A new mathematical model for biological effects of radiation

• Project/Area Number: 16H04637
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nuclear engineering
• Research Institution: Kansai University
• Principal Investigator: WADA Takahiro 関西大学, システム理工学部, 教授 (30202419)
• Co-Investigator(Kenkyū-buntansha): 坂東 昌子 大阪大学, 核物理研究センター, 協同研究員 (20025365) ; 真鍋 勇一郎 大阪大学, 工学研究科, 助教 (50533668)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000); Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 放射線 / 生体影響 / 数理モデル / 線量率 / 寿命短縮 / 生物物理 / がん

Outline of Final Research Achievements

We investigated the biological effects of radiation using a mathematical model （WAM model) which takes account of the recovery effects of the living organism. We examined the mega-mouse data of Oak Ridge National Laboratory in detail and demonstrated the validity of the WAM model. We also showed that the dose-rate dependence of the experimental data of the protracted irradiation of Drosophila can be reproduced by taking account of recovery effects in the WAM model.
We published a paper on the correlation between the incidence of childhood thyroid cancer in each municipality announced in the Fukushima Prefecture Health Survey and the radiation dose data measured several months after the earthquake. We also formulated a mathematical model to describe the life-shortening in mice in the protracted irradiation with low dose-rate radiation.

Academic Significance and Societal Importance of the Research Achievements

放射線の生体影響の議論には、直線閾値なしモデル（LNTモデル）が防護の観点から広く用いられている。しかし、生体には損傷を除去・修復する能力があり、DNAも損傷から回復することが知られている。我々の研究は、生体の修復を取り入れた数理モデル（WAMモデル）によって低線量率長期被ばくの影響を論じるものであり、学術的に重要であるだけでなく、社会的な意義も大きい。
放射線の長期影響としてがん発生の増加や寿命短縮は重要である。マウスの長期被ばく実験データを解析し、数理モデルを構築した。福島県における小児甲状腺がんと放射線量との相関を定量的に調べて論文として発表することで、科学的な議論の土台を構築した。

Research Products

• [Int'l Joint Research] Northwestern University(米国)
• [Int'l Joint Research] Northwestern University(米国)
• [Int'l Joint Research] Northwestern University(米国)
• [Int'l Joint Research] Northwestern University(米国)
• [Journal Article] Relationship between environmental radiation and radioactivity and childhood thyroid cancer found in Fukushima health management survey (2020)
  • Author(s): Hiroshi Toki, Takahiro Wada, Yuichiro Manabe, Yuichi Tsunoyama, Toshihiro Higuchi, Masako Bando
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41598-020-60999-z
  • Peer Reviewed / Open Access
• [Journal Article] Study of Mutation from DNA to Biological Evolution (2019)
  • Author(s): Bando Masako、Kinugawa Tetsuhiro、Manabe Yuichiro、Masugi Miwako、Nakajima Hiroo、Suzuki Kazuyo、Tsunoyama Yuichi、Wada Takahiro、Toki Hiroshi
  • Journal Title: International Journal of Radiation Biology Volume: accepted Issue: 10 Pages: 1-42
  • DOI: 10.1080/09553002.2019.1606957
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Verification of a dose rate-responsive dynamic equilibrium model on radiation-induced mutation frequencies in mice (2019)
  • Author(s): Tsunoyama Yuichi、Suzuki Kazuyo、Masugi-Tokita Miwako、Nakajima Hiroo、Manabe Yuichiro、Wada Takahiro、Bando Masako
