Bone regeneration device combined with nano-sized vector and miRNA
| Project/Area Number |
15H06504
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
UMEBAYASHI Mayumi 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (50754719)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨再生 / 遺伝子導入 / 再生医療 |
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| Outline of Final Research Achievements |
The aim of this research is to developed new bore regenerative device without gene transfer regent. Our team reported that gene activated matrix(GAM) which combined with 1000μg BMP4 DNA, β-TCP and atelo-collagen formed new bone after GAMs were implanted to rats' calvarium defects. However, 1000μg DNA is too much for clinical application. Therefor we focused on miRNA and new gene transfection technique.
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Report
(3 results)
Research Products
(4 results)
