The Innovative Synthesis of Bioactive Molecules based on the Molecular Mechanism of Natural Products Activity

• Project/Area Number: 16002007
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering; Chemistry
• Research Institution: Nagoya University
• Principal Investigator: ISOBE Minoru Nagoya University, 大学院・生命農学研究科, 名誉教授 (00023466)
• Co-Investigator(Kenkyū-buntansha): ICHIKAWA Yoshiyasu 高知大学, 理学部, 教授 (60193439) ; NISHIKAWA Toshio 名古屋大学, 大学院・生命農学研究科, 教授 (90208158) ; KUSE Masaki 名古屋大学, 物質科学国際研究センター, 助教 (40335013) ; KAI Hidenori 鳥取大学, 農学部, 教授 (60023412) ; ADACHI Masaatsu 名古屋大学, 生命農学研究科, 助教 (80432251)
• Project Period (FY): 2004 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥227,500,000 (Direct Cost: ¥175,000,000、Indirect Cost: ¥52,500,000); Fiscal Year 2008: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000); Fiscal Year 2007: ¥32,240,000 (Direct Cost: ¥24,800,000、Indirect Cost: ¥7,440,000); Fiscal Year 2006: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000); Fiscal Year 2005: ¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000); Fiscal Year 2004: ¥89,700,000 (Direct Cost: ¥69,000,000、Indirect Cost: ¥20,700,000)
• Keywords: 生理活性発現分子機構 / 全合成 / タンパク質分子修飾 / 相互作用 / 構造認識機構 / タンパク質脱リン酸酵素阻害剤 / 時間読みタンパク質 / テトロドトキシン / シガトキシン / 発光タンパク質 / タンパク質脱リン酸酵素阻害 / 分子間相互作用 / 光親和性標識 / タンパク脱リン酸酵素阻害 / 時間読みタンパク

Research Abstract

合成化学から生物有機化学までを統一概念とする独創的なところである。本研究で展開されるこれらの手法と結果の解析方法を、合理的分子設計にフィードバックすることは、分子科学においてアフィニティが著しく高い点で毒性物質として取り扱われるものの、活性発現の原理を理解すれば、比活性を下げることで生体系と適当な平衡点を探すことも可能となる。従って、ここで展開している分子科学は、創薬の基礎科学として位置づけることができる。合理的・論理的分子設計に基づく創薬の創製科学の基礎として社会に貢献するという意義も深い。また、純粋に生物有機化学としての価値も高い。

Research Products

• [Journal Article] Syntheses of N-Acylisoxazolidine Derivatives, related to a partial structure found in Zetekitoxin AB, a golden frog poison (2009)
  • Author(s): Nishikawa, T.; Urabe, D.; Isobe, M.
  • Journal Title: Heterocycles 79 Pages: 379-385
  • NAID: 40016543072
• [Journal Article] Differentiation of Coelenteramide Sulfates from Phosphates by means of Hydrogen/Deuterium Exchange with Ion Trap Mass Spectrometry (2009)
  • Author(s): Doi, I.; Kuse, M.; Nakashima, Y.; Tani, N.
  • Journal Title: Isobe, M. JMSS 57 Pages: 89-95
• [Journal Article] Total Synthesis of Ciguatoxin (2009)
  • Author(s): Hamajima, A.; Isobe, M.
  • Journal Title: Angew. Chem. Int. Ed. 48 Pages: 2941-2945
• [Journal Article] Higher Structure of Cereulide, an emetic toxin from Bacillus cereus, with special comparison with Valinomycin, an antibiotic from Streptomyces fulvissimus (2009)
  • Author(s): Makarasen, A.; Yoza, K.; Isobe, M.
  • Journal Title: M. Chem. Asian J. (in press)
• [Journal Article] Novel Stereocontrolled Synthesis of Highly-functionalized Cyclobutanes by Epoxide Opening through a Carbanion Intermediate in Heteroconjugate Addition (2009)
  • Author(s): Adachi, M.; Yamauchi, E.; Komada, T.; Isobe, M.
  • Journal Title: Synlett. Pages: 1157-1161
• [Journal Article] 1H NMR Aided Elucidation of Products Derived from Photodegradation of Ethyl 3-azido-4,6-difluorobenzoate in 2,2,2-Trifluoroethanol (2009)
  • Author(s): Sydnes, M. O.; Kuse, M.; Doi, I.; Isobe, M.
  • Journal Title: Tetrahedron 65 Pages: 3863-3870
• [Journal Article] 多国間学術拠点形成事業「アジアの最先端有機化学」 (2009)
  • Author(s): 磯部 稔・西川俊夫
  • Journal Title: Yakugaku Zasshi 129 Pages: 401-406
  • NAID: 110007230201
• [Journal Article] Syntheses of N-Acylisoxazolidine Derivatives, related to a partial structure found in Zetekitoxin AB, a golden frog poison (2009)
  • Author(s): Nishikawa, T. ; Urabe, D. ; Isobe, M
  • Journal Title: Heterocycles 79 Pages: 379-385
  • NAID: 40016543072
  • Peer Reviewed
• [Journal Article] Differentiation of Coelenteramide Sulfates from Phosphates by means of Hydrogen/Deuterium Exchange with Ion Trap Mass Spectrometry (2009)
  • Author(s): Doi, I. ; Kuse, M. ; Nakashima, Y. ; Tani, N. ; Isobe, M.
  • Journal Title: JMSS (in press)
  • Peer Reviewed
• [Journal Article] Total Synthesis of Ciguatoxin (2009)
  • Author(s): Hamaiima, A. ; Isobe, M.
  • Journal Title: Angew. Chem. Mt. Ed. 48 Pages: 2941-2945
  • Peer Reviewed
• [Journal Article] Higher Structure of Cereulide, an emetic toxin from Bacillus cereus, with special comparison with Valinomycin, an antibiotic from Streptomyces fulvissimus (2009)
  • Author(s): Makarasen, A. ; Yoza, K. ; Isobe, M.
  • Journal Title: Chem. Asian J. 4 Pages: 688-698
  • Peer Reviewed
• [Journal Article] Novel Stereocontrolled Synthesis of Highly-functionalized Cyclobutanes by Epoxide Opening through a Carbanion Intermediate in Heteroconiugate Addition (2009)
  • Author(s): Adachi, M. ; Yamauchi, E. ; Komada, T. ; Isobe, M
  • Journal Title: Synlett Pages: 1157-1161
  • Peer Reviewed
• [Journal Article] Molecular Heterogeneity of TIME-EA 4, a Timer Protein in Silkworm Diapause Eggs. Suthasinee Pitchayawasin-Thapphasaraphong (2009)
  • Author(s): Tani N., Isobe, M., Kai, H., Kurahashi, T., Kato,J., Trisunan. S.
  • Journal Title: Biochem. Biosciences and Biotechnology (Accepted for publication)
  • Peer Reviewed
• [Journal Article] Synthesis of four Lysine-linked cereulide analogs showing K^+ ionophoric activity as lead compounds for emetic toxin-detection by immunoassays (2009)
  • Author(s): Makarasen, A. ; Nishikawa, T. ; Isobe. M
  • Journal Title: Synthesis (in press)
  • Peer Reviewed
• [Journal Article] ^1 H NMR Aided Elucidation of Products Derived from Photodegradation of Ethyl 3-azido-4,6-difluorobenzoate in 2, 2, 2-Trifluoroethanol (2009)
  • Author(s): Sydnes, M. O. ; Kuse, M. ; Doi, I. ; Isobe, M.