  • Journal Title: International Journal of Radiation Biology Volume: - Issue: 10 Pages: 1-7
  • DOI: 10.1080/09553002.2019.1569772
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Study of Mutation from DNA to Biological Evolution (2019)
  • Author(s): Bando Masako, Kinugawa Tetsuhiro, Manabe Yuichiro, Masugi-Tokita Miwako, Nakajima Hiroo, Suzuki, Kazuyo, Tsunoyama Yuichi, Wada Takahiro, Toki Hiroshi
  • Journal Title: International Journal of Radiation Biology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Verification of a dose rate-responsive dynamic equilibrium model on radiation-induced mutation frequencies in mice (2019)
  • Author(s): Tsunoyama Yuichi, Suzuki, Kazuyo, Masugi-Tokita Miwako, Nakajima Hiroo, Manabe Yuichiro, Wada Takahiro, Bando Masako
  • Journal Title: International Journal of Radiation Biology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] 放射線の生体影響の分野横断的研究 (2018)
  • Author(s): 和田 隆宏
  • Journal Title: 日本放射線安全管理学会誌 Volume: 17 Pages: 128-131
  • Peer Reviewed
• [Journal Article] 放射線誘発変異発生頻度線量率応答モデルWAMモデルを用いたラッセルのマウス実験結果の再解析 (2018)
  • Author(s): 角山 雄一，鈴木 和代，馬杉美和子，中島 裕夫， 真鍋勇一郎，和田 隆宏，坂東 昌子
  • Journal Title: 日本放射線安全管理学会誌 Volume: 17 Pages: 138-149
  • Peer Reviewed
• [Journal Article] 特集 LNT仮説への挑戦 2016年秋の大会企画セッションから (2017)
  • Author(s): 坂東昌子、田中司朗、今井匠、真鍋勇一郎、和田隆宏
  • Journal Title: 日本原子力学会誌 Volume: 59（３） Pages: 122-134
• [Presentation] Analysis of life shortening in mice induced by radiation (2019)
  • Author(s): Takahiro Wada
  • Organizer: International Dose Effect Alliance Workshop 2019
  • Int'l Joint Research
• [Presentation] 物理屋が生物研究に関わって (2019)
  • Author(s): 坂東昌子
  • Organizer: 素粒子論研究室セミナー
  • Invited
• [Presentation] Proposal of WAM model -Is LNT suitable to describe low-dose/dose rate biological effects caused by radiation? (2018)
  • Author(s): Masako Bando, Takahiro Wada, Yuichiro Manabe, Yuichi Tsunoyama
  • Organizer: Applicability of radiation-response models to low dose protection standard
  • Int'l Joint Research
• [Presentation] Reconsideration of the concept "DDREF" based on LNT (2018)
  • Author(s): Masako Bando, Yuichiro Manabe, Takahiro Wada, Yuuichi Tsunoyama, Hiroo Nakajima
  • Organizer: 2018 Radiation research society annual meeting
  • Int'l Joint Research
• [Presentation] Dose-response relationship of childhood thyroid cancer cases found in Fukushima health management survey (2018)
  • Author(s): Yuichiro Manabe, Hiroshi Toki, Takahiro Wada, Masako Bando
  • Organizer: 2018 Radiation research society annual meeting
  • Int'l Joint Research
• [Presentation] Mathematical analysis of the life-span shortening in mice induced by radiation (2018)
  • Author(s): Takahiro Wada, Tetsuhiro Kinugawa, Yuichiro Manabe, and Masako Bando
  • Organizer: 2018 Radiation research society annual meeting
  • Int'l Joint Research
• [Presentation] Life shortening in mice with radiation (2018)
  • Author(s): Takahiro Wada
  • Organizer: International Dose Effect Alliance Workshop 2018
  • Int'l Joint Research
• [Presentation] 放射線の生体影響の分野横断的研究 (2018)
  • Author(s): 和田 隆宏
  • Organizer: 日本放射線安全管理学会 第15回 6月シンポジウム「放射線安全管理と被ばく影響の基準の根拠」
  • Invited
