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細胞レベルの個体群ダイナミクス:微生物生態・免疫系・ガンの数理研究

Research Project

Project/Area Number 08J06835
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field General mathematics (including Probability theory/Statistical mathematics)
Research InstitutionThe University of Tokyo

Principal Investigator

中岡 慎治  東京大学, 大学院・数理科学研究科, 特別研究員(PD)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2009: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2008: ¥800,000 (Direct Cost: ¥800,000)
Keywords微生物生態系 / 免疫系 / ガン / 個体群ダイナミクス / 数理モデル / 微分方程式 / シミュレーション / 数理生物学
Research Abstract

研究内容・意義と重要性
本研究では微生物生態、免疫系、ガンといった環境・医療において重要な生命現象をターゲットにし、これら生命現象に共通する資源競争、個体の成長といった細胞レベルでの基本動作や性質の理解を目指している。本年度は、昨年に引き続いて免疫系の数理研究を中心に研究を進めた。具体的に取り組んだ内容は、次の3つの課題である:(1)造血幹細胞の個体群ダイナミクス研究(2)一細胞計測系に対する数理モデル構築(3)腸内微生物による複雑代謝ネットワークの数理モデル構築。本課題は、定量的測定実験をベースに理論を構築した融合型研究と位置づけられ、異分野融合研究を促進し、生命科学の諸分野にも応用できるような枠組みを作り上げていく第一歩と位置づけられる。この課題に関する研究報告を国内で4回、国内外の国際会議で7回行った。中でも、第3回日中数理生物学コロキウムでは招待講演者として発表した。
研究費使用の主な内訳
情報収集と研究打ち合わせのため、免疫系と数理生物学・システム生物学における国内の関連する学会や研究集会へ参加し、得られた研究成果の発表などを行った。シミュレーション研究を実施するために計算専用コンピューターと研究に必要となる各種書籍を購入した。

Report

(3 results)
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (20 results) Remarks (2 results)

  • [Journal Article] レビュー:細胞傷害性T細胞による感染細胞除去率の推定2010

    • Author(s)
      中岡慎治
    • Journal Title

      数理解析研究所講究禄

      Volume: 1704 Pages: 40-46

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Effect of parental care and aggregation on population dynamics2009

    • Author(s)
      Shinji Nakaoka
    • Journal Title

      Journal of Theoretical Biology 260

      Pages: 161-171

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune impairment effect in HIV infection : Existence of risky and immunodeficiency thresholds2009

    • Author(s)
      Shinji Nakaoka
    • Journal Title

      Journal of Theoretical Biology 260

      Pages: 490-501

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mathematical analysis of an experimental study of syntrophic association in pesticide degradation2009

    • Author(s)
      Shinji Nakaoka
    • Journal Title

      Journal of Theoretical Biology 256

      Pages: 644-654

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic adaptation of parental care2009

    • Author(s)
      Shinji Nakaoka
    • Journal Title

      Bulletin of Mathematical Biology (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ポジティブフィードバックをもつ生物系モデルの解析2009

    • Author(s)
      Shinji Nakaoka
    • Journal Title

      数理解析研究所講究禄 (印刷中)

    • Related Report
      2008 Annual Research Report
  • [Journal Article]2008

    • Author(s)
      中岡慎治
    • Journal Title

      「数」の数理生物学 第3章 時間遅れのモデリング(共立出版)

      Pages: 20-20

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Daphnia revisited: local stability and bifurcation theory for physiologically structured population models explain ed by way of an example

    • Author(s)
      Shinji Nakaoka
    • Journal Title

      Journal of Mathematical Biology (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Population dynamics of hematopoietic stem cells--a mathematical study on successful transplantation--2011

    • Author(s)
      Shinji Nakaoka
    • Organizer
      BCAM Seminar
    • Place of Presentation
      Basque Center for Applied Mathematics, Spain
    • Year and Date
      2011-02-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Periodic oscillations in hematopoietic diseases2011

    • Author(s)
      Shinji Nakaoka
    • Organizer
      Far-From-Equilibrium Dynamics 2011
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of quantitative mathematical models for CD4 T cell proliferation and differentiation2011

