| Project/Area Number |
15K09818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Teraishi Toshiya 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 研究生 (90532531)
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| Research Collaborator |
KUNUGI Hiroshi
KAJIWARA Masahiro
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 安定同位体 / 呼気ガス検査 / トリプトファン / キヌレニン / うつ病 / 統合失調症 / トリプトファン呼気検査 / キヌレニン経路 |
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| Outline of Final Research Achievements |
The serotonin kynurenine (KYN) hypothesis, as well as monoamine hypothesis have gained increased attention in research into depression. We aimed to detect altered phenylalanine (Phe) and tryptophan (Trp)-KYN metabolism in major psychiatric disorders using the L-[1-13C]phenylalanine and L-[1-13C]tryptophan breath test (13C-PBT and 13C-TBT), respectively. 13C-phenylalanine (100 mg) and 13C-tryptophan (150 mg) were orally administered, and the breath 13CO2/12CO2 ratio was monitored for 120 and 180 min, respectively, in three groups: 15 patients with schizophrenia, 18 with major depressive disorder (MDD), and 21 healthy controls. In 13C-PBT, there were no significant difference in any indices between the three groups. In 13C-TBT, the cumulative recovery rate (CRR) was significantly different between the three groups. Our results suggest that 13C-TBT is a useful test to discriminate between depression and schizophrenia.
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