|Budget Amount *help
¥2,000,000 (Direct Cost : ¥2,000,000)
Fiscal Year 1991 : ¥400,000 (Direct Cost : ¥400,000)
Fiscal Year 1990 : ¥400,000 (Direct Cost : ¥400,000)
Fiscal Year 1989 : ¥1,200,000 (Direct Cost : ¥1,200,000)
Intra-uterine sensitization probably plays an important role in the pathogenesis of infantile atpic disease. There are two possible modes of intrauterine sensitization. i. e. active and passive. Active sensitization occures, when a fetus receives maternal antigens by transplacental transfer and develops antibodies against the antigens. Passive sensitization takes palce, as a fetus grows immersed in amniotic fluid containing maternal IgG antibodies and also ingests the fluid. Thus, the fetal skin and gastrointestinal tract exposed to the antibodies in the amniotic fluid are passively sensitized. Results : 1) Non-specific IgE antibodies were detectable in the amniotic fluid and cord blood of 17 cases, of which 13 cases showed the concentrations of 5-0.25 U/ml. Of the 17 cases, 14 mothers had a history of atopy diseases. 2) DP, egg white cow's milk and soya bean specific IgE antibodies were not detected in the amniotic fluid and cord blood in any of the cases examined. 3) DP specific IgG
antibodies were not detected in the amniotic fluid, but detected in the maternal blood of 25 cases and in the cord blood of 24 cases in concentrations ranging from 20-175 GRU/ml. 4) Ovalbumin specific IgG antibodies were detectable in the amniotic fluid of 8 cases and in the maternal and cord blood of all the cases. Ovomucoid specific IgG antibodies were detected in the maternal blood of 16 and in the cord blood of 14 cases. But were not detectable in the amniotic fluid in any of the cases. 5) In the amniotic fluid, lactoglobulin specific IgG antibodies were detected in 8 cases, lactoalbumin specific IgG antibodies in 11 and case in specific I, , , G antibodies in 8 cases. Conclusion : The results of this study would indicate that a fetus is not only actively sensitized by transplacental transfer of the maternal antigens, but also the fetal skin and gastrointestinal tract are passively sensitized by being exposed to IgG antibodies contained in amniotic fluid.
これら羊水中の食物特異IgG抗体の働きが,阻止抗体として働いているのか,reaginic activityを有し,胎生11週,36週の皮膚,消化管にある樹状細胞のFC受容体を感作しているのか追跡検討中である。 Less