Roles of myeloid-derived immunosuppressive cells in chemo-radiosensitivity of advanced rectal cancer.
| Project/Area Number |
15K10148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
YAMASHITA Keishi 北里大学, 医学部, 教授
WATANABE Masahiko 北里大学, 医学部, 教授
SATO Takeo 北里大学, 医学部, 講師
NAKAMURA Takatoshi 北里大学, 医学部, 准教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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|---|
| Keywords | 術前放射線化学療法 / 放射線感受性 / 進行直腸癌 / CD163 / 腫瘍関連マクロファージ / 直腸癌 / CRBP1 / 骨髄由来細胞 |
|---|
| Outline of Final Research Achievements |
We aimed to predict sensitivity to neoadjuvant chemoradiotherapy in advanced rectal cancer. Analysis of routine peripheral leukocyte fraction revealed that patients with high monocyte fraction showed poor prognosis. Immunohistochemistry indicate that accumulation of CD163+ tumor-associated macrophage was associated with refractoriness to neoadjuvant chemoradiotherapy among immunocytes (eg. myeloid-derived suppressor cells, macrophages) derived from circulating monocytes. Comprehensive molecular exploration identified CRBP1 gene as a determinant of radiation sensitivity. CRBP1 silencing by its promoter methylation was related to refractoriness to neoadjuvant chemoradiotherapy in patients with advanced rectal cancer.
In the next steps, we analyze the network between CRBP1 and recruitment of CD163 macrophage including cytokine system. These results would lead to a novel approach to clarify a mechanism of chemoradiosensitivity.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.2017
Author(s)
Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.
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Journal Title
Br J Cancer
Volume: 116
Issue: 8
Pages: 1046-56
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] CDO1遺伝子プロモーター領域のメチル化はStage III結腸癌における抗がん剤感受性亢進と相関する2016
Author(s)
横井 圭悟, 山下 継史, 石井 智, 田中 俊道, 西澤 伸恭, 五十嵐 一晴, 大泉 陽介, 小嶌 慶太, 南谷 菜穂子, 加藤 弘, 渡邊 昌彦
Organizer
日本癌学会総会
Place of Presentation
パシフィコ横浜
Year and Date
2016-10-06
Related Report
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[Presentation] 大腸癌の薬剤感受性機序解明を目指した包括的遺伝子検索2016
Author(s)
田中 俊道, 山下 継史, 石井 智, 西澤 伸恭, 横井 圭悟, 牛久 秀樹, 菊池 真理子, 古城 憲, 南谷 菜穂子, 加藤 弘, 澤登 雅和, 渡邊 昌彦
Organizer
日本癌学会総会
Place of Presentation
パシフィコ横浜
Year and Date
2016-10-06
Related Report
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[Presentation] 大腸癌の薬剤感受性機序解明を目指した包括的遺伝子検索2016
Author(s)
田中 俊道, 山下 継史, 甲斐田 武志, 田中 蓉子, 原田 宏輝, 横田 和子, 石井 智, 西澤 伸恭, 横井 圭悟, 牛久 秀樹, 菊池 真理子, 古城 憲, 南谷 菜穂子, 加藤 弘, 渡邊 昌彦
Organizer
日本分子腫瘍マーカー研究会
Place of Presentation
パシフィコ横浜
Year and Date
2016-10-05
Related Report
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