Developmen of the novel diagnostic marker for chornic fatigue tarageting circulating particles

• Project/Area Number: 15K12689
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Kansai University of Welfare Sciences
• Principal Investigator: SANAE FUKUDA 関西福祉科学大学, 健康福祉学部, 教授 (50423885)
• Research Collaborator: EGUCHI Akiko 三重大学, 医学研究科, 助教 (00598980)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 疲労 / バイオマーカー / 細胞外粒子 / 慢性疲労 / 微小粒子

Outline of Final Research Achievements

Chronic fatigue is caused by abnormalities in the neuroendocrine-immune system induced by some stress including viruses. In chronic fatigue syndrome, which is a representative disease primarily complaining of fatigue, there have been shown abnormal expression of glial cells in the brain, and various previous studies revealed one of the causes of fatigue was some inflammation. However, blood fatigue-specific-biomarkers have not been identified. In this study, we carried out it and found new biomarker. .

Research Products

• [Journal Article] Ubiquinol-10 supplementation improves fatigue, autonomic nervous function, and cognitive function in patients with chronic fatigue syndrome: An open-label study and a randomized, double-blind, placebo-controlled study. (2016)
  • Author(s): Fukuda, S., Nojima, J., Kajimoto, O., Yamaguti, K., Nakatomi, Y., Kuratsune, H., Watanabe, Y.
  • Journal Title: Biofactors Volume: 8 Issue: 4 Pages: 431-440
  • DOI: 10.1002/biof.1293
  • Peer Reviewed / Open Access
• [Journal Article] A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity. (2016)
  • Author(s): Fukuda, S., Nojima, J., Motoki, Y., Yamaguti, K., Nakatomi, Y., Okawa, N., Fujiwara, K., Watanabe, Y., Kuratsune, H.
  • Journal Title: Biol. Psychol. Volume: 118 Pages: 88-93
  • DOI: 10.1016/j.biopsycho.2016.05.005
  • Peer Reviewed / Open Access
• [Journal Article] A potential biomarker for fatigue: oxidative stress and anti-oxidative activity (2016)
  • Author(s): Sanae Fukuda, Junzo Nojima, Yukari Motoki, Kouzi Yamaguti, Yasuhito Nakatomic, Naoko Okawa, Kazumi Fujiwara, Yasuyoshi Watanabeb, Hirohiko Kuratsune
  • Journal Title: Biological Psychology Volume: 印刷中
  • Peer Reviewed
• [Presentation] ME/CFS 「ME/CFSの実態及び疫学調査」 (2016)
  • Author(s): 福田早苗
  • Organizer: 第12回日本疲労学会
  • Place of Presentation: 神奈川
  • Year and Date: 2016-05-20
• [Presentation] ミニレクチャー「コルチゾール研究Up to date: ストレス-健康の研究に向けて」指定討論 (2015)
  • Author(s): 福田早苗
  • Organizer: 第33回日本生理心理学会
  • Place of Presentation: 大阪府
  • Year and Date: 2015-05-23
• [Presentation] シンポジウム、客観的疲労評価とストレス評価-活用の可能性 (2015)
  • Author(s): 福田早苗
  • Organizer: 第11回日本疲労学会総会・学術集会
  • Place of Presentation: 山口県
  • Year and Date: 2015-05-15
• [Presentation] 「ストレス・疲労・睡眠の評価方法について」 (2015)
  • Author(s): 福田早苗
  • Organizer: 第88回日本産業衛生学会分科会産業心理技術研究会
  • Place of Presentation: 大阪府
  • Year and Date: 2015-05-13
  • Invited
• [Book] 抗疲労と香り (2016)
  • Author(s): 福田早苗、渡辺映理
  • Total Pages: 210
  • Publisher: フレグランスジャーナル社