microRNA-34a using a reporter library system2017

    • Author(s)
      Hiroshi ASAHARA
    • Organizer
      RNA 2017 Prague
    • Related Report
      2017 Annual Research Report
  • [Presentation] miRNA in Cancer, Arthritis and Homeostasis2017

    • Author(s)
      淺原弘嗣
    • Organizer
      第43回内藤カンファレンス
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of inflammatory cytokine expression by long non-coding RNA LASC2017

    • Author(s)
      千葉朋希
    • Organizer
      第19回日本RNA学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Escort-1 による炎症性サイトカインの発現制御2017

    • Author(s)
      矢野雄暉, 千葉朋希, 阿部健太郎, 淺原弘嗣
    • Organizer
      RNA2017、第19回日本RNA学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of inflammatory cytokine expression by long non-coding RNALASC2017

    • Author(s)
      Tomoki Chiba,Hiroshi Asahara.
    • Organizer
      RNA2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 転写からRNA 階層を包括した骨・軟骨形成と代謝における遺伝子発現制御機構2017

    • Author(s)
      淺原弘嗣
    • Organizer
      第35 回日本骨代謝学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] マイクロRNAによるリウマチの病態解明と治療法の開発2017

    • Author(s)
      淺原弘嗣
    • Organizer
      愛媛リウマチ研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] RNA階層と分子局在ダイナミクスを包含したシステム医学による炎症性疾患治療と再生医療の開発2017

    • Author(s)
      淺原弘嗣
    • Organizer
      「システムバイオロジーと多階層オミクス~生体分子システム(ネットワーク)の統合的理解から因果関係の予測へ~」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Analysis of RNA-binding protein promoting inflammatory cytokines2017

    • Author(s)
      淺原弘嗣
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] コドン置換型TALENライブラリーによる発現の安定化およびエフェクター機能の向上2016

    • Author(s)
      千葉 朋希〔ポスター発表〕, 浅原 弘嗣
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of targets of tumor suppressor microRNA-34a using a reporter library system2016

    • Author(s)
      Yoshiaki Ito,〔ポスター発表〕 Atsushi Inoue, Timothy Seers, Yukari Hato, Arisa Igarashi, Tatsuya Toyama, Hiroshi Asahara
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] MicroRNA-381 mimic resulted in a therapeutic effect on arthritis by confrolling several functions of fibroblast-like synobiocytes2016

    • Author(s)
      Yoko Tanaka-Watanabe〔ポスター発表〕、Shuji Takada, Shin-ichi Miyazawa, Takayuki Furumatsu, Keiichiro Nishida, HIroshi Asahara
    • Organizer
      Cold Spring Harbor Asia Conference
    • Place of Presentation
      中国、蘇州
    • Year and Date
      2016-10-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tendon Regeneration and Development by Transcription Factor Mkx2016

    • Author(s)
      Kensuke Kataoka〔ポスター発表〕、Ysoshiaki ITO,Tomoki CHIBA,Ryo NAKAMICHI,HiroshiASAHARA
    • Organizer
      Visual-JW 2016
    • Place of Presentation
      Osaka University
    • Year and Date
      2016-10-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] The High-Throughput Microscopy Screening System with Genome-Wide cDNA Expression Libraries2016

    • Author(s)
      Takahide MATSUSHIMA〔ポスター発表〕、Naoki GOSHIMA,Hiroshi ASAHARA
    • Organizer
      Visual-JW 2016
    • Place of Presentation
      大阪、大阪大学
    • Year and Date
      2016-10-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Escort1による炎症性サイトカインの転写後調節2016

    • Author(s)
      千葉朋希〔口演、優秀演題〕、矢野雄暉、淺原弘嗣
    • Organizer
      第3回JCRベーシックリサーチカンファレンス
    • Place of Presentation
      千代田区、アキバプラザ内「アキバホール」
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] DNA methylationと筋分化2016