• [Presentation] 放射線誘発変異発生頻度線量率応答モデル WAM モデルを用いたラッセルのマウス実験結果の再解析 (2018)
  • Author(s): 角山 雄一，鈴木 和代，馬杉美和子，中島 裕夫， 真鍋勇一郎，和田 隆宏，坂東 昌子
  • Organizer: 日本放射線安全管理学会 第15回 6月シンポジウム「放射線安全管理と被ばく影響の基準の根拠」
• [Presentation] マウスに対する放射線の寿命短縮の解析 (2018)
  • Author(s): 衣川 哲弘, 真鍋 勇一郎，和田 隆宏
  • Organizer: 平成30年度第1回原子力関係科学技術の基礎的研究の動向調査委員会
• [Presentation] DNA損傷量と等価線量率の関係について考える~低線量・低線量率放 射線影響の統一的・定量的理解のために~ (2018)
  • Author(s): 真鍋勇一郎, 和田隆宏, 衣川哲弘, 角山雄一, 中島裕夫, 坂東昌子
  • Organizer: 第61回日本放射線影響学会
  • Invited
• [Presentation] メスマウスに対する放射線の寿命短縮の解析 (2018)
  • Author(s): 衣川 哲弘、真鍋 勇一郎、和田 隆宏、坂東 昌子
  • Organizer: 日本原子力学会2018年秋の大会
• [Presentation] Analysis of childhood thyroid cancer incidence in Fukushima based on dose response relationship (2018)
  • Author(s): Takahiro Wada, Hiroshi Toki, Yuichiro Manabe, Toshihiro Higuchi, Masako Bando
  • Organizer: International Workshop on the Biological Effects of Radiation- bridging the gap between radiobiology and medical use of ionizing radiation
  • Int'l Joint Research
• [Presentation] Two step model for the occurrence of retinoblastoma (2018)
  • Author(s): Tetsuhiro Kinugawa, Takahiro Wada, Yuichiro Manabe
  • Organizer: International Workshop on the Biological Effects of Radiation- bridging the gap between radiobiology and medical use of ionizing radiation-
  • Int'l Joint Research
• [Presentation] The influence of low dose-rate radiation on the mutation frequency in Drosophila (2018)
  • Author(s): Tomonori Onishi, Takahiro Wada, Yuichiro Manabe, Masako Bando
  • Organizer: International Workshop on the Biological Effects of Radiation- bridging the gap between radiobiology and medical use of ionizing radiation-
  • Int'l Joint Research
• [Presentation] WAM model -a dynamic equilibrium model for the dose-rate effect (2018)
  • Author(s): Yuichi Tsunoyama, Kazuyo Suzuki, Miwako Masugi-Tokita, Hiroo Nakajima, Yuichiro Manabe, Takahiro Wada, Masako Bando
  • Organizer: International Workshop on the Biological Effects of Radiation- bridging the gap between radiobiology and medical use of ionizing radiation-
  • Int'l Joint Research / Invited
• [Presentation] WAMモデルによるショウジョウバエ突然変異における線量率効果の解析 (2018)
  • Author(s): 和田 隆宏、大西 智徳、真鍋 勇一郎、坂東 昌子
  • Organizer: 日本原子力学会 2018年春の年会
• [Presentation] 福島健康調査に見る疫学データ - チェルノブイリ・福島 (2017)
  • Author(s): 坂東昌子、土岐博、谷畑勇夫、和田隆宏、真鍋勇一郎、廣田誠子
  • Organizer: H29年第２回統計数理研究所共同利用研究集会 「経済物理学とその周辺」研究会
  • Place of Presentation: 統計数理研究所（東京都立川市）
  • Year and Date: 2017-03-23
• [Presentation] 福島健康調査に見る疫学データ - 先行調査と本格調査の分析 (2017)
  • Author(s): 和田隆宏、土岐博、谷畑勇夫、真鍋勇一郎、廣田誠子、坂東昌子
  • Organizer: H29年第２回統計数理研究所共同利用研究集会 「経済物理学とその周辺」研究会
  • Place of Presentation: 統計数理研究所（東京都立川市）
  • Year and Date: 2017-03-23
• [Presentation] 福島健康調査に見る疫学データ - 大規模土壌調査のもつ意義 (2017)
  • Author(s): 真鍋勇一郎、土岐博、谷畑勇夫、和田隆宏、廣田誠子、坂東昌子
  • Organizer: H29年第２回統計数理研究所共同利用研究集会 「経済物理学とその周辺」研究会
  • Place of Presentation: 統計数理研究所（東京都立川市）
  • Year and Date: 2017-03-23
• [Presentation] 福島での甲状腺検査と福島原発事故による放射線の影響 (2017)
  • Author(s): 土岐博、和田隆宏、真鍋勇一郎、坂東昌子、廣田誠子
  • Organizer: 日本物理学会 第７２回年次大会
  • Place of Presentation: 大阪大学豊中キャンパス（大阪府豊中市）
  • Year and Date: 2017-03-17
