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Production of novel anatomical chart of the gastrointestinal tract corresponding to the progressing medical optics: human mesentery project

Research Project

Project/Area Number 16H05399
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionHyogo Medical University

Principal Investigator

SHINOHARA Hisashi  兵庫医科大学, 医学部, 教授 (70319549)

Co-Investigator(Kenkyū-buntansha) 坂井 義治  京都大学, 医学研究科, 教授 (60273455)
高井 昭洋  愛媛大学, 医学部附属病院, 講師 (70632917)
Research Collaborator MATSUDA seiji  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Keywords消化管解剖 / 腸間膜 / 食道間膜 / 心臓下包 / 食道胃接合部 / 肛門管 / 尿道 / 3Dシミュレーション / 消化管微細解剖 / cadaver / 外科解剖学 / 微細解剖 / 食道胃接合部解剖 / 肛門管前壁解剖 / infracardiac bursa / 横紋筋 / 平滑筋 / Cadaver / 3Dシミュレーション / 骨盤底解剖 / 骨盤底筋群 / Thiel法 / 横断的消化器解剖の研究
Outline of Final Research Achievements

We have produced the novel charts of gastrointestinal tract corresponding to the progressing medical optics and surgical devices, as a keyword in “mesentery” which is a common structure of the organs. Especially, we have revealed and illustrated the topographic anatomy of the mesoesophagus, the infracardiac bursa alongside the esophagogastric junction, and muscular anatomy of the anal canal, using multimodal methods such as histological examination and computer graphics to show its development from the embryonic to adult stage. In the present study, we demonstrated that the surgical concept for malignant disease of the whole gastrointestinal organs including the esophagus, the stomach, the small and large intestines could be universalized by the mesenteric excision using the loose connective tissue spaces of the mesenteries as a surgical landmark.

Academic Significance and Societal Importance of the Research Achievements

内視鏡手術やロボット支援手術に代表される昨今の光学機器や手術デバイスの急速な進歩を享受するには,従来の古典的解剖図譜から得られる知識だけではもはや不十分である。本研究の意義は,現在の医療技術に対応した,新しいコンセプトに基づく解剖を視覚化し,外科臨床に役立つ図譜を提示したことにある。本研究で得られた食道周囲の反回神経,気管との微細解剖や,食道胃接合部に隣接する心臓下包の存在,さらに直腸癌手術で問題となる肛門管周囲の筋層構造の知見は,手術の根治性と安全性を大きく向上させるばかりか,将来的には人工知能を用いたナビゲーション手術や自動手術の開発にもつながる重要な成果である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (53 results)

All 2019 2018 2017 2016 Other

All Journal Article (17 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results) Presentation (30 results) (of which Int'l Joint Research: 10 results,  Invited: 8 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Revisiting the infracardiac bursa by multimodal methods.2019

    • Author(s)
      Nakamura T, Shinohara H, Okada T, Hisamori S, Tsunoda S, Obama K, Kurahashi Y, Takai A, Shimokawa T, Matsuda S, Makishima H, Takakuwa T, Yamada S, Sakai Y.
    • Journal Title

      J Anat,

      Volume: 印刷中 Issue: 1 Pages: 88-95

    • DOI

      10.1111/joa.12989

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laparoscopic modified lymphadenectomy in gastric cancer surgery using systematic mesogastric excision: a novel technique based on a concept2019

    • Author(s)
      Kumamoto T, Kurahashi Y, Haruta S, Niwa H, Nakanishi Y, Ozawa R, Okumura K, Ishida Y, Shinohara H.
    • Journal Title

      Langenbeck’s Arch Surg

      Volume: 印刷中 Issue: 3 Pages: 369-374

    • DOI

      10.1007/s00423-019-01770-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenteric excision of upper esophagus: a concept for rational anatomical lymphadenectomy of the recurrent laryngeal nodes in thoracoscopic esophagectomy2019

    • Author(s)
      Tsunoda S, Shinoahra H, Kanaya S, Okabe H, Tanaka E, Obama K, Hosogi H, Hisamori S, Sakai Y.
    • Journal Title

      Surg Endosc

      Volume: 印刷中 Issue: 1 Pages: 133-141

    • DOI

      10.1007/s00464-019-06741-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal diagnostic method using multidetector-row computed tomography for predicting lymph node metastasis in colorectal cancer2019

    • Author(s)
      Kumamoto T, Shindoh J, Mita H, Fujii Y, Mihara Y, Takahashi M, Takemura N, Shirakawa T, Shinohara H, Kuroyanagi H.
    • Journal Title