  • Journal Title: Tetrahedron 65 Pages: 3863-3870
  • Peer Reviewed
• [Journal Article] Selective protein modification by the hydroperoxide intermediate in a photoprotein, aequorin (2009)
  • Author(s): Doi, I, Kuse, M., Nishikawa. T., Isobe, M.
  • Journal Title: Bioorg. Med. Chem. 17 Pages: 3399-3404
  • Peer Reviewed
• [Journal Article] Substituent effect of imino-O-arenesulfonates, a coupling partner in Suzuki-Miyaura Reaction for substitution of the Pyrazine Ring : A Study for the Synthes is of Coelenterazine Analogs (2009)
  • Author(s): Makarasen, A. ; Kuse,_M. ; Nishikawa, T. ; Isobe, M.
  • Journal Title: Bulletin of Chemical Society of Japan (in press)
  • Peer Reviewed
• [Journal Article] A relaxin-like peptide purified from radial nerves induces oocyte maturation and ovulation in starfish, Asterina pectinifera (2009)
  • Author(s): Mita, M. ; Yoshikuni, M. ; Ohno, K.;Shibata, Y. ; Bindhu Paul-Pr asanth ; Suthasinee Pitchayawasin ; Isobe, M. ; Nagahama, Y.
  • Journal Title: Proc. National Academy of Sciences (published on-line)
  • Peer Reviewed
• [Journal Article] Protein Phosphatase Inhibitory Activity of Tautomycin Photoaffinity Probes Evaluated at Femto-molar Level (2008)
  • Author(s): Magne O. Sydnes, Masaki Kuse, Masakuni Kurono, Aya Shimomura, Hiroshi Ohinata, Akira Takai and Minoru Isobe
  • Journal Title: Bioorg. Med. Chem. 16 Pages: 1747-1755
• [Journal Article] Synthesis of N-Hydroxyenamide, a potential precursor of chartelline (2008)
  • Author(s): Kajii, S.; Nishikawa, T.; Isobe, M.
  • Journal Title: Tetrahedron Lett. 7 Pages: 1199-1202
• [Journal Article] One-Pot Reductive Monoalkylation of Nitro Aryls with Hydrogen over Pd/C (2008)
  • Author(s): Sydnes, M.O.; Isobe, M.
  • Journal Title: Tetrahedron Lett. 7 Pages: 1199-1202
• [Journal Article] Reductive monoalkylation of nitro aryls in one-pot (2008)
  • Author(s): Sydnes, M. O.; Kuse, M.; Isobe, M.
  • Journal Title: Tetrahedron 64
• [Journal Article] Synthetic Studies and biosynthetic considerations on marine alkaroid chartelline (2008)
  • Author(s): Nishikawa, T.; Kajii, S.; Isobe, M.
  • Journal Title: Chem. Communic. Pages: 3121-3123
• [Journal Article] Cysteine 390 is the binding site of symplectin, a photoprotein of Okinawan luminous squid, Symplectoteuthis oualaniensis (2008)
  • Author(s): Isobe, M.; Kuse, M.; Tani, N.; Fujii, T.; Matsuda, T.
  • Journal Title: Proc. Jpn. Acad., Ser. B. 84 Pages: 386-392
• [Journal Article] Regioselectivity of Larock indol synthesis using functionalized alkynes (2008)
  • Author(s): Sugino, K.; Yoshimura, H.; Nishikawa, T.; Isobe, M.
  • Journal Title: Biosci. Biotech. Biochem. 72 Pages: 2092-2102
  • NAID: 10027530880
• [Journal Article] Interactions between TIME and PIN could play a role in the system that controls the duration of diapause development and synchronization with seasonal cycles in the silkworm Bombyx mori (2008)
  • Author(s): Kai, H.; Tani, N.; Isobe, M.
  • Journal Title: Entomol. Res. 38 Pages: 179-187
• [Journal Article] Protein Phosphatase Inhibitory Activity of Tautomycin Photoaffinity Probes Evaluated at Femto-molar Level (2008)
  • Author(s): Sydnes, M.O., Kuse,M., Kurono, M., Shimomura, A., Ohinata, H., Takai. A Isobe, M.
  • Journal Title: Bioorg. Med. Chem. 16 Pages: 1747-1755
  • Peer Reviewed
• [Journal Article] Synthesis of N-Hydroxyenamide, a potential precursor of chartelline (2008)
  • Author(s): Kajii, S. ; Nishikawa, T. ; Isobe, M.
  • Journal Title: Tetrahedron Lett. 49 Pages: 594-597
  • Peer Reviewed
• [Journal Article] One-Pot Reductive Monoalkylation of Nitro Aryls with Hydrogen over Pd/C (2008)
  • Author(s): Sydnes, M. O. ; Isobe, M.
  • Journal Title: Tetrahedron Lett. 7 Pages: 1199-1202
  • Peer Reviewed
• [Journal Article] Cysteine 390 is the binding site of luminous substance with symplectin, a photoprotein of Okinawan squid, Symplectoteuthis oualaniensis (2008)
  • Author(s): Isobe, M. ; Kuse, M. ; Tani N. ; Fujii, T. ; Matsuda, T.
  • Journal Title: Proc. Jpn. Acad., Ser. B. 84 Pages: 386-392
  • NAID: 130000093921
  • Peer Reviewed
• [Journal Article] Regioselectivity of Larock indol synthesis using functionalized alkynes (2008)
  • Author(s): Sugino, K. ; Yoshimura, H. ; Nishikawa, T. ; Isobe, M.
  • Journal Title: Biosci. Biotech. Biochem. 72 Pages: 2092-2102
  • NAID: 10027530880
  • Peer Reviewed
• [Journal Article] Synthesis of N-Hydroxyenamide, a Potential Precursor of Chartelline. (2008)
  • Author(s): Kajii, S.; Nishikawa, T.; Isobe, M.
  • Journal Title: Tetrahedron Lett. 49 Pages: 594-597
  • Peer Reviewed
• [Journal Article] Determination of Solvent-Trapped Products Obtained by Photolysis of Aryl Azides in 2,2,2-Trifluoroethanol. (2008)
  • Author(s): Sydnes, M. O.; Doi, L.; Ohishi, A.; Kuse, M.; Isobe, M.
  • Journal Title: Chem. Asian J. 9 Pages: 974-981
  • Peer Reviewed
• [Journal Article] Malyngamide X: The First (7R)-Lyngbic Acid that Connectts to a New Tripeptide Backbone from the Thai Sea Hare Bursatella leachii (2007)
  • Author(s): Suntornchashwej, S.; Suwanborirux, K.; Koga, K.; Isobe, M.
  • Journal Title: Chem. Asian J. 2 Pages: 114-122
• [Journal Article] Synthesis of [18,19,21,22-13C4]-Labeled Tautomycin as an NMR probe of protein phosphatase inhibitor (2007)
  • Author(s): Isobe, M.; Kurono, M.; Tsuboi, K.; Takai, A.
