Elucidation of pathological mechanisms by integration glycans and redox
Project/Area Number |
15K14481
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Functional biochemistry
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Research Institution | Osaka International Cancer Institute (2018) Institute of Physical and Chemical Research (2015-2017) |
Principal Investigator |
Taniguchi Naoyuki 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 糖鎖オンコロジー部部長 (90002188)
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 糖鎖 / 糖転移酵素 / レドックス / SOD3 |
Outline of Final Research Achievements |
We have revealed that the antioxidative functions of SOD3 were modulated by N-glycans carried on them. SOD3 lacking complex type glycans expressed different anticancer effects compared with SOD3 carrying complex type glycans, which indicated N-glycans on SOD3 were involved in development of cancers. We also revealed that oxidative stress changed the expression levels of multiple glycosyltransferases in macrophage, which enhanced phagocytosis. These results demonstrate the biological linkage between glycans and redox. We are now trying to publish these results.
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Academic Significance and Societal Importance of the Research Achievements |
本研究は、「糖鎖」と「レドックス」という細胞が持つ一見独立した2つのシステムが密接に制御し合う協調システムを新たに見出し、Glyco-Redox制御異常を背景とする様々な疾患の病因解明と治療法探索に繋がる新しい知見を得ることを目的としていた。本研究で明らかになった、抗酸化酵素SOD3の糖鎖による機能制御、および酸化ストレスによるマクロファージの糖鎖解析と機能解明は、まさに目的としたGlyco-Redoxシステムの一端を明らかにしたものであり、今後、関連疾患の病因解明に繋がることが期待される。
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Report
(5 results)
Research Products
(47 results)
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[Journal Article] High affinity sugar ligands of C-type lectin receptor langerin.2018
Author(s)
Ota F, Hirayama T, Kizuka Y, Yamaguchi Y, Fujinawa R, Nagata M; Ismanto HS, Lepenies, Aretz J, Rademacher C, Seeberger PH; Angata T, Kitazume S, Yoshida K, Betsuyaku T, Kida K Yamasaki S, and Taniguchi N
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Journal Title
BBA - General Subjects
Volume: -
Issue: 7
Pages: 1592-1601
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 1.Imamaki R. Ogawa K, Kizuka Y, Komi Y, Kojima S, Kotani N, Honke K, Honda T, Taniguchi N, and Kitazume S2018
Author(s)
1.Imamaki R. Ogawa K, Kizuka Y, Komi Y, Kojima S, Kotani N, Honke K, Honda T, Taniguchi N, and Kitazume S
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Journal Title
Oncogene
Volume: -
Issue: 31
Pages: 4287-4299
DOI
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Peer Reviewed / Open Access
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[Journal Article] Metabolic control of T cell immune response through glycans in inflammatory bowel disease.2018
Author(s)
Dias AM, Correia A, Pereira MS, Almeida CR, Alves I, Pinto V, Catarino TA, Mendes S, Leander M, Oliva-Teles MT, Maia L, Delerue-Matos C, Taniguchi N, Lima M, Pedroto I, Marcos-Pinto R, Lago P, Reis CA, Vilanova M, Pinho SS
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Journal Title
Proc Natl Acad Sci U S A
Volume: 115(20)
Issue: 20
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Core fucosylation of the T cell receptor is required for T cell activation.2018
Author(s)
8.Liang W., Mao S., Sun S., Li M., Li Z., Yu R., Ma T., Gu J., Zhang J., Taniguchi N., Li W.
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Journal Title
Front Immunol.,
Volume: 9
Pages: 78-78
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling2017
Author(s)
4.Iijima J, Kobayashi S, Kitazume S*, Kizuka Y, Fujinawa R, Korekane H, Shibata T, Saitoh S, Akashi-Takamura S, Miyake K, Miyoshi E, and Taniguch N
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Journal Title
Glycobiology
Volume: 2017
Issue: 11
Pages: 1006-1015
DOI
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Peer Reviewed / Open Access
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[Journal Article] In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice2016
Author(s)
Tsutsui A, Ogura A, Tahara T, Nozaki S, Urano S, Hara M, Kojima S, Kurbangalieva A, Onoe H, Watanabe Y, Taniguchi N, Tanaka K
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Journal Title
Organic and Biomolecular Chemistry
Volume: -
Issue: 24
Pages: 5755-5760
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers2015
Author(s)
Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Dosaka-Akita H
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Journal Title
Oncology
Volume: 88
Issue: 14
Pages: 298-305
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease.2015
Author(s)
Ito E., Oka R., Ishi T., Korekane H., Kurimoto A., Kizuka Y., Kitazume S., Ariki S., Takahashi M., Kuroki Y., Kida K., Taniguchi N.
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Journal Title
Journal of Proteomics
Volume: 127
Pages: 386-394
DOI
Related Report
Peer Reviewed
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[Book] ベインズ・ドミニチャク生化学(原書4版)2018
Author(s)
Baynes John W., Dominiczak Marek H, 谷口 直之, 岩井 一宏, 藤井 順逸, 本家 孝一 (担当:共著)
Total Pages
728
Publisher
エルゼビア・ジャパン, 丸善出版 (発売)
ISBN
9784621301692
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