      World J Surg Oncol

      Volume: 17 Issue: 1 Pages: 39-39

    • DOI

      10.1186/s12957-019-1583-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The infracardiac bursa(心臓下包)―取り残された網嚢腔―2018

    • Author(s)
      中村達郎, 倉橋康典, 山田重人, 篠原尚
    • Journal Title

      臨床雑誌 外科

      Volume: 80 Pages: 470-473

    • Related Report
      2018 Annual Research Report
  • [Journal Article] TaTMEを安全に行うために必要な局所解剖:何がランドマークなのか2018

    • Author(s)
      岡田倫明, 板谷喜朗, 稲本将, 肥田侯矢, 河田健二, 篠原尚, 坂井義治
    • Journal Title

      臨床外科

      Volume: 73 Pages: 106-109

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 直腸癌に対するナビゲーション手術2018

    • Author(s)
      福井雄大, 岡田倫明, 河田健二, 後藤沙織, 水野礼, 板谷善朗, 稲本将, 肥田侯矢, 篠原尚, 坂井義治
    • Journal Title

      消化器外科

      Volume: 41 Pages: 1277-1286

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 食道胃接合部癌の手術に必要な局所解剖 下縦郭へのランドマークとしての心臓下包2018

    • Author(s)
      倉橋康典、中村達郎、中西保貴、小澤りえ、仁和浩貴、石田善敬、篠原尚
    • Journal Title

      臨床外科

      Volume: 73 Pages: 531-535

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 食道胃接合部の外科解剖2018

    • Author(s)
      中西保貴, 中村達郎, 篠原 尚, 他
    • Journal Title

      消化器外科

      Volume: 41 Pages: 141-150

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Universalization of the operative strategy by systematic mesogastric excision for stomach cancer with that for total mesorectal excision and complete mesocolic excision colorectal counterparts.2018

    • Author(s)
      Shinohara. H, Kurahashi Y, Haruta S, Ishida Y, Sasako M.
    • Journal Title

      Ann Gastroenterol. Surg.

      Volume: 2 Issue: 1 Pages: 28-36

    • DOI

      10.1002/ags3.12048

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ta(p)TMEに必要な肛門管外科解剖2017

    • Author(s)
      岡田倫明, 中村達郎, 篠原 尚, 坂井義治
    • Journal Title

      手術

      Volume: 71 Pages: 1587-1596

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Reply to “How should we define the no.3b lesser curvature lymph node?”2017

    • Author(s)
      Shinohara H, Haruta S, Hosogi H, Ohkura Y, Kobayashi N, Mizuno A, Okamura R, Ueno M, Sakai Y, Udagawa H.
    • Journal Title

      Gastric Cancer

      Volume: 20 Issue: 3 Pages: 560-561

    • DOI

      10.1007/s10120-016-0678-1

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphadenectomy along the infrapyloric artery may be dispensable when performing pylorus-preserving gastrectomy for early middle-third gastric cancer.2017

    • Author(s)
      Mizuno A, *Shinohara H, Haruta S, Tsunoda S, Kurahashi Y, Ohkura Y, Udagawa H, Sakai Y.
    • Journal Title

      Gastric Cancer

      Volume: 20 Issue: 3 Pages: 543-547

    • DOI

      10.1007/s10120-016-0632-2

    • NAID

      40021185824

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical knowledge for the infra-pyloric vein preservation during the laparoscopy-assisted pylorus-preserving gastrectomy2016

    • Author(s)
      Nishizawa N, Yamashita K, Shinohara H, et al.
    • Journal Title

      Digestive Surg

      Volume: 33 Issue: 5 Pages: 363-370

    • DOI

      10.1159/000445069

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Process of pancreas head as a risk factor for postoperative pancreatic fistula in laparoscopic gastric cancer surgery2016

    • Author(s)
      Kobayashi N, H.Shinohara, et al
    • Journal Title

      World J Surg

      Volume: 40 Issue: 9 Pages: 2194-2201

    • DOI

      10.1007/s00268-016-3536-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腹腔鏡下胃切除術に必要な局所解剖2016

    • Author(s)
      篠原 尚,他
    • Journal Title

      臨床外科

      Volume: 71 Pages: 671-679

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 胃全摘術2016

    • Author(s)
      春田周宇介,篠原 尚,他
    • Journal Title

      消化器外科

      Volume: 39 Pages: 173-180

    • Related Report
      2016 Annual Research Report
  • [Presentation] The Three-Dimensional Animation Illustrating the Upper Mediastinal Anatomy for Video-Assisted Transcervical Approach in Esophageal Cancer Surgery.2018

