| Project/Area Number |
15K01837
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
河原 幸江 久留米大学, 医学部, 准教授 (10279135)
西 昭徳 久留米大学, 医学部, 教授 (50228144)
大西 陽子 久留米大学, 医学部, 助教 (70727586)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 依存症 / コカイン / うつ病 / 転写因子 / 行動実験 / マウス / 酸化ストレス / 側坐核 / 薬物依存症 / 腹側被蓋野 / コカイン依存症 |
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| Outline of Final Research Achievements |
Generally, mental stress enhances irresistible impulse to addictive craving. However, the molecular mechanism is not fully understood. We reproduced this behavior in a mouse model, in which pre-exposure of mice to social defeat stress (SDS) increased cocaine preference. Motivation for preference is well known to be controlled by dopamine neurotransmission in reward system network from the ventral tegmental area to nucleus accumbens (NAc). We therefore performed microdialysis to detect dopamine levels in the NAc. Dopamine levels in the NAc increased when mice were placed in cocaine-conditioned box, and the increase in dopamine levels was significantly enhanced after SDS. As dopamine is known to be an inducer of oxidative stress, we revealed the effect of antioxidant-rich-foods or anti-oxidative reagent against cocaine preference, and the downstream molecular pathway.
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