Identification of biomarkers of autoimmune diseases using HLA imputation
Project/Area Number |
15H05670
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Osaka University (2016-2017) Tokyo Medical and Dental University (2015) |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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Keywords | 遺伝統計学 / HLA遺伝子 / バイオインフォマティクス / ゲノム / MHC領域 / HLA imputation法 / 疾患ゲノム解析 / 自己免疫疾患 |
Outline of Final Research Achievements |
The major histocompatibility complex (MHC) region at chromosome 6 defines risk of a variety of human complex diseases. The HLA imputation method can computationally impute HLA gene variants from the single nucleotide polymorphism (SNP) genotype data in the MHC region. By constructing the HLA imputation reference panel of the Japanese population (n = 900), we conducted HLA imputation analysis for the genome-wide association study (GWAS) data of autoimmune diseases including rheumatoid arthritis and Graves’ disease, which provided biomarker HLA variants with disease risk.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases2018
Author(s)
Kanai M, Akiyama M, Takahashi A, Matoba N, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Kubo M, Okada Y, Kamatani Y
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Journal Title
Nat Genet
Volume: 50
Pages: 390-400
DOI
Related Report
Peer Reviewed
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[Journal Article] Variants at HLA-A, HLA-C, and HLA-DQB1 confer risk of psoriasis vulgaris in Japanese2018
Author(s)
Hirata J, Hirota T, Ozeki T, Kanai M, Sudo T, Tanaka T, Hizawa N, Nakagawa H, Sato S, Mushiroda T, Saeki H, Tamari M, Okada Y
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Journal Title
J Invest Dermatol
Volume: 138
Pages: 542-548
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.2017
Author(s)
Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Iwasaki M, Yamaji T, Sawada N, Hachiya T, Tanno K, Shimizu A, Hozawa A, Minegishi N, Tsugane S, Yamamoto M, Kubo M, Kamatani Y
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Journal Title
Nat Genet
Volume: 49
Pages: 1458-1467
DOI
Related Report
Peer Reviewed
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[Journal Article] burdens on cell-specific pathways underlie the risk of rheumatoid arthritis2017
Author(s)
Ishigaki K, Kochi Y, Suzuki A, Tsuchida Y, Tsuchiya H, Sumitomo S, Yamaguchi K, Nagafuchi Y, Nakachi S, Kato R, Sakurai K, Shoda H, Ikari K, Taniguchi A, Yamanaka H, Miya F, Tsunoda T, Okada Y, Momozawa Y, Kamatani Y, Yamada R, Kubo M, Fujio K, Yamamoto K.
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Journal Title
Nat Genet
Volume: 49
Pages: 1120-1125
DOI
Related Report
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[Journal Article] Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis2016
Author(s)
Okada Y, Suzuki A, Ikari K, Terao C, Kochi Y, Ohmura K, Higasa K, Akiyama M, Ashikawa K, Kanai M, Hirata J, Suita N, Teo YY, Xu H, Bae SC, Takahashi A, Momozawa Y, Matsuda K, Momohara S, Taniguchi A, Yamada R, Mimori T, Kubo M, Brown MA, Raychaudhuri S, Matsuda F, Yamanaka H, Kamatani Y, Yamamoto K
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Journal Title
Am J Hum Genet
Volume: 99
Pages: 366-374
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study.2016
Author(s)
Li Z, Xia Y, Feng LN, Chen JR, Li HM, Cui J, Cai QQ, Sim KS, ..., Okada Y, Raychaudhuri S, Lim ST, Tan W, Peng RJ, Khor CC, Bei JX
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Journal Title
Lancet Oncol
Volume: 17
Pages: 1240-1247
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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