• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of SBW Fluorescence Nanothermometry Platform by Using Ceramic Nanoparticles

Research Project

Project/Area Number 16H04499
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Inorganic materials/Physical properties
Research InstitutionTokyo University of Science

Principal Investigator

SOGA Kohei  東京理科大学, 基礎工学部材料工学科, 教授 (50272399)

Co-Investigator(Kenkyū-buntansha) 横田 秀夫  国立研究開発法人理化学研究所, 光量子工学研究センター, チームリーダー (00261206)
岸本 英博  琉球大学, 医学(系)研究科(研究院), 教授 (80251213)
上村 真生  東京理科大学, 基礎工学部材料工学科, 講師 (80706888)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
KeywordsSBW / 蛍光 / 動物 / 温度 / イメージング / 近赤外 / 温度イメージング / OTN近赤外 / ナノ粒子 / 温度計測
Outline of Final Research Achievements

In the SBW near infrared wavelength region, cm-order deep tissue fluorescence imaging is known to be possible. In this project, temperature imaging was demonstrated from the information of fluorescence measurement by ratiometric method and time gated method using the SBW near infrared fluorescence. Furthermore, for utilizing the advantage of the deep tissue imaging, it was shown that three-dimensional fluorescence temperature imaging by CT method is possible. On the other hand, in the actual animal imaging, ratiometric methods have limitations in absolute temperature estimation. However, by using time gated method, it was shown to be possible to perform fluorescence temperature imaging with absolute temperatures in the deep part of the living body as three dimensional imaging.

Academic Significance and Societal Importance of the Research Achievements

生体深部の温度はこれまで不可視であった。本研究は生体深部の温度を蛍光によって三次元でイメージングが可能であることを明らかにした。本成果を応用することにより、これまでにない生体内部の情報に基づく、新たな生命現象の解明が期待されるばかりでなく、これに基づき診断や治療などの医療への展開も大きく期待される。この研究は世界的に見ても新規性が高く、実施した研究チームが世界の研究をリードする状態にある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (14 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 10 results)

  • [Journal Article] Delayed Increase in Near-Infrared Fluorescence in Cultured Murine Cancer Cells Labeled with Oxygen-Doped Single-Walled Carbon Nanotubes2018

    • Author(s)
      Sekiyama Shota、Umezawa Masakazu、Iizumi Yoko、Ube Takuji、Okazaki Toshiya、Kamimura Masao、Soga Kohei
    • Journal Title

      Langmuir

      Volume: 35 Issue: 3 Pages: 831-837

    • DOI

      10.1021/acs.langmuir.8b03789

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer2018

    • Author(s)
      Sekiyama Shota、Umezawa Masakazu、Kuraoka Shuhei、Ube Takuji、Kamimura Masao、Soga Kohei
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-018-35354-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tuning the thermal sensitivity of β-NaYF 4 : Yb 3+ , Ho 3+ , Er 3+ nanothermometers for optimal temperature sensing in OTN-NIR (NIR II/III) biological window2018

    • Author(s)
      Wortmann L.、Suyari S.、Ube T.、Kamimura M.、Soga K.
    • Journal Title

      Journal of Luminescence

      Volume: 198 Pages: 236-242

    • DOI

      10.1016/j.jlumin.2018.01.049

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ratiometric near-infrared fluorescence nanothermometry in the OTN-NIR (NIR II/III) biological window based on rare-earth doped β-NaYF4 nanoparticles2017

    • Author(s)
      Masao KAMIMURA, Taiki MATSUMOTO, Satoru SUYARI, Masakazu UMEZAWA, Kohei SOGA
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 5 Issue: 10 Pages: 1917-1925

    • DOI

      10.1039/c7tb00070g

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] OTN(over-1000-nm) NIR PHOSPHORS FOR BIOMEDICAL APPLICATIONS2018

    • Author(s)
      Kohei SOGA, Gil YEROSLAVSKY, Karina NIGOGHOSSIAN, Masakazu UMEZAWA, Kyohei OKUBO and Masao KAMIMURA
    • Organizer
      Phosphor Safari 2018 (International Symposium for Phosphor Materials)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Materials and System Development for Near Infrared Biophotonics with Transparency [Plenary]2018

    • Author(s)
      Kohei SOGA
    • Organizer
      ADVANCED CERAMICS AND APPLICATION VII
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nanomatter Fluorescence Imaging in Animal Bodies2018

    • Author(s)
      Kohei SOGA, Masao KAMIMURA, Masakazu UMEZAWA
    • Organizer
      12th International Conference on Ceramic Materials and Components for Energy and Environmental Applications (CMCEE 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 近赤外バイオメディカルイメージングの最近の動向 [特別講演]2017

    • Author(s)
      曽我公平
    • Organizer
      臨床麻酔学会第37回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 第2の生体の窓(SBW)から見るバイオイメージングの未来形2017

    • Author(s)
      曽我公平、上村真生
    • Organizer
      第26回日本バイオイメージング学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 波長1000 nmを超える近赤外(OTN-NIR)蛍光in vivoイメージング2017

    • Author(s)
      上村 真生、曽我 公平
    • Organizer
      第26回日本バイオイメージング学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] SBW(Second Biological Window) におけるバイオフォトニクスの現状と展開2017

    • Author(s)
      梅澤雅和、上村真生、曽我公平
    • Organizer
      第30回 日本動物細胞工学会2017年度大会 (JAACT2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] OTN-NIR (NIR II/III) におけるバイオメディカル光イメージング2017

    • Author(s)
      曽我 公平
    • Organizer
      第12回日本分子イメージング学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Luminescent Probe Design for Biophotonics in the OTN-NIR (NIR II/III) Biological Window2016

    • Author(s)
      Kohei SOGA, Masao KAMIMURA
    • Organizer
      International Symposium on Luminescence, Spectroscopy and Applications (Phosphor Safari 2016)
    • Place of Presentation
      Hong Kong Baptist University, Hong Kong
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nanostructure for Nanothermometry by Using Ceramic Nanophosphors2016

    • Author(s)
      Kohei SOGA, Masao KAMIMURA
    • Organizer
      The 8th International Conference on Technological Advances of Thin Films & Surface Coatings (ThinFilms2016)
    • Place of Presentation
      Holiday Inn Atrium, Singapore
    • Year and Date
      2016-07-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi