| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We previously revealed that stromal cell-derived factor-1 (SDF-1) is involved in the changes in the number of bone marrow stem cells during the bone repair process in mice. Moreover, we reported that plasminogen (Plg) deficiency delays bone repair. We investigated the roles of Plg in the changes in bone marrow stem cells during bone repair. Plg deficiency significantly blunted a decrease in the number of HSCs after bone injury in mice. Plg deficiency significantly blunted the number of SDF-1- and Osterix-double-positive cells in the endosteum around the lesion as well as mRNA levels of SDF-1 and transforming growth factor-b (TGF-b) elevated by bone injury. TGF-b signaling inhibition significantly blunted a decrease in the number of HSCs after bone injury. The present study showed that Plg is critical for the changes in bone marrow HSCs, TGF-b and SDF-1 at the damaged site during bone repair in mice.
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