Volatile anesthetic and GLP-1 induced cardiac protection synergism is dependent on the activation of autophagy.

• Project/Area Number: 15H06448
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology
• Research Institution: The University of Tokushima
• Principal Investigator: KASAI Asuka 徳島大学, 病院, 特任助教 (90756892)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 吸入麻酔薬 / イソフルラン / オートファジー / 心筋保護 / 虚血再灌流障害 / GLP-1 / インクレチン / 心筋保護作用 / プレコンディショニング

Outline of Final Research Achievements

We confirmed that volatile anesthetic-induced and GLP-1-induced cardiac preconditioning protects against ischemia-reperfusion injury in mice. Additionally, our results show that volatile anesthetic and GLP-1 induced cardiac protection synergism is dependent on the activation of autophagy.

Research Products

• [Journal Article] Normothermic cardiopulmonary bypass in patient with Waldenstrom's macroglobulinemia and cryoglobulinemia: Case report. (2017)
  • Author(s): Siho Satomi, Asuka Kasai, Eisuke Hamaguchi, Yasuo M. Tsutsumi, and Katsuya Tanaka.
  • Journal Title: A&A Case Reports Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels (2016)
  • Author(s): Michiko Kinoshita, Yasuo M. Tsutsumi, Kohei Fukuta, Asuka Kasai, and Katsuya Tanaka.
  • Journal Title: The Journal of Medical Investigation Volume: 63 Issue: 1.2 Pages: 80-84
  • DOI: 10.2152/jmi.63.80
  • NAID: 130005141048
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels. (2016)
  • Author(s): Michiko Kinoshita, Yasuo M. Tsutsumi, Kohei Fukuta, Asuka Kasai, and Katsuya Tanaka.
  • Journal Title: Journal of Medical Investigation Volume: 63 Pages: 80-84
  • NAID: 130005141048
  • Peer Reviewed / Open Access
• [Journal Article] Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolins-3 expression. (2015)
  • Author(s): Eisuke Hamaguchi, Katsuya Tanaka, Rie Tsutsumi, Yoko Sakai, Kohei Fukuta, Asuka Kasai, and Yasuo M. Tsutsumi
  • Journal Title: European Review for Medical and Pharmacological Science Volume: 19 Pages: 1285-1290
  • Peer Reviewed / Open Access
• [Presentation] 侵襲時の代謝破綻と糖負荷の影響 (2016)
  • Author(s): 堤保夫、香留希実子、笠井飛鳥、濵口英佑、酒井陽子、田中克哉
  • Organizer: 第63回日本麻酔科学会
  • Place of Presentation: マリンメッセ福岡（福岡県・福岡市）
• [Presentation] クリオグロブリン血症を合併したマクログロブリン血症患者における開心術の麻酔経験 (2016)
  • Author(s): 里見志帆、東島祥代、笠井飛鳥、角田奈美、堤保夫、田中克哉
  • Organizer: 第53回日本麻酔科学会中国・四国支部学術集会
  • Place of Presentation: 岡山コンベンションセンター(岡山県・岡山市）
• [Remarks] 徳島大学医学部麻酔・疼痛治療医学分野 業績集
  • URL: http://tokudaimasui.jp/study/