| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
We reported that expression of Mas-related gene X2 (MrgX2), a G-protein coupled receptor, on mast cells was upregulated in the skin of patients with severe chronic urticaria compared with healthy controls. Histamine was released from skin mast cells via MrgX2 in response to substance P, which was released from neuron in response to stress. These results might explain the mechanism of exacerbation of chronic urticaria by stress. MrgX2 is expressed on human synovial mast cells and MrgX2 might be involved in the pathogenesis of rheumatoid arthritis.
|
