Establishment of peri-implantitis treatment based on radical disinfection technique

Research Project

Project/Area Number	15H05033
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Tohoku University
Principal Investigator	Sasaki Keiichi 東北大学, 歯学研究科, 教授 (30178644)
Co-Investigator(Kenkyū-buntansha)	庭野吉己東北大学, 歯学研究科, 教授 (40375184) 菅野太郎東北大学, 歯学研究科, 教授 (30302160) 中村圭祐東北大学, 歯学研究科, 講師 (30431589) 天雲太一東北大学, 歯学研究科, 助教 (80451425)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000) Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000) Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords	水酸化ラジカル / インプラント周囲炎 / ラジカル殺菌 / 医療機器
Outline of Final Research Achievements	In this project, in vitro and in vivo tests were performed with an aim of application of radical disinfection technique to treatment for peri-implantitis. In vivo test, where peri-implantitis caused around implants installed in dogs were treated with radical disinfection technique. However, there was no significant difference between the test and control groups. Thus, to find more suitable treatment conditions, in vitro test was additionally performed. The results demonstrated that the radical disinfection technique could recondition the titanium surface that had been previously contaminated by bacteria for subsequent osteoblastic cells. Therefore, future study should focus more on the establishment of treatment condition that enables to acquire re-osseointegration around the implants suffering from peri-implantitis.