  • Journal Title: Chem. Asia J. 2 Pages: 377-385
• [Journal Article] Geldanamycin derivatives and neuroprotective Effect on Cultured P19-derived neurons (2007)
  • Author(s): Sarin Tadtong,S.; Meksuriyen, D.; Tanasupawat,S.; Isobe, M.; Suwanborirux. K.
  • Journal Title: Bioorg. Med. Chem. Lett. 17 Pages: 2939-2943
• [Journal Article] Total synthesis of malyngamide X and its 7'S-epi-Isomer (2007)
  • Author(s): Suntornchashwej, S.; Suwanborirux, K.; Isobe, M.
  • Journal Title: Tetrahedron 63 Pages: 3217-3226
• [Journal Article] Synthesis of the second generation photoaffinity probes of tautomycin (2007)
  • Author(s): Sydnes, M. O.; Isobe, M.
  • Journal Title: Tetrahedron 63 Pages: 2593-2603
• [Journal Article] Synthesis of Symmetric HIJ-ring model of Ciguatoxin (2007)
  • Author(s): Nonomiya, A.; Hamajima, A.; Isobe, M.
  • Journal Title: Tetrahedron 63 Pages: 5886-5894
• [Journal Article] Determination of Solvent-Trapped Products Obtained by Photolysis of Aryl Azides in 2,2,2-Trifluoroethanol (2007)
  • Author(s): Sydnes, M. O.; Doi, I.; Ohishi, A.; Kuse, M.; Isobe, M.
  • Journal Title: Chem. Asian J. 3 Pages: 102-112
• [Journal Article] フグ毒テトロドトキシンの最初の不斉全合成 (2007)
  • Author(s): 磯部 稔・大藪 紀雄・西川 俊夫
  • Journal Title: 有機合成化学協会誌 65(#5) Pages: 492-501
  • NAID: 10020138036
• [Journal Article] Total Synthesis of Malyngamide X and Its 7'S-Epi-isomer. (2007)
  • Author(s): Suntornchashwej, S.; Suwanborirux, K.; Isobe, M.
  • Journal Title: Tetrahedron 63 Pages: 3217-3226
  • Peer Reviewed
• [Journal Article] Protein Phosphatase Inhibitory Activity of Tautomycin Photoaffinity Probes Evaluated at Femto-molar Level. (2007)
  • Author(s): Sydnes, M. O.; Kuse, M.; Kurono, M.; Shimomura, A.; Ohinata, H.; Takai, A.; Isobe, M.
  • Journal Title: Bioorg. Med. Chem. 16 Pages: 1747-1755
  • Peer Reviewed
• [Journal Article] Malyngamide X, the first 7R-lyngbic acid connecting to a new tripeptide backbone from the Thai sea hare Bursatella leachii (2007)
  • Author(s): Suchada Suntornchashwej, Khanit Suwanborirux, Kazushi Koga, Minoru Isobe
  • Journal Title: Chem. Asian J 2 Pages: 114-122
• [Journal Article] Synthesis of [18,19,21,22-13C4]-labeled tautomycin as NMR probe of protein phosphatase inhibitor. (2007)
  • Author(s): Isobe, M., Kurono, M., Tsuboi, K., Takai, A.
  • Journal Title: Chemistry-An Asia Journal
• [Journal Article] Geldanamycin Derivatives and Neuroprotective Effect on Cultured P19-Derived Neurons (2007)
  • Author(s): Sarin Tadtong, Duangdeun Meksuriyen, Somboon Tanasupawat, Minoru Isobe, Khanit Suwanborirux.
  • Journal Title: Bioorganic Med. Chem. Lett.
• [Journal Article] Total Synthesis of Malyngamide X and Its 7'S-epi-Isomer. (2007)
  • Author(s): Suntornchashwej, S., Suwanborirux, K., Isobe, M.
  • Journal Title: Tetrahedron
• [Journal Article] Synthesis of the Second Generation Photoaffinity Probes of Tautomycin. (2007)
  • Author(s): Sydnes, M.O., Isobe, M.
  • Journal Title: Tetrahedron
• [Journal Article] Synthesis of Symmetric HIJ-ring of Ciguatoxin. (2007)
  • Author(s): Nonomiya, A., Hamajima, A., Isobe, M.
  • Journal Title: Tetrahedron
• [Journal Article] Convergent Synthesis of the Right-Hand Segment of Ciguatoxin (2006)
  • Author(s): Hamajima, A.; Isobe, M.
  • Journal Title: Org. Lett. 8(#6) Pages: 1205-1208
• [Journal Article] Synthesis of β-analogues of C-mannosyltryptophan, a novel C-glycosylamino acid found in proteins (2006)
  • Author(s): Nishikawa,T.; Koide,Y.; Kanakubo,A.; Yoshimura.H.; Isobe,M.
  • Journal Title: Org. Biol. Chem. 4 Pages: 1268-1277
• [Journal Article] Synthesis of Urea-Tethered Neoglycoconjugates and Pseudooligosaccharides in Water (2006)
  • Author(s): Ichikawa, Y.; Matsukawa, Y.; Isobe, M.
  • Journal Title: J. Am. Chem. Soc. 128(#12) Pages: 3934-3938
• [Journal Article] Novel Functional Group Transformation from Acetylene Cobalt Complex to Ketone via Ligand Exchange (2006)
  • Author(s): Hamajima, A.; Nakata, H.; Goto, M.; Isobe, M.
  • Journal Title: Chem. Lett. 35(#4) Pages: 464-465
  • NAID: 10018126077
• [Journal Article] An Efficient Total Synthesis of Optically Active Tetrodotoxin from Levoglucosenone (2006)
  • Author(s): Urabe, D.; Nishikawa, T.; Isobe, M.
  • Journal Title: Chem. Asian J. 1-2 Pages: 125-135
• [Journal Article] The Molecular Mechanism of the Termination of Insect Diapause, Part 1: A Timer Protein, TIME-EA4, in the Diapause Eggs of the Silkworm Bombyx mori is a Metallo-Glycoprotein (2006)
  • Author(s): Isobe, M.; Kai, H.; Kurahashi, T.; Suwan, S.; Pitchayawasin-T. S.; Franz, T.; Tani, N.; Higashi, K.; Nishida, H.
  • Journal Title: Chem Bio Chem. 7 Pages: 1590-1598
• [Journal Article] Biological Activity of the Functional Epitope of Ciguatoxin Fragment AB on the Neuroblastoma Sodium Channel in Tissue Culture (2006)
  • Author(s): Hokama, Y.; Chun, K. E.; Campora, C. E.; Higa, N.; Suma, C.; Hamajima, A.; Isobe, M.
  • Journal Title: J. Clinical Laboratory Analysis 20 Pages: 126-132
• [Journal Article] One-pot transformation of trichloroacetamide into readily deprotectable carbamates (2006)
  • Author(s): Nishikawa, T.; Urabe, D.; Tomita, M.; Tsujimoto, T.; Iwabuchi, T.; Isobe, M.
  • Journal Title: Org. Lett. 8 Pages: 3263-3265
• [Journal Article] Antifungal Azaphilones from the Fungus Chaetomium cupreum CC3003 (2006)
  • Author(s): Kanokmedhakul,S.; Kanokmedhakul,K.; Nasomjai,P.; Louangsysouphanh,S.; Soytong,K.; Isobe,M.; Kongsaeree, P.; Prabpai, S.; Suksamrarn, A.