• [Presentation] 低線量・低線量率放射線の影響を巡る知見 Dose-Response Relationship (2017)
  • Author(s): 坂東昌子、土岐博、和田隆宏、真鍋勇一郎、廣田誠子
  • Organizer: 日本物理学会 第７２回年次大会
  • Place of Presentation: 大阪大学豊中キャンパス（大阪府豊中市）
  • Year and Date: 2017-03-17
• [Presentation] A mathematical model for the effects of radiation to the induced cancer in mice (2017)
  • Author(s): Takahiro Wada, Yuichiro Manabe, Masako Bando
  • Organizer: APS (American Physical Society) March Meeting 2017
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2017-03-13
  • Int'l Joint Research
• [Presentation] From mutation to cancer -bridging the gap between radiobiology and medical use of ionizing radiation- (2017)
  • Author(s): Takahiro Wada
  • Organizer: International Dose Effect Alliance Workshop 2017
  • Int'l Joint Research
• [Presentation] Bridging the gap between radiobiology and medical use of ionizing radiation - JSPS committee -multidisciplinary research on biological effects of radiation- (2017)
  • Author(s): Takahiro Wada, Yuichiro Manabe, Masako Bando, Yoshiharu Yonekura
  • Organizer: ICRP-ERPW 2017(4th International Symposium on the System of radiological Protection and the 2nd European Radiation Protection Research Week)
  • Int'l Joint Research
• [Presentation] Analysis of childhood thyroid cancer incidence in Fukushima based on dose response relationship (2017)
  • Author(s): Takahiro Wada, Hiroshi Toki, Yuichiro Manabe, Toshihiro Higuchi, Masako Bando
  • Organizer: ICRP-ERPW 2017(4th International Symposium on the System of radiological Protection and the 2nd European Radiation Protection Research Week)
  • Int'l Joint Research
• [Presentation] A mathematical model to evaluate radiation-related biological effects - toward a unified and quantitative understanding (2017)
  • Author(s): Yuichiro Manabe, Takahiro Wada, Masako Bando
  • Organizer: ICRP-ERPW 2017(4th International Symposium on the System of radiological Protection and the 2nd European Radiation Protection Research Week)
  • Int'l Joint Research
• [Presentation] Ethics vs science - Lessons from Fukushima crisis (2017)
  • Author(s): Masako Bando, Takahiro Wada, Yuichiro Manabe, Yuichi Tsunoyama, Hiroo Nakajima, Toshihiro Higuchi
  • Organizer: ICRP-ERPW 2017(4th International Symposium on the System of radiological Protection and the 2nd European Radiation Protection Research Week)
  • Int'l Joint Research
• [Presentation] From DDREF to EDR - what the history of LNT indicates (2017)
  • Author(s): Masako Bando, Takahiro Wada, Yuichiro Manabe
  • Organizer: ICRP-ERPW 2017(4th International Symposium on the System of radiological Protection and the 2nd European Radiation Protection Research Week)
  • Int'l Joint Research / Invited
• [Presentation] マウスにおける放射線による寿命短縮の数理的解析 (2017)
  • Author(s): 和田 隆宏, 真鍋 勇一郎, 坂東 昌子
  • Organizer: 経済・社会への分野横断的研究会
• [Presentation] マウスにおける放射線による寿命短縮の数理的解析 (2017)
  • Author(s): 和田隆宏, 衣川哲弘, 真鍋勇一郎, 坂東昌子
  • Organizer: 日本物理学会 2017年秋季大会
• [Presentation] がんの多段階モデルの解析～網膜芽細胞腫を対象として～ (2017)
  • Author(s): 真鍋勇一郎, 和田隆宏, 中島裕夫, 土岐博, 坂東昌子
  • Organizer: 日本物理学会 2017年秋季大会
• [Presentation] がんの多段階モデル一般論 (2017)
  • Author(s): 坂東昌子, 真鍋勇一郎, 和田隆宏, 中島裕夫, 土岐博
