The serum concentration of SEMA4A in eye diseases
| Project/Area Number |
15K10912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University (2016-2017)
Fukuoka University (2015) |
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Principal Investigator |
Yukio Sassa 九州大学, 医学研究院, 共同研究員 (80580315)
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| Co-Investigator(Kenkyū-buntansha) |
奥野 龍禎 大阪大学, 医学系研究科, 助教 (00464248)
石橋 達朗 九州大学, 大学病院, 病院長 (30150428)
向野 利寛 福岡大学, 医学部, 教授 (40117106)
福島 修一郎 大阪大学, 基礎工学研究科, 助教 (40362644)
吉田 茂生 九州大学, 大学病院, 助手 (50363370)
安井 武史 徳島大学, 大学院社会産業理工学研究部(理工学域), 教授 (70314408)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | SEMA4A / 視神経炎 / 炎症性眼疾患 / SHG顕微鏡 / 網膜下線維化 / 血管新生モデル / 血清濃度 / 硝子体濃度 / 原田病 |
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| Outline of Final Research Achievements |
We evaluated the serum concentrations of SEMA4A in eye diseases. The average serum concentration of SEMA4A in all patients evaluated was 3702+/-8583U/ｍl(n=248). In the optic neuritis patients, SEMA4A might be higher than other diseases(5746+/12390U/ml, n=12). SEMA4A might also be higher in patients with Vogt-Koyanagi-Harada disease.(12502+/-11202U/ml, n=5). The vitreous concentration of SEMA4A was much lower compared with the serum concentration( 232+/-95.6U/ml n=12).SEMA4A might play a role on progressing these eye diseases but might not be useful as a specific biomarker.The further study must be needed to clarify these results because of the small sample number.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Tenascin-C promotes angiogenesis in fibrovascular membranes in eyes with proliferative diabetic retinopathy.2016
Author(s)
Kobayashi Y,Yoshida S, Zhou Y, Nakama T, Ishikawa K, Arima M, Nakao S, Sassa Y, Takeda A, Hisatomi T, Ikeda Y, Matsuda A,
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Journal Title
Mol Vis.
Volume: 30
Pages: 436-45
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Overexpression of CD163 in vitreous and fibrovascular membranes of patients with proliferative diabetic retinopathy: possible involvement of periostin.2015
Author(s)
Kobayashi Y, Yoshida S, Nakama T, Zhou Y, Ishikawa K, Arita R, Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T, Ishibashi T
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Journal Title
Br J Ophthalmol.
Volume: 99(4)
Pages: 451-456
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased Expression of M-CSF and IL-13 in Vitreous of Patients with Proliferative Diabetic Retinopathy: Implications for M2 Macrophage-involving Fibrovascular Membrane Formation2015
Author(s)
Shigeo Yoshida, Yoshiyuki Kobayashi, Takahito Nakama, Yedi Zhou, Keijiro Ishikawa, Ryoichi Arita, Shintaro Nakao, Masanori Miyazaki, Yukio Sassa, Yuji Oshima, Kenji Izuhara, Toshihiro Kono, and Tatsuro Ishibashi
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Journal Title
Br J Ophthalmol.
Volume: 99(5)
Pages: 629-634
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased vitreous concentrations of MCP-1 and IL-6 after vitrectomy in patients with proliferative diabetic retinopathy: Possible relation to postoperative macular edema2015
Author(s)
Kubo Y, Kobayashi Y, Zhou Y, Nakama T, Yamaguchi M, Tachibana T, Ishikawa K, Arita R, Nakao S, Sassa Y, Oshima Y, Kono T, Ishibashi T.
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Journal Title
Br J Ophthalmol.
Volume: 99(7)
Pages: 960-966
Related Report
Peer Reviewed / Open Access
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