  • Journal Title: J. Nat. Prod. 69 Pages: 891-895
• [Journal Article] Time-measurement-regulating peptide PIN may alter a timer conformation of Time Interval Measuring Enzyme (TIME) (2006)
  • Author(s): Ti, Xiaonan; Tani N.; Isobe, M.; Kai, H.
  • Journal Title: J. Insect Physiology 52 Pages: 461-467
• [Journal Article] Syntheses of Naturally Occurring Terphenyls and Its Related Compounds (2006)
  • Author(s): Sawayama, Y.; Tsujimoto, T.; Sugino, K.; Nishikawa, T.; Isobe,M.; Kawagishi, H.
  • Journal Title: Biosci. Biotech. Biochem. 70(#12) Pages: 2998-3003
• [Journal Article] Molecular Diversity of Valinomycin, a 36-Membered Cyclic Depsipeptide, Which was Detected by Means of HPLC-Q-TOF-MS on Hydrolysate Dipeptides (2006)
  • Author(s): Pitchayawasin- Thapphasaraphong,S.; Isobe, M.
  • Journal Title: ITE Letters on Batteries, New Technologies & Medicine 7 Pages: 465-473
• [Journal Article] Synthesis of Urea-Tethered Disaccharides in Water (2006)
  • Author(s): Ichikawa, Y.; Matsukawa, Y.; Tamura, M.; Ohara, F.; Isobe, M.; Kotsuki H.
  • Journal Title: Chem. Asian J. 1 Pages: 717-723
• [Journal Article] Synthesis of ・-analogues of C-mannosyltryptophan, a novel C-glycosylamino acid found in proteins (2006)
  • Author(s): Nishikawa, T.; Koide, Y.; Kanakubo, A.; Yoshimura, H.; Isobe, M.
  • Journal Title: Org. Biomol. Chem. 4 Pages: 1268-1277
• [Journal Article] Stereocontrolled Route to Vicinal Diamines by[3.3] Sigmatropic Rearrangement of Allyl Cyanate: Asymmetric Synthesis of anti-(2R,3R)-and syn-(2R,3S)-2,3-Diaminobutanoic Acids (2006)
  • Author(s): Ichikawa, Y.; Egawa, H.; Ito, T.; Isobe, M.; Nakano, K.; Kotsuki, H.
  • Journal Title: Org. Lett. 8(#25) Pages: 5737-5740
• [Journal Article] Stereoselective C-Alkynylation, Allenylation, and Prop-2-ynylation Leading to Sugar Glycosides (2006)
  • Author(s): Saeeng, R.; Isobe, M.
  • Journal Title: Chem. Lett. Highlight Review 35(#6) Pages: 552-557
  • NAID: 10019162120
• [Journal Article] Convergent Synthesis of Right Hand Segment of Ciguatoxin. (2006)
  • Author(s): Hamajima, A., Isobe, M.
  • Journal Title: Organic Lett. 8 Pages: 1205-1208
• [Journal Article] Synthesis of beta-Analogues of C-Mannosyltryptophan, a Novel C-Glycosylamino Acid Found in Proteins. (2006)
  • Author(s): Nishikawa, T., Koide, Y., Kanakubo, A., Yoshimura, H., Isobe, M.
  • Journal Title: Org. Biol. Chem. 4 Pages: 1268-1277
• [Journal Article] Urea Glycoside Synthesis in Water. (2006)
  • Author(s): Ichikawa, Y., Matsukawa, Y., Isobe, M.
  • Journal Title: J. Am. Chem. Soc. 128 Pages: 3934-3938
• [Journal Article] Novel functional group transformation from acetylene cobalt complex to ketone via ligand exchange. (2006)
  • Author(s): Hamajima, A., Nakata, H., Goto, M., Isobe, M.
  • Journal Title: Chem. Lett. 35 Pages: 464-465
  • NAID: 10018126077
• [Journal Article] An Efficient Total Synthesis of Optically Active Tetrodotoxin from Levoglucosenone. (2006)
  • Author(s): Urabe, D., Nishikawa, T., Isobe, M.
  • Journal Title: Chem. Asian J. 1-2 Pages: 125-135
• [Journal Article] A Molecular Mechanism of the Termination of Insect Diapause-a Timer Protein, TIME-EA4 in the Diapause Eggs of the Silkworm, Bombyx mori. (2006)
  • Author(s): Isobe, M., Kai, H., Kurahashi, T., Suwan.S., Pitchayawasin-T.S., Franz, T., Tani, N., Higashi, K., Nishida, H.
  • Journal Title: ChemBioChem. 7 Pages: 1590-1598
• [Journal Article] Biological Activity of the Functional Epitope of Ciguatoxin Fragment AB on the Neuroblastoma Sodium Channel in Tissue Culture. (2006)
  • Author(s): Hokama, Y., Chun, K.E., Campora, C.E., Higa, N., Suma, C., Hamajima, A., Isobe, M.
  • Journal Title: J. Clinical Laboratory Analysis 20 Pages: 126-132
• [Journal Article] One-pot transformation of trichloroacetamide into readily deprotectable carbamates. (2006)
  • Author(s): Nishikawa, T., Urabe, D., Tomita, M., Tsujimoto, T., Iwabuchi, T., Isobe, M.
  • Journal Title: Org. Lett. 8 Pages: 3263-3265
• [Journal Article] Antifungal Azaphilones from the Fungus Chaetomium cupreum CC3003. (2006)
  • Author(s): Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Pitak Nasomjai, Sysavad Louangsysouphanh, Kasem Soytong, Minoru Isobe, Palangpon Kongsaeree, Samran Prabpai, Apichart Suksamrarnr.
  • Journal Title: J. Nat. Prod. 69 Pages: 891-895
• [Journal Article] Time-measurement-regulating peptide PIN may alter a timer conformation of Time Interval Measuring Enzyme (TIME). (2006)
  • Author(s): Ti, Xiaonan, Tani N., Isobe, M., Kai, H.
  • Journal Title: J. Insect Physiology 52 Pages: 461-467
• [Journal Article] Syntheses of Naturally Occurring Terphenyls and Its Related Compounds. (2006)
  • Author(s): Y.Sawayama, T.Tsujimoto, K.Sugino, T Nishikawa, M.Isobe, H.Kawagishi
  • Journal Title: Biosci. Biotech. Biochem. 70 Pages: 2998-3003
• [Journal Article] Molecular Diversity of Valinomycin, a 36-Membered Cyclic Depsipeptide, Which was Detected by Means of HPLC-Q-TOF-MS on Hydrolysate Dipeptides. (2006)
  • Author(s): Suthasinee Pitchayawasin-Thapphasaraphong, Isobe, M.
  • Journal Title: ITE Letters on Batteries, New Technologies ＆ Medicine 7 Pages: 465-471
• [Journal Article] Synthesis of Urea-Tethered Disaccharides in Water. (2006)
  • Author(s): Ichikawa, Y., Matsukawa, Y., Tamura M., Ohara, F., Isobe, M., Kotsuki H.
  • Journal Title: Chem. Asian J. 1 Pages: 717-723
• [Journal Article] Synthesis of beta-Analogues of C-Mannosyltryptophan, a Novel C-Glycosylamino Acid Found in Proteins (2006)
  • Author(s): Ichikawa, Y., Ito, T., Isobe, M.