    • Author(s)
      Shinji Nakaoka
    • Organizer
      T lymphocyte dynamics in acute and chronicviral infection
    • Place of Presentation
      Wellcome Trust, central London, UK
    • Related Report
      2010 Annual Research Report
  • [Presentation] A mathematical model of hematopoiesis--theoretical conditions for successful transplantation--2011

    • Author(s)
      Shinji Nakaoka
    • Organizer
      The 1st International Symposium on Innovative Mathematical Modelling
    • Place of Presentation
      University of Tokyo, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] 免疫応答のダイナミクス研究:CD4+T細胞の細胞増殖分化の数理モデル研究2010

    • Author(s)
      中岡慎治
    • Organizer
      京都駅前セミナー
    • Place of Presentation
      龍谷大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗原刺激に対するCD4+T細胞の応答プロファイルの数理研究2010

    • Author(s)
      中岡慎治
    • Organizer
      第20回日本数理生物学会年会
    • Place of Presentation
      北海道大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一細胞計測実験に対する定量的数理モデルの開発2010

    • Author(s)
      中岡慎治
    • Organizer
      第3回定量生物学の会年会
    • Place of Presentation
      東京大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Daphnia revisited : an example of local stability and bifurcation analyses for physiologically structured population models2010

    • Author(s)
      Shinji Nakaoka
    • Organizer
      Nonlinear Dynamics of Natural Systems
    • Place of Presentation
      Eindhoven, The Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynamics of immune cell division and proliferation2010

    • Author(s)
      Shinji Nakaoka
    • Organizer
      Conference on Computational and Mathematical Population Dynamics
    • Place of Presentation
      Bordeaux, France
    • Related Report
      2010 Annual Research Report
  • [Presentation] A mathematical model for cell division, death and differentiation of CD4 positive T cells2010

    • Author(s)
      Shinji Nakaoka
    • Organizer
      Summer 2010 Thematic Program on the Mathematics of Drug Resistance in Infectious Diseases
    • Place of Presentation
      Tronto, Fields Institute, Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mathematical study on hematopoiesis2010

    • Author(s)
      Shinji Nakaoka
    • Organizer
      The Third China-Japan Colloquium of Mathematical Biology
    • Place of Presentation
      Beijing, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mathematical study on dynamic regulation of neutrophil differentiation and related genetic diseases2010

    • Author(s)
      Shinji Nakaoka
    • Organizer
      The Second Workshop of Synthetic Immunology
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] 農薬分解菌の栄養共生関係の実験・理論研究2009

    • Author(s)
      中岡慎治
    • Organizer
      際個体群生態学会2009
    • Place of Presentation
      同志社大学
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 基本再生産数によるアリー効果の定式化2009

    • Author(s)
      中岡慎治
    • Organizer
      第19回日本数理生物学会年会
    • Place of Presentation
      東京大学
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD4陽性T細胞の細胞内・細胞間ダイナミクス2009

    • Author(s)
      中岡慎治
    • Organizer
      第19回日本数理生物学会年会
    • Place of Presentation
      東京大学
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Intra/inter-cellular dynamics of CD4 positive cells2009

    • Author(s)
      中岡慎治
    • Organizer
      International Symposium on Complex Systems Biology
    • Place of Presentation
      University of Tokyo, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mathematical study on syntrophic associations2008

    • Author(s)
      Shinji Nakaoka
    • Organizer
      Differential Equations and Applications to Mathematical Biology
    • Place of Presentation
      Le Havre, France
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of trade-offs between benefit and cost from aggregative behavior2008

    • Author(s)
      Shinji Nakaoka
    • Organizer
      Workshop on Population Dynamics and Mathematical Biology
    • Place of Presentation
      CIRM Luminy, France
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mathematical study on programmed CTL proliferation profiles2008

    • Author(s)
      Shinji Nakaoka
    • Organizer
      7th ESMTB Conference
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2008 Annual Research Report
  • [Presentation] Microbial coexistence mediated by syntrophic association : A mathematical approach2008

    • Author(s)
      Shinji Nakaoka
    • Organizer
      第六回中国数理生物学会年会
    • Place of Presentation
      泰安, 中国
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.ms.u-tokyo.ac.jp/~snakaoka/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ms.u-tokyo.ac.jp/~snakaoka/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2024-03-26  

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