Study on the serotonin kynurenine hypothesis by the stable isotope breath test in mood disorder
Project/Area Number |
15K09818
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
Teraishi Toshiya 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 研究生 (90532531)
|
Research Collaborator |
KUNUGI Hiroshi
KAJIWARA Masahiro
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 安定同位体 / 呼気ガス検査 / トリプトファン / キヌレニン / うつ病 / 統合失調症 / トリプトファン呼気検査 / キヌレニン経路 |
Outline of Final Research Achievements |
The serotonin kynurenine (KYN) hypothesis, as well as monoamine hypothesis have gained increased attention in research into depression. We aimed to detect altered phenylalanine (Phe) and tryptophan (Trp)-KYN metabolism in major psychiatric disorders using the L-[1-13C]phenylalanine and L-[1-13C]tryptophan breath test (13C-PBT and 13C-TBT), respectively. 13C-phenylalanine (100 mg) and 13C-tryptophan (150 mg) were orally administered, and the breath 13CO2/12CO2 ratio was monitored for 120 and 180 min, respectively, in three groups: 15 patients with schizophrenia, 18 with major depressive disorder (MDD), and 21 healthy controls. In 13C-PBT, there were no significant difference in any indices between the three groups. In 13C-TBT, the cumulative recovery rate (CRR) was significantly different between the three groups. Our results suggest that 13C-TBT is a useful test to discriminate between depression and schizophrenia.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] 13C-phenylalanine breath test and serum biopterin in schizophrenia, bipolar disorder and major depressive disorder.2018
Author(s)
Toshiya Teraishi, Masahiro Kajiwara, Hiroaki Hori, Daimei Sasayama, Shinsuke Hidese, Junko Matsuo, Ikki Ishida, Yuji Ozeki, Miho Ota, Kotaro Hattori, Teruhiko Higuchi, Hiroshi Kunugi
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Journal Title
Journal of Psychiatric Research
Volume: 99
Pages: 142-150
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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