  • Journal Title: Org. Biol. Chem. 4 Pages: 1268-1277
• [Journal Article] Tetrabromohydroquinone and riboflavin are possibly responsible for green luminescence in the luminous acorn worm, Ptychodera flava (2005)
  • Author(s): Kanakubo, A.; Koga, K.; Isobe, M.; Yoza, K.
  • Journal Title: Luminescence 20 Pages: 397-400
• [Journal Article] Regioselective hydrosilylation of terminal acetylenes via acetylene-Co2(CO)4dppm complex; effects of the ligands in acetylenedicobalt complex (2005)
  • Author(s): Tojo, S.; Isobe, M.
  • Journal Title: Tetrahedron Lett. 46 Pages: 381-384
• [Journal Article] Stereocontrolled Synthesis of the Oxabicyclo[2.2.1]heptane Segment of Solanoeclepin A (2005)
  • Author(s): Tojo, S.; Isobe, M.
  • Journal Title: Synthesis No.8 Pages: 1237-1244
• [Journal Article] Stereocontrolled syntheses of α-C-mannosyltryptophan and its analogues (2005)
  • Author(s): Nishikwa, T.; Koide, Y.; Kajii, S.; Wada, K.; Ishikawa, M.; Isobe, M.
  • Journal Title: Org. Biomol. Chem. 3 Pages: 687-700
• [Journal Article] Synthesis of Silylallene Glycosides and Diene Diglycosides by C-Glycosidation of D-Glucal with 1,4-Bis(trimethylsilyl)-2-butyne (2005)
  • Author(s): Saeeng, R.; Isobe, M.
  • Journal Title: Org. Lett. 7(#8) Pages: 1585-1588
• [Journal Article] Isolation of brominated quinones showing chemiluminescence activity from luminous acorn worm, Ptychodera flava (2005)
  • Author(s): Kanakubo, A.; Isobe, M.
  • Journal Title: Bioorg. Med. Chem. 13 Pages: 2741-2747
• [Journal Article] Novel Synthetic Route of Coelenterazines-2-synthesis of Various Dehydrocoelenterazine Analogs (2005)
  • Author(s): Kondo. N.; Kuse M.; Mutarapat, T.; Thasana, N.; Isobe, M.
  • Journal Title: Heterocycles 65(#4) Pages: 843-856
  • NAID: 40006693669
• [Journal Article] Synthesis of azide-fluoro-dehydrocoelenterazine analog as a photoaffinity-labeling Probe and Photolysis of azide-fluoro-coelenterazine (2005)
  • Author(s): Kuse, M.; Doi, I.; Kondo, N.; Kageyama, Y.; Isobe, M.
  • Journal Title: Tetrahedron 61 Pages: 5754-5762
• [Journal Article] Allyl Cyanate-to-isocyanate Rearrangement for the Synthesis of Quaternary Stereocenter with Nitrogen Substituent (2005)
  • Author(s): Ichikawa, Y.; Yamauchi, E.; Isobe, M.
  • Journal Title: Biosci. Biotechnol. Biochem. 69(#5) Pages: 939-943
  • NAID: 130000030324
• [Journal Article] Action of aluminum, novel TPC1-type channel inhibitor, against salicylate-induced and cold-shock-induced calcium influx in tobacco BY-2 cells (2005)
  • Author(s): Lin, C.; Yu Y.; Kadono, T.; Iwata, M.; Umemura, K.; Furuichi, T.; Kuse, M.; Isobe, M.; Yamamoto, Y.; Matsumoto, H.; Yoshizuka, K.; Kawano, T.
  • Journal Title: Biochem. Biphys. Res. Commun. 332 Pages: 823-830
• [Journal Article] Hectochlorin and Morpholine Derivatives from the Thai Sea Hare, Bursatella leachii (2005)
  • Author(s): Suntornchashwej, S.; Chaichit, N.; Isobe, M.; Suwanborirux, K.
  • Journal Title: J. Nat. Prod. 68 Pages: 951-955
• [Journal Article] Total synthesis of Glycosinnamoylsperimidin D (2005)
  • Author(s): Nishiyama, T.; Ichikawa, Y.; Isobe, M.
  • Journal Title: Angew. Chem. Int. Ed. Engl. 44 Pages: 4372-4375
• [Journal Article] Synthesis of (+)-Conagenin (2005)
  • Author(s): Matsukawa, Y.; Isobe, M.; Kotsuki, H.; Ichikawa, Y.
  • Journal Title: J. Org.Chem. 70(#13) Pages: 5339-5341
• [Journal Article] Stereoselective Allyl Amine Synthesis through Enantioselective Addition of Diethylzinc and [1,3]-Chirality Transfer: Synthesis of Lentiginosine and Polyoxamic Acid Derivative (2005)
  • Author(s): Ichikawa, Y.; Ito, T.; Isobe, M.
  • Journal Title: Eur. J. Chem. 11 Pages: 1949-1957
• [Journal Article] Tetrabromohydroquinone and riboflavin are responsible for green luminescence in the luminous acorn worm, Plychodera flava (2005)
  • Author(s): Kanakubo, A., Koga, K., Yoza, K., Isobe, M.
  • Journal Title: Luminescence 20 Pages: 397-400
• [Journal Article] Stereocontrolled syntheses of alpha-C-mannosyltryptophan and its analogues. (2005)
  • Author(s): Nishikwa, T., Koide, Y., Kajii, S., Wada, K., Ishikawa, M., Isobe, M
  • Journal Title: Org. Biomol. Chem. 3 Pages: 687-700
• [Journal Article] Isolation of brominated quinones showing chemiluminescence activity from luminous acorn worm, Ptychodera flava (2005)
  • Author(s): Kanakubo, A., Isobe, M
  • Journal Title: Bioorganic and Medicinal Chemistry 13 Pages: 2741-2747
• [Journal Article] Novel Synthetic Route of Coelenterazines-2-synthesis of Various Dehydrocoelenterazine Analogs. (2005)
  • Author(s): Kondo.N., Kuse M., Mutarapata Thumnoon, Thasana, Noppom, Isobe, M.
  • Journal Title: J.Heterocyclic Chemistry 65 Pages: 843-856
  • NAID: 40006693669
• [Journal Article] Synthesis of Azide-Fluoro-Dehydrocoelenterazine analog as a Photoaffinity-Labeling Probe and Photolysis of Azide-Fluoro-Coelenterazine. (2005)
  • Author(s): Kuse, M., Doi, I., Kondo, N., Kageyama, Y., Isobe, M
  • Journal Title: Tetrahedron 61 Pages: 5754-5762
• [Journal Article] Hectochlorin and Morpholine Derivatives from the Thai Sea Hare, Bursatella leachii. (2005)
  • Author(s): Suchada Suntornchashwej, Narongsak Chaichit, Minoru Isobe, Khanit Suwanborirux
  • Journal Title: J. Nat. Prod 68 Pages: 951-955
• [Journal Article] Regioselectivity in hydrosilylation reaction of terminal acetylenes ; effect of the ligands in acetylenedicobalt complex. (2005)
  • Author(s): Tojo, S., Isobe, M
  • Journal Title: Tetrahedron Lett. 46 Pages: 381-384
• [Journal Article] Synthesis of silylallene glycosides and diene-diglycosides from C-glycosidation of D-glucal with 1,4-bis(trimethylsilyl)-2-butyne. (2005)
  • Author(s): Saeeng, R., Isobe, M.