    • Author(s)
      Shinohara H, Kurahashi Y, Ozawa R, Nakanishi Y, Niwa H,Ishida Y
    • Organizer
      The International Society for Dieases of the Esophagus
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Laparoscopic Transhiatal Lower Mediastinal Lymphadenectomy for Esphagogastric Junctional Cancer:The Infracardiac Bursaasa Landmark.2018

    • Author(s)
      Kurahashi Y, Nakamura T, Ozawa R, Nakanishi Y, Niwa H, Ishida Y, Shinohara H
    • Organizer
      The International Society for Dieases of the Esophagus
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Revisting the Esophagogastic Junction Anatomy: Where Is the Infracardiac Bursa?2018

    • Author(s)
      Nakamura T, Shinohara H, Okada T, Hisamori S,Tsunoda S, ObamavK, Kurahashi Y, Takai A, Takakuwa T, Yamada S, Sakai Y
    • Organizer
      The International Society for Dieases of the Esophagus
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Embryology-based surgery for cardia cancer: The infra-cardiac bursa as a landmark during surgery.2018

    • Author(s)
      Shinohara H
    • Organizer
      KSELS 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systematic Mesogastric Excision based on Anatomy and Embryological Principles for Lymphadenectomy in Gastric Cancer Surgery.2018

    • Author(s)
      Shinohara H
    • Organizer
      4th Chinese of GI Laparoscopy & 2nd Membrane Anatomy Exposition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 食道胃接合がん 胸腹連続性を考える2018

    • Author(s)
      篠原尚
    • Organizer
      第90回日本胃癌学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Transhiatal lower mediastinal lymphadenectomy with the infracardiac bursa as a landmark.2018

    • Author(s)
      Kurahashi Y, Nakamura T, Ozawa R, Nakanishi Y, Niwa H, Ishida Y, Shinohara H
    • Organizer
      第73回日本消化器外科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Semi-Automatic Surgeryを目指したシュミレーション画像の作成―ミクロからマクロへ、マクロからMRIシュミレーション画像へー2018

    • Author(s)
      岡田倫明、中村達郎、多代尚広、吉富摩美、渡邊武志、肥田候矢、河田健二、高井昭洋、下川哲哉、松田正司、篠原尚、坂井義治
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 裂孔ヘルニア合併食道胃接合部癌の術中に観察しえた心臓下包~心臓下包と裂孔ヘルニアの関係~2018

    • Author(s)
      倉橋康典、中村達郎、小澤りえ、中西保貴、仁和浩貴、石田善敬、菊池正二郎、笹子三津留、篠原尚
    • Organizer
      第90回日本胃癌学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Trans-perineal APRにおける尿道可視化を目的とした発光カテーテルの使用2018

    • Author(s)
      岡田倫明,河田健二,福井雄大,多代尚広,稲本将,吉冨摩美,渡邊武志,肥田侯矢,坂井義治
    • Organizer
      第72回手術手技研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Four-level concept to facilitate the understanding of the surgical anatomy for the anterior dissection of Ta(p)TME in Male2018

    • Author(s)
      Okada T, Nakamura T, Kiyasu Y, Takai A, Hida K, Kawada K, Matsuda S, Hasegawa S, Shinohara H, Sakai Y
    • Organizer
      第73回日本消化器外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Four-level concept based on three-dimensional muscular structure to facilitate the understanding of surgical anatomy for anterior dissection in trans-anal ISR/APR of male2018

    • Author(s)
      Okada T, Nakamura N, Hida K, Kawada K, Takai A, Shimokawa T, Matsuda S, Hasegawa S, Shinohara H, Sakai Y
    • Organizer
      European society of coloproctology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食道胃接合がん 胸腹連続性を考える.2018

    • Author(s)
      篠原尚
    • Organizer
      第90回日本胃癌学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] infracardiac bursaに関する臨床解剖および発生学的検証2017

    • Author(s)
      中村達郎,篠原 尚,坂井義治,他
    • Organizer
      第122回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Soft cadaverを用いた男性の肛門管前壁解剖の解明2017

    • Author(s)
      岡田倫明,篠原 尚,坂井義治,他
    • Organizer
      第122回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食道胃接合部の“閉鎖腔”とinfracardiac bursaの関連性2017

    • Author(s)
      中村達郎, 岡田倫明, 高井昭洋, 篠原 尚, 坂井義治, 他
    • Organizer
      第71回 手術手技研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食道胃接合部の微細解剖~Infracardiac bursa~2017

