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The mechanism of hepatocyte injury in chronic hepatitis B

Research Project

Project/Area Number 07670622
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Women's Medical College

Principal Investigator

KATO Tatsuko  Department of Medicine Tokyo Women's Medical College, Instructor, 医学部, 助手 (20177455)

Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Keywordschronic hepatitis B / pre-S2-type / CTL / Pre-S2タイプ / HBV
Research Abstract

To elucidate the precise mechanisms of the generation of chronic hepatitis B,we first examined the uncleotide sequences of HBV and found that the pre-S2 region of hepatitis B virus (HBV) was classified into three types according to their nucleotide sequences. Subsequently, we examined the pre-S2 type in 45HBV-infected chronic hepatitis B patients together with HLA class I phenotype and disease activity. The HLA-A24 antigen was found in 27 of 32 type I pre-S2 HBV-infected patients with active hepatitis, whereas of 6 patients with inactive disease, none had HLA-A24. Serial studies in 13 patients with HLA-A24 showed that with remission of hepatitis, clearance of type I pre-S2 HBV was seen in all patients. Furthermore, we were successful to establish the CTL clones that recognize the molecular complex composed by HLA-A24 and the pre-S2 peptide. These results suggest that HLA-A24 expression in the setting of type I pre-S2 HBV infection may play a role in the pathogenesis of chronic hepatitis B.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

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