development of a new remedy for muscular dystrophies
| Project/Area Number |
15K08312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
浜田 博喜 岡山理科大学, 理学部, 教授 (10164914)
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| Co-Investigator(Renkei-kenkyūsha) |
NIKAIDO Koki 札幌医科大学, 医学部, 小児科学講座 (90359993)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | SIRT1 / レスベラトロール / 筋ジストロフィー / オートファジー / マイトファジー / 活性酸素 / 臨床研究 / ミトコンドリア / ROS / Duchenne型 / Becker型 / 福山型 |
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| Outline of Final Research Achievements |
There exists few remedy to muscular dystrophies (MD) except glucocorticoids, but there is no report of glucocorticoids for extending walking ability more than 2 years. We found that resveratrol, an activator of SIRT1, is effective on dystrophin-deficient mdx mice.
In the present study, we found that autophagy of damaged mitochondria containing deleted mitochondria DNA was suppressed in mdx mice. Damaged mitochondria liberate high levels of reactive oxygen species (ROS). Resveratrol reactivated the autophagy, which cleared damaged mitochondria and reduced ROS. Administration of resveratrol to 11 MD patients for 24 weeks showed resveratrol was effective on MD. Resveratrol significantly increased motor function and enhanced muscle strength with quantitative muscle testing. Thus, resveratrol will be a promising remedy for MD.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.2015
Author(s)
Di Sante G, Wang L, Wang C, Jiao X, Casimiro MC, Chen K, Pestell TG, Yaman I, Di Rocco A, Sun X, Horio Y, Powell MJ, He X, McBurney MW, Pestell RG.
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Journal Title
Mol Endocrinol
Volume: ２９
Issue: 1
Pages: 200-212
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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