Prediction and Prevention of childhood Allergy
Project/Area Number |
01570554
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Pediatrics
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Research Institution | Osaka Medical College |
Principal Investigator |
SASAKI Sei Osaka Medical College. Department of Pediatrics. Lecturer, 医学部, 講師 (90084962)
|
Project Period (FY) |
1989 – 1991
|
Project Status |
Completed (Fiscal Year 1991)
|
Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1991: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1990: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1989: ¥1,200,000 (Direct Cost: ¥1,200,000)
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Keywords | Prediction of atopy / ovalbumin IgG antibody / ovomucoid IgG antibody / cow's milk IgG antibody in amniotic fluid / intrauterine active sensitization / intrauterine passive sensitization / IgE antibody in amniotic fluid / food IgG antibody in cord flood / 羊水中オボムエイドIgG抗体 / 胎内感作 / 経母乳感体 / 臍帶血食物IgG抗体 / アトピ-発症の予測値(prediction value) / 羊水IgE抗体 / 羊水オバルブミンIgG抗体 / 羊水オボムコイドIgG抗体 / 臍帯血オバルブミンIgG,IgG_4抗体 / 臍帯血オボムコイドIgG,IgG_4抗体 / 食物抗原胎内感作 / 食物抗原経母乳感作 / 臍帯血オバルブミンIgG・IgG_4抗体 / 臍帯血オバムコイトIgG・IgG_4抗体 |
Research Abstract |
Intra-uterine sensitization probably plays an important role in the pathogenesis of infantile atpic disease. There are two possible modes of intrauterine sensitization. i. e. active and passive. Active sensitization occures, when a fetus receives maternal antigens by transplacental transfer and develops antibodies against the antigens. Passive sensitization takes palce, as a fetus grows immersed in amniotic fluid containing maternal IgG antibodies and also ingests the fluid. Thus, the fetal skin and gastrointestinal tract exposed to the antibodies in the amniotic fluid are passively sensitized. Results : 1) Non-specific IgE antibodies were detectable in the amniotic fluid and cord blood of 17 cases, of which 13 cases showed the concentrations of 5-0.25 U/ml. Of the 17 cases, 14 mothers had a history of atopy diseases. 2) DP, egg white cow's milk and soya bean specific IgE antibodies were not detected in the amniotic fluid and cord blood in any of the cases examined. 3) DP specific IgG antibodies were not detected in the amniotic fluid, but detected in the maternal blood of 25 cases and in the cord blood of 24 cases in concentrations ranging from 20-175 GRU/ml. 4) Ovalbumin specific IgG antibodies were detectable in the amniotic fluid of 8 cases and in the maternal and cord blood of all the cases. Ovomucoid specific IgG antibodies were detected in the maternal blood of 16 and in the cord blood of 14 cases. But were not detectable in the amniotic fluid in any of the cases. 5) In the amniotic fluid, lactoglobulin specific IgG antibodies were detected in 8 cases, lactoalbumin specific IgG antibodies in 11 and case in specific I, , , G antibodies in 8 cases. Conclusion : The results of this study would indicate that a fetus is not only actively sensitized by transplacental transfer of the maternal antigens, but also the fetal skin and gastrointestinal tract are passively sensitized by being exposed to IgG antibodies contained in amniotic fluid.
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Report
(4 results)
Research Products
(30 results)