| Budget Amount *help |
¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000)
Fiscal Year 2017: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2015: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
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| Outline of Final Research Achievements |
Although it was believed that rhodopsins cannot pump non-proton cations, we discovered a light-driven sodium pump rhodopsin in 2013. This project aims at revealing the structure of sodium pump rhodopsins. In collaboration with Nureki Lab of Univ. Tokyo, we successfully crystalized a light-driven sodium pump KR2, and proposed a model of sodium pumping. We also performed light-induced difference FTIR spectroscopy, such as low-temperature, time-resolved, and attenuated total reflection (ATR) methods, to sodium pump rhodopsins, and obtained important structural information. We reported more than 50 articles in Nature, Nature Commun., JACS, Angew., PNAS, JPC Letters and JBC during the project period.
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