    • Author(s)
      淺原弘嗣
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡、福岡国際会議場
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 新規DAMPsタンパク質のスクリーニングと機能解析2016

    • Author(s)
      松島隆英〔ポスター発表〕、五島直樹、淺原弘嗣
    • Organizer
      第3回JCRベーシックリサーチカンファレンス
    • Place of Presentation
      千代田区、アキバプラザ内「アキバホール」
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] リポーターライブラリーシステムによるmicroRNA-34aの標的遺伝子の同定2016

    • Author(s)
      伊藤義晃〔ポスター発表〕、井上敦、Timothy Seers、波戸ゆかり、五十嵐ありさ、遠山竜也、淺原弘嗣
    • Organizer
      第3回JCRベーシックリサーチカンファレンス
    • Place of Presentation
      千代田区、アキバプラザ内「アキバホール」
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] microRNA-381による関節炎の制御2016

    • Author(s)
      田中陽子〔ポスター発表〕、高田修治、宮澤慎一、古松毅之、西田敬一郎、淺原弘嗣
    • Organizer
      第3回JCRベーシックリサーチカンファレンス
    • Place of Presentation
      千代田区、アキバプラザ内「アキバホール」
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sox9の発言制御機構2016

    • Author(s)
      淺原弘嗣
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ゲノム編集技術と医学研究・難病治療への応用2016

    • Author(s)
      淺原弘嗣
    • Organizer
      日本線維筋痛症学会第8回学術集会
    • Place of Presentation
      墨田区、KFCホール
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ゲノム編集技術と医学研究・難病治療への応用2016

    • Author(s)
      浅原弘嗣
    • Organizer
      第44回日本臨床免疫学会総会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] RBMS2による炎症性サイトカインの発現制御2016

    • Author(s)
      矢野雄暉〔口演〕、千葉朋希、阿部健太郎、伊藤義晃、淺原弘嗣
    • Organizer
      RNAフロンティアミーティング2016
    • Place of Presentation
      北海道ニセコ、いこいの湯宿 いろは
    • Year and Date
      2016-09-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis2016

    • Author(s)
      Hiroshi Asahara
    • Organizer
      Stem Cell, Growth Factor Signaling and Bone Biology
    • Place of Presentation
      杭州
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mkxを介した腱・靭帯の分子ネットワークの解析と応用2016

    • Author(s)
      浅原弘嗣〔ポスター発表〕、伊藤義晃、千葉朋希、松島隆英、佐藤天平、片岡健輔
    • Organizer
      学際・国際的高度人材育成 ライフイノベーションマテリアル創製共同研究プロジェクト
    • Place of Presentation
      名古屋、名古屋大学 ES 館
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腱組織の恒常性維持と再生の分子メカニズムの解析2016

    • Author(s)
      浅原弘嗣〔ポスター発表〕、片岡健輔、中道亮、鈴木英嗣、内藤昌志、望月祐輔、幸田直己、森雅樹、篠原正弘、伊藤義晃、嘉山智大
    • Organizer
      第2回日本骨免疫学会
    • Place of Presentation
      沖縄、ホテルモントレ沖縄スパ&リゾート
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脊椎動物の体軸形成においてLin28a/let-7経路はポリコーム遺伝子発現制御を介してHoxコードを調節している2016

    • Author(s)
      佐藤天平〔ポスター発表〕、浅原弘嗣
    • Organizer
      第2回日本骨免疫学会
    • Place of Presentation
      沖縄ホテルモントレ沖縄スパ&リゾート、
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 遺伝子編集技術を応用したリウマチ研究2016

    • Author(s)
      浅原弘嗣
    • Organizer
      千葉大学筑波大学カンファレンス
    • Place of Presentation
      東京、ベルサール八重洲
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] MICRORNA-381 AMELIORATES ARTHRITIS BY CONTROLLING FUNCTIONS OF FIBROBLAST-LIKE SYNOVIOCYTES,WHICH ARE AFFECTED BY A TO I RNA EDITING2016

