Search for new biomarkers and Survey of cerebrovascular disease due to cancer-related hypercoagulability

• Project/Area Number: 15K08915
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Osaka University
• Principal Investigator: Sakaguchi Manabu 大阪大学, 医学系研究科, 招へい教員 (70432474)
• Project Period (FY): 2015-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: がん / 脳梗塞 / 多施設共同前向き観察研究 / 悪性腫瘍関連脳血管障害 / 悪性腫瘍関連動脈血栓症 / 悪性腫瘍合併脳梗塞 / 悪性腫瘍 / 脳卒中 / 過凝固状態 / 登録業務推進 / 研究事務局の再整備 / 関連論文の発表 / 研究プロトコール修正承認 / 全施設倫理審査承認 / 症例登録開始 / 血液検体採取 / REDcapｼｽﾃﾑ構築 / 一括検査体制 / 準備会議 / 国際学会参加

Outline of Final Research Achievements

We conducted a multicenter prospective observational study of active cancer and ischemic stroke at nine stroke centers in Japan. Eligible patients were followed up to 1 year after ischemic stroke. During the study periods, 135 patients who had active cancer and ischemic stroke were enrolled (median age, 75 years; 52 [38.5%] were female). The most common type of cancer was lung cancer, and 77 (57.0%) patients had and advanced cancer. Analyses showed that the survival probability after ischemic stroke was 54.1% at 1 year. The cumulative incidence of recurrent stroke and major bleeding were 10.3% and 9.0%, respectively.

Academic Significance and Societal Importance of the Research Achievements

本研究は、がん合併脳梗塞の実態調査を多施設共同前向き観察研究で行なった、我が国初めての研究である。がん患者が高齢化しており、がん患者の併存症管理の重要性が高まっている。その中でも、がんと脳卒中は共通のリスク因子があり、重要な疾患である。活動性がんを有するがん患者が脳梗塞を発症した場合、半数以上でステージ３以上の進行がんであること、１年後の生存率が54.1％であることは、今後のがん診療・脳卒中診療を行う上で、重要な知見となる。

Research Products

• [Journal Article] The Effect of Chemotherapy on Stroke Risk in Cancer Patients. (2020)
  • Author(s): Kitano T, Sasaki T, Gon Y, Todo K, Okazaki S, Kitamura T, Kitamura Y, Sakaguchi M, Sobue T, Matsumura Y, Hattori S, Mochizuki H.
  • Journal Title: Thrombosis and Haemostasis Volume: 120 Issue: 04 Pages: 714-723
  • DOI: 10.1055/s-0040-1708484
  • Peer Reviewed
• [Journal Article] Cancer is an independent predictor of poor outcomes in patients following intracerebral hemorrhage. (2018)
  • Author(s): Gon Y, Todo K, Mochizuki H, Sakaguchi M.
  • Journal Title: European Journal of Neurology Volume: 25 Issue: 1 Pages: 128-134
  • DOI: 10.1111/ene.13456
  • Peer Reviewed
• [Journal Article] Recurrent Stroke Due to Metastatic Pulmonary Tumor Emboli as an Important Clinical Entity. (2017)
  • Author(s): Takasugi J, Sakaguchi M, Oyama N, Gon Y, Terasaki Y, Sasaki T, Nakahara S, Ohshima K, Hori Y, Morii E, Mochizuki H.
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 26 Issue: 6 Pages: 108-110
  • DOI: 10.1016/j.jstrokecerebrovasdis.2017.03.012
  • Peer Reviewed
• [Journal Article] Ischemic stroke in cancer patients treated with direct oral anticoagulants for venous thromboembolism. (2017)
  • Author(s): Gon Y, Sakaguchi M, Takasugi J, Mochizuki H.
  • Journal Title: Thrombosis Research Volume: 154 Pages: 16-18
  • DOI: 10.1016/j.thromres.2017.03.026
  • Peer Reviewed
• [Journal Article] Validation of an algorithm that determines stroke diagnostic code accuracy in a Japanese hospital-based cancer registry using electronic medical records. (2017)
  • Author(s): Gon Y, Kabata D, Yamamoto K, Shintani A, Todo K, Mochizuki H, Sakaguchi M.
  • Journal Title: BMC Medical Informatics and Decision Making Volume: 17 Issue: 1 Pages: 157-164
  • DOI: 10.1186/s12911-017-0554-x
  • Peer Reviewed / Open Access
• [Journal Article] がん患者に潜む血栓塞栓症のリスク～脳梗塞～ (2017)
  • Author(s): 坂口 学
  • Journal Title: Thrombosis Medicine Volume: 7-2 Pages: 92-99
• [Presentation] Cryptogenic stroke と悪性腫瘍 (2022)
  • Author(s): 坂口 学
  • Organizer: 第25回日本栓子検出と治療学会
  • Invited
• [Presentation] がんと脳卒中： がん関連血栓症による脳梗塞の診断と治療 (2021)
  • Author(s): 坂口 学
  • Organizer: 第53回日本動脈硬化学会総会
  • Invited
• [Presentation] シンポジウム”担癌患者の脳卒中” がん関連血栓症 (2021)
  • Author(s): 坂口 学
  • Organizer: 第45回日本脳卒中学会学術集会
• [Presentation] The Effect of Chemotherapy on Stroke Risk in Cancer Patients. (2020)
  • Author(s): Kitano T, Sasaki T, Gon Y, Todo K, Okazaki S, Kitamura T, Kitamura Y, Sakaguchi M, Sobue T, Matsumura Y, Hattori S, Mochizuki H
  • Organizer: International Stroke Conference 2020
  • Int'l Joint Research
• [Presentation] 肺癌切除術後に発症した虚血性脳血管障害の臨床的特徴 (2018)
  • Author(s): 大薗達彦、権泰史、渡辺光太郎、北野貴也、藤堂謙一、佐々木勉、坂口学、中村元、貴島晴彦、奥村明之進、望月秀樹
  • Organizer: 第43回日本脳卒中学会学術集会
• [Presentation] 悪性腫瘍関連脳卒中 (2017)
  • Author(s): 坂口 学
  • Organizer: 第4回日本心血管脳卒中学会学術集会
  • Invited
• [Presentation] シンポジウム３：脳梗塞診断、治療のトピックス 脳梗塞における塞栓源検出-悪性腫瘍 (2017)
  • Author(s): 坂口 学
  • Organizer: 第20回日本栓子検出と治療学会
  • Invited