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Developmen of the novel diagnostic marker for chornic fatigue tarageting circulating particles

Research Project

Project/Area Number 15K12689
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionKansai University of Welfare Sciences

Principal Investigator

SANAE FUKUDA  関西福祉科学大学, 健康福祉学部, 教授 (50423885)

Research Collaborator EGUCHI Akiko  三重大学, 医学研究科, 助教 (00598980)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords疲労 / バイオマーカー / 細胞外粒子 / 慢性疲労 / 微小粒子
Outline of Final Research Achievements

Chronic fatigue is caused by abnormalities in the neuroendocrine-immune system induced by some stress including viruses. In chronic fatigue syndrome, which is a representative disease primarily complaining of fatigue, there have been shown abnormal expression of glial cells in the brain, and various previous studies revealed one of the causes of fatigue was some inflammation. However, blood fatigue-specific-biomarkers have not been identified. In this study, we carried out it and found new biomarker. .

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (4 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Ubiquinol-10 supplementation improves fatigue, autonomic nervous function, and cognitive function in patients with chronic fatigue syndrome: An open-label study and a randomized, double-blind, placebo-controlled study.2016

    • Author(s)
      Fukuda, S., Nojima, J., Kajimoto, O., Yamaguti, K., Nakatomi, Y., Kuratsune, H., Watanabe, Y.
    • Journal Title

      Biofactors

      Volume: 8 Issue: 4 Pages: 431-440

    • DOI

      10.1002/biof.1293

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity.2016

    • Author(s)
      Fukuda, S., Nojima, J., Motoki, Y., Yamaguti, K., Nakatomi, Y., Okawa, N., Fujiwara, K., Watanabe, Y., Kuratsune, H.
    • Journal Title

      Biol. Psychol.

      Volume: 118 Pages: 88-93

    • DOI

      10.1016/j.biopsycho.2016.05.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A potential biomarker for fatigue: oxidative stress and anti-oxidative activity2016

    • Author(s)
      Sanae Fukuda, Junzo Nojima, Yukari Motoki, Kouzi Yamaguti, Yasuhito Nakatomic, Naoko Okawa, Kazumi Fujiwara, Yasuyoshi Watanabeb, Hirohiko Kuratsune
    • Journal Title

      Biological Psychology

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] ME/CFS 「ME/CFSの実態及び疫学調査」2016

    • Author(s)
      福田早苗
    • Organizer
      第12回日本疲労学会
    • Place of Presentation
      神奈川
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] ミニレクチャー「コルチゾール研究Up to date: ストレス-健康の研究に向けて」指定討論2015

    • Author(s)
      福田早苗
    • Organizer
      第33回日本生理心理学会
    • Place of Presentation
      大阪府
    • Year and Date
      2015-05-23
    • Related Report
      2015 Research-status Report
  • [Presentation] シンポジウム、客観的疲労評価とストレス評価-活用の可能性2015

    • Author(s)
      福田早苗
    • Organizer
      第11回日本疲労学会総会・学術集会
    • Place of Presentation
      山口県
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 「ストレス・疲労・睡眠の評価方法について」2015

    • Author(s)
      福田早苗
    • Organizer
      第88回日本産業衛生学会分科会産業心理技術研究会
    • Place of Presentation
      大阪府
    • Year and Date
      2015-05-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 抗疲労と香り2016

    • Author(s)
      福田早苗、渡辺映理
    • Total Pages
      210
    • Publisher
      フレグランスジャーナル社
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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