Molecular mechanisms of production of the novel second messenger cGAMP and its inflammatory signaling
| Project/Area Number |
15K19024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MOTANI Kou 徳島大学, 先端酵素学研究所(オープンイノベ), 助教 (70609049)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | DNA / 炎症 / cGAMP / cGAS / 免疫学 |
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| Outline of Final Research Achievements |
Self-DNA accumulating in the body causes inflammation, leading to development of lethal anemia or polyarthritis. In this study, I found that the novel pro-inflammatory molecule cyclic GMP-AMP (cGAMP) was produced in cells by accumulation of DNA. In addition, DNA-induced production of cGAMP and inflammatory cytokines were prevented by deletion of cGAMP synthase (cGAS). Thus, cGAS and cGAMP would be useful therapeutic target for the DNA-induced inflammatory diseases.
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Report
(4 results)
Research Products
(7 results)
