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2017 Fiscal Year Final Research Report

Structural study of light-driven sodium pump

Research Project

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Project/Area Number 15H02391
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics
Research InstitutionNagoya Institute of Technology

Principal Investigator

Kandori Hideki  名古屋工業大学, 工学(系)研究科(研究院), 教授 (70202033)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsロドプシン / ナトリウムポンプ / 光反応サイクル / 結晶構造解析 / 赤外分光
Outline of Final Research Achievements

Although it was believed that rhodopsins cannot pump non-proton cations, we discovered a light-driven sodium pump rhodopsin in 2013. This project aims at revealing the structure of sodium pump rhodopsins. In collaboration with Nureki Lab of Univ. Tokyo, we successfully crystalized a light-driven sodium pump KR2, and proposed a model of sodium pumping. We also performed light-induced difference FTIR spectroscopy, such as low-temperature, time-resolved, and attenuated total reflection (ATR) methods, to sodium pump rhodopsins, and obtained important structural information. We reported more than 50 articles in Nature, Nature Commun., JACS, Angew., PNAS, JPC Letters and JBC during the project period.

Free Research Field

生物物理学

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Published: 2019-03-29  

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