  • Journal Title: Org. Lett. 7 Pages: 1585-1588
• [Journal Article] Allyl Cyanate-to-isocyanate Rearrangement for the Synthesis of Quaternary Stereocenter with Nitrogen Substituent. (2005)
  • Author(s): Ichikawa, Y., Yamauchi, E., Isobe, M.
  • Journal Title: Biosci. Biotechnol. Biochem. 69 Pages: 939-943
  • NAID: 130000030324
• [Journal Article] Action of aluminum, novel TPC1-type channel inhibitor, against salicylate-induced and cold-shock-induced calcium influx in tobacco BY-2 cells. (2005)
  • Author(s): Lin C., Yu Y., Kadono T., Iwata M., Umemura K., Furuichi T., Kuse M., Isobe M., Yamamoto Y., Matsumoto H., Yoshizuka K., Kawano T.
  • Journal Title: Biochem. Biphys. Res. Commun. 332 Pages: 823-830
• [Journal Article] Total synthesis of Glycosinnamoylsperimidin D. (2005)
  • Author(s): Nishiyama, T., Ichikawa, Y., Isobe, M.
  • Journal Title: Angew Chem. Int. Ed Engl. 44 Pages: 4372-4375
• [Journal Article] Synthesis of(+)-Conagenin. (2005)
  • Author(s): Matsukawa, Y., Isobe, M., Kotsuki, H., Ichikawa, Y.
  • Journal Title: J.Org.Chem. 70 Pages: 5339-5341
• [Journal Article] Stereoselective Allyl Amine Synthesis via Enantioselective Addition of Diethylzinc and [1,3]-Chirality Transfer. Synthesis of Lentiginosine and Polyoxamic Acid Derivative. (2005)
  • Author(s): Ichikawa, Y., Ito, T., Isobe, M.
  • Journal Title: Eur. J. Chem. Pages: 1949-1957
• [Journal Article] Stereocontrolled Synthesis of Oxabicyclo[2.2.1]heptane Segment on Solanoe-clepin A. (2005)
  • Author(s): Tojo, S., Isobe, M.
  • Journal Title: Tetrahedron Lett 46 Pages: 381-384
• [Journal Article] Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin,An Unnaturel Analogue of Puffer Fish Toxin (2004)
  • Author(s): Nishikawa, T.; Urabe, D.; Yoshida,K.; Iwabuchi, T.; Asai, M.; Isobe, M.
  • Journal Title: Chem. Euro. J. 10 Pages: 452-462
• [Journal Article] Molecular diverrsity of cereulide detected by means of nano-HPLC-ESI-Q-TOF-MS (2004)
  • Author(s): Pitchayawasin, S.; Isobe, M.; Kuse, M.; Franz, T.; Agata,N.; Ohta, M.
  • Journal Title: Int. J. Mass Spectrometry 235 Pages: 123-129
• [Journal Article] Novel synthetic route of aryl-aminopyrazine (2004)
  • Author(s): Kuse, M.; Kondo, N.; Ohyabu, Y.; Isobe, M.
  • Journal Title: Tetrahedron 60 Pages: 835-840
• [Journal Article] Glycocinnasperimicin D Synthetic Studies: Synthesis of Cinnamoyl Glycosides via Iodination-Heck Reaction Sequence Starting from Phenyl Glycosides (2004)
  • Author(s): Nishiyama, T.; Ichikawa, Y.; Isobe, M.
  • Journal Title: Synlett 1 Pages: 89-92
• [Journal Article] A novel stereoselective carbon-chain extension reaction at the C-6 position of 1,6-anhydropyranose (2004)
  • Author(s): Nishikawa, T.; Mishima, Y.; Ohyabu, N.; Isobe, M.
  • Journal Title: Tetrahedron Lett. 45 Pages: 175-178
• [Journal Article] Stereoselective Synthesis of the Fully Functionalized HIJ-ring Framework of Ciguatoxin (2004)
  • Author(s): Baba, T.; Takai, S.; Sawada, N.; Isobe, M.
  • Journal Title: Synlett Pages: 603-608
• [Journal Article] Differentiation of sulfate and phosphate by H/D exchange mass spectrometry:application to isoflavone (2004)
  • Author(s): Kanakubo, A.; Isobe, M.
  • Journal Title: J. Mass Spectromet. 39 Pages: 1260-1267
• [Journal Article] Synthesis of Model Compound Containing an Indole Spiro-β-lactam Moiety with Vinylchloride in Chartelline (2004)
  • Author(s): Nishikawa, T.; Kajii, S.; Isobe, M.
  • Journal Title: Chem. Lett. 33 Pages: 440-441
  • NAID: 10012847264
• [Journal Article] Synthesis of photoaffinity probes of tautomycin (2004)
  • Author(s): Kurono, M.; Shimomura, A.; Isobe, M.
  • Journal Title: Tetrahedron 60 Pages: 1773-1780
• [Journal Article] α-C-Mannosyltryptophan is not recognized by conventional mannose-binding lectins (2004)
  • Author(s): Nishikawa, T.; Kajii, S.; Sato, C.; Yasukawa, Z.; Kitajima, K.; Isobe, M.
  • Journal Title: Bioorg. Med. Chem. 12 Pages: 2343-2348
• [Journal Article] Structure of pentasaccharide of glycopeptide from TIME-EA4, N-glycoprotein in Silkworm Diapause Eggs (2004)
  • Author(s): Pitchayawasin, S.; Isobe, M.; Tani, N.; Kai, H.
  • Journal Title: Bioorg. Med. Chem. Lett. 14 Pages: 2527-2531
• [Journal Article] Synthesis and Physical Nature of Fluorescent Photoaffinity Probe for the Bioorganic Studies on Tautomycin, a Protein Phosphatase Type 1 Selective Inhibitor (2004)
  • Author(s): Kurono, M.; Isobe, M.
  • Journal Title: Chem. Lett. 33 Pages: 452-453
  • NAID: 10012847370
• [Journal Article] Stereospecific synthesis of urea-tethered neoglycoconjugates starting from glucopyranosyl carbamates (2004)
  • Author(s): Ichikawa, Y.; Nishiyama T.; Isobe, M.
  • Journal Title: Tetrahedron 60 Pages: 2621-2627
• [Journal Article] Aluminum as a specific inhibitor of plant TPC1 Ca2+ channels (2004)
  • Author(s): Kawano, T.; Kadono, T.; Fumoto, K.; Lapeyrie, F.; Kuse, M.; Isobe, M.; Furuichi, T.; Muto, S.
  • Journal Title: Biochem. Biophysic. Res. Communi. 324 Pages: 40-45
• [Journal Article] Synthesis, Characterization, and Reaction of Crystalline Fisher's Glycopyranosyl Isocyanate (2004)
  • Author(s): Ichikawa, Y.; Matsukawa, Y.; Nishiyama, T.; Isobe, M.
  • Journal Title: Eur. J. Org. Chem. Pages: 586-591
• [Journal Article] An Efficient Total Synthesis of Optically Active Tetrodotoxin (2004)
  • Author(s): Nishikawa, T.; Urabe, D.; Isobe, M.
