Examination of the mechanisms by which SOX2 promotes cell proliferation in esophageal cancer
Project/Area Number |
15K19040
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human genetics
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Research Institution | Tokyo Medical and Dental University (2016-2017) Kyoto Prefectural University of Medicine (2015) |
Principal Investigator |
GEN Yasuyuki 東京医科歯科大学, 難治疾患研究所, 助教 (80596156)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | SOX2 / esophageal cancer / miRNA / 食道扁平上皮癌 / PTEN |
Outline of Final Research Achievements |
Our previous study revealed that the SOX2 gene is frequently amplified and overexpressed in esophageal squamous cell carcinoma (ESCC), and that SOX2 promotes ESCC cell proliferation in vitro and in vivo via upreguation of AKT/mTOR signaling pathway. In the present study, we showed that SOX2 increased the expression of miR-19a-3p indirectly. miR-19a-3p upregulated AKT signaling pathway by repressing PTEN, a negative regulator of AKT. Furthermore, we showed that AKT/mTOR dual inhibitor suppressed the proliferation of SOX2-amplifed ESCC cells.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Loss of PAR-3 protein expression is associated with invasion, lymph node metastasis, and poor survival in esophageal squamous cell carcinoma.2017
Author(s)
Kitaichi T, Yasui K, Gen Y, Dohi O, Iwai N, Tomie A, Yamada N, Terasaki K, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Sumida Y, Mitsuyoshi H, Naito Y, Zen Y, Itoh Y.
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Journal Title
Hum Pathol
Volume: 62
Pages: 134-140
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.2016
Author(s)
Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M.
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Journal Title
Cancer Cell
Volume: 29
Pages: 935-948
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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