Analysis of regulation of chondrocyte differentiation by SIK3 and lipid metabolism
| Project/Area Number |
15H02561
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2017: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2016: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2015: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
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| Keywords | 軟骨細胞 / 分化 / SIK3 / コンディショナルノックアウトマウス / Sox9 / 軟骨 / 遺伝子改変マウス / iPS細胞 / 細胞分化 / ＳＩＫ３ / ノックアウトマウス / 関節軟骨 |
|---|
| Outline of Final Research Achievements |
Cartilage plays important roles in joint motion and bone growth. In this project, we created conditional knockout mice and found that SIK3 regulates properties of articular cartilage and can be a target molecule for osteoarthritis. We showed that a SIK3 inhibitor rescues the mice with the osteoarthritis model and can be a lead molecule for drug. In a separate experiment, we found a molecule that sustains chondrocytic properties of chondrocytes. This compound inhibited degradation of Sox9 which is important for maintenance of chondrocytic phenotype.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.2016
Author(s)
Yahara Y, Takemori H, Okada M, Kosai A, Yamashita A, Kobayashi T, Fujita K, Itoh Y, Nakamura M, Fuchino H, Kawahara N, Fukui N, Watanabe A, Kimura T, Tsumaki N.
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Journal Title
Nat Commun
Volume: 7
Issue: 1
Pages: 10959-10959
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] 医学書院2017
Author(s)
妻木範行
Total Pages
6
Publisher
標準整形外科学 第13版
Related Report
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[Book] 月刊細胞2016
Author(s)
妻木範行
Total Pages
6
Publisher
ニュー・サイエンス社
Related Report
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