Position-controlled graphene with high quality and glycan-functionalized graphene devices for influenza virus
| Project/Area Number |
15H03986
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Electron device/Electronic equipment
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
Maehashi Kenzo 東京農工大学, 工学(系)研究科(研究院), 教授 (40229323)
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| Co-Investigator(Kenkyū-buntansha) |
大野 恭秀 徳島大学, 大学院社会産業理工学研究部(理工学域), 准教授 (90362623)
金井 康 大阪大学, 産業科学研究所, 助教 (30721310)
生田 昂 東京農工大学, 工学(系)研究科(研究院), 助教 (80805929)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | グラフェン / インフルエンザウイルス / 糖鎖 / 核形成位置制御法 / マイクロ・ナノデバイス / ナノ材料 |
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| Outline of Final Research Achievements |
There are global concerns about threat of pandemic caused by the human-infectious avian influenza virus. Graphene devices realize such high-sensitive electrical detection of the targets, owing to graphene’s high carrier mobility. In this study, we have succeeded in growing position-controlled graphene which has high carrier mobility by tuning the nucleation density on catalytic copper surface. Moreover, graphene was functionalized using sialoglycans and employed for the selective detection of lectins from Sambucus sieboldiana and Maackia amurensis as alternatives of the human and avian influenza viruses. Glycan-functionalized graphene devices selectively monitored the sialoglycan-specific binding reactions at subnanomolar sensitivity.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] Reaction of Viral Proteins and Sialoglycan on Biomimetic Graphene Surface Measured by Liquid Atomic Force Microscope and Graphene Field-Effect Transistor2017
Author(s)
Kaho Kamada, Takao Ono, Ryota Hayashi, Yasushi Kanai, Koichi Inoue, Yasuhide Ohno, Kenzo Maehashi, Yohei Watanabe, Shin-ichi Nakakita, Yasuo Suzuki, Toshio Kawahara, Sonia. A. Contera and Kazuhiko Matsumoto
Organizer
59th Electronic Materials Conference
Related Report
Int'l Joint Research
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[Presentation] Developments of the nano-carbon bio sensors using glycan for influenza virus2016
Author(s)
Toshio Kawahara, Hiroaki Hiramatsu, Yasuo Suzuki, Shinichi Nakakita, Yasuhide Ohno, Kenzo Maehashi, Kazuhiko Matsumoto, Kazumasa Okamoto, Teruaki Matsuba, and Risa Utsunomiya
Organizer
13th International Conference on Atomically Controlled Surfaces, Interfaces and Nanostructures
Related Report
Int'l Joint Research
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