Clarification of pathogenesis in patients with dermatomyositis and rapidly progressive interstitial lung disease for new therapeutic approach
| Project/Area Number |
15K09534
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Tokai University |
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Principal Investigator |
SATO Shinji 東海大学, 医学部, 教授 (90276238)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Noriko 東海大学, 医学部, 助教 (50734406)
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| Research Collaborator |
NOGI Shinichi 東海大学, 医学部付属病院, 非常勤医師
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 抗MDA5抗体 / 皮膚筋炎 / 急速進行性間質性肺炎 / 抗体価 / 予後予測 / 再発予測 / 減少率 / 自己抗体 / 抗CADM-140抗体 / 無筋症性皮膚筋炎 / 予後 / サイトカイン |
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| Outline of Final Research Achievements |
Dermatomyositis (DM) is sometimes accompanied by rapidly progressive interstitial lung disease (RP-ILD) especially in patients with clinically amyopathic dermatomyositis (CADM), a clinical subtype of DM. It is known that RP-ILD with DM has a very poor prognosis despite of intensive treatment with high-dose corticosteroid and immunosuppressive agents. Anti-CADM-140/MDA5 (Melanoma Differentiation-Associated Gene 5) antibody (anti-MDA5 antibody) is one of DM-specific autoantibodies and is well known by its close association with RP-ILD. In this study, it was suspected that IL-6 might be involved in the pathogenesis of DM and RP-ILD according to the results of cytokine profile. Our findings also highlight the usefulness of this antibody not only in the prediction of RP-ILD but also in monitoring of the disease activity and prediction of disease outcome both in short-term and long-term follow up.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Initial predictors of poor survival in myositis-associated interstitial lung disease: a multicenter cohort of 497 patients2018
Author(s)
Shinji Sato, Kenichi Masui, Naoshi Nishina, Yasushi Kawaguchi, Atsushi Kawakami, Maasa Tamura, Kei Ikeda, Takahiro Nunokawa, Yoshinori Tanino, Katsuaki Asakawa, Yuko Kaneko, Takahisa Gono, Taro Ukichi, Shinjiro Kaieda, Taio Naniwa, Masataka Kuwana, et al
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Journal Title
Rheumatology (Oxford)
Volume: NA
Issue: 7
Pages: 1212-1221
DOI
Related Report
Peer Reviewed
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[Journal Article] Radiological and Pathological Correlation in Anti-MDA5 Antibody-positive Interstitial Lung Disease: Rapidly Progressive Perilobular Opacities and Diffuse Alveolar Damage2016
Author(s)
Haruka Chino,Akimasa Sekine,Tomohisa Baba,Tae Iwasawa,Koji Okudela,Tomiko Takemura,Harumi Itoh,Shini Sato,Yasuo Suzuki,Takashi Ogura
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Journal Title
Internal Medicine
Volume: 55
Issue: 16
Pages: 2241-2246
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
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[Presentation] Predictive Modeling of Mortality in Polymyositis/Dermatomyositis Patients with Interstitial Lung Disease Based on Combination of Serum Myositis-Specific Autoantibodies and Conventional Biomarkers.2017
Author(s)
Gono T, Masui K, Kawaguchi Y, Ikeda K, Kawakami A, Tamura M, Tanino Y, Nunokawa T, Kaneko Y, Sato S, Asakawa K, Nishina N, Kuwana M.
Organizer
2017 ACR/ARHP Annual Meeting
Related Report
Int'l Joint Research
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