Development of novel cancer vaccine therapy using oncolytic Ad-REIC
Project/Area Number |
15K20093
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Okayama University |
Principal Investigator |
huang peng 岡山大学, 医歯薬学総合研究科, 助教 (00610841)
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Research Collaborator |
KUMON HIROMI 岡山大学, 医歯薬学総合研究科, 特命教授 (30144760)
NASU YASUTOMO 岡山大学, 医歯薬学総合研究科, 教授 (20237572)
WATANABE MASAMI 岡山大学, 大学病院, 教授 (70444677)
UEKI HIDEO 岡山大学, 医学部, 技術専門職員 (90537218)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 限増殖型アデノウイルスベクター / REIC/DKK-3 / 癌ワクチン / 抗癌免疫活性化 / 制限増殖型アデノウイルスベクター / 抗癌免疫制御 / 免疫活性 |
Outline of Final Research Achievements |
Reduced expression in immortalized cells (REIC)/Dickkopf 3 (Dkk-3) is a tumor suppressor gene that is downregulated in various cancers. We recently developed a novel specific replication-selective adenovirus Ad-REIC, to achieve more effective therapeutic outcomes and anti-cancer immune escape. In this study, we assessed the anti-tumor immunity effects of replication-selective adenovirus Ad-REIC, and the mechanism had been verify.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Lycorine induces apoptosis of bladder cancer T24 cells by inhibiting phospho-Akt and activating the intrinsic apoptotic cascade2017
Author(s)
Wang C, Wang Q, Li X, Jin Z, Xu P, Xu N, Xu A, Xu Y, Zheng S, Zheng J, Liu C, Huang P.
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Journal Title
Biochem Biophys Res Commun
Volume: 483
Issue: 1
Pages: 197-202
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding.2016
Author(s)
Ruma IM, Putranto EW, Kondo E, Murata H, Watanabe M, Huang P, Kinoshita R, Futami J, Inoue Y, Yamauchi A, Sumardika IW, Youyi C, Yamamoto K, Nasu Y, Nishibori M, Hibino T, Sakaguchi M.
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Journal Title
Clin Exp Metastasis
Volume: 33
Issue: 6
Pages: 609-627
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Influence of a single-nucleotide polymorphism of the DNA mismatch repair-related gene exonuclease-1 (rs9350) with prostate cancer risk among Chinese people.2016
Author(s)
Zhang Y, Li P, Xu A, Chen J, Ma C, Sakai A, Xie L, Wang L, Na Y, Kaku H, Xu P, Jin Z, Li X, Guo K, Shen H, Zheng S, Kumon H, Liu C, Huang P
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Journal Title
Tumour Biol
Volume: 37
Issue: 5
Pages: 6653-6659
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model2015
Author(s)
Guo K, Huang P, Xu N, Xu P, Kaku H, Zheng S, Xu A, Matsuura E, Liu C, Kumon H
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Journal Title
Oncotarget
Volume: 6
Issue: 25
Pages: 21137-21147
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] The proof of concept of REIC/Dkk-3 gene therapy for thoracic malignancies2016
Author(s)
Shinichi Toyooka, Ken Suzawa, Kazuhiko Shien, Masakiyo Sakaguchi, Masami Watanabe, Peng Huang, Kei Namba, Hidejiro Torigoe, Hiroki Sato, Junichi Soh, Hiromasa Yamamoto, Yuho Maki, Kazunori Tsukuda, Shuta Tomida, Yasutomo Nasu, Hiromi Kumon, Shinichiro Miyoshi.
Organizer
Tenth AACR-JCA Joint Conference
Place of Presentation
Maui USA
Year and Date
2016-02-16
Related Report
Int'l Joint Research