    • Author(s)
      Y.Tanaka〔ポスター発表〕, S.Takada, H.Iizasa, A.Hatzigeorgiou, S.-I.Miyazawa, T.Furumatsu, K.Nishida, H.Asahara
    • Organizer
      Annual European Congress of Rheumatology
    • Place of Presentation
      イギリス、ロンドン
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Bone biology2016

    • Author(s)
      浅原弘嗣
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯根膜恒常性維持の新たなメカニズム-転写因子Mohawk homeobox(Mkx)の機能解明-2015

    • Author(s)
      幸田直己、篠原正浩、伊藤義明、市野瀬志津子、森山啓司、浅原弘嗣
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県、神戸市)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脊椎動物の体軸形成において、Lin28a/let-7経路はポリコーム遺伝子発現制御を介してHoxコードを調節している2015

    • Author(s)
      佐藤天平、浅原弘嗣
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県、神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規先天性四肢形成障害関連遺伝子Bhlha9の機能解析2015

    • Author(s)
      片岡健輔、松島隆英、浅原弘嗣
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県、神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inflammatory signal regulation at RNA level2015

    • Author(s)
      Hiroshi Asahara,Tomoki Chiba,Kentaro Abe,Yoshiaki Ito
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Functional analysis of microRNA/target gene interaction and its requirement of the axial body patterning2015

    • Author(s)
      Tempei Sato、Hiroshi Asahara
    • Organizer
      第17回日本RNA学会年会
    • Place of Presentation
      ライフォート札幌(北海道、札幌市)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 正常な骨格筋分化には筋前駆細胞におけるde novo DNAメチル化が必要である2015

    • Author(s)
      内藤昌志、森雅樹、田中栄、浅原弘嗣
    • Organizer
      第1回日本骨免疫学会
    • Place of Presentation
      ホテルブリーズベイマリーナ(沖縄県、京都郡)
    • Year and Date
      2015-07-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯根膜における転写因子Mkxの機能解析2015

    • Author(s)
      幸田直己、篠原正浩、伊藤義晃、市野瀬志津子、森山啓司、浅原弘嗣
    • Organizer
      第1回日本骨免疫学会
    • Place of Presentation
      ホテルブリーズベイマリーナ(沖縄県、京都郡)
    • Year and Date
      2015-07-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] The critical role of miRNAs at the edge of Hox-code during skeletal development2014

    • Author(s)
      浅原 弘嗣、佐藤 天平、乾 雅史
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Analysis of miRNAs in cartilage by TALEN/CRISPR genome editing techniques2014

    • Author(s)
      Hiroshi Asahara
    • Organizer
      7th International Conference on Osteoporosis and Bone Research,2014
    • Place of Presentation
      Conference and Exibition Center, Xiamen, 中国
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Developmental function of Hox-embedded microRNAs in mice2014

    • Author(s)
      Tempei Sato, Moe Tamano, Masafumi Inui, Shuji Takada, Hiroshi Asahara
    • Organizer
      第16回日本RNA学会年会
    • Place of Presentation
      ウインクあいち, 愛知県
    • Year and Date
      2014-07-22
    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京医科歯科大学 大学院医歯学総合研究科 システム発生・再生医学分野

    • URL

      https://www.tmdusystemsbiomedicine.com/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 東京医科歯科大学 大学院医歯学総合研究科 システム発生・再生医学分野

    • URL

      https://www.tmdusystemsbiomedicine.com/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京医科歯科大学 大学院医歯学総合研究科 システム発生・再生医学分野

    • URL

      http://www.tmd.ac.jp/grad/syst/asahsyst/index.html

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 肝がんモデルマウスおよび肝がん治療用の医薬2015

    • Inventor(s)
      淺原 弘嗣、 伊藤 義晃
    • Industrial Property Rights Holder
      淺原 弘嗣、 伊藤 義晃
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-11-26
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2022-02-28  

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