  • Journal Title: Angew. Chem. Int. Ed. 43 Pages: 4782-4785
• [Journal Article] Urea Glycoside Synthesis in Water (2004)
  • Author(s): Ichikawa, Y.; Matsukawa, Y.; Isobe, M.
  • Journal Title: Synlett Pages: 1019-1022
• [Journal Article] Novel Synthesis of Bromoindolenine with Spiro-β-lactam in Chartelline (2004)
  • Author(s): Nishikawa, T.; Kajii, S.; Isobe, M.
  • Journal Title: Synlett Pages: 2025-2027
• [Journal Article] Demarcation of diapause development by cold and its relation to time-interval activation of TIME-ATPase in eggs of the silkworm, Bombyx mori (2004)
  • Author(s): Ti, X.; Tuzuki, N.; Tani, N.; Morigami, E.; Isobe, M.; Kai, H.
  • Journal Title: J. Insect Physiol. 50 Pages: 1053-1064
• [Journal Article] Total synthesis of (+)-Blasticidin S (2004)
  • Author(s): Ichikawa, Y.; Hirata, K.; Ohbayashi, M.; Isobe, M.
  • Journal Title: Chem.A Eur. J. 10 Pages: 3241-3251
• [Journal Article] A novel deprotection of trichloroacetamide (2004)
  • Author(s): Urabe, D.; Sugino, K.; Nishikawa, T.; Isobe, M.
  • Journal Title: Tetrahedron Lett. 45 Pages: 9405-9407
• [Journal Article] 天然物全合成と医薬化学-タンパク質脱リン酸酵素阻害剤を例として- (2004)
  • Author(s): 磯部 稔・黒野 昌邦
  • Journal Title: 化学と工業(化学工業社) #8 Pages: 610-617
• [Journal Article] インターバルタイマータンパク質TIME、ねじまきPIN付き (2004)
  • Author(s): 甲斐 英則・谷 直樹・磯部 稔
  • Journal Title: 時間生物学 10(#1) Pages: 28-34
  • NAID: 10013423160
• [Journal Article] 連載天然物化学とその周辺 フグ毒テトロドトキシンの不斉全合成 (2004)
  • Author(s): 磯部 稔・西川 俊夫
  • Journal Title: 化学と工業(化学工業社) 57(#1) Pages: 1183-1186
• [Journal Article] Novel Synthetic Route of Aryl-aminopyrazine. (2004)
  • Author(s): Kuse, M., Kondo, N., Ohyabu, Y., Isobe, M.
  • Journal Title: Tetrahedron 60 Pages: 835-840
• [Journal Article] Synthesis of photoaffinity probes of tautomycin. (2004)
  • Author(s): Kurono, M., Shimomura, A., Isobe M.
  • Journal Title: Tetrahedron 60 Pages: 1773-1780
• [Journal Article] Structure of Pentasaccharide of Glycopeptide from TIME-EA4, N-Glycoprotein in Silkworm Diapause Eggs. (2004)
  • Author(s): Pitchayawasin, S., Isobe, M., Tani, N., Kai, H.
  • Journal Title: Bioorganic & Medicinal Chem. Lett 14 Pages: 2527-2531
• [Journal Article] An efficient total synthesis of optically active tetrodotoxin. (2004)
  • Author(s): Nishikawa, T., Urabe, D., Isobe, M.
  • Journal Title: Angew.Chem.Int.Ed. 43 Pages: 4782-4785
• [Journal Article] Total synthesis of (+)-Blasticidin S. (2004)
  • Author(s): Ichikawa, Y., Hirata, K., Ohbayashi, M., Isobe, M.
  • Journal Title: Chem.Eur.J. 10 Pages: 3241-3251
• [Journal Article] Stereoselective synthesis of the fully functionalized HIJ-ring framework of ciguatoxin (2004)
  • Author(s): Baba, T., Takai, S., Sawada, N., Isobe, M.
  • Journal Title: Synlett Pages: 603-608
• [Journal Article] フグ毒テトロドトキシンの不斉全合成 (2004)
  • Author(s): 磯部 稔, 西川 俊夫
  • Journal Title: 化学と工業 Pages: 4-4
  • NAID: 10013742123
• [Journal Article] Molecular Heterogeneity of TIME-EA4, a Timer Protein in Silkworm Diapause Eggs. Suthasinee Pitchayawasin-Thapphasaraphong
  • Author(s): Naoki Tani, Minoru Isobe, Hidenori Kai, Takuya Kurahashi, Junko Kato, Saikwan Trisunan
  • Journal Title: Biochem. Biosciences and Biotechnology (in press)
• [Journal Article] Synthesis of four Lysine-linked cereulide analogs showing K+ ionophoric activity as lead compounds for emetic toxin-detection by immunoassays
  • Author(s): Makarasen, A.; Nishikawa, T.; Isobe, M.
  • Journal Title: Synthesis (in press)
• [Journal Article] Selective protein modification by the hydroperoxide intermediate in a photoprotein, aequorin
  • Author(s): Issei Doi, Masaki Kuse, Toshio Nishikawa and Minoru Isobe
  • Journal Title: Bioorg. Med. Chem. 17 Pages: 3399-3404
• [Journal Article] Substituent effect of imino-O-arenesulfonates, a coupling partner in Suzuki-Miyaura Reaction for substitution of the Pyrazine Ring: A Study for the Synthesis of Coelenterazine Analogs
  • Author(s): Makarasen, A.; Kuse, M.; Nishikawa, T.; Isobe, M.
