A new mathematical model for biological effects of radiation
| Project/Area Number |
16H04637
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nuclear engineering
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| Research Institution | Kansai University |
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Principal Investigator |
WADA Takahiro 関西大学, システム理工学部, 教授 (30202419)
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| Co-Investigator(Kenkyū-buntansha) |
坂東 昌子 大阪大学, 核物理研究センター, 協同研究員 (20025365)
真鍋 勇一郎 大阪大学, 工学研究科, 助教 (50533668)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 放射線 / 生体影響 / 数理モデル / 線量率 / 寿命短縮 / 生物物理 / がん |
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| Outline of Final Research Achievements |
We investigated the biological effects of radiation using a mathematical model （WAM model) which takes account of the recovery effects of the living organism. We examined the mega-mouse data of Oak Ridge National Laboratory in detail and demonstrated the validity of the WAM model. We also showed that the dose-rate dependence of the experimental data of the protracted irradiation of Drosophila can be reproduced by taking account of recovery effects in the WAM model.
We published a paper on the correlation between the incidence of childhood thyroid cancer in each municipality announced in the Fukushima Prefecture Health Survey and the radiation dose data measured several months after the earthquake. We also formulated a mathematical model to describe the life-shortening in mice in the protracted irradiation with low dose-rate radiation.
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| Academic Significance and Societal Importance of the Research Achievements |
放射線の生体影響の議論には、直線閾値なしモデル（LNTモデル）が防護の観点から広く用いられている。しかし、生体には損傷を除去・修復する能力があり、DNAも損傷から回復することが知られている。我々の研究は、生体の修復を取り入れた数理モデル（WAMモデル）によって低線量率長期被ばくの影響を論じるものであり、学術的に重要であるだけでなく、社会的な意義も大きい。
放射線の長期影響としてがん発生の増加や寿命短縮は重要である。マウスの長期被ばく実験データを解析し、数理モデルを構築した。福島県における小児甲状腺がんと放射線量との相関を定量的に調べて論文として発表することで、科学的な議論の土台を構築した。
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Report
(5 results)
Research Products
(61 results)
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[Presentation] Ethics vs science - Lessons from Fukushima crisis2017
Author(s)
Masako Bando, Takahiro Wada, Yuichiro Manabe, Yuichi Tsunoyama, Hiroo Nakajima, Toshihiro Higuchi
Organizer
ICRP-ERPW 2017(4th International Symposium on the System of radiological Protection and the 2nd European Radiation Protection Research Week)
Related Report
Int'l Joint Research
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[Presentation] After Fukushima, what we did & how we should do for the future2016
Author(s)
Masako Bando, Takahiro Wada, Hiroshi Toki, Isao Tanihata, Yuichito Manabe, Toshihiro Higuchi, Seiko Hirota, Tetsushi Shima
Organizer
International Dose Effects Alliance Workshop 2016
Place of Presentation
Charlotte, NC, USA
Year and Date
2016-11-09
Related Report
Int'l Joint Research / Invited
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[Presentation] 放射線影響の多段階モデル2016
Author(s)
和田隆宏、真鍋勇一郎、坂東昌子
Organizer
日本物理学会 ２０１６年秋季大会
Place of Presentation
金沢大学角間キャンパス（石川県金沢市）
Year and Date
2016-09-13
Related Report
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