Functional analysis of monocyte-lineage blood cells and control of damage-associated molecular patterns (DAMPs) under the whole-body responses to injury/illness
| Project/Area Number |
15H05009
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Keio University |
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Principal Investigator |
NAMIKI JUN 慶應義塾大学, 医学部(信濃町), 客員准教授 (20189195)
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| Research Collaborator |
SUZUKI Sayuri
HAYASHIDA Kei
SHIBUSAWA Takayuki
TAMURA Tomoyoshi
ISHIHAMA Yasushi
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 生体侵襲 / ヒストン / 敗血症 / 肝損傷 / 心肺停止蘇生後 / 単球 / DAMPs / 急性侵襲 / 臨床 / 生態学 |
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| Outline of Final Research Achievements |
Expression of HLA-DR temporary decreased in peripheral monocytes of patients with severe trauma, suggesting that a response reflecting the compensatory anti-inflammatory response syndrome that worsen the prognosis after trauma. Phosphorylation of Histone H3 was observed in monocytes of severe sepsis patients and may be an indicator for broken monocytes after the whole-body responses to injury/illness.
It is known that damage-associated molecular patterns (DAMPs) release into the bloodstream after the whole-body responses to injury/illness and worsen the prognosis. HMGB-1 and total Histone H3 related to poor prognosis in septic patients. Our study of liver injury model mice showed especially total Histone H3 may be a target molecule for control of DAMPs.
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| Academic Significance and Societal Importance of the Research Achievements |
従来は全身反応を引き起こす分子として炎症性サイトカインなどの液性因子が注目されてきた。本研究では、体循環中の細胞成分とくに単球系細胞の反応と組織傷害関連物質（DAMPs）との関連に着目し、『組織傷害により体循環に放出されたDAMPs が単球を活性化して炎症性サイトカインの産生や組織因子の発現・放出、さらには単球の崩壊による更なるDAMPsの放出を引き起こして病態の急性転化をきたす』との仮説に基づき、重症生体侵襲の病態において重症度や転帰と関連するDAMPsや単球細胞の反応が新たな治療ターゲットとなる可能性が明らかになった。
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Report
(5 results)
Research Products
(6 results)
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[Presentation] Quantitative assessment of pupillary light reflex for early prediction of outcomes after out-of-hospital cardiac arrest: a multicentre prospective observational study.2018
Author(s)
Tamura T, Namiki J, Sugawara Y, Sekine K, Yo K, Kanaya T, Yokobori S, Roberts R, Abe T, Yokota H, Sasaki J
Organizer
The 5th SG-ANZICS 2018 Asia Pacific Intensive Care Forum
Related Report
Int'l Joint Research
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