  • Journal Title: Bulletin of Chemical Society of Japan (in press)
  • NAID: 10025126416
• [Presentation] (2008)
  • Author(s): M. ISOBE
  • Organizer: Stanford-Roche Lecture(Host, Prof. Justin DuBois)
  • Place of Presentation: Stanford University
  • Year and Date: 2008-04-23
• [Presentation] Stanford-Roche Lecture (2008)
  • Author(s): M. ISOBE
  • Organizer: Stanford University
  • Place of Presentation: Stanford University, U. S. A
  • Year and Date: 2008-04-23
• [Presentation] (2008)
  • Author(s): M. ISOBE
  • Organizer: PACCON2008 (Pure and Applied Chemistry 2008, Plenaryt Lecture, (Organizer; Noojaree Prasitpan)
  • Place of Presentation: Sofitel Hotel, Bangkok, Thailand
• [Presentation] Synthetic Studies on Ciguatoxin (2008)
  • Author(s): M. ISOBE
  • Organizer: IUPAC ICOS-17, Invited Paper
  • Place of Presentation: Dejong, Korea
• [Presentation] Total Synthesis of Natural Products and Chemical Biology (2008)
  • Author(s): M. Isobe
  • Organizer: 3rd International Conference on Cutting-Edge Organic Chemistry in Asia, Plenary Lecture(Organizer, Yao, Zhu-Jun)
  • Place of Presentation: Liu Ying Hotel, Hangzhou, China
• [Presentation] 15^<th> ISBC 2008 (International Symposium on Bioluminescence and Chemiluminescence", Plenary Lecture (2008)
  • Author(s): M. ISOBE
  • Organizer: 15^<th> ISBC 2008 (International Symposium on Bioluminescence and Chemiluminescence", Plenary Lecture
  • Place of Presentation: Shanghai, China
• [Presentation] Total Synthesis of Natural Products and Chemical Biology (2008)
  • Author(s): M. ISOBE
  • Organizer: 3^<rd> International Conference on Cutting-Edge Organic Chemistry in Asia, Plenary Lecture
  • Place of Presentation: Liu Ying Hotel, Hangzhou, China
• [Presentation] Marine Natural Products-Total Synthesis toward Chemical Biology (2007)
  • Author(s): M. Isobe, A. Hamajima, A. Nonoyama and T. Fujii
  • Organizer: US-Japan Seminar (JSPS-NSF), Invited Paper(Organizer, Chris Ireland)
  • Place of Presentation: Park City, Uta, USA
• [Presentation] The Total Synthesis of Natural Products inspiring Chemical Biology (2007)
  • Author(s): M. Isobe
  • Organizer: 2nd Intrernational Conference on Cutting-Edge Organic Chemistry in Asia, Invited Paper
  • Place of Presentation: Grand Hotel, Busan, Korea
• [Presentation] 6th Bioorganic Studies on Novel Molecular Mechanism of Bioactivity Expression by Natural Products through the Target Proteins-Case Studies on Photoproteins- (2007)
  • Author(s): Minoru Isobe
  • Organizer: Princess Congress VI(PC-6), Invited Lecture
  • Place of Presentation: Shangri-La Hotel, Bangkok, Thailand
• [Presentation] Bioorganic Studies on Novel Molecular Mechanism of Bioactivity Expression by Natural Products through the Target Proteins: Caroteins: Case Studies on Photoproteins. (2007)
  • Author(s): Minoru Isobe
  • Organizer: The Sixth Princess Chulabhorn Internation al Science Congress
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Synthetic studies toward ciguatoxin (2006)
  • Author(s): M. ISOBE
  • Organizer: IUPAC International Conference of Organic Chemistry (ICOS-16), Invited Lecture
  • URL: http://www.relaq.mx/RLQ/IUPAC_ICOS-16.html
  • Place of Presentation: Merida, Mexico
• [Presentation] (2006)
  • Author(s): M. ISOBE
  • Organizer: Balticum Organicum Syntheticum(BOS06); Invited Paper
  • Place of Presentation: Tallinn, Estonia
• [Presentation] Innovations in Chemical Biology on the Bridge of Eurasia (2006)
  • Author(s): M. ISOBE
  • Organizer: The 9th Eurasia Conference on Chemical Sciences(EuAsC2S-9); Plenary Lecture,
  • Place of Presentation: Antalya, Turkey
• [Presentation] Chemical Biological Chemistry of Natural Products on the basis of Organic Synthesis (2006)
  • Author(s): M. ISOBE
  • Organizer: Post Symposium of the 1st International Conference on Cutting-Edge Organic Chemistry in Asia, Keynote Lecture
  • Place of Presentation: Hsinchu, Taiwan
• [Presentation] Light-emitting protein and time-interval-measuring proteins give the functions by complex formation with natural prodeucts (2005)
  • Author(s): ISOBE, Minoru
  • Organizer: Pacifichem 2005, Interface of Chemistry and Biology Symposium Invited Paper #1574, Invited Lecture
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2005-12-19
• [Presentation] Synthetic studies toward ciguatoxin (2005)
  • Author(s): ISOBE, Minoru
  • Organizer: Invited Lecture at Pacifichem 2005, Chemicalr Synthesis of Polycyclic Ethers Symposium Invited Paper #246
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2005-12-16
• [Presentation] (2005)
  • Author(s): ISOBE, Minoru
  • Organizer: UC Irvine-Pfiser Symposium, Plenary Lecture
  • Place of Presentation: UCLA
  • Year and Date: 2005-12-09
• [Presentation] (2004)
  • Author(s): M. ISOBE
  • Organizer: IUPAC ISBOC-7(7th International Symposium of Bioorganic Chemistry)
  • Place of Presentation: Sheffield, U.K.
• [Book] Elegant Total Synthesis of Natural Product, Chapter 8-Medium size Ether Ring (2009)
  • Author(s): Isobe, M.; Pattarawarapan, M.; Phakhodee, W.; Charoonniyomporn, S.; Hamajima, A.
  • Publisher: Weily VCH(in press)
• [Book] C-Glycosylation, Chapter 3.8(Ed. Fraser-Reid, B., Tatsuta, K., Thiem J.) (2008)
  • Author(s): Nishikawa, T.; Adachi, M.; Isobe, M. Glycoscience
  • Publisher: Springer-Verlag Berlin Heiderberg
• [Book] 天然物化学・生物有機化学 I -天然物化学-, 朝倉化学大系13 (2008)
  • Author(s): 北川 勲・磯部 稔
  • Publisher: 朝倉書店
• [Book] 天然物化学・生物有機化学 II -生物有機化学-, 朝倉化学大系14 (2008)
  • Author(s): 北川 勲・磯部 稔
  • Publisher: 朝倉書店
• [Book] 「天然物化学・生物有機化学I-天然物化学-」朝倉化学大系13巻 (2008)
  • Author(s): 北川勲・磯部稔
  • Total Pages: 369
  • Publisher: 朝倉書店
• [Book] 「天然物化学・生物有機化学II-全合成・生物有機化学-」朝倉化学大系14巻 (2008)
  • Author(s): 北川勲・磯部稔
  • Total Pages: 278
  • Publisher: 朝倉書店
• [Book] 「フグ毒テトロドトキシンの最初の全合成」 (2007)
  • Author(s): 磯部 稔、大藪紀雄、西川俊夫
  • Publisher: 有機合成化学協会誌65号
• [Book] 天然物全合成にかけた夢-結果に一喜一憂し、そして感動する-, 化学者たちの感動の瞬間-興奮に満ちた51の発見物語(有機合成化学協会編) (2006)
  • Author(s): 磯部 稔
  • Publisher: 化学同人
• [Book] 天然物全合成にかけた夢(化学者たちの感動の瞬間・分担執筆) (2006)
  • Author(s): 磯部 稔
  • Publisher: 化学同人・有機合成化学協会(編)
• [Book] 天然物合成研究と新反応開発・シガトキシンを例として, 現代化学増刊43, 最新有機合成化学-ヘテロ原子・遷移金属化合物を用いる合成(奈良坂 紘一・岩澤 伸治編) (2005)
  • Author(s): 磯部 稔・高井 繁幸・馬場 貴之・濱嶋 祥就
  • Publisher: 東京化学同人
• [Book] 天然物合成研究と新反応開発---シガトキシンを例として--- (2005)
  • Author(s): 磯部 稔, 高井繁幸, 馬場貴之, 濱嶋祥就
  • Publisher: 東京化学同人『最新有機合成化学--ヘテロ原子・遷移金属化合物を用いる合成(奈良坂紘一・岩澤伸治編)』
• [Remarks]
  • URL: http://www.agr.nagoya-u.ac.jp/~organic/index2.html
• [Remarks]
  • URL: http://www.agr.nagoya-u.ac.jp/~organic/index2.html
• [Patent(Industrial Property Rights)] トビイカ発光タンパク質、トビイカ発光タンパク質をコードする遺伝子 (2001)
  • Inventor(s): 磯部 稔
  • Industrial Property Rights Holder: 磯部 稔
  • Filing Date: 2001-05-01
  • Acquisition Date: 2006-01-20