    • Author(s)
      中村達郎, 岡田倫明, 高井昭洋, 篠原 尚, 坂井義治, 他
    • Organizer
      第71回 日本食道学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食道胃接合部右側に存在する閉鎖腔の発生学的検証2017

    • Author(s)
      中村達郎, 岡田倫明, 高井昭洋, 篠原 尚, 坂井義治, 他
    • Organizer
      第30回 日本内視鏡外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 解剖所見に基づいたTransanal-ISRの前壁切離方法2017

    • Author(s)
      岡田倫明, 中村達郎, 高井昭洋, 篠原 尚, 坂井義治, 他
    • Organizer
      第30回 近畿内視鏡外科研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] hree steps technique of transanal ISR based on the surgical anatomy of male2017

    • Author(s)
      Tomoaki Okada, Hida Koya, Kenji Kawada, Yoshiharu Sakai
    • Organizer
      13th Asia-Pacific Congress of Endoscopic & Laparoscopic Surgery
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 局所再発症例に3Dシミュレータと術中ナビゲーションで挑む2017

    • Author(s)
      岡田倫明, 坂井義治, 他
    • Organizer
      第30回日本内視鏡外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Systematic mesogastric excision based on embryological principles for D2 lymphadenectomy in gastric cance surgery2017

    • Author(s)
      Shinohara H, Kurahashi Y, Niwa H, Oshima T, Kikuchi S, and Sasako M.
    • Organizer
      12th International Gastric Cancer Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] pplication of systematic mesogastric excision cconcept to modified D1 or D1 + lymphadenectomy in gastric cancer surgery using three-dimensional geography.2017

    • Author(s)
      Kurahashi Y, Shinohara H, Niwa H, Oshima T, Kikuchi S, and Sasako M.
    • Organizer
      12th International Gastric Cancer Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anatomy and Embryology of the Stomach2017

    • Author(s)
      Shinohara H
    • Organizer
      Annual Congress of Korean Surgical Society 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 発生・解剖の理解2017

    • Author(s)
      篠原尚
    • Organizer
      第72回日本消化器外科学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 胃癌に対するリンパ郭清としての網嚢切除は不要である。2017

    • Author(s)
      篠原尚、石田善敬、仁和浩貴、倉橋康典、中西保貴、小澤りえ、笹子三津留
    • Organizer
      第79回日本臨床外科学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 幽門下領域の微細化一坊に基づいた6番リンパ節の亜分類とその合理的郭清2017

    • Author(s)
      篠原尚、倉橋康典、石田善敬、仁和浩貴、中西保貴、小澤りえ、笹子三津留
    • Organizer
      第30回日本内視鏡外科学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 腸間膜の発生と解剖から考える胃癌根治手術2016

    • Author(s)
      篠原 尚、他
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 胃間膜の計画的切除による胃癌リンパ郭清の概念と鏡視下での実践2016

    • Author(s)
      篠原 尚、他
    • Organizer
      第41回日本外科系連合学会学術集会
    • Place of Presentation
      ナレッジキャピタルコングレコンベンションセンター(大阪府大阪市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 3D構築図に基づいた間膜の計画的切除による胃癌リンパ郭清の検証2016

    • Author(s)
      篠原 尚、他
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Book] Maingot’s Abdominal Operations 13th edition2018

    • Author(s)
      Shinohara H, Sasako M
    • Total Pages
      1504
    • Publisher
      McGraw-Hill, New York
    • ISBN
      9780071843072
    • Related Report
      2018 Annual Research Report
  • [Book] ビジュアルサージカル消化器外科手術上部消化管―イラストと動画で達人の手技を身につけるー2018

    • Author(s)
      篠原 尚
    • Total Pages
      192
    • Publisher
      秀潤社
    • ISBN
      9784780909661
    • Related Report
      2018 Annual Research Report
  • [Book] Laparoscopic Surgery for Colorectal Cancer2016

    • Author(s)
      Shinohara H, Hasegawa S, Tsunoda S, Hosogi H, Sakai Y
    • Total Pages
      238
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Remarks] 京都大学消化管外科

    • URL

      http://gisurg.kuhp.kyoto-u.ac.jp/info

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 愛媛大学医学部附属病院

    • URL

      https://www.hsp.ehime-u.ac.jp/upload/department_contents_file//22_588f03a67ca0d.pdf

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 兵庫医科大学上部消化管外科

    • URL

      http://www.hyo-med.ac.jp/department/gi-surgery/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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