  • Organizer: 日本物理学会 2017年秋季大会
• [Presentation] 勝沼ショウジョウバエ集団における致死遺伝子動態のモデル解析 (2016)
  • Author(s): 和田隆宏、真鍋勇一郎、坂東昌子
  • Organizer: 第３回ゲノム多様性解析ワークショップ
  • Place of Presentation: 北海道大学（北海道札幌市）
  • Year and Date: 2016-12-05
• [Presentation] After Fukushima, what we did & how we should do for the future (2016)
  • Author(s): Masako Bando, Takahiro Wada, Hiroshi Toki, Isao Tanihata, Yuichito Manabe, Toshihiro Higuchi, Seiko Hirota, Tetsushi Shima
  • Organizer: International Dose Effects Alliance Workshop 2016
  • Place of Presentation: Charlotte, NC, USA
  • Year and Date: 2016-11-09
  • Int'l Joint Research / Invited
• [Presentation] 低線量放射線生体影響における数理モデルの有用性 (2016)
  • Author(s): 真鍋勇一郎、和田隆宏、角山雄一、中島裕夫、中村一成、坂東昌子
  • Organizer: 日本放射線影響学会 第５９回大会
  • Place of Presentation: ＪＭＳアステールプラザ（広島県広島市）
  • Year and Date: 2016-10-26
  • Invited
• [Presentation] The Role of Scientists - What we laerned after Fukushima (2016)
  • Author(s): Masako Bando, Yuichiro Manabe, Takahiro Wada
  • Organizer: Radiation Protection Week 2016
  • Place of Presentation: University of Oxford, UK
  • Year and Date: 2016-09-19
  • Int'l Joint Research
• [Presentation] Is LNT the best model for risk estimation? - Proposal of a new mathematical model for biological effects of radiation (2016)
  • Author(s): Takahiro Wada, Yuichiro Manabe, Masako Bando
  • Organizer: Radiation Protection Week 2016
  • Place of Presentation: University of Oxford, UK
  • Year and Date: 2016-09-19
  • Int'l Joint Research
• [Presentation] 放射線影響の多段階モデル (2016)
  • Author(s): 和田隆宏、真鍋勇一郎、坂東昌子
  • Organizer: 日本物理学会 ２０１６年秋季大会
  • Place of Presentation: 金沢大学角間キャンパス（石川県金沢市）
  • Year and Date: 2016-09-13
• [Presentation] もぐらたたきモデルによる発がん率の評価 (2016)
  • Author(s): 真鍋勇一郎、和田隆宏、角山雄一、中島裕夫、中村一成、坂東昌子
  • Organizer: 日本物理学会 ２０１６年秋季大会
  • Place of Presentation: 金沢大学角間キャンパス（石川県金沢市）
  • Year and Date: 2016-09-13
• [Presentation] LNT仮説への挑戦としてのWAMモデル (2016)
  • Author(s): 真鍋勇一郎
  • Organizer: 日本原子力学会 ２０１６年秋の大会
  • Place of Presentation: 久留米シティプラザ（福岡県久留米市）
  • Year and Date: 2016-09-07
  • Invited
• [Presentation] 低線量放射線影響の歴史的経緯と現状 (2016)
  • Author(s): 坂東昌子
  • Organizer: 日本原子力学会 ２０１６年秋の大会
  • Place of Presentation: 久留米シティプラザ（福岡県久留米市）
  • Year and Date: 2016-09-07
  • Invited
• [Presentation] 低線量放射線のヒトへの影響～物理学知見からの提案～ (2016)
  • Author(s): 真鍋勇一郎、和田隆宏、角山雄一、中島裕夫、坂東昌子
  • Organizer: 保物セミナー2016
  • Place of Presentation: 大阪科学技術センター（大阪府大阪市）
  • Invited
• [Presentation] 放射線の生体影響を定量評価可能にするもぐらたたきモデルについて～その概要と可能性～ (2016)
  • Author(s): 真鍋勇一郎、和田隆宏、角山雄一、中島裕夫、坂東昌子
  • Organizer: 低線量放射線とその影響に関するシンポジウム
  • Place of Presentation: 核融合科学研究所（岐阜県土岐市）
  • Invited
• [Remarks] 低線量放射線研究会
  • URL: https://www.rcnp.osaka-u.ac.jp/~manabe/project.html
• [Remarks] WAMシミュレーター
  • URL: http://radi.rirc.kyoto-u.ac.jp/wam/aboutWAM.html
• [Remarks] 低線量放射線研究会
  • URL: https://www.rcnp.osaka-u.ac.jp/~manabe/pproject.html
• [Remarks] 放射線の生体影響に関する国際会議
  • URL: https://www.rcnp.osaka-u.ac.jp/~ber2018
• [Funded Workshop] International Workshop on the Biological Effects of Radiation- bridging the gap between radiobiology and medical use of ionizing radiation- (2018)